The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Peroxynitrite rapidly permeates phospholipid membranes
Open accessAbstract
Peroxynitrite (ONOO − ) is a potent oxidant implicated in a number of pathophysiological processes. The activity of ONOO − is related to its accessibility to biological targets before its spontaneous decomposition ( t 1/2 ≈ 1 s at pH 7.4, 37°C). Using model phospholipid vesicular systems and manganese porphyrins as reporter molecules, we demonstrated that ONOO − freely crosses phospholipid membranes. The calculated permeability coefficient for ONOO − is ≈8.0 × 10 −4 cm⋅s −1 , which compares well with that of water and is ≈400 times greater than that of superoxide. We suggest that ONOO − is a significant biological effector molecule not only because of its reactivity but also because of its high diffusibility.
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Cited by
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Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
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Thiol chemistry and specificity in redox signaling
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Unraveling peroxynitrite formation in biological systems
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Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology
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Metadata
- Authors
- Marla, S. S., Lee, J., & Groves, J. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-12-23
- Volume
- 94
- Issue
- 26
- Pages
- 14243-14248
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1967865106
- Cited by
- 306
- References
- 47
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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