Large Scale Gene Expression Analysis of Osteoclastogenesisin Vitro and Elucidation of NFAT2 as a Key Regulator

Self-Organizing Maps

Kohonen, T. (1995) · Springer series in information sciences · doi:10.1007/978-3-642-56927-2 · Cited by 16,032

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

Schena, M., Shalon, D., Davis, R. W., & Brown, P. O. (1995) · Science · doi:10.1126/science.270.5235.467 · Cited by 9,609

Untitled work

(1975) · CERN Document Server (European Organization for Nuclear Research) · Cited by 5,958

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116

Serial Analysis of Gene Expression

Velculescu, V. E., Zhang, L., Vogelstein, B., & Kinzler, K. W. (1995) · Science · doi:10.1126/science.270.5235.484 · Cited by 3,713

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27489 · Cited by 3,374

Expression monitoring by hybridization to high-density oligonucleotide arrays

Lockhart, D. J., Dong, H., Byrne, M. C., Follettie, M. T., Gallo, M. V., Chee, M. S., Mittmann, M., Wang, C., Kobayashi, M., Norton, H., et al. (1996) · Nature Biotechnology · doi:10.1038/nbt1296-1675 · Cited by 2,841

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

Rao, A., Luo, C. H., & Hogan, P. G. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.707 · Cited by 2,592

Osteoclast differentiation and activation

Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670

Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701

Transcriptional regulation by calcium, calcineurin, and NFAT

Hogan, P. G., Chen, L., Nardone, J., & Rao, A. (2003) · Genes & Development · doi:10.1101/gad.1102703 · Cited by 1,991

Genetic regulation of osteoclast development and function

Teitelbaum, S. L., & Ross, F. P. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1122 · Cited by 1,720

The molecular understanding of osteoclast differentiation

Asagiri, M., & Takayanagi, H. (2007) · Bone · doi:10.1016/j.bone.2006.09.023 · Cited by 1,363

IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology

Tat, S. K., Marc, P., Théoleyre, S., Heymann, D., & Fortun, Y. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2003.10.005 · Cited by 990

IL-1 mediates TNF-induced osteoclastogenesis

Shi, W., Kitaura, H., Zhou, P., Ross, F. P., & Teitelbaum, S. L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23394 · Cited by 805

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T., & Matsuo, K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.012 · Cited by 777

Osteoclasts: What Do They Do and How Do They Do It?

Teitelbaum, S. L. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060834 · Cited by 730

Osteoclast differentiation by RANKL and OPG signaling pathways

Udagawa, N., Koide, M., Nakamura, M., Nakamichi, Y., Yamashita, T., Uehara, S., Kobayashi, Y., Furuya, Y., Yasuda, H., Fukuda, C., et al. (2020) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01162-6 · Cited by 765

Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond

Walsh, M. C., & Choi, Y. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00511 · Cited by 599

Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos

Matsuo, K., Galson, D. L., Chen, Z., Peng, L., Laplace, C., Wang, K. Z. Q., Bachler, M. A., Amano, H., Aburatani, H., Ishikawa, H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313973200 · Cited by 570

Osteoclasts: New Insights

Feng, X., & Teitelbaum, S. L. (2013) · Bone Research · doi:10.4248/br201301003 · Cited by 562

Bone remodeling: an operational process ensuring survival and bone mechanical competence

Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482

Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation

Ikeda, F., Nishimura, R., Matsubara, T., Tanaka, S., Inoue, J., Reddy, S. V., Hata, K., Yamashita, K., Hiraga, T., Watanabe, T., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419657 · Cited by 468

Essential Role of p38 Mitogen-activated Protein Kinase in Cathepsin K Gene Expression during Osteoclastogenesis through Association of NFATc1 and PU.1

Matsumoto, M., Kogawa, M., Wada, S., Takayanagi, H., Tsujimoto, M., Katayama, S., Hisatake, K., & Nogi, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408795200 · Cited by 436

The role of NFAT in osteoclast formation

TAKAYANAGI, H. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.071 · Cited by 442

Mechanistic insight into osteoclast differentiation in osteoimmunology

Takayanagi, H. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0612-6 · Cited by 413

NF-κB p50 and p52 Regulate Receptor Activator of NF-κB Ligand (RANKL) and Tumor Necrosis Factor-induced Osteoclast Precursor Differentiation by Activating c-Fos and NFATc1

Yamashita, T., Yao, Z., Li, F., Zhang, Q., Badell, I. R., Schwarz, E. M., Takeshita, S., Wagner, E. F., Noda, M., Matsuo, K., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610701200 · Cited by 414

