Cited by 212Metabolism, Diabetes, and CancerAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

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Adiponectin Activates AMP-activated Protein Kinase in Muscle Cells via APPL1/LKB1-dependent and Phospholipase C/Ca2+/Ca2+/Calmodulin-dependent Protein Kinase Kinase-dependent Pathways

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Zhou, Lijun, Deepa, Sathyaseelan S., Etzler, Julie C., Ryu, Jiyoon, Mao, Xuming, Fang, Qichen, Liu, Dianna D., Torres, Jesus M., Jia, Weiping, Lechleiter, James D., Liu, Feng, Dong, Lily Q.·2009·Journal of Biological Chemistry

DOI 10.1074/jbc.m109.028357PMC PMC2755964

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Abstract

The binding of the adaptor protein APPL1 to adiponectin receptors is necessary for adiponectin-induced AMP-activated protein kinase (AMPK) activation in muscle, yet the underlying molecular mechanism remains unknown. Here we show that in muscle cells adiponectin and metformin induce AMPK activation by promoting APPL1-dependent LKB1 cytosolic translocation. APPL1 mediates adiponectin signaling by directly interacting with adiponectin receptors and enhances LKB1 cytosolic localization by anchoring this kinase in the cytosol. Adiponectin also activates another AMPK upstream kinase Ca2+/calmodulin-dependent protein kinase kinase by activating phospholipase C and subsequently inducing Ca2+ release from the endoplasmic reticulum, which plays a minor role in AMPK activation. Our results show that in muscle cells adiponectin is able to activate AMPK via two distinct mechanisms as follows: a major pathway (the APPL1/LKB1-dependent pathway) that promotes the cytosolic localization of LKB1 and a minor pathway (the phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathway) that stimulates Ca2+ release from intracellular stores.

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Authors: Zhou, L., Deepa, S. S., Etzler, J. C., Ryu, J., Mao, X., Fang, Q., Liu, D. D., Torres, J. M., Jia, W., Lechleiter, J. D., Liu, F., & Dong, L. Q.
Affiliations: Shanghai Jiao Tong University (CN)
The University of Texas at San Antonio Health Science Center (US)
Corresponding author: Dong, Lily Q.
ORCID: Zhou, Lijun
Deepa, Sathyaseelan S.
Ryu, Jiyoon
Mao, Xuming
Fang, Qichen
Jia, Weiping
Lechleiter, James D.
Liu, Feng
Dong, Lily Q.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2009-08
Volume: 284
Issue: 33
Pages: 22426-22435
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m109.028357
PMC: PMC2755964
OpenAlex: W1973591364
Cited by: 212
References: 60
Citations by year: 2026: 9 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 13 · 2021: 16 · 2020: 15 · 2019: 15 · 2018: 14 · 2017: 6 · 2016: 12 · 2015: 9 · 2014: 18 · 2013: 18 · 2012: 10
FWCI: 5.77
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 4089 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (PPG AG19316, P01AG019316, T32AG021890)
National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK76902, R01 DK69930, R01DK069930, R01DK076902)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: adiponectin, AMPK, APPL1, LKB1, muscle cells, adiponectin receptors, metformin, phospholipase C, calcium signaling, endoplasmic reticulum calcium release, cytosolic translocation, AMPK activation
MeSH terms: AMP-Activated Protein Kinase Kinases, Animals, Calcium, Carrier Proteins, Humans, Models, Biological, Muscles, Subcellular Fractions, Protein Serine-Threonine Kinases, Microscopy, Confocal, Adaptor Proteins, Signal Transducing, Mice, Adiponectin, Calcium-Calmodulin-Dependent Protein Kinase Kinase, AMP-Activated Protein Kinases

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Adiponectin Activates AMP-activated Protein Kinase in Muscle Cells via APPL1/LKB1-dependent and Phospholipase C/Ca2+/Ca2+/Calmodulin-dependent Protein Kinase Kinase-dependent Pathways

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