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Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

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Kyriakis, John M., Avruch, Joseph·1996·Journal of Biological Chemistry

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Eukaryotic cells respond to extracellular stimuli by recruiting signal transduction pathways, many of which employ protein Ser/Thr kinases of the ERK1 family. The ubiquity of ERKs and their upstream activators, the MEKs, in signal transduction was first appreciated from studies of yeast (1, 2). Although a 54-kDa rat liver c-Jun kinase (SAPK-p54α1) with properties similar to the Ras-regulated MAPKs had been characterized (3, 4, 5), the physiologic roles and regulation of this and related mammalian enzymes have emerged only recently.

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Authors: Kyriakis, J. M., & Avruch, J.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1996-10
Volume: 271
Issue: 40
Pages: 24313-24316
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.271.40.24313
OpenAlex: W2047263793
Cited by: 1,084
References: 1
FWCI: 36.37
Type: journal article
Language: en
Open access: hybrid

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Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

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