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Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells
Open accessAbstract
The existence of circulating microRNAs (miRNAs) in the blood of cancer patients has raised the possibility that miRNAs may serve as a novel diagnostic marker. However, the secretory mechanism and biological function of extracellular miRNAs remain unclear. Here, we show that miRNAs are released through a ceramide-dependent secretory machinery and that the secretory miRNAs are transferable and functional in the recipient cells. Ceramide, whose biosynthesis is regulated by neutral sphingomyelinase 2 (nSMase2), triggers secretion of small membrane vesicles called exosomes. The decreased activity of nSMase2 with a chemical inhibitor, GW4869, and a specific small interfering RNA resulted in the reduced secretion of miRNAs. Complementarily, overexpression of nSMase2 increased extracellular amounts of miRNAs. We also revealed that the endosomal sorting complex required for transport system is unnecessary for the release of miRNAs. Furthermore, a tumor-suppressive miRNA secreted via this pathway was transported between cells and exerted gene silencing in the recipient cells, thereby leading to cell growth inhibition. Our findings shed a ray of light on the physiological relevance of secretory miRNAs.
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“CD9 and CD63 serve as the most commonly used identifiers of exosomes and have been targeted for selective isolation [37, 38].”
From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [38]
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“Intriguingly, miRNAs can be released from cancer cells into body fluids via secreting exosomes particles [6,13].”
From Bioinformatic Interrogation of 5p-arm and 3p-arm Specific miRNA Expression Using TCGA Datasets (2015) · cites this paper as [13]
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“TSG101 and Alix are two other proteins sometimes used as exosome markers [38, 46, 47].”
From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [38]
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1 retracted
RETRACTED: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
Taylor, D. D., & Gerçel-Taylor, Ç. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.04.033 · Cited by 2,333
RetractedValadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969
A microRNA expression signature of human solid tumors defines cancer gene targets
Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510565103 · Cited by 5,697
Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001
Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X., et al. (2008) · Cell Research · doi:10.1038/cr.2008.282 · Cited by 4,560
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,760
Causes and consequences of microRNA dysregulation in cancer
Croce, C. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2634 · Cited by 3,039
Biogenesis of small RNAs in animals
Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 2,814
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- Fleischhacker, 2007, Biochim. Biophys. Acta, 1775, 181
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Items 501–600 of 1,002
Tsujiura, M., Komatsu, S., Ichikawa, D., Shiozaki, A., Konishi, H., Takeshita, H., Moriumura, R., Nagata, H., Kawaguchi, T., Hirajima, S., et al. (2014) · Gastric Cancer · doi:10.1007/s10120-014-0363-1 · Cited by 96
Circulating and Urinary microRNAs in Kidney Disease
Lorenzen, J. M., & Thum, T. (2012) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01170212 · Cited by 96
Jingushi, K., Uemura, M., Ohnishi, N., Nakata, W., Fujita, K., Naito, T., Fujii, R., Saichi, N., Nonomura, N., Tsujikawa, K., et al. (2017) · International Journal of Cancer · doi:10.1002/ijc.31080 · Cited by 97
Latest advances in extracellular vesicles: from bench to bedside
Yamamoto, T., Kosaka, N., & Ochiya, T. (2019) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2019.1629835 · Cited by 100
Self-citationNicolini, A., Ferrari, P., & Biava, P. M. (2021) · Cancers · doi:10.3390/cancers13040822 · Cited by 98
Li, S., Stöckl, S., Lukas, C., Herrmann, M., Brochhausen, C., König, M. A., Johnstone, B., & Grässel, S. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02317-6 · Cited by 96
Exosomal CD47 Plays an Essential Role in Immune Evasion in Ovarian Cancer
Shimizu, A., Sawada, K., Kobayashi, M., Yamamoto, M., Yagi, T., Kinose, Y., Kodama, M., Hashimoto, K., & Kimura, T. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0956 · Cited by 96
The Role of MiRNA in Cancer: Pathogenesis, Diagnosis, and Treatment
Uzuner, E., Ulu, G. T., Gürler, S. B., & Baran, Y. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1170-8_18 · Cited by 96
Zhang, J., Zhao, C., ZHANG, S.-H., Yu, D., Chen, Y., Liu, Q., Shi, M., Ni, C.-R., & Zhu, M.-H. (2013) · Oncology Reports · doi:10.3892/or.2013.2960 · Cited by 96
Persistent upregulation of U6:SNORD44 small RNA ratio in the serum of breast cancer patients
Appaiah, H. N., Goswami, C. P., Mina, L. A., Badve, S., Sledge, G. W., Liu, Y., & Nakshatri, H. (2011) · Breast Cancer Research · doi:10.1186/bcr2943 · Cited by 96
Tanaka, K., Miyata, H., Yamasaki, M., Sugimura, K., Takahashi, T., Kurokawa, Y., Nakajima, K., Takiguchi, S., Mori, M., & Doki, Y. (2013) · Annals of Surgical Oncology · doi:10.1245/s10434-013-3093-4 · Cited by 95
Extracellular microRNAs are dynamic non-vesicular biomarkers of muscle turnover
Roberts, T. C., Godfrey, C., McClorey, G., Vader, P., Briggs, D. A., Gardiner, C., Aoki, Y., SARGENT, I. L., Morgan, J. E., & Wood, M. J. A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt724 · Cited by 99
Hu, Y., Li, D., Wu, A., Qiu, X., Di, W. J., Huang, L. H., & Qiu, L. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.02.009 · Cited by 95
Cheray, M., Etcheverry, A., Jacques, C., Pacaud, R., Bougras-Cartron, G., Aubry, M., Denoual, F., Peterlongo, P., Nadaradjane, A., Briand, J., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01155-z · Cited by 95
B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3
Fei, F., Joo, E. J., Tarighat, S. S., Schiffer, I., Paz, H., Fabbri, M., Abdel‐Azim, H., Groffen, J., & Heisterkamp, N. (2015) · Oncotarget · doi:10.18632/oncotarget.3409 · Cited by 94
Alexander, M., Ramstead, A. G., Bauer, K. M., Lee, S.-H., Runtsch, M. C., Wallace, J. A., Huffaker, T. B., Larsen, D. K., Tolmachova, T., Seabra, M. C., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700904 · Cited by 95
Svenningsen, P., Sabaratnam, R., & Jensen, B. L. (2019) · Acta Physiologica · doi:10.1111/apha.13346 · Cited by 95
Arenaccio, C., Anticoli, S., Manfredi, F., Chiozzini, C., Olivetta, E., & Federico, M. (2015) · Retrovirology · doi:10.1186/s12977-015-0216-y · Cited by 94
Exosomes: A Role for Naturally Occurring Nanovesicles in Cancer Growth, Diagnosis and Treatment
Srivastava, A., Filant, J., Moxley, K. M., Sood, A. K., McMeekin, S., & Ramesh, R. (2015) · Current Gene Therapy · doi:10.2174/1566523214666141224100612 · Cited by 95
Exosomal miRNAs in hepatocellular carcinoma development and clinical responses
Li, S., Yao, J., Xie, M., Liu, Y., & Zheng, M. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0579-3 · Cited by 97
Circulating microRNAs: novel biomarkers for cardiovascular diseases?
