The human glucocorticoid receptor: molecular basis of biologic function

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622 · see citing works

Williams Textbook of Endocrinology

Melmed, S., & Polonsky, K. С. (2016) · Elsevier eBooks · doi:10.1016/c2013-0-15980-6 · Cited by 3,716 · see citing works

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

Heery, D. M., Kalkhoven, E., Hoare, S., & Parker, M. G. (1997) · Nature · doi:10.1038/42750 · Cited by 2,134 · see citing works

Nuclear Receptor Coregulators: Cellular and Molecular Biology

McKenna, N. J., Lanz, R. B., & O’Malley, B. W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0366 · Cited by 1,905 · see citing works

Primary structure and expression of a functional human glucocorticoid receptor cDNA

Hollenberg, S. M., Weinberger, C., Ong, E. S., Cerelli, G., Oro, A. E., Lebo, R. V., Thompson, E. B., Rosenfeld, M. G., & Evans, R. M. (1985) · Nature · doi:10.1038/318635a0 · Cited by 1,871 · see citing works

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

Jonat, C., Rahmsdorf, H. J., Park, K.-K., Cato, A. C. B., Gebel, S., Ponta, H., & Herrlich, P. (1990) · Cell · doi:10.1016/0092-8674(90)90395-u · Cited by 1,544 · see citing works

Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators

McKenna, N. J., & O'Malley, B. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00641-4 · Cited by 1,463 · see citing works

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

Schüle, R., Rangarajan, P. N., Kliewer, S. A., Ransone, L. J., Bolado, J., Yang, N., Verma, I. M., & Evans, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90397-w · Cited by 1,204 · see citing works

Williams' Textbook of Endocrinology.

(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-816_5 · Cited by 1,156 · see citing works

DNA binding of the glucocorticoid receptor is not essential for survival

Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81183-6 · Cited by 1,068 · see citing works

Two signals mediate hormone‐dependent nuclear localization of the glucocorticoid receptor.

Picard, D., & Yamamoto, K. R. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02654.x · Cited by 960 · see citing works

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation

Cole, T. J., Blendy, J. A., Monaghan, A. P., Krieglstein, K., Schmid, W., Aguzzi, A., Fantuzzi, G., Hummler, E., Unsicker, K., & Schütz, G. (1995) · Genes & Development · doi:10.1101/gad.9.13.1608 · Cited by 946 · see citing works

Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to Glucocorticoids

Bamberger, C. M., Schulte, H. M., & Chrousos, G. P. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-3-245 · Cited by 892 · see citing works

Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors

Scheinman, R. I., Gualberto, A., Jewell, C. M., Cidlowski, J. A., & Baldwin, A. S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.943 · Cited by 819 · see citing works

Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition

Bledsoe, R. K., Montana, V. G., Stanley, T. B., Delves, C. J., Apolito, C. J., McKee, D. D., Consler, T. G., Parks, D. J., Stewart, E. L., Willson, T. M., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00817-6 · Cited by 818 · see citing works

Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB and Steroid Receptor-Signaling Pathways

McKay, L. I., & Cidlowski, J. A. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0375 · Cited by 805 · see citing works

Nuclear Receptor Coregulators: Cellular and Molecular Biology

McKenna, N. J. (1999) · Endocrine Reviews · doi:10.1210/er.20.3.321 · Cited by 782 · see citing works

Crystallographic comparison of the estrogen and progesterone receptor’s ligand binding domains

Tanenbaum, D. M., Wang, Y., Williams, S. P., & Sigler, P. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.5998 · Cited by 742 · see citing works

Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling

Thornton, J. W., Need, E. F., & Crews, D. P. (2003) · Science · doi:10.1126/science.1086185 · Cited by 700 · see citing works

GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.

Hong, H., Kohli, K. K., Trivedi, A. A., Johnson, D. L., & Stallcup, M. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4948 · Cited by 694 · see citing works

Functional interactions between Stat5 and the glucocorticoid receptor

Stöcklin, E., Wissler, M., Gouilleux, F., & Groner, B. (1996) · Nature · doi:10.1038/383726a0 · Cited by 675 · see citing works

Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions

Thornton, J. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091553298 · Cited by 674 · see citing works

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

Pratt, W. B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80556-0 · Cited by 644 · see citing works

Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression

Ito, K., Yamamura, S., Essilfie-Quaye, S., Cosio, B., Ito, M., Barnes, P. J., & Adcock, I. M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050466 · Cited by 638 · see citing works

Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

Galon, J., Franchimont, D., Hiroi, N., Frey, G., Boettner, A., Ehrhart-Bornstein, M., O’shea, J. J., Chrousos, G. P., & Bornstein, S. R. (2002) · The FASEB Journal · doi:10.1096/fj.01-0245com · Cited by 606 · see citing works

Evolution of Hormone-Receptor Complexity by Molecular Exploitation

Bridgham, J. T., Carroll, S. M., & Thornton, J. W. (2006) · Science · doi:10.1126/science.1123348 · Cited by 601 · see citing works

GRIP1, a Transcriptional Coactivator for the AF-2 Transactivation Domain of Steroid, Thyroid, Retinoid, and Vitamin D Receptors

Hong, H., Kohli, K. K., Garabedian, M. J., & Stallcup, M. R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2735 · Cited by 553 · see citing works

Crossing the Nuclear Envelope: Hierarchical Regulation of Nucleocytoplasmic Transport

Terry, L. J., Shows, E. B., & Wente, S. R. (2007) · Science · doi:10.1126/science.1142204 · Cited by 543 · see citing works

A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP‐1.

