A critical assessment of some biomarker approaches linked with dietary intake

Crews, H.; Alink, G.; Andersen, R.; Braesco, V.; Holst, B.; Maiani, G.; Ovesen, L.; Scotter, M.; Solfrizzo, M.; van den Berg, R.; Verhagen, H.; Williamson, G.

doi:10.1079/bjn2001337

Cited by 99Antioxidant Activity and Oxidative StressNutritional Studies and DietPhytochemicals and Antioxidant Activities

A critical assessment of some biomarker approaches linked with dietary intake

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Crews, H., Alink, G., Andersen, R., Braesco, V., Holst, B., Maiani, G., Ovesen, L., Scotter, M. +4 more·2001·British Journal Of Nutrition

DOI 10.1079/bjn2001337

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Abstract

In this review many examples are given of the complexities involved in using some biomarkers in relation to assessing the effects of dietary exposure, when there is frequently a need to determine changes following long-term low level exposure to dietary components. These range from understanding why the biomarker might be valuable and how best it can be measured, to the pitfalls which can occur in the interpretation of data. Analytical technique is considered in relation to folate and selenium, and flavonoid and carotenoid species are used to illustrate how the metabolism of a compound may alter the validity or adequacy of a marker. Vitamin A is discussed in relation to the difficulties which can arise when there are several biomarkers that may be available to assess exposure to one nutrient. Vitamin B12 is discussed in relation to the dietary choices made by individuals. Possible interactions and the role of measuring total antioxidant capacity is considered in some detail. In contrast to most nutrients, there is a marked lack of biomarkers of either exposure or effect for most non-nutrients. The role of biological effect monitoring is considered for dietary contaminants, fumonisins and polyhalogenated aromatic hydrocarbons. Aflatoxins are discussed to exemplify food contaminants for which the biomarker approach has been extensively studied. Finally some compounds which are deliberately added to foods and some which appear as processing contaminants are each considered briefly in relation to the requirement for a biomarker of exposure to be developed.

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Vitamin C and selenium in erythrocyte glutathione peroxidase show saturable effects and may not be suitable at high exposure levels.
“Biomarkers such as vitamin C or selenium in erythrocyte glutathione peroxidase show saturable effects and may not be suitable for use at high levels of exposure (29,42).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [29]
Ceramide synthase is inhibited by exposure to the mycotoxin fumonisins.
“ceramide synthase is inhibited by exposure to the mycotoxin fumonisins (29).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [29]
The activity of selenium-containing enzymes such as erythrocyte glutathione peroxidase depends on selenium intake.
“the activity of selenium-containing enzymes such as erythrocyte glutathione peroxidase depends on selenium intake”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [29]
Lipophilic markers such as carotenoids and lipids, and erythrocyte-associated biomarkers such as folate and fatty acids, have longer half-lives of weeks to months.
“Lipophilic markers (carotenoids, lipids) (36) or biomarkers associated with erythrocytes (folate, fatty acids) (29) have longer half-lives (week to month) because of the equilibrium of biomarkers between blood and fatty tissues, or because of their integration into erythrocytes.”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [29]

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Authors: Crews, H., Alink, G., Andersen, R., Braesco, V., Holst, B., Maiani, G., Ovesen, L., Scotter, M., Solfrizzo, M., van den Berg, R., Verhagen, H., & Williamson, G.
Affiliations: Fera Science (United Kingdom) (GB)
Wageningen University & Research (NL)
Danish Veterinary and Food Administration (DK)
Centre de Recherche en Nutrition Humaine d'Auvergne (FR)
Norwich Research Park (GB)
Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione (IT)
National Research Council (IT)
Corresponding author: Crews, H.
ORCID: Andersen, R.
Braesco, V.
Scotter, M.
Solfrizzo, M.
Verhagen, H.
Williamson, G.
Venue: British Journal Of Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2001-08
Volume: 86
Issue: S1
Pages: S5-S35
ISSN: 0007-1145 (ISSN-L)
1475-2662
DOI: 10.1079/bjn2001337
OpenAlex: W2053345817
Cited by: 99
References: 317
Citations by year: 2026: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 7 · 2012: 3
FWCI: 0.79
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 2046 d)
Locations: British Journal Of Nutrition (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
TNO Repository (submittedVersion)
Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
Research Portal (Queen's University Belfast) (submittedVersion)
Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords: dietary biomarkers, dietary exposure assessment, folic acid, selenium, flavonoids, carotenoids, vitamin A, vitamin B12, total antioxidant capacity, aflatoxins, fumonisins, polyhalogenated aromatic hydrocarbons, food contaminants, food additives, processing contaminants, biomarker interpretation
MeSH terms: Aflatoxins, Antioxidants, Brassica, Carotenoids, Developing Countries, Diet, Environmental Exposure, Flavonoids, Folic Acid, Food Additives, Food Analysis, Food Contamination, Free Radicals, Humans, Intestinal Absorption, Meat, Neoplasms, Nutritional Status, Polycyclic Aromatic Hydrocarbons, Predictive Value of Tests, Selenium, Sensitivity and Specificity, Vitamin A, Vitamin B Deficiency, Vitamin B 12, Reproducibility of Results, Biomarkers, Selenium Compounds, Genetic Predisposition to Disease

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