The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index, and 1 are not checked yet.
Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells
Open accessAbstract
The existence of circulating microRNAs (miRNAs) in the blood of cancer patients has raised the possibility that miRNAs may serve as a novel diagnostic marker. However, the secretory mechanism and biological function of extracellular miRNAs remain unclear. Here, we show that miRNAs are released through a ceramide-dependent secretory machinery and that the secretory miRNAs are transferable and functional in the recipient cells. Ceramide, whose biosynthesis is regulated by neutral sphingomyelinase 2 (nSMase2), triggers secretion of small membrane vesicles called exosomes. The decreased activity of nSMase2 with a chemical inhibitor, GW4869, and a specific small interfering RNA resulted in the reduced secretion of miRNAs. Complementarily, overexpression of nSMase2 increased extracellular amounts of miRNAs. We also revealed that the endosomal sorting complex required for transport system is unnecessary for the release of miRNAs. Furthermore, a tumor-suppressive miRNA secreted via this pathway was transported between cells and exerted gene silencing in the recipient cells, thereby leading to cell growth inhibition. Our findings shed a ray of light on the physiological relevance of secretory miRNAs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“CD9 and CD63 serve as the most commonly used identifiers of exosomes and have been targeted for selective isolation [37, 38].”
From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [38]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Intriguingly, miRNAs can be released from cancer cells into body fluids via secreting exosomes particles [6,13].”
From Bioinformatic Interrogation of 5p-arm and 3p-arm Specific miRNA Expression Using TCGA Datasets (2015) · cites this paper as [13]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“TSG101 and Alix are two other proteins sometimes used as exosome markers [38, 46, 47].”
From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [38]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
Taylor, D. D., & Gerçel-Taylor, Ç. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.04.033 · Cited by 2,333
RetractedValadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969
A microRNA expression signature of human solid tumors defines cancer gene targets
Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510565103 · Cited by 5,697
Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001
Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X., et al. (2008) · Cell Research · doi:10.1038/cr.2008.282 · Cited by 4,560
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,760
Causes and consequences of microRNA dysregulation in cancer
Croce, C. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2634 · Cited by 3,039
Biogenesis of small RNAs in animals
Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 2,814
Research works printed but not linked: 1
- Fleischhacker, 2007, Biochim. Biophys. Acta, 1775, 181
Cited by
Sorted by citations
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287
Arroyo, J. D., Chevillet, J. R., Kroh, E. M., Ruf, I. K., Pritchard, C. C., Gibson, D. F., Mitchell, P. S., Bennett, C. F., Pogosova-Agadjanyan, E. L., Stirewalt, D. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019055108 · Cited by 3,294
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
Vickers, K. C., Palmisano, B. T., Shoucri, B. M., Shamburek, R. D., & Remaley, A. T. (2011) · Nature Cell Biology · doi:10.1038/ncb2210 · Cited by 2,741
Current knowledge on exosome biogenesis and release
Hessvik, N. P., & Llorente, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2595-9 · Cited by 2,362
Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function
Zhang, J., Li, S., Li, L., Li, M., Guo, C., Yao, J., & Mi, S. (2015) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2015.02.001 · Cited by 1,901
Sphingolipids and their metabolism in physiology and disease
Hannun, Y. A., & Obeid, L. M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.107 · Cited by 2,117
Characterization of extracellular circulating microRNA
Turchinovich, A., Weiz, L., Langheinz, A., & Burwinkel, B. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr254 · Cited by 1,941