Dimmeler, S., & Zeiher, A. M. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq221 · Cited by 93
Zhang, W., Peng, P., Kuang, Y., Yang, J., Cao, D., You, Y., & Shen, K. (2015) · Tumor Biology · doi:10.1007/s13277-015-4105-8 · Cited by 92
The biology of circulating micro RNA s in cardiovascular disease
Min, P., & Chan, S. Y. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12475 · Cited by 98
Montoro‐García, S., Shantsila, E., Marín, F. R., Blann, A. D., & Lip, G. Y. H. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0198-4 · Cited by 92
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Searles, C. D. (2024) · Current Cardiology Reports · doi:10.1007/s11886-023-02014-1 · Cited by 92
Cell-Free Seminal mRNA and MicroRNA Exist in Different Forms
Li, H., Huang, S., Guo, C., Guan, H.-T., & Xiong, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034566 · Cited by 92
Utility of Circulating MicroRNAs as Clinical Biomarkers for Cardiovascular Diseases
Kondkar, A. A., & Abu‐Amero, K. K. (2015) · BioMed Research International · doi:10.1155/2015/821823 · Cited by 93
Clinical Impact of Down-Regulated Plasma miR-92a Levels in Non-Hodgkin's Lymphoma
Ohyashiki, K., Umezu, T., Yoshizawa, S., Ito, Y., Ohyashiki, M., Kawashima, H., Tanaka, M., Kuroda, M., & Ohyashiki, J. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016408 · Cited by 91
Biogenesis, delivery, and function of extracellular RNA
Patton, J. G., Franklin, J. L., Weaver, A. M., Vickers, K. C., Zhang, B., Coffey, R. J., Ansel, K. M., Blelloch, R. H., Goga, A., Huang, B., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27494 · Cited by 92
Umezu, T., Imanishi, S., Azuma, K., Kobayashi, C., Yoshizawa, S., Ohyashiki, K., & Ohyashiki, J. H. (2017) · Blood Advances · doi:10.1182/bloodadvances.2016003251 · Cited by 92
Cell-secreted vesicles containing microRNAs as regulators of gamete maturation
da Silveira, J. C., de Ávila, A. C. F. C. M., Garrett, H. L., Bruemmer, J. E., Winger, Q. A., & Bouma, G. J. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0200 · Cited by 92
Tumor-derived exosomes, microRNAs, and cancer immune suppression
Graner, M. W., Schnell, S. M., & Olin, M. R. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0689-6 · Cited by 92
miRNAs as Influencers of Cell–Cell Communication in Tumor Microenvironment
Conti, I., Varano, G., Simioni, C., Laface, I., Milani, D., Rimondi, E., & Neri, L. M. (2020) · Cells · doi:10.3390/cells9010220 · Cited by 94
Interplay Between Exosomes, microRNAs and Toll-Like Receptors in Brain Disorders
Paschon, V., Takada, S. H., Ikebara, J. M., de Sousa, É., Raeisossadati, R., Ulrich, H., & Kihara, A. H. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9142-1 · Cited by 95
Harling, L., Lambert, J., Ashrafian, H., Darzi, A. W., Gooderham, N. J., & Athanasiou, T. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw245 · Cited by 90
Mesenchymal stem cell–derived small extracellular vesicles and bone regeneration
Wang, X., & Thomsen, P. (2020) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13478 · Cited by 91
Circulating miR-18a: a sensitive cancer screening biomarker in human cancer.
Komatsu, S., Ichikawa, D., Takeshita, H., Morimura, R., Hirajima, S., Tsujiura, M., Kawaguchi, T., Miyamae, M., Nagata, H., Konishi, H., et al. (2014) · PubMed · Cited by 90
Namazi, H., Mohit, E., Namazi, I., Rajabi, S., Samadian, A., Hajizadeh‐Saffar, E., Aghdami, N., & Baharvand, H. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26621 · Cited by 90
Recent progress toward the use of circulating microRNAs as clinical biomarkers
Ghai, V., & Wang, K. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1828-2 · Cited by 95
Motawi, T. K., Shaker, O. G., Ismail, M. F., & Sayed, N. H. (2017) · Scientific Reports · doi:10.1038/s41598-017-11180-6 · Cited by 90
The clinical potential of adipogenesis and obesity-related microRNAs
Zaiou, M., Amri, H. E., & Bakillah, A. (2017) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2017.10.015 · Cited by 92
The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype
Mebratu, Y. A., Soni, S., Rosas, L., Rojas, M. M., Horowitz, J. C., & Nho, R. S. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00124.2023 · Cited by 95
Chen, L., & Brigstock, D. R. (2016) · FEBS Letters · doi:10.1002/1873-3468.12448 · Cited by 91
Emerging role of exosome signalling in maintaining cancer stem cell dynamic equilibrium
Sun, Z., Wang, L., Dong, L., & Wang, X. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13676 · Cited by 91
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Zhao, C., Zhang, J., Zhang, S., Yu, D., Chen, Y., Liu, Q., Shi, M., Ni, C.-R., & Zhu, M.-H. (2013) · Oncology Reports · doi:10.3892/or.2013.2420 · Cited by 88
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Sempere, L. F., Keto, J. L., & Fabbri, M. (2017) · Cancers · doi:10.3390/cancers9070071 · Cited by 89
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Detassis, S., Grasso, M., Vescovo, V. D., & Denti, M. A. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00086 · Cited by 88
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Enomoto, Y., Li, P., Jenkins, L. M. M., Anastasakis, D. G., Lyons, G. C., Hafner, M., & Leonard, W. J. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-021-00352-2 · Cited by 89
Luque, A., Farwati, A., Crovetto, F., Crispi, F., Figueras, F., Gratacós, E., & Aran, J. M. (2014) · Scientific Reports · doi:10.1038/srep04882 · Cited by 88
Iftikhar, H., & Carney, G. E. (2016) · BioEssays · doi:10.1002/bies.201500130 · Cited by 87
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Deng, D., Liu, Z., & Du, Y. (2010) · Advances in genetics · doi:10.1016/b978-0-12-380864-6.00005-5 · Cited by 87
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Nair, N., Kumar, S., Góngora, E., & Gupta, S. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1546-x · Cited by 87
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Yuan, H., Mischoulon, D., Fava, M., & Otto, M. W. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.06.058 · Cited by 86
Jovičić, A., & Gitler, A. D. (2017) · PLOS ONE · doi:10.1371/journal.pone.0171418 · Cited by 86
Komatsu, S., Ichikawa, D., Takeshita, H., Konishi, H., Nagata, H., Hirajima, S., Kawaguchi, T., Arita, T., Shiozaki, A., Fujiwara, H., et al. (2012) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2012.681373 · Cited by 86
Sebastiani, G., Nigi, L., Grieco, G. E., Mancarella, F., Ventriglia, G., & Dotta, F. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0611-4 · Cited by 87
D’Souza, R. F., Markworth, J. F., Aasen, K. M. M., Zeng, N., Cameron‐Smith, D., & Mitchell, C. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181594 · Cited by 86
Boyer, M. J., Kimura, Y., Akiyama, T. H., Baggett, A., Preston, K. J., Scalia, R. G., Eguchi, S., & Rizzo, V. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1781427 · Cited by 86
Emerging concepts on the role of exosomes in lipid metabolic diseases
Record, M., Poirot, M., & Silvente‐Poirot, S. (2013) · Biochimie · doi:10.1016/j.biochi.2013.06.016 · Cited by 88
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Fujita, Y., Yoshioka, Y., Ito, S., Araya, J., Kuwano, K., & Ochiya, T. (2014) · Clinical Therapeutics · doi:10.1016/j.clinthera.2014.05.006 · Cited by 86
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Guay, C., Jacovetti, C., Nesca, V., Motterle, A., Tugay, K., & Regazzi, R. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01654.x · Cited by 88
Wang, L., Wang, C., Jia, X., & Yu, J. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000494793 · Cited by 85
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Self-citationLovett, J. A. C., Durcan, P., & Myburgh, K. H. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01149 · Cited by 85
Basu, S., & Bhattacharyya, S. N. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku346 · Cited by 84
Zietzer, A., Hosen, M. R., Wang, H., Goody, P. R., Sylvester, M., Latz, E., Nickenig, G., Werner, N., & Jansen, F. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1786967 · Cited by 84
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Hirai, K., Ousaka, D., Fukushima, Y., Kondo, M., Eitoku, T., Shigemitsu, Y., Hara, M., Baba, K., Iwasaki, T., Kasahara, S., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abb3336 · Cited by 87