Ca 2+ ‐NFATc1 signaling is an essential axis of osteoclast differentiation

Negishi‐Koga, T., & Takayanagi, H. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00821.x · Cited by 415

Calcineurin/NFAT Signaling in Osteoblasts Regulates Bone Mass

Winslow, M. M., Pan, M., Starbuck, M. W., Gallo, E. M., Deng, L., Karsenty, G., & Crabtree, G. R. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.006 · Cited by 355

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

Aliprantis, A. O., Ueki, Y., Sulyanto, R. M., Park, A., Sigrist, K. S., Sharma, S. M., Ostrowski, M. C., Olsen, B. R., & Glimcher, L. H. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35711 · Cited by 350

Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL–RANK signaling system

Tanaka, S., Nakamura, K., Takahasi, N., & Suda, T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00327.x · Cited by 325

Sphingosine 1‐phosphate as a regulator of osteoclast differentiation and osteoclast–osteoblast coupling

Ryu, J., Kim, H. J., Chang, E., Huang, H., Banno, Y., & Hong‐Hee, K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601430 · Cited by 332

Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis

Zhao, B., Takami, M., Yamada, A., Wang, X., Koga, T., Hu, X., Tamura, T., Ozato, K., Choi, Y., Ivashkiv, L. B., et al. (2009) · Nature Medicine · doi:10.1038/nm.2007 · Cited by 316

Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio

Bostancı, N., İlgenli, T., Emingil, G., Afacan, B., Han, B., Töz, H., Atilla, G., Hughes, F. J., & Belibasakis, G. N. (2007) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2007.01061.x · Cited by 292

TNF.ALPHA. and pathologic bone resorption

Boyce, B., Li, P., Yao, Z., Zhang, Q., Badell, I. R., Schwarz, E. M., O’Keefe, R. J., & Xing, L. (2005) · The Keio Journal of Medicine · doi:10.2302/kjm.54.127 · Cited by 262

MCP-1 Is Induced by Receptor Activator of Nuclear Factor-κB Ligand, Promotes Human Osteoclast Fusion, and Rescues Granulocyte Macrophage Colony-stimulating Factor Suppression of Osteoclast Formation

Kim, M. S., Day, C. J., & Morrison, N. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412713200 · Cited by 259

Nuclear Factor of Activated T Cells c1 Induces Osteoclast-associated Receptor Gene Expression during Tumor Necrosis Factor-related Activation-induced Cytokine-mediated Osteoclastogenesis

Kim, K., Kim, J. H., Lee, J., Jin, H., Lee, S., Fisher, D. E., Kook, H. Y., Kim, K. K., Choi, Y., & Kim, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505815200 · Cited by 247

The Calcineurin/Nuclear Factor of Activated T Cells Signaling Pathway Regulates Osteoclastogenesis in RAW264.7 Cells

Hirotani, H., Tuohy, N. A., Woo, J.-T., Stern, P. H., & Clipstone, N. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m213067200 · Cited by 248

Impaired Micro-RNA Pathways Diminish Osteoclast Differentiation and Function

Sugatani, T., & Hruska, K. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805777200 · Cited by 196

Matrix Metalloproteinases in Bone Resorption, Remodeling, and Repair

Paiva, K. B. S., & Granjeiro, J. M. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.05.001 · Cited by 245

Parathyroid Hormone Stimulates Osteoblastic Expression of MCP-1 to Recruit and Increase the Fusion of Pre/Osteoclasts

Li, X., Qin, L., Bergenstock, M., Bevelock, L. M., Novack, D. V., & Partridge, N. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611781200 · Cited by 240

Osteoclast precursors, RANKL/RANK, and immunology

Xing, L., Schwarz, E. M., & Boyce, B. F. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00336.x · Cited by 236

RANK‐mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis

Gohda, J., Akiyama, T., Koga, T., Takayanagi, H., Tanaka, S., & Inoue, J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600564 · Cited by 233

Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus

Evans, K. E., & Fox, S. W. (2007) · BMC Cell Biology · doi:10.1186/1471-2121-8-4 · Cited by 201

Osteoclasts are important for bone angiogenesis

Cackowski, F. C., Anderson, J. L., Patrene, K. D., Choksi, R. J., Shapiro, S. D., Windle, J. J., Blair, H. C., & Roodman, G. D. (2010) · Blood · doi:10.1182/blood-2009-08-237628 · Cited by 188