The exosome journey: from biogenesis to uptake and intracellular signalling
Gurung, S., Perocheau, D. P. B., Touramanidou, L., & Baruteau, J. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00730-1 · Cited by 1,912
RNA delivery by extracellular vesicles in mammalian cells and its applications
O’Brien, K., Breyne, K., Ughetto, S., Laurent, L. C., & Breakefield, X. O. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0251-y · Cited by 1,811
Biogenesis and secretion of exosomes
Kowal, J., Tkach, M., & Théry, C. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.05.004 · Cited by 1,781
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
Mittelbrunn, M., Gutiérrez‐Vázquez, C., Villarroya‐Beltri, C., González, S., Sánchez‐Cabo, F., González, M. A., Bernad, A., & Sánchez‐Madrid, F. (2011) · Nature Communications · doi:10.1038/ncomms1285 · Cited by 1,818
Abels, E. R., & Breakefield, X. O. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0366-z · Cited by 1,755
Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells
Ohno, S.-I., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A., Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2012.180 · Cited by 1,666
Self-citationApplying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper
Lener, T., Gimona, M., Aigner, L., Börger, V., Buzas, E., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., del Portillo, H. A., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.30087 · Cited by 1,491
Self-citationMicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
Fabbri, M., Paone, A., Calore, F., Galli, R., Gaudio, E., Santhanam, R., Lovat, F., Fadda, P., Mao, C., Nuovo, G. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209414109 · Cited by 1,434
MicroRNAs in body fluids—the mix of hormones and biomarkers
Cortez, M. A., Bueso-Ramos, C., Ferdin, J., Lopez‐Berestein, G., Sood, A. K., & Călin, G. A. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.76 · Cited by 1,497
Extracellular vesicles in cancer — implications for future improvements in cancer care
Xu, R., Rai, A., Chen, M., Suwakulsiri, W., Greening, D. W., & Simpson, R. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0036-9 · Cited by 1,472
Akers, J. C., Gonda, D., Kim, R., Carter, B. S., & Chen, C. C. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1084-8 · Cited by 1,423
“TSG101 and Alix are two other proteins sometimes used as exosome markers [38, 46, 47].”
Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory
Poggio, M., Hu, T., Pai, C.-C., Chu, B., Belair, C. D., Chang, A., Montabana, E., Lang, U. E., Fu, Q., Fong, L., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.016 · Cited by 1,376
Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis
Kosaka, N., Iguchi, H., & Ochiya, T. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01650.x · Cited by 1,147
Self-citationAtheroprotective communication between endothelial cells and smooth muscle cells through miRNAs
Hergenreider, E., Heydt, S., Tréguer, K., Boettger, T., Horrevoets, A. J. G., Zeiher, A. M., Scheffer, M. P., Frangakis, A. S., Yin, X., Mayr, M., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2441 · Cited by 1,329
Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.
Montecalvo, A., Larregina, A. T., Shufesky, W. J., Beer Stolz, D., Sullivan, M. L. G., Karlsson, J. M., Baty, C. J., Gibson, G. A., Erdos, G., Wang, Z., et al. (2012) · Blood · doi:10.1182/blood-2011-02-338004 · Cited by 1,429
Extracellular vesicles for drug delivery.
Vader, P., Mol, E. A., Pasterkamp, G., & Schiffelers, R. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.02.006 · Cited by 1,319
Ying, W., Riopel, M., Bandyopadhyay, G., Dong, Y., Birmingham, A., Seo, J. B., Ofrecio, J. M., Wollam, J., Hernandez-Carretero, A., Fu, W., et al. (2017) · Cell · doi:10.1016/j.cell.2017.08.035 · Cited by 1,191
MicroRNAs in metabolism and metabolic disorders
Rottiers, V., & Näär, A. M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3313 · Cited by 1,156
Quantitative and stoichiometric analysis of the microRNA content of exosomes
Chevillet, J. R., Kang, Q., Ruf, I. K., Briggs, H., Vojtech, L. N., Hughes, S. M., Cheng, H. H., Arroyo, J. D., Meredith, E. K., Gallichotte, E. N., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408301111 · Cited by 1,137
Characterization of human plasma-derived exosomal RNAs by deep sequencing.
