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Combined use of leptin and mechanical stress has osteogenic effects on ossification of the posterior longitudinal ligament

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Cyclo-oxygenase-Independent Inhibition of Apoptosis and Stimulation of Proliferation by Leptin in Human Colon Cancer Cells

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Effects of leptin on endothelial function with OB-Rb gene transfer in Zucker fatty rats

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Leptin Receptor Compound Heterozygosity in Humans and Animal Models

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Ablation of Leptin Receptor-Mediated ERK Activation Impairs Host Defense against Gram-Negative Pneumonia

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The role of leptin in central nervous system diseases

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Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer

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Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice

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Inhibition of leptin-induced IL-1β expression by glucocorticoids in the brain

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Cardiovascular and Sympathetic Effects of Disrupting Tyrosine 985 of the Leptin Receptor

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Regulación central de la ingestión alimentaria y el gasto energético: acciones moleculares de la insulina, la leptina y el ejercicio físico

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Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone

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Identification and Saturable Nature of Signaling Pathways Induced by Metreleptin in Humans: Comparative Evaluation of In Vivo, Ex Vivo, and In Vitro Administration

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H2O2 and Src-dependent transactivation of the EGF receptor mediates the stimulatory effect of leptin on renal ERK and Na+, K+-ATPase

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Leptin and prolactin modulate the expression of SOCS-1 in association with interleukin-6 and tumor necrosis factor-α in mammary cells: a role in differentiated secretory epithelium

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Two opposite signaling outputs are driven by the KIR2DL1 receptor in human CD4+ T cells

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Sodium tungstate regulates food intake and body weight through activation of the hypothalamic leptin pathway

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Leptin Promotes cPLA2 Gene Expression through Activation of the MAPK/NF-κB/p300 Cascade

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Adipocytokines in renal transplant recipients

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Molecular mechanisms and neural mediators of leptin actionPreprint

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Therapeutic Approaches of Leptin in Alzheimers Disease

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Protein tyrosine phosphatase-1B contributes to LPS-induced leptin resistance in male rats

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The tyrosine phosphatase SHP‐2 regulates differentiation and apoptosis of individual primary T lymphocytes

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Leptin: From structural insights to the design of antagonists

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Seasonal leptin resistance is associated with impaired signalling via JAK2-STAT3 but not ERK, possibly mediated by reduced hypothalamic GRB2 protein

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The Regulation of the Male Hypothalamic-Pituitary-Gonadal Axis and Testosterone Production by Adipokines

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Therapeutic potential of leptin receptor modulators

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Leptin’s metabolic and immune functions can be uncoupled at the ligand/receptor interaction level

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Influence of Antioxidants on Leptin Metabolism and its Role in the Pathogenesis of Obesity

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The Role of Novel Biomarkers of Cardiovascular Disease in Chronic Kidney Disease: Focus on Adiponectin and Leptin

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A peroxisome-proliferator activated receptor-γ ligand could regulate the expression of leptin receptor on human hepatic stellate cells

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Leptin in Tumor Microenvironment

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A role of phosphodiesterase-3B pathway in mediating leptin action on proopiomelanocortin and neurotensin neurons in the hypothalamus

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Leptin-based therapeutics

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Influence of the core circadian gene “Clock” on obesity and leptin resistance in mice

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Roles of Gangliosides in Hypothalamic Control of Energy Balance: New Insights

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Two Isoforms of the Leptin Receptor Are Enhanced in Pregnancy-Specific Tissues and Soluble Leptin Receptor Is Enhanced in Maternal Serum with Advancing Gestation in the Baboon1

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Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2

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Phosphatidylinositol‐3 kinase mediates the sweet suppressive effect of leptin in mouse taste cells

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Antagonizing leptin: current status and future directions

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Phosphodiesterase-3B is expressed in proopiomelanocortin and neuropeptide Y neurons in the mouse hypothalamus

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Metabolic regulation by protein tyrosine phosphatases

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Amylin and Leptin interaction: Role During Pregnancy, Lactation and Neonatal Development

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Association Between Serum Leptin Level and Mortality in Kidney Transplant Recipients

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Leptin Receptors

Schulz, L. C., & Widmaier, E. P. (2006) · Springer eBooks · doi:10.1007/978-0-387-31416-7_2 · Cited by 13

