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Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells
Open accessAbstract
The existence of circulating microRNAs (miRNAs) in the blood of cancer patients has raised the possibility that miRNAs may serve as a novel diagnostic marker. However, the secretory mechanism and biological function of extracellular miRNAs remain unclear. Here, we show that miRNAs are released through a ceramide-dependent secretory machinery and that the secretory miRNAs are transferable and functional in the recipient cells. Ceramide, whose biosynthesis is regulated by neutral sphingomyelinase 2 (nSMase2), triggers secretion of small membrane vesicles called exosomes. The decreased activity of nSMase2 with a chemical inhibitor, GW4869, and a specific small interfering RNA resulted in the reduced secretion of miRNAs. Complementarily, overexpression of nSMase2 increased extracellular amounts of miRNAs. We also revealed that the endosomal sorting complex required for transport system is unnecessary for the release of miRNAs. Furthermore, a tumor-suppressive miRNA secreted via this pathway was transported between cells and exerted gene silencing in the recipient cells, thereby leading to cell growth inhibition. Our findings shed a ray of light on the physiological relevance of secretory miRNAs.
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“CD9 and CD63 serve as the most commonly used identifiers of exosomes and have been targeted for selective isolation [37, 38].”
From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [38]
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“Intriguingly, miRNAs can be released from cancer cells into body fluids via secreting exosomes particles [6,13].”
From Bioinformatic Interrogation of 5p-arm and 3p-arm Specific miRNA Expression Using TCGA Datasets (2015) · cites this paper as [13]
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“TSG101 and Alix are two other proteins sometimes used as exosome markers [38, 46, 47].”
From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [38]
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1 retracted
RETRACTED: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
Taylor, D. D., & Gerçel-Taylor, Ç. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.04.033 · Cited by 2,333
RetractedValadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969
A microRNA expression signature of human solid tumors defines cancer gene targets
Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510565103 · Cited by 5,697
Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001
Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X., et al. (2008) · Cell Research · doi:10.1038/cr.2008.282 · Cited by 4,560
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,760
Causes and consequences of microRNA dysregulation in cancer
Croce, C. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2634 · Cited by 3,039
Biogenesis of small RNAs in animals
Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 2,814
Research works printed but not linked: 1
- Fleischhacker, 2007, Biochim. Biophys. Acta, 1775, 181
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Seyhan, A. A. (2015) · Molecular BioSystems · doi:10.1039/c5mb00064e · Cited by 43
Oncogenic Regulation of Extracellular Vesicle Proteome and Heterogeneity
Choi, D., Spinelli, C., Montermini, L., & Rak, J. W. (2018) · PROTEOMICS · doi:10.1002/pmic.201800169 · Cited by 43
Pathophysiological Role and Potential Therapeutic Exploitation of Exosomes in Ovarian Cancer
Shimizu, A., Sawada, K., & Kimura, T. (2020) · Cells · doi:10.3390/cells9040814 · Cited by 43
Ikert, H., Lynch, M. D. J., Doxey, A. C., Giesy, J. P., Servos, M. R., Katzenback, B. A., & Craig, P. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.588313 · Cited by 43
Piazzesi, A., Afsar, S. Y., & van Echten‐Deckert, G. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13063 · Cited by 43
Hu, Q., Zang, X., Ding, Y., Gu, T., Shi, J., Li, Z., Cai, G., Liu, D., Wu, Z., & Hong, L. (2021) · Theriogenology · doi:10.1016/j.theriogenology.2021.10.021 · Cited by 43
miRNAs as Predictive Factors in Early Diagnosis of Gestational Diabetes Mellitus
Juchnicka, I., Kuźmicki, M., Niemira, M., Bielska, A., Sidorkiewicz, I., Zbucka-Krętowska, M., Kretowski, A. J., & Szamatowicz, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.839344 · Cited by 43
Exercise, Skeletal Muscle and Circulating microRNAs
Russell, A. P., & Lamon, S. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.018 · Cited by 43
Small molecule with big role: MicroRNAs in cancer metastatic microenvironments
Su, Y., Li, X., Ji, W., Sun, B., Xu, C., Li, Z., Qian, G., & Su, C. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.10.024 · Cited by 42
Urinary cell-free microRNA-106b as a novel biomarker for detection of bladder cancer
Zhou, X.-J., Zhang, X., Yang, Y., Li, Z., Du, L., Dong, Z., Qu, A., Jiang, X., Li, P., & Wang, C. (2014) · Medical Oncology · doi:10.1007/s12032-014-0197-z · Cited by 42
Circulating microRNAs: macro-utility as markers of prostate cancer?
