PGC-1α Integrates Insulin Signaling, Mitochondrial Regulation, and Bioenergetic Function in Skeletal Muscle

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

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Resveratrol improves health and survival of mice on a high-calorie diet

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Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

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Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of <i>PGC1</i> and <i>NRF1</i>

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

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Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

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Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy.

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Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents

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SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B

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The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

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Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

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Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals.

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Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

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Bioenergetic Analysis of Peroxisome Proliferator-activated Receptor γ Coactivators 1α and 1β (PGC-1α and PGC-1β) in Muscle Cells

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PPAR-γ regulates osteoclastogenesis in mice

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The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men

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Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo

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Impaired Mitochondrial Substrate Oxidation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Patients

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PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes

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Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance

Liu, L., Zhang, Y., Chen, N., Shi, X., Tsang, B., & Yu, Y.-H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30565 · Cited by 356 · see citing works

Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk

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A role for the transcriptional coactivator PGC-1α in muscle refueling.

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Modest PGC-1α Overexpression in Muscle in Vivo Is Sufficient to Increase Insulin Sensitivity and Palmitate Oxidation in Subsarcolemmal, Not Intermyofibrillar, Mitochondria

Benton, C. R., Nickerson, J. G., Lally, J., Han, X.-X., Holloway, G. P., Glatz, J. F. C., Luiken, J. J. F. P., Graham, T. E., Heikkila, J. J., & Bonen, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m704332200 · Cited by 214 · see citing works

Reduced Expression of Nuclear-Encoded Genes Involved in Mitochondrial Oxidative Metabolism in Skeletal Muscle of Insulin-Resistant Women With Polycystic Ovary Syndrome

Skov, V., Glintborg, D., Knudsen, S., Jensen, T. E., Kruse, T. A., Tan, Q., Brusgaard, K., Beck‐Nielsen, H., & Højlund, K. (2007) · Diabetes · doi:10.2337/db07-0275 · Cited by 202 · see citing works

Thiazolidinediones and Rexinoids Induce Peroxisome Proliferator-Activated Receptor-Coactivator (PGC)-1α Gene Transcription: An Autoregulatory Loop Controls PGC-1α Expression in Adipocytes via Peroxisome Proliferator-Activated Receptor-γ Coactivation

Hondares, E., Mora, O., Yubero, P., de la Concepción, M. L. R., Iglesias, R., Giralt, M., & Villarroya, F. (2006) · Endocrinology · doi:10.1210/en.2006-0070 · Cited by 183 · see citing works

Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance

Choi, C. S., Fillmore, J. J., Kim, J. K., Liu, Z., Kim, S., Collier, E. F., Kulkarni, A. S., Distefano, A. G., Hwang, Y.-J., Kahn, M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci13579 · Cited by 182 · see citing works

Pioglitazone and Rosiglitazone Have Different Effects on Serum Lipoprotein Particle Concentrations and Sizes in Patients With Type 2 Diabetes and Dyslipidemia

Deeg, M. A., Buse, J. B., Goldberg, R. B., Kendall, D. M., Zagar, A. J., Jacober, S. J., Khan, M. A., Perez, A. T., Tan, M. H., & on behalf of the GLAI Study Investigators (2007) · Diabetes Care · doi:10.2337/dc06-1903 · Cited by 179 · see citing works

Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression

Blendea, M. C., Jacobs, D., Stump, C. S., McFarlane, S. I., Ogrin, C., Bahtyiar, G., Stas, S., Kumar, P., Sha, Q., Ferrario, C. M., et al. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00402.2004 · Cited by 171 · see citing works

Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1α and PPARβ/δ gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus

Mensink, M., Hesselink, M. K. C., Russell, A. P., Schaart, G., Sels, J.-P., & Schrauwen, P. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803567 · Cited by 160 · see citing works

Overexpression of peroxisome proliferator-activated receptor γ coactivator-1α down-regulates GLUT4 mRNA in skeletal muscles.

Miura, S., Kai, Y., Ono, M., & Ezaki, O. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304312200 · Cited by 146 · see citing works

Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients.

Boden, G., Homko, C., Mozzoli, M., Showe, L. C., Nichols, C., & Cheung, P. (2005) · Diabetes · doi:10.2337/diabetes.54.3.880 · Cited by 129 · see citing works

Respiratory Uncoupling in Skeletal Muscle Delays Death and Diminishes Age-Related Disease

Gates, A. C., Bernal‐Mizrachi, C., Chinault, S. L., Chu, F., Schneider, J. G., Coleman, T., Malone, J. P., Townsend, R. R., Chakravarthy, M. V., & Semenkovich, C. F. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.010 · Cited by 113 · see citing works

Overexpression of UCP3 in cultured human muscle lowers mitochondrial membrane potential, raises ATP/ADP ratio, and favors fatty acid versus glucose oxidation

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Insulin Signaling and Glucose Transport in Skeletal Muscle From First-Degree Relatives of Type 2 Diabetic Patients

Karlsson, H., Ahlsén, M., Zierath, J. R., Wallberg‐Henriksson, H., & Koistinen, H. A. (2006) · Diabetes · doi:10.2337/db05-0853 · Cited by 88 · see citing works

Insulin Signal Transduction in Skeletal Muscle From Glucose-Intolerant Relatives With Type 2 Diabetes

Storgaard, H., Song, X. M., Jensen, C. B., Madsbad, S., Björnholm, M., Vaag, A. A., & Zierath, J. R. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2770 · Cited by 82 · see citing works

Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation

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Exercise reverses high-fat diet-induced impairments on compartmentalization and activation of components of the insulin-signaling cascade in skeletal muscle

Yaspelkis, B. B., Lessard, S. J., Reeder, D. W., Limon, J. J., Saito, M., Rivas, D. A., Kvasha, I. A., & Hawley, J. A. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00230.2007 · Cited by 34 · see citing works