Heck, S., Kullmann, M. K., Gast, A., Ponta, H., Rahmsdorf, H. J., Herrlich, P. A., & Cato, A. C. B. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06726.x · Cited by 516 · see citing works

Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes

Lu, N. Z., & Cidlowski, J. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.025 · Cited by 455 · see citing works

The Dominant Negative Activity of the Human Glucocorticoid Receptor β Isoform

Oakley, R. H., Jewell, C. M., Yudt, M. R., Bofetiado, D. M., & Cidlowski, J. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27857 · Cited by 451 · see citing works

Crystal Structure of an Ancient Protein: Evolution by Conformational Epistasis

Ortlund, E., Bridgham, J., Redinbo, M., & Thornton, J. W. (2007) · Science · doi:10.1126/science.1142819 · Cited by 438 · see citing works

Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities

Ding, X. F., Anderson, C. M., Ma, H., Hong, H., Uht, R. M., Kushner, P. J., & Stallcup, M. R. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.2.0065 · Cited by 434 · see citing works

Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor

Reichardt, H. M., Tuckermann, J. P., Göttlicher, M., Vujic, M., Weih, F., Angel, P., Herrlich, P., & Schütz, G. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7168 · Cited by 429 · see citing works

A New First Step in Activation of Steroid Receptors

Davies, T. H., Ning, Y.-M., & Sánchez, E. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100531200 · Cited by 427 · see citing works

Molecular mechanisms of glucocorticoid action and resistance

Schaaf, M. J. M., & Cidlowski, J. A. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00263-7 · Cited by 417 · see citing works

Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functionsProceedings of Xth International Congress on Hormonal Steroids, Quebec, Canada, 17–21 June 1998.

McKenna, N. J., Xu, J., Nawaz, Z., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00144-7 · Cited by 408 · see citing works

Interaction of Steroid Hormone Receptors with the Transcription Initiation Complex

Beato, M., & Sánchez‐Pacheco, A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-6-587 · Cited by 402 · see citing works

Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition

van Rossum, E. F. C. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.333 · Cited by 381 · see citing works

Transcriptional cross-talk, the second mode of steroid hormone receptor action

Göttlicher, M., Heck, S., & Herrlich, P. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050242 · Cited by 380 · see citing works

Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance

Hurley, D. M., Accili, D., Stratakis, C. A., Karl, M., Vamvakopoulos, N., Rorer, E., Constantine, K., Taylor, S. I., & Chrousos, G. P. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115046 · Cited by 370 · see citing works

The human glucocorticoid receptor: One gene, multiple proteins and diverse responses

Zhou, J., & Cidlowski, J. A. (2005) · Steroids · doi:10.1016/j.steroids.2005.02.006 · Cited by 369 · see citing works

Coordinate Regulation of Transcription and Splicing by Steroid Receptor Coregulators

Auboeuf, D., Hönig, A., Berget, S. M., & O’Malley, B. W. (2002) · Science · doi:10.1126/science.1073734 · Cited by 357 · see citing works

Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications

Nader, N., Chrousos, G. P., & Kino, T. (2009) · The FASEB Journal · doi:10.1096/fj.08-117697 · Cited by 341 · see citing works

A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels

van Rossum, E. F. C., Koper, J. W., Huizenga, N. A. T. M., Uitterlinden, A. G., Janssen, J. A. M. J. L., Brinkmann, A. O., Grobbee, D. E., de Jong, F. H., van Duyn, C. M., Pols, H. A. P., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.10.3128 · Cited by 329 · see citing works

Deciphering the Phosphorylation “Code” of the Glucocorticoid Receptor in Vivo

Wang, Z., Frederick, J., & Garabedian, M. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110530200 · Cited by 321 · see citing works

Modulation of Glucocorticoid Receptor Function via Phosphorylation

ISMAILI, N., & GARABEDIAN, M. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.007 · Cited by 318 · see citing works

Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index

van Rossum, E. F. C., Koper, J. W., van den Beld, A. W., Uitterlinden, A. G., Arp, P., Ester, W. A., Janssen, J. A. M. J. L., Brinkmann, A. O., de Jong, F. H., Grobbee, D. E., et al. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01888.x · Cited by 315 · see citing works

Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase

Rogatsky, I., Logan, S. K., & Garabedian, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2050 · Cited by 297 · see citing works

Glucocorticoid action networks and complex psychiatric and/or somatic disorders

Chrousos, G. P., & Kino, T. (2007) · Stress · doi:10.1080/10253890701292119 · Cited by 292 · see citing works

Interference between pathway‐specific transcription factors: glucocorticoids antagonize phorbol ester‐induced AP‐1 activity without altering AP‐1 site occupation in vivo.