Bidirectional Signaling through EphrinA2-EphA2 Enhances Osteoclastogenesis and Suppresses Osteoblastogenesis

Irie, N., Takada, Y., Watanabe, Y., Matsuzaki, Y., Naruse, C., Asano, M., Iwakura, Y., Suda, T., & Matsuo, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807598200 · Cited by 182

TNF‑α and RANKL promote osteoclastogenesis by upregulating RANK via the NF‑κB pathway

Luo, G., Li, F., Li, X., Wang, Z., & Zhang, B. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8698 · Cited by 179

Regulation of apoptosis in osteoclasts and osteoblastic cells

Xing, L., & Boyce, B. F. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.072 · Cited by 171

Convergent signaling by acidosis and receptor activator of NF-κB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts

Komarova, S. V., Pereverzev, A., Shum, J., Sims, S. M., & Dixon, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406874102 · Cited by 161

Minireview: Transcriptional Regulation in Development of Bone

Kobayashi, T., & Kronenberg, H. M. (2004) · Endocrinology · doi:10.1210/en.2004-1343 · Cited by 164

Giant cell tumor of bone: A basic science perspective

Cowan, R. W., & Singh, G. (2012) · Bone · doi:10.1016/j.bone.2012.10.002 · Cited by 159

Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-κB transactivation by RANKL

Huang, H., Ryu, J., Ha, J., Chang, E.-J., Kim, H. J., Kim, H.-M., Kitamura, T., Lee, Z. H., & Kim, H. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401882 · Cited by 156

NFATc1 regulation of the human β3 integrin promoter in osteoclast differentiation

Crotti, T. N., Flannery, M. R., Walsh, N. C., Fleming, J. D., Goldring, S. R., & McHugh, K. P. (2006) · Gene · doi:10.1016/j.gene.2005.12.012 · Cited by 157

MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts

Vallet, S., Raje, N. S., Ishitsuka, K., Hideshima, T., Podar, K., Chhetri, S., Pozzi, S., Breitkreutz, I., Kiziltepe, T., Yasui, H., et al. (2007) · Blood · doi:10.1182/blood-2007-05-093294 · Cited by 152

N ew M olecules in the T umor N ecrosis F actor L igand and R eceptor S uperfamilies with I mportance for P hysiological and P athological B one R esorption

Lerner, U. H. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500202 · Cited by 147

Inflammation and Bone Metabolism in Rheumatoid Arthritis: Molecular Mechanisms of Joint Destruction and Pharmacological Treatments

Maeda, K., Yoshida, K., Nishizawa, T., Otani, K., Yamashita, Y., Okabe, H., Hadano, Y., Kayama, T., Kurosaka, D., & Saito, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052871 · Cited by 153

TAK1-dependent Signaling Requires Functional Interaction with TAB2/TAB3

Besse, A., Lamothe, B., Campos, A. D., Webster, W. K., Maddineni, U., Lin, S., Wu, H., & Darnay, B. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608867200 · Cited by 147

Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases

Takegahara, N., Kim, H., & Choi, Y. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01157-7 · Cited by 161

Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone-resorbing activity, and apoptosis pathway

Akiyama, T., Dass, C. R., & Choong, P. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0530 · Cited by 137

Regulatory roles and molecular signaling of TNF family members in osteoclasts

Feng, X. (2005) · Gene · doi:10.1016/j.gene.2005.01.014 · Cited by 132

RANKL biology

Takegahara, N., Kim, H., & Choi, Y. (2022) · Bone · doi:10.1016/j.bone.2022.116353 · Cited by 136

Macrophage fusion: are somatic and cancer cells possible partners?

Vignery, A. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.02.008 · Cited by 123

Transcriptional regulation of bone and joint remodeling by NFAT

Sitara, D., & Aliprantis, A. O. (2009) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00849.x · Cited by 120

The RING Domain and First Zinc Finger of TRAF6 Coordinate Signaling by Interleukin-1, Lipopolysaccharide, and RANKL

Lamothe, B., Campos, A. D., Webster, W. K., Gopinathan, A., Hur, L., & Darnay, B. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802749200 · Cited by 122

Osteoimmunology: Major and Costimulatory Pathway Expression Associated with Chronic Inflammatory Induced Bone Loss

Crotti, T. N., Dharmapatni, A. A. S. S. K., Alias, E., & Haynes, D. R. (2015) · Journal of Immunology Research · doi:10.1155/2015/281287 · Cited by 113