Selth, L. A., Tilley, W. D., & Butler, L. M. (2012) · Endocrine Related Cancer · doi:10.1530/erc-12-0010 · Cited by 42
Maida, Y., Takakura, M., Nishiuchi, T., Yoshimoto, T., & Kyo, S. (2015) · Cancer Medicine · doi:10.1002/cam4.545 · Cited by 42
Extracellular Vesicles: How Drug and Pathology Interfere With Their Biogenesis and Function
Cesselli, D., Parisse, P., Aleksova, A., Veneziano, C., Cervellin, C., Zanello, A., & Beltrami, A. P. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01394 · Cited by 44
Extracellular Vesicles from Thyroid Carcinoma: The New Frontier of Liquid Biopsy
Rappa, G., Puglisi, C., Santos, M. F., Forte, S., Memeo, L., & Lorico, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051114 · Cited by 42
Exosomes Facilitate Transmission of Enterovirus A71 From Human Intestinal Epithelial Cells
Huang, H., Lin, J., Chiang, H.-C., Huang, P.-N., Lin, Q.-D., & Shih, S. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa174 · Cited by 42
Exosomal miRNAs in hepatitis B virus related liver disease: a new hope for biomarker
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Roy, D., Modi, A., Khokhar, M., Sankanagoudar, S., Yadav, D., Sharma, S., Purohit, P., & Sharma, P. (2020) · Current Diabetes Reviews · doi:10.2174/1573399816666200503035035 · Cited by 42
Xu, X., Liu, Y., Li, Y., Chen, H., Zhang, Y., Liu, J., Deng, S., Zheng, Y., Sun, X., Wang, J., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01810-9 · Cited by 42
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Lara-Barba, E., Araya, M. J., Hill, C. N., Bustamante-Barrientos, F. A., Ortloff, A., Garcia, C. M., Gálvez‐Jirón, F., Pradenas, C., Luque‐Campos, N., Maita, G., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.768771 · Cited by 42
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Durante, G., Broseghini, E., Comito, F., Naddeo, M., Milani, M., Salamon, I., Campione, E., Dika, E., & Ferracin, M. (2022) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2022.2049243 · Cited by 47
Zhu, Q., Kang, J., Miao, H., Feng, Y., Xiao, L., Hu, Z., Liao, D., Huang, Y. Q., Jin, J., & He, S. (2014) · FEBS Journal · doi:10.1111/febs.12826 · Cited by 42
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Wang, F., Chen, C., & Wang, D. W. (2014) · Frontiers of Medicine · doi:10.1007/s11684-014-0379-2 · Cited by 41
Isolation and Characterization of a microRNA-size Secretable Small RNA in Streptococcus sanguinis
Choi, J.-W., Kwon, T., Hong, S., & Lee, H. (2016) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-016-0770-5 · Cited by 41
Ishii, N., Araki, K., Yokobori, T., Hagiwara, K., Gantumur, D., Yamanaka, T., Handa, T., Tsukagoshi, M., Igarashi, T., Watanabe, A., et al. (2018) · Cancer Science · doi:10.1111/cas.13847 · Cited by 41
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Liester, M. B. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109468 · Cited by 45
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Beeraka, N. M., Doreswamy, S. H., Sadhu, S. P., Srinivasan, A., Pragada, R. R., Madhunapantula, S. V., & Aliev, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186818 · Cited by 42
Zhou, R., Wang, L., Zhao, G., Chen, D., Song, X., Momtazi‐Borojeni, A. A., & Yuan, H. (2020) · IUBMB Life · doi:10.1002/iub.2396 · Cited by 41
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Luo, L., Wu, Z., Wang, Y., & Li, H. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01171-1 · Cited by 41
Saikumar, J., Ramachandran, K., & Vaidya, V. S. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2013.216044 · Cited by 41
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Kosaka, N., Yoshioka, Y., Hagiwara, K., Tominaga, N., & Ochiya, T. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-453-1_1 · Cited by 41
Self-citationAl‐Kafaji, G., Naieb, Z. A., & Bakhiet, M. (2015) · Oncology Letters · doi:10.3892/ol.2015.4014 · Cited by 41
Ghosh, S., Bose, M., Ray, A., & Bhattacharyya, S. N. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-11-1521 · Cited by 40
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Movahedpour, A., Ahmadi, N., Ghasemi, Y., Savardashtaki, A., & Shabaninejad, Z. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29053 · Cited by 40
Esmaeili, A., Hosseini, S., & Eslaminejad, M. B. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03585-w · Cited by 40
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Self-citationIkeda, A., Nagayama, S., Sumazaki, M., Konishi, M., Fujii, R., Saichi, N., Muraoka, S., Saigusa, D., Shimada, H., Sakai, Y., et al. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0827 · Cited by 40
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Tao, R., Zhang, X., Guo, J., Xiang, A., Tang, N., Liu, J., & Mao, Z. (2022) · Cancers · doi:10.3390/cancers15010205 · Cited by 40