König, H., Ponta, H., Rahmsdorf, H. J., & Herrlich, P. A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05283.x · Cited by 271 · see citing works

Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification

Duma, D., Jewell, C. M., & Cidlowski, J. A. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.09.009 · Cited by 267 · see citing works

A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo

Huizenga, N. A. T. M. (1998) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.1.144 · Cited by 265 · see citing works

The Three-dimensional Structures of Antagonistic and Agonistic Forms of the Glucocorticoid Receptor Ligand-binding Domain

Kauppi, B., Jakob, C., Färnegårdh, M., Yang, J., Ahola, H., Alarcon, M., Calles, K., Engström, O., Harlan, J., Muchmore, S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212711200 · Cited by 250 · see citing works

Primary cortisol resistance in man. A glucocorticoid receptor-mediated disease.

Chrousos, G. P., Vingerhoeds, A. C. M., Brandon, D. D., Eil, C., Pugeat, M., Devroede, M., Loriaux, D. L., & LIPSETT, M. B. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110565 · Cited by 249 · see citing works

A Glucocorticoid Receptor Gene Marker Is Associated with Abdominal Obesity, Leptin, and Dysregulation of the Hypothalamic‐Pituitary‐Adrenal Axis

Rosmond, R., Chagnon, Y. C., Holm, G., Chagnon, M., Përusse, L., Lindell, K., Carlsson, B., Bouchard, C., & Björntorp, P. A. (2000) · Obesity Research · doi:10.1038/oby.2000.24 · Cited by 247 · see citing works

Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene

Karl, M., Lamberts, S. W., Detera-Wadleigh, S. D., Encio, I. J., Stratakis, C. A., Hurley, D. M., Accili, D., & Chrousos, G. P. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.3.8445027 · Cited by 241 · see citing works

Intracellular Glucocorticoid Signaling: A Formerly Simple System Turns Stochastic

Chrousos, G. P., & Kino, T. (2005) · Science s STKE · doi:10.1126/stke.3042005pe48 · Cited by 241 · see citing works

p38 Mitogen-Activated Protein Kinase (MAPK) Is a Key Mediator in Glucocorticoid-Induced Apoptosis of Lymphoid Cells: Correlation between p38 MAPK Activation and Site-Specific Phosphorylation of the Human Glucocorticoid Receptor at Serine 211

Miller, A. L., Webb, M. S., Copik, A. J., Wang, Y., Johnson, B. H., Kumar, P., & Thompson, E. B. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0528 · Cited by 241 · see citing works

Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation

Itoh, M., Adachi, M., Yasui, H., Takekawa, M., Tanaka, H., & Imai, K. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0144 · Cited by 238 · see citing works

Syndromes of Glucocorticoid Resistance

Chrousos, G. P., Detera-Wadleigh, S. D., & Karl, M. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-11-199312010-00009 · Cited by 235 · see citing works

Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance

Koper, J. W., Stolk, R. P., de Lange, P., Huizenga, N. A. T. M., Molijn, G. J., Pols, H. A. P., Grobbee, D. E., Karl, M., de Jong, F. H., Brinkmann, A. O., et al. (1997) · Human Genetics · doi:10.1007/s004390050425 · Cited by 230 · see citing works

Gene Family Evolution and Homology: Genomics Meets Phylogenetics

Thornton, J. W., & DeSalle, R. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.41 · Cited by 225 · see citing works

Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor- B and Steroid Receptor-Signaling Pathways

McKay, L. I. (1999) · Endocrine Reviews · doi:10.1210/er.20.4.435 · Cited by 223 · see citing works

Discrimination between NL1- and NL2-Mediated Nuclear Localization of the Glucocorticoid Receptor

Savory, J. G. A., Hsu, B., Laquian, I. R., Giffin, W., Reich, T., Haché, R. J. G., & Lefebvre, Y. A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1025 · Cited by 222 · see citing works

A mutation of the glucocorticoid receptor in primary cortisol resistance.