Expression, signaling, and function of P2X7 receptors in bone

Grol, M. W., Panupinthu, N., Korčok, J., Sims, S. M., & Dixon, S. J. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9139-1 · Cited by 110

The role of miR‐29 family in disease

Horita, M., Farquharson, C., & Stephen, L. A. (2021) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29896 · Cited by 113

The role of SH3BP2 in the pathophysiology of cherubism

Reichenberger, E., Levine, M. A., Olsen, B. R., Papadaki, M. E., & Lietman, S. A. (2012) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-7-s1-s5 · Cited by 110

Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells

Mohamed, S. G.-K., Sugiyama, E., Shinoda, K., Taki, H., Hounoki, H., Abdel-Aziz, H. O., Maruyama, M., Kobayashi, M., Ogawa, H., & Miyahara, T. (2007) · Bone · doi:10.1016/j.bone.2007.05.016 · Cited by 120

Siglec-15 Protein Regulates Formation of Functional Osteoclasts in Concert with DNAX-activating Protein of 12 kDa (DAP12)

Ishida‐Kitagawa, N., Tanaka, K., Bao, X., Kimura, T., Miura, T., Kitaoka, Y., Hayashi, K., Sato, M., Maruoka, M., Ogawa, T., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324194 · Cited by 106

Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis

Joyce-Shaikh, B., Bigler, M. E., Chao, C., Murphy, E. E., Blumenschein, W. M., Adamopoulos, I. E., Heyworth, P. G., Antonenko, S. V., Bowman, E. P., McClanahan, T. K., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20090516 · Cited by 103

Roles for NF-κB and c-Fos in osteoclasts

Boyce, B. F., Yamashita, T., Yao, Z., Zhang, Q., Li, F., & Xing, L. (2005) · Journal of Bone and Mineral Metabolism · doi:10.1007/bf03026317 · Cited by 101

New Insights on Human Polyomavirus JC and Pathogenesis of Progressive Multifocal Leukoencephalopathy

Bellizzi, A., Anzivino, E., Rodio, D. M., Palamara, A. T., Nencioni, L., & Pietropaolo, V. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/839719 · Cited by 101

Activating transcription factor 4 regulates osteoclast differentiation in mice

Cao, H., Yu, S., Yao, Z., Galson, D. L., Jiang, Y., Zhang, X., Fan, J., Lu, B., Guan, Y., Luo, M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42106 · Cited by 100

RANKL-independent modulation of osteoclastogenesis

Feng, W., Guo, J., & Li, M. (2019) · Journal of Oral Biosciences · doi:10.1016/j.job.2019.01.001 · Cited by 99

MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner

Miyamoto, K., Ninomiya, K., Sonoda, K., Miyauchi, Y., Hoshi, H., Iwasaki, R., Miyamoto, H., Yoshida, S., Sato, Y., Morioka, H., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.04.020 · Cited by 94

c-Fos plays an essential role in the up-regulation of RANK expression in osteoclast precursors within the bone microenvironment

Arai, A., Mizoguchi, T., Harada, S., Kobayashi, Y., Nakamichi, Y., Yasuda, H., Penninger, J. M., Yamada, K., Udagawa, N., & Takahashi, N. (2012) · Journal of Cell Science · doi:10.1242/jcs.099986 · Cited by 95

Neural Stem Cells Directly Differentiated from Partially Reprogrammed Fibroblasts Rapidly Acquire Gliogenic Competency

Matsui, T. K., Takano, M., Yoshida, K., Ono, S., Fujisaki, C., Matsuzaki, Y., Toyama, Y., Nakamura, M., Okano, H., & Akamatsu, W. (2012) · Stem Cells · doi:10.1002/stem.1091 · Cited by 93

Examining the relationship between diet-induced acidosis and cancer

Robey, I. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-72 · Cited by 93

Expression Profile of RhoGTPases and RhoGEFs During RANKL-Stimulated Osteoclastogenesis: Identification of Essential Genes in Osteoclasts

Brazier, H., Stephens, S., Ory, S., Fort, P., Morrison, N. A., & Blangy, A. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060613 · Cited by 90

Exosomal Release of L-Plastin by Breast Cancer Cells Facilitates Metastatic Bone Osteolysis

Tiedemann, K., Sadvakassova, G., Mikolajewicz, N., Juhas, M., Sabirova, Z., Tabariès, S., Gettemans, J., Siegel, P. M., & Komarova, S. V. (2018) · Translational Oncology · doi:10.1016/j.tranon.2018.11.014 · Cited by 88

