Cited by 154Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

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A post-tetanic time window for the reinforcement of long-term potentiation by appetitive and aversive stimuli

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Seidenbecher, Thomas, Reymann, Klaus G., Balschun, Detlef·1997·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.94.4.1494PMC PMC19819

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Abstract

Current theories on the encoding and storage of information in the brain commonly suppose that a short-term memory is converted into a lasting one; thus, it becomes consolidated over time. Within a finite period after training, such a short-term memory can be reinforced by behavioral and humoral stimuli. We have found that, long-term potentiation (LTP), a likely candidate for a memory-encoding mechanism at the cellular level, displays similar features. LTP in the dentate gyrus of freely moving rats was reinforced after its induction by appetitive and aversive stimuli. The efficacy of these stimuli terminates about 1 h after tetanization, which may reflect the time constants of the mechanisms underlying the consolidation that takes place. The reinforcement by appetitive and aversive stimulation was blocked by the β-adrenergic antagonist propranolol, implicating norepinephrine in the underlying cellular processes.

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Authors: Seidenbecher, T., Reymann, K. G., & Balschun, D.
Affiliations: Leibniz Institute for Neurobiology (DE)
ORCID: Balschun, Detlef
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1997-02-18
Volume: 94
Issue: 4
Pages: 1494-1499
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.94.4.1494
PMC: PMC19819
OpenAlex: W1974502920
Cited by: 154
References: 35
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 3
FWCI: 2.95
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: long-term potentiation, post-tetanic potentiation, memory consolidation, dentate gyrus, appetitive stimuli, aversive stimuli, norepinephrine, beta-adrenergic blockade, propranolol, short-term memory, synaptic plasticity
MeSH terms: Adrenergic beta-Antagonists, Animals, Appetitive Behavior, Male, Memory, Memory, Short-Term, Propranolol, Punishment, Reinforcement, Psychology, Reward, Tetany, Time Factors, Rats, Wistar, Long-Term Potentiation, Dentate Gyrus, Rats

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A post-tetanic time window for the reinforcement of long-term potentiation by appetitive and aversive stimuli

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