Huang, X., Yuan, T., Tschannen, M., Sun, Z., Jacob, H., Du, M., Liang, M., Dittmar, R. L., Liu, Y., Liang, M., et al. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-319 · Cited by 932
Exosomes: Therapy delivery tools and biomarkers of diseases
Barile, L., & Vassalli, G. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.020 · Cited by 1,053
Lipids in exosomes: current knowledge and the way forward
Skotland, T., Sandvig, K., & Llorente, A. (2017) · Progress in Lipid Research · doi:10.1016/j.plipres.2017.03.001 · Cited by 1,030
Creemers, E. E., Tijsen, A. J., & Pinto, Y. M. (2012) · Circulation Research · doi:10.1161/circresaha.111.247452 · Cited by 1,035
Bang, C., Bátkai, S., Dangwal, S., Gupta, S. K., Foinquinos, A., Holzmann, A., Just, A., Remke, J., Zimmer, K., Zeug, A., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70577 · Cited by 995
Exosomes in tumor microenvironment influence cancer progression and metastasis
Kahlert, C., & Kalluri, R. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1020-6 · Cited by 888
Record, M., Carayon, K., Poirot, M., & Silvente‐Poirot, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.10.004 · Cited by 893
Grange, C., Tapparo, M., Collino, F., Vitillo, L., Damasco, C., Deregibus, M. C., Tetta, C., Bussolati, B., & Camussi, G. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0241 · Cited by 873
Exosomes as mediators of intercellular crosstalk in metabolism
Isaac, R., Reis, F. C. G., Ying, W., & Olefsky, J. M. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.006 · Cited by 860
Context-specific regulation of extracellular vesicle biogenesis and cargo selection
Dixson, A. C., Dawson, T. R., Vizio, D. D., & Weaver, A. M. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00576-0 · Cited by 847
Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy
Ibrahim, A., Cheng, K., & Marbán, E. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.04.006 · Cited by 836
Kosaka, N., Iguchi, H., Hagiwara, K., Yoshioka, Y., Takeshita, F., & Ochiya, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.446831 · Cited by 791
Self-citationExosomes maintain cellular homeostasis by excreting harmful DNA from cells
Takahashi, A., Okada, R., Nagao, K., Kawamata, Y., Hanyu, A., Yoshimoto, S., Takasugi, M., Watanabe, S., Kanemaki, M. T., Obuse, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms15287 · Cited by 761
Secreted microRNAs: a new form of intercellular communication
Chen, X., Liang, H., Zhang, J., Zen, K., & Zhang, C.-Y. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.12.001 · Cited by 690
MicroRNA sequence codes for small extracellular vesicle release and cellular retention
García-Martín, R., Wang, G., Brandão, B. B., Zanotto, T. M., Shah, S., Patel, S. K., Schilling, B., & Kahn, C. R. (2021) · Nature · doi:10.1038/s41586-021-04234-3 · Cited by 775
Exosome mediated communication within the tumor microenvironment
Milane, L. S., Singh, A., Mattheolabakis, G., Suresh, M., & Amiji, M. M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.06.029 · Cited by 752
Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology
Skotland, T., Hessvik, N. P., Sandvig, K., & Llorente, A. (2019) · Journal of Lipid Research · doi:10.1194/jlr.r084343 · Cited by 730
Mateescu, B., Kowal, E. J. K., van Balkom, B. W. M., Bartel, S., Bhattacharyya, S. N., Buzás, E. I., Buck, A. H., de Candia, P., Chow, F. W., Das, S., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1286095 · Cited by 757
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
Alexander, M., Hu, R., Runtsch, M. C., Kagele, D. A., Mosbruger, T. L., Tolmachova, T., Seabra, M. C., Round, J. L., Ward, D. M., & O’Connell, R. M. (2015) · Nature Communications · doi:10.1038/ncomms8321 · Cited by 769
Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704
Assessing sample and miRNA profile quality in serum and plasma or other biofluids
Blöndal, T., Nielsen, S. J., Baker, A., Andreasen, D., Mouritzen, P., Teilum, M. W., & Dahlsveen, I. K. (2012) · Methods · doi:10.1016/j.ymeth.2012.09.015 · Cited by 702
miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges
Zhou, S., Jin, J.-P., Wang, J., Zhang, Z., Freedman, J. H., Zheng, Y., & Cai, L. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2018.30 · Cited by 690
Kooijmans, S. A. A., Stremersch, S., Braeckmans, K., de Smedt, S. C., Hendrix, A., Wood, M. J. A., Schiffelers, R. M., Raemdonck, K., & Vader, P. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.014 · Cited by 663
Extracellular microRNA: A new source of biomarkers
Etheridge, A., Lee, I., Hood, L., Galas, D. J., & Wang, K. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.03.004 · Cited by 673
Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction
Shurtleff, M. J., Temoche-Diaz, M. M., Karfilis, K. V., Ri, S., & Schekman, R. (2016) · eLife · doi:10.7554/elife.19276 · Cited by 621
Bala, S., Petrášek, J., Mundkur, S., Catalano, D., Levin, I., Ward, J. A., Alao, H., Kodys, K., & Szabó, G. (2012) · Hepatology · doi:10.1002/hep.25873 · Cited by 637
Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine
Hade, M. D., Suire, C. N., & Suo, Z. (2021) · Cells · doi:10.3390/cells10081959 · Cited by 642
Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics
Tenchov, R., Sasso, J. M., Wang, X., Liaw, W., Chen, C., & Zhou, Q. A. (2022) · ACS Nano · doi:10.1021/acsnano.2c08774 · Cited by 642
Ratti, M., Lampis, A., Ghidini, M., Salati, M., Mirchev, M. B., Valeri, N., & Hahne, J. C. (2020) · Targeted Oncology · doi:10.1007/s11523-020-00717-x · Cited by 632
The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance
Watt, M. J., Miotto, P. M., De Nardo, W., & Montgomery, M. K. (2019) · Endocrine Reviews · doi:10.1210/er.2019-00034 · Cited by 615
Bhaskaran, M., & Mohan, M. (2013) · Veterinary Pathology · doi:10.1177/0300985813502820 · Cited by 642
Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics
Armstrong, J. P. K., Holme, M. N., & Stevens, M. M. (2017) · ACS Nano · doi:10.1021/acsnano.6b07607 · Cited by 616
Donoso‐Quezada, J., Ayala‐Mar, S., & González‐Valdez, J. (2021) · Traffic · doi:10.1111/tra.12803 · Cited by 621
MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells
Okoye, I., Coomes, S. M., Pelly, V. S., Czieso, S., Papayannopoulos, V., Tolmachova, T., Seabra, M. C., & Wilson, M. S. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.019 · Cited by 619
Brites, D., & Fernandes, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00476 · Cited by 599
“Exosomal miRNAs may constitute biomarkers of a specific disease, as their serum levels are altered in a variety of pathological conditions (Kosaka et al., 2010a; Etheridge et al., 2011; Mo et al., 2012).”
BackgroundSzabó, G., & Bala, S. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.87 · Cited by 601
Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells
Pigati, L., Yaddanapudi, S. C., Iyengar, R., Kim, D.-J., Hearn, S., Danforth, D. N., Hastings, M. L., & Duelli, D. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013515 · Cited by 601
Maacha, S., Bhat, A. A., Jimenez, L., Raza, A., Haris, M., Shahab Uddin, M. S., & Grivel, J. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0965-7 · Cited by 583
The role of microRNAs in human diseases
Tüfekci, K. U., Öner, M. G., Meuwissen, R. L. J., & Genç, Ş. (2014) · Methods in molecular biology · doi:10.1007/978-1-62703-748-8_3 · Cited by 566
Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells.