A discordance in rosiglitazone mediated insulin sensitization and skeletal muscle mitochondrial content/activity in Type 2 diabetes mellitus

Pagel, I., Schwartz, D. R., Arena, R. A., Minerbi, D. C., Johnson, D., Waclawiw, M. A., Cannon, R. O., Balaban, R. S., Tripodi, D. J., & Sack, M. N. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00782.2007 · Cited by 21 · see citing works

Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

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Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial

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Attenuated mTOR Signaling and Enhanced Autophagy in Adipocytes from Obese Patients with Type 2 Diabetes

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The neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review

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Mitochondrial dysfunction in diabetic cardiomyopathy

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Mitochondrially derived peptides as novel regulators of metabolism

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A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis

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Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance

Hoeks, J., van Herpen, N. A., Mensink, M., Moonen-Kornips, E., van Beurden, D., Hesselink, M. K. C., & Schrauwen, P. (2010) · Diabetes · doi:10.2337/db10-0519 · Cited by 156 · see citing works

SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity

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The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin Resistance

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SRT1720 Induces Mitochondrial Biogenesis and Rescues Mitochondrial Function after Oxidant Injury in Renal Proximal Tubule Cells

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Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review

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The Drosophila PGC‐1 homologue Spargel coordinates mitochondrial activity to insulin signalling

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PPARγ stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss

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Glitazone Treatment and Incidence of Parkinson’s Disease among People with Diabetes: A Retrospective Cohort Study

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Platelet Mitochondrial Dysfunction is Evident in Type 2 Diabetes in Association with Modifications of Mitochondrial Anti-Oxidant Stress Proteins

Avila, C., Huang, R., Stevens, M., Aponte, A. M., Tripodi, D., Kim, K., & Sack, M. N. (2011) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0031-1285833 · Cited by 112 · see citing works

Effect of puerarin in promoting fatty acid oxidation by increasing mitochondrial oxidative capacity and biogenesis in skeletal muscle in diabetic rats

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LRP6 Enhances Glucose Metabolism by Promoting TCF7L2-Dependent Insulin Receptor Expression and IGF Receptor Stabilization in Humans

Singh, R., Aguiar, R. B. D., Naik, S., Mani, S., Ostadsharif, K., Wencker, D., Sotoudeh, M., Malekzadeh, R., Sherwin, R. S., & Mani, A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.009 · Cited by 98 · see citing works

Regulation of the Transcription Factor EB-PGC1α Axis by Beclin-1 Controls Mitochondrial Quality and Cardiomyocyte Death under Stress

Ma, X., Liu, H., Murphy, J. T., Foyil, S. R., Godar, R. J., Abuirqeba, H., Weinheimer, C. J., Barger, P. M., & Diwan, A. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01091-14 · Cited by 96 · see citing works

PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease

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Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma

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GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis

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The Implication of PGC-1α on Fatty Acid Transport across Plasma and Mitochondrial Membranes in the Insulin Sensitive Tissues

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Agonism of the 5-Hydroxytryptamine 1F Receptor Promotes Mitochondrial Biogenesis and Recovery from Acute Kidney Injury

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The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPK-dependent

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Mitostasis, Calcium and Free Radicals in Health, Aging and Neurodegeneration

Godoy, J. A., Ríos, J. A., Picón-Pagès, P., Herrera-Fernández, V., Swaby, B., Crepin, G., Vicente, R., Fernández‐Fernández, J. M., & Muñoz, F. J. (2021) · Biomolecules · doi:10.3390/biom11071012 · Cited by 73 · see citing works

Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors

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Catalpol Ameliorates Insulin Sensitivity and Mitochondrial Respiration in Skeletal Muscle of Type-2 Diabetic Mice Through Insulin Signaling Pathway and AMPK/SIRT1/PGC-1α/PPAR-γ Activation

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Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart

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Low‐Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1/PGC‐1α in Skeletal Muscle

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The Emerging Characterization of Lysine Residue Deacetylation on the Modulation of Mitochondrial Function and Cardiovascular Biology

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Leucine treatment enhances oxidative capacity through complete carbohydrate oxidation and increased mitochondrial density in skeletal muscle cells

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Circadian regulation of adipose function

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Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function

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Mitochondrial dysfunction in insulin resistance: differential contributions of chronic insulin and saturated fatty acid exposure in muscle cells

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Myocardial infarction in rats causes partial impairment in insulin response associated with reduced fatty acid oxidation and mitochondrial gene expression

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Pecans and Its Polyphenols Prevent Obesity, Hepatic Steatosis and Diabetes by Reducing Dysbiosis, Inflammation, and Increasing Energy Expenditure in Mice Fed a High-Fat Diet

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Metabolic Profiling of Female Tg2576 Mouse Brains Provides Novel Evidence Supporting Intranasal Low-Dose Pioglitazone for Long-Term Treatment at an Early Stage of Alzheimer’s Disease

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Toward Ameliorating Insulin Resistance: Targeting a Novel PAK1 Signaling Pathway Required for Skeletal Muscle Mitochondrial Function

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Skeletal muscle disorders as risk factors for type 2 diabetes

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Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer’s Disease

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Treatment with the synthetic PPARG ligand pioglitazone ameliorates early ovarian alterations induced by dehydroepiandrosterone in prepubertal rats

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Metabolic therapy in cardiac surgery - “Optimizing the engine's fuel supply and more…”

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A Comparative Peptidomic Characterization of Cultured Skeletal Muscle Tissues Derived From db/db Mice

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Molecular Pathways in Diabetic Cardiomyopathy and the Role of Anti-hyperglycemic Drugs Beyond Their Glucose Lowering Effect

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