Biomarkers of fruit and vegetable intake in human intervention studies: a systematic review

Baldrick, Francina R.; Woodside, Jayne V.; Elborn, J. Stuart; Young, Ian S.; McKinley, Michelle C.

doi:10.1080/10408398.2010.482217

Cited by 109Nutritional Studies and DietPhytochemicals and Antioxidant ActivitiesAntioxidant Activity and Oxidative Stress

Biomarkers of fruit and vegetable intake in human intervention studies: a systematic review

Baldrick, Francina R., Woodside, Jayne V., Elborn, J. Stuart, Young, Ian S., McKinley, Michelle C.·2011·Critical Reviews in Food Science and Nutrition

DOI 10.1080/10408398.2010.482217

Open this paper in CoChat — free account

Abstract

Observational evidence consistently shows that consumption of a diet rich in fruit and vegetables may offer protection against diseases such as cardiovascular disease and cancer. Assessment of dietary intake is complex and prone to many sources of error. More objective biomarkers of fruit and vegetable intake are therefore of interest. The aim of this review is to examine the usefulness of the main biomarkers of fruit and vegetable intake to act as objective indicators of compliance in dietary intervention studies. A comprehensive search of the literature was conducted using six databases. Suitable papers were selected and relevant data extracted. The papers were categorized into 3 sub-groups: whole diet interventions; mixed fruit and vegetable interventions; and studies involving individual varieties of fruits or vegetables. Ninety-six studies were included in the review. Overall, the most commonly measured, and most consistently responsive, biomarkers were the carotenoids and vitamin C. Based on the results of this systematic review, it remains prudent to measure a panel of biomarkers in fruit and vegetable intervention studies. The only possible exception to this is "fruit only" intervention studies where assessment of vitamin C alone may suffice.

Integrity signals

Registry

Crossref · 10.1080/10408398.2010.482217

Cites

148 of 148 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Polyphenols, carotenoids, and vitamin C have been used as surrogate biomarkers of fruit and vegetable intake.
“polyphenols, carotenoids, and vitamin C for fruit and vegetables (17,18)”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [17]

A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Vogt, T. M., Cutler, J. A., Windhauser, M. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361601 · Cited by 5,981 · see citing works
Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease
de Lorgeril, M., Renaud, S., Salen, P., Monjaud, I., Mamelle, N., Martin, J. L., Guidollet, J., Touboul, P., & Delaye, J. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92580-1 · Cited by 2,122 · see citing works
The Effect of Fruit and Vegetable Intake on Risk for Coronary Heart Disease
Joshipura, K. J., Hu, F. B., Manson, J. E., Stampfer, M. J., Rimm, E. B., Speizer, F. E., Colditz, G., Ascherio, A., Rosner, B., Spiegelman, D., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-12-200106190-00010 · Cited by 1,396 · see citing works
Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies
