Post-translational Modifications Regulate Class IIa Histone Deacetylase (HDAC) Function in Health and Disease

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TRANSCRIPTIONAL CONTROL OF MUSCLE DEVELOPMENT BY MYOCYTE ENHANCER FACTOR-2 (MEF2) PROTEINS

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Class II Histone Deacetylases Act as Signal-Responsive Repressors of Cardiac Hypertrophy

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A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

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PrDOS: prediction of disordered protein regions from amino acid sequence

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Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis

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SAINT: probabilistic scoring of affinity purification–mass spectrometry data

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Enzymatic Activity Associated with Class II HDACs Is Dependent on a Multiprotein Complex Containing HDAC3 and SMRT/N-CoR

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Class II histone deacetylases: versatile regulators

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Histone deacetylases, transcriptional control, and cancer

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Regulation of transcription factors by neuronal activity

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Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli

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Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3- 3-dependent cellular localization

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Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases

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Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

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HDAC4 deacetylase associates with and represses the MEF2 transcription factor

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Deacetylase Enzymes

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Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5

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Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases

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CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy

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Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5

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Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling

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BCoR, a novel corepressor involved in BCL-6 repressionPreprint

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Stress Pathways and Heart Failure

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AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5

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Targeting the Receptor-G q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy

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The δ isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload

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Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repressionPreprint

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Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling Reveals System-Wide Modulation of Protein-Protein Interactions

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A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy

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Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathwayPreprint

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Regulation of Histone Deacetylase 4 by Binding of 14-3-3 Proteins

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Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

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Association of Class II Histone Deacetylases with Heterochromatin Protein 1: Potential Role for Histone Methylation in Control of Muscle Differentiation

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Cloning and characterization of a histone deacetylase, HDAC9

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Class IIa histone deacetylases: regulating the regulators

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Requirement of protein kinase D1 for pathological cardiac remodeling

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Mechanism for Nucleocytoplasmic Shuttling of Histone Deacetylase 7

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Association of COOH-terminal-binding Protein (CtBP) and MEF2-interacting Transcription Repressor (MITR) Contributes to Transcriptional Repression of the MEF2 Transcription Factor

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Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

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HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21

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HDAC7, a Thymus-Specific Class II Histone Deacetylase, Regulates Nur77 Transcription and TCR-Mediated Apoptosis

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Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

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HDAC5 is a novel injury‐regulated tubulin deacetylase controlling axon regeneration

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Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme.

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CaMKIIδ Isoforms Differentially Affect Calcium Handling but Similarly Regulate HDAC/MEF2 Transcriptional Responses

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Enhanced Insulin Action Due to Targeted GLUT4 Overexpression Exclusively in Muscle

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A Limited Group of Class I Histone Deacetylases Acts To Repress Human Immunodeficiency Virus Type 1 Expression

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MEF‐2 function is modified by a novel co‐repressor, MITR

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Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS

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Intracellular Trafficking of Histone Deacetylase 4 Regulates Neuronal Cell Death

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Histone Deacetylase 4 Possesses Intrinsic Nuclear Import and Export Signals

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Histone Deacetylase 5 Acquires Calcium/Calmodulin-Dependent Kinase II Responsiveness by Oligomerization with Histone Deacetylase 4

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Class II Histone Deacetylases Are Directly Recruited by BCL6 Transcriptional Repressor

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HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration

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Novel Nuclear Roles for Testis-Specific ACTL7A and ACTL7B Supported by In Vivo Characterizations and AI Facilitated In Silico Mechanistic Modeling with Implications for Epigenetic Regulation in SpermiogenesisPreprint

Ferrer, P., Upadhyay, S., Cai, J. J., & Clement, T. M. (2024) · eLife · doi:10.7554/elife.95378.1

Purinergic signaling promotes gliomagenesis through nuclear calcium transientsPreprint

Wang, S., Richter, J., Kim, C., Ronnen, R., Cai, J., Song, Y., Haddock, S., Stoessel, M. B., Dada, H., Gross, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.11.724407

BindingDB Entry 50008262: Recent advances in class IIa histone deacetylases research.

BindingDB (2021) · UC San Diego · doi:10.7270/q2vm4gmz

Post-translational modifications talk and crosstalk to class IIa histone deacetylases

Guttzeit, S., & Backs, J. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.08.007 · Cited by 14 · see citing works

Roles and post‐translational regulation of cardiac class IIa histone deacetylase isoforms

Weeks, K. L., & Avkiran, M. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.282442 · Cited by 40 · see citing works

Role of histone deacetylase 2 and its posttranslational modifications in cardiac hypertrophy

Eom, G. H., & Kook, H. Y. (2015) · BMB Reports · doi:10.5483/bmbrep.2015.48.3.242 · Cited by 29 · see citing works

Posttranslational modifications of histone deacetylases: Implications for cardiovascular diseases

Eom, G. H., & Kook, H. Y. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.02.012 · Cited by 98 · see citing works

Regulation of Class IIa HDAC Activities: It is Not Only Matter of Subcellular Localization

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