Protein Kinase C Activation by Helicobacter pylori in Human Gastric Epithelial Cells Limits Interleukin-8 Production Through Suppression of Extracellular Signal-Regulated Kinase

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Effect of leptin on prolactin and insulin-like growth factor-I secretion by cultured rat endometrial stromal cells

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Adipocytokines: Emerging therapeutic targets for pain management

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Exploring Leptin Antagonism in Ophthalmic Cell Models

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Leptin receptor expressing neurons express phosphodiesterase-3B (PDE3B) and leptin induces STAT3 activation in PDE3B neurons in the mouse hypothalamus

Sahu, M., & Sahu, A. (2015) · Peptides · doi:10.1016/j.peptides.2015.08.011 · Cited by 11

Maternal obesity and ovarian failure: is leptin the culprit?

Sharma, Y., & Galvão, A. M. (2022) · Animal Reproduction · doi:10.1590/1984-3143-ar2023-0007 · Cited by 12

Breast feeding, obesity, and asthma association: clinical and molecular views

Kian, N., Bagheri, A., Salmanpour, F., Soltani, A., Mohajer, Z., Samieefar, N., Barekatain, B., & Kelishadi, R. (2023) · Clinical and Molecular Allergy · doi:10.1186/s12948-023-00189-0 · Cited by 12

Leptin enhances STAT-3 phosphorylation in HC11 cell line: Effect on cell differentiation and cell viability

Motta, M., Accornero, P., Taulli, R., Bernabei, P., Desrivières, S., & Baratta, M. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.09.010 · Cited by 10

Leptin inhibits the Na+/K+ ATPase in Caco-2 cells via PKC and p38MAPK

Zein, O. E., Usta, J. A., Moussawi, L. E., & Kreydiyyeh, S. I. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.12.004 · Cited by 10

Unravelling the Alzheimer's pathogenesis: Molecular and cellular pathways to neurodegeneration and therapeutic targets

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Intracellular interplay between cholecystokinin and leptin signalling for satiety control in rats

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Are common leptin promoter polymorphisms associated with restenosis after coronary stenting?

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Beyond nutrition: neuropeptide signaling and muscle mass maintenance in chronic kidney disease

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Leptin promotes tendon stem/progenitor cell senescence through the AKT-mTOR signaling pathway

Lei, C., Li, Y., Chen, J., Nie, D., Song, X., Lei, C., Zhou, Y., Wang, W., & Sun, J. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114274 · Cited by 6

Changes in Appetite Regulation-Related Signaling Pathways in the Brain of Mice Supplemented with Non-nutritive Sweeteners

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Obesity and chronic leptin resistance foster insulin resistance

Dey, S., Murmu, N., Böse, M., Ghosh, S., & Giri, B. (2021) · BLDE University Journal of Health Sciences · doi:10.4103/bjhs.bjhs_29_20 · Cited by 9

Research Advances on Suppressor of Cytokine Signaling 3 (SOCS3) in Animal Carbohydrate and Lipid Metabolism Processes

Liu, W., & Wang, X. (2022) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2022.1100.1108 · Cited by 6

KLF13 Regulates the Activity of the GH-Induced JAK/STAT Signaling by Targeting Genes Involved in the Pathway

Ávila-Mendoza, J., Delgado-Rueda, K., Urban-Sosa, V. A., Carranza, M., Luna, M., Martínez-Moreno, C. G., & Arámburo, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311187 · Cited by 6

Cytokines in Skeletal Muscle Growth and Decay

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Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain

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Central leptin pathways in metabolic homeostasis

Zhao, Y., Laule, C. F., & Rahmouni, K. (2025) · Clinical Science · doi:10.1042/cs20257748 · Cited by 5

Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer

Marques, V., Arella, F., Afonso, M. B., Santos, A. A., & Rodrigues, C. M. P. (2023) · Clinical Science · doi:10.1042/cs20230411 · Cited by 5

Leptin Involvement in Primary Brain and Pituitary Tumors: Therapeutic Potential, Prognostic Value, and Proposed Diagnostic Application

