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Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors
Open accessAbstract
The protein tyrosine phosphatase SHP-2 has been proposed to serve as a regulator of leptin signaling, but its specific roles are not fully examined. To directly investigate the role of SHP-2, we employed dominant negative strategies in transfected cells. We show that a catalytically inactive mutant of SHP-2 blocks leptin-stimulated ERK phosphorylation by the long leptin receptor, ObRb. SHP-2, lacking two C-terminal tyrosine residues, partially inhibits ERK phosphorylation. We find similar effects of the SHP-2 mutants after examining stimulation of an ERK-dependent egr-1 promoter-construct by leptin. We also demonstrate ERK phosphorylation and egr-1 mRNA expression in the hypothalamus by leptin. Analysis of signaling by ObRb lacking intracellular tyrosine residues or by the short leptin receptor, ObRa, enabled us to conclude that two pathways are critical for ERK activation. One pathway does not require the intracellular domain of ObRb, whereas the other pathway requires tyrosine residue 985 of ObRb. The phosphatase activity of SHP-2 is required for both pathways, whereas activation of ERK via Tyr-985 of ObRb also requires tyrosine phosphorylation of SHP-2. SHP-2 is thus a positive regulator of ERK by leptin receptors, and both the adaptor function and the phosphatase activity of SHP-2 are critical for this regulation.
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“Phosphorylation of Tyr985 recruits SH2-domain-containing phosphatase-2 (SHP-2) to LepRb, leading to the activation of the extracellular signal regulated (ERK) signaling pathway in cultured cells, as well as the recruitment of suppressor of cytokine signaling-3 (SOCS-3), a negative regulator of LepRb signaling (6, 21, 22).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [21]
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Metadata
- Authors
- Bjørbæk, C., Buchholz, R. M., Davis, S. M., Bates, S. H., Pierroz, D. D., Gu, H., Neel, B. G., Myers, M. G., & Flier, J. S.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Joslin Diabetes Center (US)
- Corresponding author
- Flier, Jeffrey S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 276
- Issue
- 7
- Pages
- 4747-4755
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2123126462
- Semantic Scholar
- 611dde37fd76b46071411d3b23e750b6a97b4a24
- Cited by
- 364
- References
- 63
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 10 · 2019: 5 · 2018: 12 · 2017: 14 · 2016: 9 · 2015: 12 · 2014: 25 · 2013: 17 · 2012: 19
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01-CA-49152, F32CA072144, R01CA049152, CA72144)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK050693, DK-50693, DK-R37-28082, R37DK028082, R01-DK-56731, R01DK056731)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- SHP2, leptin receptor, ERK activation, Obras, protein tyrosine phosphatase, EGR1, leptin signaling, tyrosine phosphorylation, dominant-negative mutant, hypothalamus, receptor tyrosine kinase signaling
- MeSH terms
- Animals, Carrier Proteins, DNA-Binding Proteins, Cricetinae, Hypothalamus, Male, Mice, Inbred C57BL, Models, Biological, Mutation, Phosphorylation, Promoter Regions, Genetic, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Receptors, Cell Surface, RNA, Messenger, Transcription Factors, Transcription, Genetic, Transfection, Trans-Activators, CHO Cells, Protein Tyrosine Phosphatases, Immediate-Early Proteins, Leptin, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Intracellular Signaling Peptides and Proteins, Mitogen-Activated Protein Kinase 3, STAT3 Transcription Factor, Mice, Early Growth Response Protein 1, Janus Kinase 2, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Receptors, Leptin, Protein Tyrosine Phosphatase, Non-Receptor Type 11
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