Squadrito, M. L., Baer, C., Burdet, F., Maderna, C., Gilfillan, G. D., Lyle, R., Ibberson, M., & De Palma, M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.035 · Cited by 604
Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes
Katsuda, T., Tsuchiya, R., Kosaka, N., Yoshioka, Y., Takagaki, K., Oki, K., Takeshita, F., Sakai, Y., Kuroda, M., & Ochiya, T. (2013) · Scientific Reports · doi:10.1038/srep01197 · Cited by 579
Self-citationCirculating microRNAs as novel biomarkers for diabetes mellitus
Guay, C., & Regazzi, R. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.86 · Cited by 563
Exosomes: immune properties and potential clinical implementations
Chaput, N., & Théry, C. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0233-9 · Cited by 590
Guduric‐Fuchs, J., O’Connor, A., Camp, B., O’Neill, C. L., Medina, R. J., & Simpson, D. A. C. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-357 · Cited by 574
Kogure, T., Lin, W.-L., Yan, I. K., Braconi, C., & Patel, T. (2011) · Hepatology · doi:10.1002/hep.24504 · Cited by 551
Exosomes for targeted siRNA delivery across biological barriers
Andaloussi, S. E., Lakhal‐Littleton, S., Mäger, I., & Wood, M. J. A. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.008 · Cited by 555
The Biology of Cancer Exosomes: Insights and New Perspectives
Ruivo, C. F., Adem, B., Silva, M. G., & Melo, S. A. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0994 · Cited by 547
Extracellular miRNAs: the mystery of their origin and function
Turchinovich, A. A., Weiz, L., & Burwinkel, B. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.08.003 · Cited by 534
Intercellular Communication by Exosome-Derived microRNAs in Cancer
Hannafon, B. N., & Ding, W. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140714240 · Cited by 537
Mesenchymal‐stem‐cell‐derived exosomes accelerate skeletal muscle regeneration
Nakamura, Y., Miyaki, S., Ishitobi, H., Matsuyama, S., Nakasa, T., Kamei, N., Akimoto, T., Higashi, Y., & Ochi, M. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.03.031 · Cited by 511
Exosomes: New players in cell–cell communication
Bang, C., & Thum, T. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.08.007 · Cited by 517
Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity
Li, J., Liu, K., Liu, Y., Xu, Y., Zhang, F., Yang, H., Liu, J., Pan, T., Chen, J., Wu, M., et al. (2013) · Nature Immunology · doi:10.1038/ni.2647 · Cited by 510
Extracellular membrane vesicles in the three domains of life and beyond
Gill, S., Catchpole, R. J., & Forterre, P. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy042 · Cited by 523
Nanopore-based detection of circulating microRNAs in lung cancer patients
Wang, Y., Zheng, D., Tan, Q., Wang, M., & Gu, L. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.147 · Cited by 496
Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer
Matsumura, T., Sugimachi, K., Iinuma, H., Takahashi, Y., Kurashige, J., Sawada, G., Ueda, M., Uchi, R., Ueo, H., Takano, Y., et al. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.201 · Cited by 453
Self-citationExtracellular vesicles as drug delivery systems: Lessons from the liposome field
van der Meel, R., Fens, M. H. A. M., Vader, P., van Solinge, W. W., Eniola‐Adefeso, O., & Schiffelers, R. M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.07.049 · Cited by 498
Dreux, M., Garaigorta, U., Boyd, B. S., Décembre, É., Chung, J., Whitten-Bauer, C., Wieland, S. F., & Chisari, F. V. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.08.010 · Cited by 496
Circulating microRNAs: Association with disease and potential use as biomarkers
Reid, G., Kirschner, M. B., & van Zandwijk, N. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.11.004 · Cited by 472
Biogenesis and function of ESCRT-dependent extracellular vesicles
Juan, T., & Fürthauer, M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.022 · Cited by 479
microRNA Therapeutics in Cancer — An Emerging Concept
