The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
NeuroEVs: Characterizing Extracellular Vesicles Generated in the Neural Domain
Abstract
Intercellular communication has recently been shown to occur via transfer of cargo loaded within extracellular vesicles (EVs). Present within all biofluids of the body, EVs can contain various signaling factors, including coding and noncoding RNAs (e.g., mRNA, miRNA, lncRNA, snRNA, tRNA, yRNA), DNA, proteins, and enzymes. Multiple types of cells appear to be capable of releasing EVs, including cancer, stem, epithelial, immune, glial, and neuronal cells. However, the functional impact of these circulating signals among neural networks within the brain has been difficult to establish given the complexity of cellular populations involved in release and uptake, as well as inherent limitations of examining a biofluid. In this brief commentary, we provide an analysis of the conceptual and technical considerations that limit our current understanding of signaling mediated by circulating EVs relative to their impact on neural function. Dual Perspectives Companion Paper:Extracellular Vesicles and Neurodegenerative Diseases, by Andrew F. Hill
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“However, selective isolation of neuron-derived sEVs using peripheral biofluids is currently not feasible because of the lack of a neuron-specific biomarker [24].”
From Differential RNA packaging into small extracellular vesicles by neurons and astrocytes (2021) · cites this paper as [24]
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“Identification of cellular origin of the sEVs in the circulation, specifically from CNS cells such as neurons, has been challenging due to the absence of specific protein markers [24].”
From Differential RNA packaging into small extracellular vesicles by neurons and astrocytes (2021) · cites this paper as [24]
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“…results in the release of EVs containing insulin-degrading enzyme along with decreased expression of amyloid- (Glebov et al., 2015); this finding is consistent with the documented correlation in humans between high levels of serotonin and reduced levels of amyloidin patients (Cirrito et al., 2011).”
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Sorted by citations
Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer’s disease pathogenesis
Yuyama, K., Sun, H., Fujii, R., Hemmi, I., Ueda, K., & Igeta, Y. (2024) · Brain · doi:10.1093/brain/awad361 · Cited by 47
Differential RNA packaging into small extracellular vesicles by neurons and astrocytes
Luo, X., Jean-Toussaint, R., Sacan, A., & Ajit, S. K. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00757-4 · Cited by 32
Metadata
- Authors
- Fowler, C. D.
- ORCID
- Fowler, Christie D.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2019-11-20
- Volume
- 39
- Issue
- 47
- Pages
- 9262-9268
- ISSN
- 0270-6474
- 1529-2401
- Cited by
- 35
- References
- 10
- Language
- en
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