Malchoff, D. M., Brufsky, A., REARDON, G. E., McDermott, P., Javier, E. C., Bergh, C. ‐., Rowe, D. W., & Malchoff, C. D. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116410 · Cited by 213 · see citing works

Generalized Glucocorticoid Resistance: Clinical Aspects, Molecular Mechanisms, and Implications of a Rare Genetic Disorder

Charmandari, E., Kino, T., Ichijo, T., & Chrousos, G. P. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0040 · Cited by 201 · see citing works

Two Polymorphisms in the Glucocorticoid Receptor Gene Directly Affect Glucocorticoid-Regulated Gene Expression

Russcher, H., Smit, P., van den Akker, E. L. T., van Rossum, E. F. C., Brinkmann, A. O., de Jong, F. H., Lamberts, S. W. J., & Koper, J. W. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0646 · Cited by 200 · see citing works

Intracellular Localization of the Glucocorticoid Receptor: Evidence for Cytoplasmic and Nuclear Localization*

Wikström, A., Bakke, O., Okret, S., Brönnegård, M., & Gustafsson, J.-Α. (1987) · Endocrinology · doi:10.1210/endo-120-4-1232 · Cited by 192 · see citing works

Abdominal Visceral Fat is Associated with a BclI Restriction Fragment Length Polymorphism at the Glucocorticoid Receptor Gene Locus

Buemann, B., Vohl, M., Chagnon, M., Chagnon, Y. C., Gagnon, J., Përusse, L., Dionne, F. T., Després, J., Tremblay, A., Nadeau, A., et al. (1997) · Obesity Research · doi:10.1002/j.1550-8528.1997.tb00292.x · Cited by 189 · see citing works

DNA binding domains in diverse nuclear receptors function as nuclear export signals

Black, B. E., Holaska, J. M., Rastinejad, F., & Paschal, B. M. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00537-1 · Cited by 189 · see citing works

Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor

Tian, S., Poukka, H., Palvimo, J. J., & Jänne, O. A. (2002) · Biochemical Journal · doi:10.1042/bj20021085 · Cited by 182 · see citing works

Physical and functional association of RNA polymerase II and the proteasome.

Gillette, T., Gonzalez, F., Delahodde, A., Johnston, S. A., & Kodadek, T. (2004) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0305411101 · Cited by 182 · see citing works

Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation.

Karl, M., Lamberts, S. W. J., Koper, J. W., Katz, D. A., Huizenga, N. A. T. M., Kino, T., Haddad, B. R., Hughes, M. R., & Chrousos, G. P. (1996) · PubMed · Cited by 180 · see citing works

An association between a Bc1I restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women.

Weaver, J. U., Hitman, G., & Kopelman, P. (1992) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0090295 · Cited by 180 · see citing works

Glucocorticoid receptor (GR) β has intrinsic, GRα-independent transcriptional activity

Kino, T., Manoli, I., Kelkar, S., Wang, Y., Su, Y. A., & Chrousos, G. P. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.110 · Cited by 175 · see citing works

AP-1--glucocorticoid receptor crosstalk taken to a higher level

Karin, M., & Chang, L. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1690447 · Cited by 167 · see citing works

Spontaneous Hypercortisolism without Cushing's Syndrome

Vingerhoeds, A. C. M., Thijssen, J. H. H., & Schwarz, F. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-43-5-1128 · Cited by 167 · see citing works

Proteasomal inhibition enhances glucocorticoid receptor transactivation and alters its subnuclear trafficking

Deroo, B. J., Rentsch, C., Sampath, S., Young, J., DeFranco, D. B., & Archer, T. K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4113-4123.2002 · Cited by 164 · see citing works

The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults

van Rossum, E. F. C., Voorhoeve, P. G., te Velde, S. J., Koper, J. W., Delemarre-van de Waal, H. A., Kemper, H. C. G., & Lamberts, S. W. J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031422 · Cited by 164 · see citing works

Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance

Ruiz, M., Lind, U., Gåfvels, M. E., Eggertsen, G., Carlstedt‐Duke, J., Nilsson, L., Holtmann, M. H., Stierna, P., Wikström, A., & Werner, S. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01323.x · Cited by 164 · see citing works

Potentiation of glucocorticoid receptor transcriptional activity by sumoylation

Le Drean, Y., Mincheneau, N., Le Goff, P., & Michel, D. (2002) · Endocrinology · doi:10.1210/en.2002-220135 · Cited by 159 · see citing works

Multiple Promoters Exist in the Human GR Gene, One of Which Is Activated by Glucocorticoids

Breslin, M. B., Geng, C.-D., & Vedeckis, W. V. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.8.0696 · Cited by 157 · see citing works

Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy

Holmstrom, S. R., Antwerp, M. E. V., & Iñiguez-Lluhı́, J. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2136933100 · Cited by 154 · see citing works

Tissue glucocorticoid resistance/hypersensitivity syndromes

Kino, T., Martino, M. U. D., Charmandari, E., Mirani, M., & Chrousos, G. P. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00218-8 · Cited by 150 · see citing works

The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients

Blasio, A. M. D., van Rossum, E. F. C., Maestrini, S., Berselli, M. E., Tagliaferri, M., Podestà, F., Koper, J. W., Liuzzi, A., & Lamberts, S. W. J. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01798.x · Cited by 143 · see citing works