Shah, M., Ferrajoli, A., Sood, A. K., Lopez‐Berestein, G., & Călin, G. A. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.09.017 · Cited by 461
Leukemia cell to endothelial cell communication via exosomal miRNAs
Umezu, T., Ohyashiki, K., Kuroda, M., & Ohyashiki, J. H. (2012) · Oncogene · doi:10.1038/onc.2012.295 · Cited by 446
Mesenchymal Stem Cell-Derived Exosomes Promote Fracture Healing in a Mouse Model
Furuta, T., Miyaki, S., Ishitobi, H., Ogura, T., Kato, Y., Kamei, N., Miyado, K., Higashi, Y., & Ochi, M. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0285 · Cited by 444
The biology of extracellular vesicles: The known unknowns
Margolis, L. B., & Sadovsky, Y. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000363 · Cited by 460
Ng, Y. H., Rome, S., Jalabert, A., Forterre, A. V., Singh, H., Hincks, C., & Salamonsen, L. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058502 · Cited by 453
Bellingham, S. A., Coleman, B. M., & Hill, A. F. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks832 · Cited by 461
Karolina, D. S., Armugam, A., Subramaniam, T., Wong, M. T. K., Lim, S. C., Sum, C. F., & Jeyaseelan, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022839 · Cited by 445
Essandoh, K., Yang, L., Wang, X., Huang, W. C., Qin, D., Hao, J., Wang, Y., Zingarelli, B., Peng, T., & Fan, G. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.08.010 · Cited by 435
Buratta, S., Tancini, B., Sagini, K., Delo, F., Chiaradia, E., Urbanelli, L., & Emiliani, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072576 · Cited by 446
Baggish, A. L., Hale, A., Weiner, R. B., Lewis, G. D., Systrom, D., Wang, F., Wang, T. J., & Chan, S. Y. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.213363 · Cited by 431
HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells
Tabet, F., Vickers, K. C., Cuesta Torres, L. F., Wiese, C. B., Shoucri, B. M., Lambert, G., Catherinet, C., Prado-Lourenco, L., Levin, M. G., Thacker, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4292 · Cited by 428
Exosome/microvesicle-mediated epigenetic reprogramming of cells.
Camussi, G., Deregibus, M. C., Bruno, S., Grange, C., Fonsato, V., & Tetta, C. (2011) · Europe PMC (PubMed Central) · Cited by 428
Exosomes: new molecular targets of diseases
Samanta, S., Rajasingh, S., Drosos, N., Zhou, Z., Dawn, B., & Rajasingh, J. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.162 · Cited by 437
The therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles
Katsuda, T., Kosaka, N., Takeshita, F., & Ochiya, T. (2013) · PROTEOMICS · doi:10.1002/pmic.201200373 · Cited by 432
Self-citation
Metadata
- Authors
- Kosaka, N., Iguchi, H., Yoshioka, Y., Takeshita, F., Matsuki, Y., & Ochiya, T.
- Affiliations
- National Cancer Center Research Institute (JP)
- Sumitomo Dainippon Pharma (Japan) (JP)
- Corresponding author
- Ochiya, Takahiro
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 285
- Issue
- 23
- Pages
- 17442-17452
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC2878508
- OpenAlex
- W2119043140
- Cited by
- 1,934
- References
- 29
- Citations by year
- 2026: 55 · 2025: 59 · 2024: 93 · 2023: 91 · 2022: 101 · 2021: 185 · 2020: 148 · 2019: 131 · 2018: 139 · 2017: 148 · 2016: 164 · 2015: 142 · 2014: 153 · 2013: 131 · 2012: 115
- FWCI
- 34.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- National Institute of Biomedical Innovation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- extracellular microRNAs, microRNA secretion, ceramide, neutral sphingomyelinase 2, exosomes, intercellular transfer, tumor suppressor microRNA, gene silencing, tumor cell growth inhibition, tumor markers, GW4869
- MeSH terms
- Aniline Compounds, Animals, Benzylidene Compounds, Biological Transport, Chlorocebus aethiops, Humans, Neoplasms, Sphingomyelin Phosphodiesterase, Biomarkers, Tumor, Culture Media, Conditioned, COS Cells, Gene Silencing, RNA Interference, RNA, Small Interfering, MicroRNAs, Exosomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
