Mitochondrial Inhibitor as a New Class of Insulin Sensitizer

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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

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Cellular mechanisms of insulin resistance

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

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Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

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Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I

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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

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Regulation of Muscle Fiber Type and Running Endurance by PPARδ

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Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States

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AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

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Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

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Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes

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Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

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Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

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Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1

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Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

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Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

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Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals.

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Endurance Exercise as a Countermeasure for Aging

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Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes

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Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

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Emerging role of adipose tissue hypoxia in obesity and insulin resistance

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Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I

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Thiazolidinediones, Like Metformin, Inhibit Respiratory Complex I

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Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts

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Inhibition of mitochondrial proton F0F1‐ATPase/ATP synthase by polyphenolic phytochemicals

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Mitochondrial Diabetes

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Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria.

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Berberine improves glucose metabolism through induction of glycolysis

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Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

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Mechanism of inhibition of bovine F 1 -ATPase by resveratrol and related polyphenols

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PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes

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Mitochondria are impaired in the adipocytes of type 2 diabetic mice.

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A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans

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Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

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Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk

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Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways

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ATP Synthase and the Actions of Inhibitors Utilized To Study Its Roles in Human Health, Disease, and Other Scientific Areas

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Cardiolipin Remodeling by ALCAT1 Links Oxidative Stress and Mitochondrial Dysfunction to Obesity

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Increased Malonyl-CoA Levels in Muscle From Obese and Type 2 Diabetic Subjects Lead to Decreased Fatty Acid Oxidation and Increased Lipogenesis; Thiazolidinedione Treatment Reverses These Defects

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Targeting the AMPK pathway for the treatment of Type 2 diabetes

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A potential link between muscle peroxisome proliferator- activated receptor-α signaling and obesity-related diabetes

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Berberine Improves Glucose Metabolism in Diabetic Rats by Inhibition of Hepatic Gluconeogenesis

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Chronic Exposure to the Herbicide, Atrazine, Causes Mitochondrial Dysfunction and Insulin Resistance

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Skeletal Muscle Mitochondrial Functions, Mitochondrial DNA Copy Numbers, and Gene Transcript Profiles in Type 2 Diabetic and Nondiabetic Subjects at Equal Levels of Low or High Insulin and Euglycemia

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Muscle-Specific Loss of Apoptosis-Inducing Factor Leads to Mitochondrial Dysfunction, Skeletal Muscle Atrophy, and Dilated Cardiomyopathy

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Asian Indians Have Enhanced Skeletal Muscle Mitochondrial Capacity to Produce ATP in Association With Severe Insulin Resistance

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Mitochondrial dysfunction induces triglyceride accumulation in 3T3-L1 cells: role of fatty acid β-oxidation and glucose

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The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin Resistance

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Fish oil increases mitochondrial phospholipid unsaturation, upregulating reactive oxygen species and apoptosis in rat colonocytes

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Peroxidative damage to cardiac mitochondria: cytochrome oxidase and cardiolipin alterations

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Overexpression of peroxisome proliferator-activated receptor γ coactivator-1α down-regulates GLUT4 mRNA in skeletal muscles.

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Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation

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Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance

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A Common Polymorphism in the Promoter of UCP2 Contributes to the Variation in Insulin Secretion in Glucose-Tolerant Subjects

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Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients.

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PGC-1α Integrates Insulin Signaling, Mitochondrial Regulation, and Bioenergetic Function in Skeletal Muscle

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Marked Differences between Two Isoforms of Human Pyruvate Dehydrogenase Kinase

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Role of Insulin in the Pathogenesis of Free Fatty Acid-Induced Insulin Resistance in Skeletal Muscle

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Docosahexaenoic acid accumulates in cardiolipin and enhances HT-29 cell oxidant production

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Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis

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Mitochondrial dysfunction induces aberrant insulin signalling and glucose utilisation in murine C2C12 myotube cells

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Imaging diacylglycerol dynamics at organelle membranes

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Effect of hyperglycemia on mitochondrial respiration in type 2 diabetes.

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Pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) deficiency attenuates the long-term negative effects of a high-saturated fat diet

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In Vino Veritas: A Tale of Two Sirt1s?

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Muscular mitochondrial dysfunction and type 2 diabetes mellitus

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Induction of mitochondrial nitrative damage and cardiac dysfunction by chronic provision of dietary ω-6 polyunsaturated fatty acids

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Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance

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Endurance exercise as a countermeasure for aging. Diabetes 2008;57:2933–2942

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Challenges in drug discovery for thiazolidinedione substitute

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Large enhancement of skeletal muscle cell glucose uptake and suppression of hepatocyte glucose-6-phosphatase activity by weak uncouplers of oxidative phosphorylation

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Lactate Production and Pyruvate Dehydrogenase Activity in Fat and Skeletal Muscle From Diabetic Rats

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Combretastatin A-4 activates AMP-activated protein kinase and improves glucose metabolism in db/db mice

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