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Ilie, I. R. P., & Georgescu, C. E. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2015.06.001 · Cited by 84
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Wang, J., Yeung, B. Z., Cui, M., Peer, C. J., Lu, Z., Figg, W. D., Wientjes, M. G., Woo, S., & Au, J. L. ‐. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.10.020 · Cited by 85
Src in endosomal membranes promotes exosome secretion and tumor progression
Hikita, T., Kuwahara, A., Watanabe, R., Miyata, M., & Oneyama, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-39882-z · Cited by 86
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Zhao, L., Yu, J., Wang, J., Li, H., Che, J., & Cao, B. (2017) · Journal of Cancer · doi:10.7150/jca.18026 · Cited by 83
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Shen, K., Cao, Z., Zhu, R., You, L., & Zhang, T. (2019) · Clinical and Translational Medicine · doi:10.1186/s40169-019-0250-9 · Cited by 86
Liang, D., White, R. G., & Waterhouse, P. M. (2012) · PLANT PHYSIOLOGY · doi:10.1104/pp.112.197129 · Cited by 83
Horiguchi, H., Kobune, M., Kikuchi, S., Yoshida, M., Murata, M., Murase, K., Iyama, S., Takada, K., Sato, T., Ono, K., et al. (2016) · Haematologica · doi:10.3324/haematol.2015.134932 · Cited by 89
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Liang, H., Gong, F., Zhang, S., Zhang, C., Zen, K., & Chen, X. (2013) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1208 · Cited by 84
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Tsai, K., Liao, Y., Wu, C., Hu, L., Li, S., Chan, W., Ho, M., Lai, C., Kao, H., Fang, W., et al. (2012) · Genes, Chromosomes and Cancer · doi:10.1002/gcc.21924 · Cited by 68
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Osmai, M., Osmai, Y., Bang‐Berthelsen, C. H., Pallesen, E. M. H., Vestergaard, A. L., Novotny, G. W., Pociot, F., & Mandrup-Poulsen, T. R. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2719 · Cited by 84
Mach, N., Plancade, S., Pacholewska, A., Lecardonnel, J., Rivière, J., Moroldo, M., Vaiman, A., Morgenthaler, C., Beinat, M., Nevot, A., et al. (2016) · Scientific Reports · doi:10.1038/srep22932 · Cited by 82
Mizuta, Y., Akahoshi, T., Guo, J., Zhang, S., Narahara, S., Kawano, T., Murata, M., Tokuda, K., Eto, M., Hashizume, M., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02015-9 · Cited by 82
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Shehzad, A., Islam, S. U., Shahzad, R., Khan, S., & Lee, Y. S. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107806 · Cited by 84
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Metadata
- Authors
- Kosaka, N., Iguchi, H., Yoshioka, Y., Takeshita, F., Matsuki, Y., & Ochiya, T.
- Affiliations
- National Cancer Center Research Institute (JP)
- Sumitomo Dainippon Pharma (Japan) (JP)
- Corresponding author
- Ochiya, Takahiro
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 285
- Issue
- 23
- Pages
- 17442-17452
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC2878508
- OpenAlex
- W2119043140
- Cited by
- 1,934
- References
- 29
- Citations by year
- 2026: 55 · 2025: 59 · 2024: 93 · 2023: 91 · 2022: 101 · 2021: 185 · 2020: 148 · 2019: 131 · 2018: 139 · 2017: 148 · 2016: 164 · 2015: 142 · 2014: 153 · 2013: 131 · 2012: 115
- FWCI
- 34.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- National Institute of Biomedical Innovation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- extracellular microRNAs, microRNA secretion, ceramide, neutral sphingomyelinase 2, exosomes, intercellular transfer, tumor suppressor microRNA, gene silencing, tumor cell growth inhibition, tumor markers, GW4869
- MeSH terms
- Aniline Compounds, Animals, Benzylidene Compounds, Biological Transport, Chlorocebus aethiops, Humans, Neoplasms, Sphingomyelin Phosphodiesterase, Biomarkers, Tumor, Culture Media, Conditioned, COS Cells, Gene Silencing, RNA Interference, RNA, Small Interfering, MicroRNAs, Exosomes
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