Phosphorylation and Inhibition of Rat Glucocorticoid Receptor Transcriptional Activation by Glycogen Synthase Kinase-3 (GSK-3)

Rogatsky, I., Waase, C. L. M., & Garabedian, M. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14315 · Cited by 139 · see citing works

Glycogen Synthase Kinase 3β-Mediated Serine Phosphorylation of the Human Glucocorticoid Receptor Redirects Gene Expression Profiles

Galliher-Beckley, A. J., Williams, J. G., Collins, J. B., & Cidlowski, J. A. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00808-08 · Cited by 136 · see citing works

The N363S Polymorphism of the Glucocorticoid Receptor: Potential Contribution to Central Obesity in Men and Lack of Association with Other Risk Factors for Coronary Heart Disease and Diabetes Mellitus1

Dobson, M. G., Redfern, C. P. F., Unwin, N. C., & Weaver, J. U. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7465 · Cited by 132 · see citing works

Female Pseudohermaphroditism Caused by a Novel Homozygous Missense Mutation of the GR Gene

Mendonca, B. B., Leite, M. V., de Castro, M., Kino, T., Elias, L. L. K., Bachega, T. A. S. S., Arnhold, I. J. P., Chrousos, G. P., & Latronico, A. C. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8379 · Cited by 131 · see citing works

Cyclin-Dependent Kinase 5 Differentially Regulates the Transcriptional Activity of the Glucocorticoid Receptor through Phosphorylation: Clinical Implications for the Nervous System Response to Glucocorticoids and Stress

Kino, T., Ichijo, T., Amin, N. D., Kesavapany, S., Wang, Y., Kim, N., Rao, S., Player, A. N., Zheng, Y., Garabedian, M. J., et al. (2007) · Molecular Endocrinology · doi:10.1210/me.2006-0345 · Cited by 129 · see citing works

The constitution of a progesterone response element

Lieberman, B. A., Bona, B. J., Edwards, D. P., & Nordeen, S. K. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.4.8388996 · Cited by 128 · see citing works

A Novel, C-Terminal Dominant Negative Mutation of the GR Causes Familial Glucocorticoid Resistance through Abnormal Interactions with p160 Steroid Receptor Coactivators

Vottero, A., Kino, T., Combe, H., Lecomte, P., & Chrousos, G. P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8520 · Cited by 125 · see citing works

Ca2+-Dependent Nuclear Export Mediated by Calreticulin

Holaska, J. M., Black, B. E., Rastinejad, F., & Paschal, B. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6286-6297.2002 · Cited by 113 · see citing works

Linking the ubiquitin–proteasome pathway to chromatin remodeling/modification by nuclear receptors

Kinyamu, H. K., Chen, J., & Archer, T. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01680 · Cited by 112 · see citing works

Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes

Kino, T., & Chrousos, G. P. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1690437 · Cited by 109 · see citing works

Association of Coronary Artery Disease With Glucocorticoid Receptor N363S Variant

Lin, R. C. Y., Wang, X.-L., & Morris, B. (2003) · HYPERTENSION · doi:10.1161/01.hyp.0000055342.40301.dc · Cited by 109 · see citing works

Increased Expression of the Glucocorticoid Receptor-A Translational Isoform as a Result of the ER22/23EK Polymorphism

Russcher, H., van Rossum, E. F. C., de Jong, F. H., Brinkmann, A. O., Lamberts, S. W. J., & Koper, J. W. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0467 · Cited by 108 · see citing works

Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking

Kino, T., Stauber, R. H., Resau, J. H., Pavlakis, G. N., & Chrousos, G. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.8017 · Cited by 105 · see citing works

A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity

Charmandari, E., Raji, A., Kino, T., Ichijo, T., Tiulpakov, A. N., Zachman, K., & Chrousos, G. P. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1920 · Cited by 103 · see citing works

Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men

van Rossum, E. F. C., Feelders, R. A., van den Beld, A. W., Uitterlinden, A. G., Janssen, J. A. M. J. L., Ester, W. A., Brinkmann, A. O., Grobbee, D. E., de Jong, F. H., Pols, H. A. P., et al. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.01.027 · Cited by 101 · see citing works

Pituitary-Adrenal Function in the Squirrel Monkey

Brown, G. M., Grota, L. J., Penney, D. P., & Reichlin, S. (1970) · Endocrinology · doi:10.1210/endo-86-3-519 · Cited by 100 · see citing works

Protracted Nuclear Export of Glucocorticoid Receptor Limits Its Turnover and Does Not Require the Exportin 1/CRM1-Directed Nuclear Export Pathway

Liu, J., & DeFranco, D. B. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.1.0398 · Cited by 100 · see citing works

