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A post-tetanic time window for the reinforcement of long-term potentiation by appetitive and aversive stimuli
Open accessAbstract
Current theories on the encoding and storage of information in the brain commonly suppose that a short-term memory is converted into a lasting one; thus, it becomes consolidated over time. Within a finite period after training, such a short-term memory can be reinforced by behavioral and humoral stimuli. We have found that, long-term potentiation (LTP), a likely candidate for a memory-encoding mechanism at the cellular level, displays similar features. LTP in the dentate gyrus of freely moving rats was reinforced after its induction by appetitive and aversive stimuli. The efficacy of these stimuli terminates about 1 h after tetanization, which may reflect the time constants of the mechanisms underlying the consolidation that takes place. The reinforcement by appetitive and aversive stimulation was blocked by the β-adrenergic antagonist propranolol, implicating norepinephrine in the underlying cellular processes.
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“Numerous other studies have replicated and extended this finding to show that a variety of arousing experiences, such as water immersion, exposure to novel places and objects, and spatial learning occurring around the time of the delivery of tetanizing stimulation, all increased the duration of LTP in CA1 and DG (e.g., Seidenbecher et al. [202]; Frey [203]; Li et al. [204]; Straube et al. [205];”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Seidenbecher et al. [202]
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Method
Metadata
- Authors
- Seidenbecher, T., Reymann, K. G., & Balschun, D.
- Affiliations
- Leibniz Institute for Neurobiology (DE)
- ORCID
- Balschun, Detlef
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1997-02-18
- Volume
- 94
- Issue
- 4
- Pages
- 1494-1499
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC19819
- OpenAlex
- W1974502920
- Cited by
- 154
- References
- 35
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 3
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, post-tetanic potentiation, memory consolidation, dentate gyrus, appetitive stimuli, aversive stimuli, norepinephrine, beta-adrenergic blockade, propranolol, short-term memory, synaptic plasticity
- MeSH terms
- Adrenergic beta-Antagonists, Animals, Appetitive Behavior, Male, Memory, Memory, Short-Term, Propranolol, Punishment, Reinforcement, Psychology, Reward, Tetany, Time Factors, Rats, Wistar, Long-Term Potentiation, Dentate Gyrus, Rats
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