Bikis, C., Tzanavari, T., Alexandraki, K., & Theocharis, S. E. (2018) · Hormones and Cancer · doi:10.1007/s12672-018-0327-8 · Cited by 4

Relationship between plasma leptin or soluble cleaved leptin-receptor concentrations and glucocorticoid sensitivity of peripheral blood mononuclear cells in patients with nephrotic syndrome

Henmi, K., Yoshida, M., Yoshikawa, N., Nakabayashi, I., & Hirano, T. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.07.013 · Cited by 3

Acute anti‐obesity effects of intracerebroventricular 11β‐ HSD 1 inhibitor administration in diet‐induced obese mice

Seo, M., Islam, S. A., & Moon, S. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12580 · Cited by 3

An In Silico Study Investigating Camptothecin-Analog Interaction with Human Protein Tyrosine Phosphatase, SHP2 (PTPN11)

Bajia, D., & Derwich, K. (2023) · Pharmaceuticals · doi:10.3390/ph16070926 · Cited by 3

Roles of Leptin in Cancer Progression

Kang, Y., & Moon, A. (2010) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2010.18.4.363 · Cited by 3

Neurochemical Aspects of Alzheimer Disease

Farooqui, A. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-15889-1_1 · Cited by 2

Regulatory role of Heparan sulfate in leptin signaling

Nagai, N., Shioiri, T., Hatano, S., Sugiura, N., & Watanabe, H. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111456 · Cited by 2

Therapeutic Potential of Anti‐Diabetes Drugs and Anti‐Dyslipidemia Drugs to Mitigate Head and Neck Cancer Risk in Metabolic Syndrome

Yeom, S., Lee, D. H., & Song, J. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70446 · Cited by 3

Brain effects of leptin: What intracellular mechanism?

Rahmouni, K. (2003) · Current Diabetes Reports · doi:10.1007/s11892-003-0001-5 · Cited by 2

МОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ ДЕЙСТВИЯ ЛЕПТИНА НА ГИПОТАЛАМО-ГИПОФИЗАРНО-ГОНАДНУЮ ОСЬ, "Цитология"

Бахтюков, А. А., & Shpakov, A. O. (2018) · Tsitologiya · doi:10.7868/s0041377118100016 · Cited by 2

Decreased sensitivity to the anorectic effects of leptin in mice that lack a Pomc-specific neural enhancer

Na, E. S., Lam, D. D., Yokosawa, E. B., Adams, J. M., Olson, D. P., & Low, M. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0244793 · Cited by 2

Distributions and associations of single nucleotide polymorphisms in the leptin gene of Bos taurus and Bos indicus cattle

Fischer, Jr. (2007) · doi:10.31390/gradschool_theses.4301 · Cited by 2

Leptin Signaling in the Cardiovascular System

Karmazyn, M., Purdham, D. M., Rajapurohitam, V., & Zeidan, A. (2008) · Springer eBooks · doi:10.1007/978-0-387-09552-3_20 · Cited by 2

Cross-Regulation of JAK-STAT Signaling: Implications for Approaches to Combat Chronic Inflammatory Diseases and Cancers

Rutherford, C. L., Hayley, D., & Timothy, M. (2012) · InTech eBooks · doi:10.5772/36588 · Cited by 1

The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition

Hadley, C. K., Galgano, L., Gui, Y., Silva, A. C., Porter, D. T., Wu, Y., Lai, Y., Torti, M., & Çakır, I. (2026) · Nature Communications · doi:10.1038/s41467-026-69008-9 · Cited by 1

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

Li, C., & Friedman, J. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9677 · Cited by 176

Activation of Downstream Signals by the Long Form of the Leptin Receptor

Banks, A. S., Davis, S. M., Bates, S. H., & Myers, M. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14563 · Cited by 797

A model of activation of the protein tyrosine phosphatase SHP-2 by the human leptin receptor

Löthgren, A., McCartney, M., Thuresson, E. R., & James, S. R. (2001) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00257-0 · Cited by 10

Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

Carpenter, L. R., Farruggella, T. J., Symes, A. J., Karow, M. L., Yancopoulos, G. D., & Stahl, N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6061 · Cited by 176

Leptin Receptor Signaling and the Regulation of Mammalian Physiology

Myers, M. G. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.287 · Cited by 463