Clinical aspects of glucocorticoid sensitivity

Lamberts, S. W. J., Huizenga, A. T. M., de Lange, P., de Jong, F. H., & Koper, J. W. (1996) · Steroids · doi:10.1016/0039-128x(96)00005-0 · Cited by 99 · see citing works

Natural Glucocorticoid Receptor Mutants Causing Generalized Glucocorticoid Resistance: Molecular Genotype, Genetic Transmission, and Clinical Phenotype

Charmandari, E., Kino, T., Souvatzoglou, E., Vottero, A., Bhattacharyya, N., & Chrousos, G. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030450 · Cited by 98 · see citing works

Glucocorticoid Action Networks—An Introduction to Systems Biology

Chrousos, G. P., Charmandari, E., & Kino, T. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032026 · Cited by 90 · see citing works

Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor N363S variant

Lin, R. C. Y., Wang, X. L., Dalziel, B., Caterson, I. D., & Morris, B. J. (2003) · Obesity Research · doi:10.1038/oby.2003.111 · Cited by 83 · see citing works

v-mosOncoproteins Affect the Nuclear Retention and Reutilization of Glucocorticoid Receptors

Ming Xin, Q. I., Hamilton, B. J., & DeFranco, D. B. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-8-1279 · Cited by 83 · see citing works

The N363S Polymorphism of the Glucocorticoid Receptor: Potential Contribution to Central Obesity in Men and Lack of Association with Other Risk Factors for Coronary Heart Disease and Diabetes Mellitus

Dobson, M. G. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.5.2270 · Cited by 81 · see citing works

A Novel Point Mutation in Helix 11 of the Ligand-Binding Domain of the Human Glucocorticoid Receptor Gene Causing Generalized Glucocorticoid Resistance

Charmandari, E., Kino, T., Ichijo, T., Jubiz, W., Mejia, L., Zachman, K., & Chrousos, G. P. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2830 · Cited by 80 · see citing works

Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and abdominal fat in the Québec Family Study

Ukkola, O. H., Përusse, L., Chagnon, Y. C., Després, J., & Bouchard, C. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801735 · Cited by 77 · see citing works

Molecular Mechanisms of Immunosuppression and Anti-Inflammatory Activities by Glucocorticoids

DiDonato, J. A., Saatcioglu, F., & Karin, M. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/154.2_pt_2.s11 · Cited by 77 · see citing works

Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms

CHARMANDARI, E., KINO, T., & CHROUSOS, G. P. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.014 · Cited by 76 · see citing works

Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphisms

van Rossum, E. V., Roks, P. H. M., de Jong, F. D., Brinkmann, A. O., Pols, H. A., Koper, J., & Lamberts, S. W. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02132.x · Cited by 74 · see citing works

Interaction of the Ubc9 human homologue with c-Jun and with the glucocorticoid receptor

Göttlicher, M., Heck, S., Doucas, V., Wade, E. J., Kullmann, M. K., Cato, A. C. B., Evans, R. M., & Herrlich, P. A. (1996) · Steroids · doi:10.1016/0039-128x(96)00032-3 · Cited by 72 · see citing works

The N363S polymorphism in the glucocorticoid receptor gene is associated with overweight in subjects with type 2 diabetes mellitus

Roussel, R., Reis, A. F., Dubois‐Laforgue, D., Bellanné‐Chantelot, C., Timsit, J., & Velho, G. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01831.x · Cited by 72 · see citing works

Kinetics of glucocorticoid receptor phosphorylation in intact cells. Evidence for hormone-induced hyperphosphorylation after activation and recycling of hyperphosphorylated receptors.

Ortí, E., Hu, L. M., & Munck, A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53026-x · Cited by 70 · see citing works

Association of Glucocorticoid Receptor Polymorphism A3669G in Exon 9β with Reduced Central Adiposity in Women

Syed, A. A., Irving, J. A. E., Redfern, C. P. F., Hall, A. G., Unwin, N. C., White, M. J., Bhopal, R. S., & Weaver, J. U. (2006) · Obesity · doi:10.1038/oby.2006.86 · Cited by 69 · see citing works

Rush hour at the promoter: How the ubiquitin-proteasome pathway polices the traffic flow of nuclear receptor-dependent transcription

Dennis, A. P., & O’Malley, B. W. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.12.015 · Cited by 67 · see citing works

Protein Tyrosine Kinase cDNAs from Amphioxus, Hagfish, and Lamprey: Isoform Duplications Around the Divergence of Cyclostomes and Gnathostomes

Suga, H., Hoshiyama, D., Kuraku, S., Katoh, K., Kubokawa, K., & Miyata, T. (1999) · Journal of Molecular Evolution · doi:10.1007/pl00006581 · Cited by 67 · see citing works

Squirrel Monkey Immunophilin FKBP51 Is a Potent Inhibitor of Glucocorticoid Receptor Binding¹