Dimasi, C. G., Darby, J. R. T., & Morrison, J. L. (2023) · The Journal of Physiology · doi:10.1113/jp284137 · Cited by 42
Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis
Chang, S.-H., & Hla, T. (2014) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000040 · Cited by 40
Antibody-Based Assays for Phenotyping of Extracellular Vesicles
Pugholm, L. H., Revenfeld, A. L., Søndergaard, E. K. L., & Jørgensen, M. M. (2015) · BioMed Research International · doi:10.1155/2015/524817 · Cited by 40
Dirksen, K., Verzijl, T., van den Ingh, T. S. G. A. M., Vernooij, J. C. M., van der Laan, L. J. W., Burgener, I. A., Spee, B., & Fieten, H. (2016) · The Veterinary Journal · doi:10.1016/j.tvjl.2016.01.010 · Cited by 40
Lian, J., Zhu, X., Du, J., Huang, B., Zhao, F., Ma, C., Guo, R., Zhang, Y., Ji, L., Yahaya, B. H., et al. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.01.025 · Cited by 39
Inyang, K. E., Evans, C. M., Heussner, M., Petroff, M. G., Reimers, M., Vermeer, P. D., Tykocki, N. R., Folger, J. K., & Laumet, G. O. (2022) · Pain · doi:10.1097/j.pain.0000000000003045 · Cited by 39
Mir, R., Baba, S. K., Elfaki, I., Algehainy, N. A., Alanazi, M. A., Altemani, F. H., Tayeb, F. J., Barnawi, J., Husain, E., Bedaiwi, R. I., et al. (2024) · Journal of Cancer · doi:10.7150/jca.98426 · Cited by 39
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Finn, N. A., Eapen, D. J., Manocha, P., Kassem, H. A., Lassegue, B. P., Ghasemzadeh, N., Quyyumi, A. A., & Searles, C. D. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.08.034 · Cited by 39
Kagiya, T. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4091741 · Cited by 39
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Shalaby, T., Achini, F., & Grotzer, M. A. (2016) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2016.12 · Cited by 40
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García‐Seisdedos, D., Babiy, B., Lerma, M., Casado, M. E., Martı́nez-Botas, J., Lasunción, M. A., Pastor, Ó., & Busto, R. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158638 · Cited by 39
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Sanada, T., Sano, T., Sotomaru, Y., Alshargabi, R., Yamawaki, Y., Yamashita, A., Matsunaga, H., Iwashita, M., Shinjo, T., Kanematsu, T., et al. (2020) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2020.100757 · Cited by 39
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Self-citationLi, J., Sun, L., Chen, Y., Zhu, J., Shen, J., Wang, J., Gu, Y., Zhang, G., Wang, M., Shi, T., et al. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-021-02991-8 · Cited by 39
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Olioso, D., Dauriz, M., Bacchi, E., Negri, C., Santi, L., Bonora, E., & Moghetti, P. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01820 · Cited by 39
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Chen, J., Xu, R., Xia, J., Huang, J., Su, B., & Wang, S. (2019) · Pathology - Research and Practice · doi:10.1016/j.prp.2019.03.008 · Cited by 38
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Self-citationVatandoost, N., Amini, M., Iraj, B., Momenzadeh, S., & Salehi, R. (2015) · Gene · doi:10.1016/j.gene.2015.07.015 · Cited by 37
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Metadata
- Authors
- Kosaka, N., Iguchi, H., Yoshioka, Y., Takeshita, F., Matsuki, Y., & Ochiya, T.
- Affiliations
- National Cancer Center Research Institute (JP)
- Sumitomo Dainippon Pharma (Japan) (JP)
- Corresponding author
- Ochiya, Takahiro
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 285
- Issue
- 23
- Pages
- 17442-17452
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC2878508
- OpenAlex
- W2119043140
- Cited by
- 1,934
- References
- 29
- Citations by year
- 2026: 55 · 2025: 59 · 2024: 93 · 2023: 91 · 2022: 101 · 2021: 185 · 2020: 148 · 2019: 131 · 2018: 139 · 2017: 148 · 2016: 164 · 2015: 142 · 2014: 153 · 2013: 131 · 2012: 115
- FWCI
- 34.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- National Institute of Biomedical Innovation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- extracellular microRNAs, microRNA secretion, ceramide, neutral sphingomyelinase 2, exosomes, intercellular transfer, tumor suppressor microRNA, gene silencing, tumor cell growth inhibition, tumor markers, GW4869
- MeSH terms
- Aniline Compounds, Animals, Benzylidene Compounds, Biological Transport, Chlorocebus aethiops, Humans, Neoplasms, Sphingomyelin Phosphodiesterase, Biomarkers, Tumor, Culture Media, Conditioned, COS Cells, Gene Silencing, RNA Interference, RNA, Small Interfering, MicroRNAs, Exosomes
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