Differential expression of receptor activator of nuclear factor‐κB ligand and osteoprotegerin mRNA in periodontal diseases

Bostancı, N., İlgenli, T., Emingil, G., Afacan, B., Han, B., Töz, H., Berdeli, A., Atilla, G., McKay, I. J., Hughes, F. J., et al. (2006) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2006.00946.x · Cited by 87

RANK Ligand-induced Elevation of Cytosolic Ca2+ Accelerates Nuclear Translocation of Nuclear Factor κB in Osteoclasts

Komarova, S. V., Pilkington, M. F., Weidema, A. F., Dixon, S. J., & Sims, S. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206421200 · Cited by 87

Signal transduction pathways regulating osteoclast differentiation and function

Tanaka, S., Nakamura, I., Inoue, J., Oda, H., & Nakamura, K. (2003) · Journal of Bone and Mineral Metabolism · doi:10.1007/s007740300021 · Cited by 89

Destroy to Rebuild: The Connection Between Bone Tissue Remodeling and Matrix Metalloproteinases

Hardy, E., & Fernández-Patrón, C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00047 · Cited by 86

p38 Mitogen-Activated Protein Kinase Is Crucially Involved in Osteoclast Differentiation But Not in Cytokine Production, Phagocytosis, or Dendritic Cell Differentiation of Bone Marrow Macrophages

Li, X., Udagawa, N., Takami, M., Sato, N., Kobayashi, Y., & Takahashi, N. (2003) · Endocrinology · doi:10.1210/en.2003-0166 · Cited by 85

TRAFs in RANK Signaling

Darnay, B. G., Besse, A., Poblenz, A. T., Lamothe, B., & Jacoby, J. J. (2007) · Springer eBooks · doi:10.1007/978-0-387-70630-6_12 · Cited by 85

Key roles of the OPG–RANK–RANKL system in bone oncology

Baud’huin, M., Duplomb, L., Velasco, C. R., Fortun, Y., Heymann, D., & Padrines, M. (2007) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.7.2.221 · Cited by 84

NFATc1 regulates lymphatic endothelial development

Kulkarni, R. M., Greenberg, J. M., & Akeson, A. L. (2009) · Mechanisms of Development · doi:10.1016/j.mod.2009.02.003 · Cited by 75

Calmodulin is a critical regulator of osteoclastic differentiation, function, and survival

Seales, E. C., Micoli, K., & McDonald, J. M. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20659 · Cited by 80

mTORC1 Inhibits NF-κB/NFATc1 Signaling and Prevents Osteoclast Precursor Differentiation, In Vitro and In Mice

Zhang, Y., Xu, S., Li, K., Tan, K. W., Liang, K., Wang, J., Shen, J., Zou, W., Hu, L., Cai, D., et al. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3172 · Cited by 78

Inhibition of Osteoclast Differentiation and Bone Resorption by N-Methylpyrrolidone

Ghayor, C., Correro, R. M., Lange, K., Karfeld‐Sulzer, L. S., Grätz, K. W., & Weber, F. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.223297 · Cited by 80

Active caspase‐3 is required for osteoclast differentiation

Szymczyk, K. H., Freeman, T. A., Adams, C. S., Srinivas, V., & Steinbeck, M. J. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20770 · Cited by 79

Platelet Dysfunction and a High Bone Mass Phenotype in a Murine Model of Platelet-Type von Willebrand Disease

Suva, L. J., Hartman, E., Dilley, J. D., Russell, S., Akel, N. S., Skinner, R. A., Hogue, W. R., Budde, U., Varughese, K. I., Kanaji, T., et al. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070417 · Cited by 75

Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis

Muruganandan, S., Dranse, H. J., Rourke, J. L., McMullen, N. M., & Sinal, C. J. (2013) · Stem Cells · doi:10.1002/stem.1450 · Cited by 73

Orai1‐mediated calcium entry plays a critical role in osteoclast differentiation and function by regulating activation of the transcription factor NFATc1

Hwang, S., & Putney, J. W. (2011) · The FASEB Journal · doi:10.1096/fj.11-194399 · Cited by 75

Activation of peroxisome proliferator-activated receptor γ inhibits TNF-α-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression

Hounoki, H., Sugiyama, E., Mohamed, S. G.-K., Shinoda, K., Taki, H., Abdel-Aziz, H. O., Maruyama, M., Kobayashi, M., & Miyahara, T. (2008) · Bone · doi:10.1016/j.bone.2007.11.016 · Cited by 75