Denny, W. B., Valentine, D. L., Reynolds, P. D., Smith, D. F., & Scammell, J. G. (2000) · Endocrinology · doi:10.1210/en.141.11.4107 · Cited by 66 · cited 1× · see citing works

A Novel Point Mutation in the Amino Terminal Domain of the Human Glucocorticoid Receptor (hGR) Gene Enhancing hGR-Mediated Gene Expression

Charmandari, E., Ichijo, T., Jubiz, W., Baid, S. K., Zachman, K., Chrousos, G. P., & Kino, T. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0892 · Cited by 65 · see citing works

Functional Characterization of the Natural Human Glucocorticoid Receptor (hGR) Mutants hGRαR477H and hGRαG679S Associated with Generalized Glucocorticoid Resistance

Charmandari, E., Kino, T., Ichijo, T., Zachman, K., Alatsatianos, A., & Chrousos, G. P. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1893 · Cited by 64 · see citing works

An Active Nuclear Retention Signal in the Glucocorticoid Receptor Functions as a Strong Inducer of Transcriptional Activation

Carrigan, A., Walther, R. F., Salem, H. A., Wu, D., Atlas, E., Lefebvre, Y. A., & Haché, R. J. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m602931200 · Cited by 62 · see citing works

Glucocorticoid receptor ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9.

Cho, S., Kagan, B. L., Blackford, J., Szapary, D., & Simons, S. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0134 · Cited by 54 · see citing works

Differential Regulation of Synthetic Glucocorticoids on Gene Expression Levels of Glucocorticoid-Induced Leucine Zipper and Interleukin-2

Smit, P., Russcher, H., de Jong, F. H., Brinkmann, A. O., Lamberts, S. W. J., & Koper, J. W. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2298 · Cited by 54 · see citing works

Familial/Sporadic Glucocorticoid Resistance Syndrome and Hypertension

Kino, T., Vottero, A., Charmandari, E., & Chrousos, G. P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04416.x · Cited by 50 · see citing works

The glucocorticoid receptor gene, longevity, and the complex disorders of Western societies

Chrousos, G. P. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.05.006 · Cited by 48 · see citing works

Role of the C terminus of the glucocorticoid receptor in hormone binding and agonist/antagonist discrimination.

Zhang, S., Liang, X., & Danielsen, M. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.1.8838142 · Cited by 48 · see citing works

Multiple Promoters Exist in the Human GR Gene, One of Which Is Activated by Glucocorticoids

Breslin, M. B. (2001) · Molecular Endocrinology · doi:10.1210/me.15.8.1381 · Cited by 40 · see citing works

A Critical Region in the Mineralocorticoid Receptor for Aldosterone Binding and Activation by Cortisol: Evidence for a Common Mechanism Governing Ligand Binding Specificity in Steroid Hormone Receptors

Rogerson, F. M., Yao, Y.-Z., Elsass, R. E., Dimopoulos, N., Smith, B. J., & Fuller, P. J. (2007) · Molecular Endocrinology · doi:10.1210/me.2006-0246 · Cited by 39 · see citing works

Tissue-specific glucocorticoid resistance-hypersensitivity syndromes: Multifactorial states of clinical importance

Kino, T., & Chrousos, G. P. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.123708 · Cited by 38 · see citing works

Residues in the Ligand Binding Domain That Confer Progestin or Glucocorticoid Specificity and Modulate the Receptor Transactivation Capacity

Robin-Jagerschmidt, C., Wurtz, J., Guillot, B., et al. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.7.0484 · Cited by 36 · see citing works

Glucocorticoid Receptor Mutants Demonstrate Increased Motility Inside the Nucleus of Living Cells: Time of Fluorescence Recovery After Photobleaching (FRAP) Is an Integrated Measure of Receptor Function

Kino, T., Liou, S.-H., Charmandari, E., & Chrousos, G. P. (2004) · Molecular Medicine · doi:10.2119/2005-00026.kino · Cited by 34 · see citing works

A TthIII1 polymorphism on the 5′ flanking region of the glucocorticoid receptor gene (GRL)

Detera‐Wadleigh, S. D., Encı́o, I., Rollins, D. Y., et al. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.8.1960-a · Cited by 28 · see citing works

Role of the C terminus of the glucocorticoid receptor in hormone binding and agonist/antagonist discrimination

Zhang, S. (1996) · Molecular Endocrinology · doi:10.1210/me.10.1.24 · Cited by 21 · see citing works

Hormone resistance and hypersensitivity states

Chrousos, G. P., Olefsky, J. M., & Samols, E. (2002) · Cited by 16 · see citing works

Residues in the Ligand Binding Domain That Confer Progestin or Glucocorticoid Specificity and Modulate the Receptor Transactivation Capacity

Robin-Jagerschmidt, C. (2000) · Molecular Endocrinology · doi:10.1210/me.14.7.1028 · Cited by 15 · see citing works

