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Fourier Transform Mass Spectrometry

Open access
Scigelova, Michaela, Hornshaw, Martin, Giannakopulos, Anastassios, Makarov, Alexander·2011·Molecular & Cellular Proteomics
DOI 10.1074/mcp.m111.009431
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Abstract

This article provides an introduction to Fourier transform-based mass spectrometry. The key performance characteristics of Fourier transform-based mass spectrometry, mass accuracy and resolution, are presented in the view of how they impact the interpretation of measurements in proteomic applications. The theory and principles of operation of two types of mass analyzer, Fourier transform ion cyclotron resonance and Orbitrap, are described. Major benefits as well as limitations of Fourier transform-based mass spectrometry technology are discussed in the context of practical sample analysis, and illustrated with examples included as figures in this text and in the accompanying slide set. Comparisons highlighting the performance differences between the two mass analyzers are made where deemed useful in assisting the user with choosing the most appropriate technology for an application. Recent developments of these high-performing mass spectrometers are mentioned to provide a future outlook.

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Metadata

Authors
Scigelova, M., Hornshaw, M., Giannakopulos, A., & Makarov, A.
Venue
Molecular & Cellular Proteomics
Publisher
Elsevier BV
Published
2011-07
Volume
10
Issue
7
Pages
M111.009431
ISSN
1535-9476 (ISSN-L)
DOI
10.1074/mcp.m111.009431
OpenAlex
W2048557976
Cited by
224
References
3
FWCI
6.98
Type
journal article
Language
en
Open access
hybrid
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CoChat. (2026). Citation check: Fourier Transform Mass Spectrometry. https://app.cochat.ai/papers/10.1074/mcp.m111.009431
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Scigelova, M., Hornshaw, M., Giannakopulos, A., & Makarov, A. (2011). Fourier Transform Mass Spectrometry. Molecular & Cellular Proteomics. https://doi.org/10.1074/mcp.m111.009431

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