Medicarpin inhibits osteoclastogenesis and has nonestrogenic bone conserving effect in ovariectomized mice

Tyagi, A. M., Gautam, A. K., Kumar, A., Srivastava, K., Bhargavan, B., Trivedi, R., Saravanan, S., Yadav, D. K., Singh, N., Pollet, C., et al. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.05.016 · Cited by 74

A formyl peptide receptor agonist suppresses inflammation and bone damage in arthritis

Kao, W. W. ‐., Gu, R., Jia, Y., Wei, X., Fan, H., Harris, J., Zhang, Z., Quinn, J. M. W., Morand, E. F., & Yang, Y. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12768 · Cited by 72

Inhibition of titanium particle-induced osteoclastogenesis through inactivation of NFATc1 by VIVIT peptide

Liu, F., Zhu, Z., Mao, Y., Liu, M., Tang, T., & Qiu, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.018 · Cited by 71

JMJD5, a Jumonji C (JmjC) Domain-containing Protein, Negatively Regulates Osteoclastogenesis by Facilitating NFATc1 Protein Degradation

Youn, M., Yokoyama, A., Fujiyama, S., Ohtake, F., Minehata, K., Yasuda, H., Suzuki, T., Kato, S., & Imai, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.323105 · Cited by 70

Inhibition of osteoclast differentiation and bone resorption by sauchinone

Han, K.-Y., Yang, D., Chang, E.-J., Lee, Y., Huang, H., Sung, S. H., Lee, Z. H., Kim, Y. C., & Kim, H. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.044 · Cited by 71

ASIC1a induces synovial inflammation via the Ca 2+ /NFATc3/ RANTES pathway

Zhang, Y., Qian, X., Yang, X., Niu, R., Song, S., Zhu, F., Zhu, C., Peng, X., & Chen, F. (2019) · Theranostics · doi:10.7150/thno.37200 · Cited by 69

Role of OSCAR Signaling in Osteoclastogenesis and Bone Disease

Nedeva, I. R., Vitale, M., Elson, A., Hoyland, J. A., & Bella, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.641162 · Cited by 72

Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand

Balkan, W., Martinez, A. F., Fernández, I. C., Rodriguez, M. A., Pang, M., & Troen, B. R. (2009) · Gene · doi:10.1016/j.gene.2009.06.013 · Cited by 68

Neutrophil extracellular traps mediate bone erosion in rheumatoid arthritis by enhancing RANKL‐induced osteoclastogenesis

Schneider, A. H., Taira, T. M., Públio, G. A., Prado, D. D. S., Yabuta, P. B. D., dos Santos, J. C., Machado, C. C., de Souza, F. F. L., Venturini, L. G. R., de Oliveira, R. D. R., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16227 · Cited by 72

Anthraquinone compounds from Morinda officinalis inhibit osteoclastic bone resorption in vitro

Bao, L., Qin, L., Liu, L., Wu, Y., Han, T., Xue, L., & Zhang, Q. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.08.013 · Cited by 68

Gene array identification of osteoclast genes: Differential inhibition of osteoclastogenesis by cyclosporin A and granulocyte macrophage colony stimulating factor

Day, C. J., Kim, M. S., Stephens, S., Simcock, W. E., Aitken, C. J., Nicholson, G. C., & Morrison, N. A. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10780 · Cited by 52

RANK-L induces the expression of NFATc1, but not of NFκB subunits during osteoclast formation

Zhu, L., Zaidi, S., Moonga, B. S., Troen, B. R., & Sun, L. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.212 · Cited by 23

The Calcineurin/Nuclear Factor of Activated T Cells Signaling Pathway Regulates Osteoclastogenesis in RAW264.7 Cells

Hirotani, H., Tuohy, N. A., Woo, J.-T., Stern, P. H., & Clipstone, N. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m213067200 · Cited by 248

Receptor Activator of Nuclear Factor-κB Ligand-Induced Nuclear Factor of Activated T Cells (C1) Autoregulates Its Own Expression in Osteoclasts and Mediates the Up-Regulation of Tartrate-Resistant Acid Phosphatase

Fretz, J. A., Shevde, N. K., Singh, S., Darnay, B. G., & Pike, J. W. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0333 · Cited by 27

CCR1 Acts Downstream of NFAT2 in Osteoclastogenesis and Enhances Cell Migration

Ishida, N., Hayashi, K., Hattori, A., Yogo, K., Kimura, T., & Takeya, T. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.051001 · Cited by 41