Novel Causes of Generalized Glucocorticoid Resistance

Charmandari, E., & Kino, T. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-980196 · Cited by 13 · see citing works

Adrenal insufficiency

Charmandari, E., Nicolaides, N. C., & Chrousos, G. P. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61684-0 · Cited by 644 · see citing works

Stress, the Stress System and the Role of Glucocorticoids

Nicolaides, N. C., Kyratzi, E., Lamprokostopoulou, A., Chrousos, G. P., & Charmandari, E. (2015) · Neuroimmunomodulation · doi:10.1159/000362736 · Cited by 477 · see citing works

Stress, epigenetics and depression: A systematic review

Park, C., Rosenblat, J. D., Brietzke, E., Pan, Z., Lee, Y., Cao, B., Zuckerman, H., Kalantarova, A., & McIntyre, R. S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.010 · Cited by 465 · see citing works

The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain

Bellavance, M.-A., & Rivest, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00136 · Cited by 419 · see citing works

Steroidogenesis in the skin: Implications for local immune functions

Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works

Epigenetics and the regulation of stress vulnerability and resilience

Zannas, A. S., & West, A. E. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.003 · Cited by 211 · see citing works

Circadian endocrine rhythms: the hypothalamic–pituitary–adrenal axis and its actions

Nicolaides, N. C., Charmandari, E., Chrousos, G. P., & Kino, T. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12464 · Cited by 183 · see citing works

The circadian clock and glucocorticoids – interactions across many time scales

Dickmeis, T., Weger, B. D., & Weger, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.05.012 · Cited by 144 · see citing works

Optimized glucocorticoid therapy: teaching old drugs new tricks

Strehl, C., & Buttgereit, F. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.01.026 · Cited by 118 · see citing works

Glucocorticoid resistance as a major drive in sepsis pathology

Dendoncker, K., & Libert, C. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.04.002 · Cited by 85 · see citing works

Recent advances in the molecular mechanisms determining tissue sensitivity to glucocorticoids: novel mutations, circadian rhythm and ligand-induced repression of the human glucocorticoid receptor

Nicolaides, N. C., Charmandari, E., Chrousos, G. P., & Kino, T. (2014) · BMC Endocrine Disorders · doi:10.1186/1472-6823-14-71 · Cited by 83 · see citing works

Encoding and decoding mechanisms of pulsatile hormone secretion

Walker, J. J., Terry, J. R., Tsaneva‐Atanasova, K., Armstrong, S. P., McArdle, C. A., & Lightman, S. L. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02087.x · Cited by 78 · see citing works

Mechanisms of brain glucocorticoid resistance in stress-induced psychopathologies

Merkulov, V. M., Merkulova, T. I., & Bondar, N. P. (2017) · Biochemistry (Moscow) · doi:10.1134/s0006297917030142 · Cited by 65 · see citing works

Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased mortality

Vardas, K., Ilia, S., Sertedaki, A., Charmandari, E., Briassouli, E., Goukos, D., Apostolou, K., Psarra, K., Botoula, E., Tsagarakis, S., et al. (2017) · Intensive Care Medicine Experimental · doi:10.1186/s40635-017-0123-8 · Cited by 58 · see citing works

Novel insights into the molecular mechanisms underlying generalized glucocorticoid resistance and hypersensitivity syndromes

Nicolaides, N. C., & Charmandari, E. (2017) · Hormones · doi:10.14310/horm.2002.1728 · Cited by 52 · see citing works

SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress

Zayed, A., Baranowski, C., Compagnion, A.-C., Vernochet, C., Karaki, S., Cuttoli, R. D.-D., Saint-Jour, E., Bhattacharya, S., Marti, F., Vanhoutte, P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29380-8 · Cited by 17 · see citing works

Glucocorticoid receptor and Cancer

Stewart, J. K. (2021) · Journal of Steroids & Hormonal Science

Mouse Zac1, a Transcriptional Coactivator and Repressor for Nuclear Receptors

Huang, S., & Stallcup, M. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1855-1867.2000 · Cited by 148 · see citing works

Mechanisms of disease: regulation of glucocorticoid and receptor levels – impact on the metabolic syndrome

Witchel, S. F., & DeFranco, D. B. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0323 · Cited by 58 · see citing works

Potentiation of glucocorticoid-mediated gene expression by the novel benzoquinone derivative (2E)-3-65-(2,3-dimethoxy-o-methyl-1,4-benzoquinoyl)9- 2-nonyl-2-propenoic acid (E3330)

Tanaka, H. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)90087-x

Potentiation of glucocorticoid-mediated gene expression by the novel benzoquinone derivative (2E)-3-[5-(2,3-dimethoxy-o-methyl-1,4-benzoquinoyl)]-2-nonyl-2-propenoic acid (E3330)

Tanaka, H., Makino, Y., Hiramoto, M., Handa, H., & Makino, I. (1995) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(95)90133-7 · Cited by 3 · see citing works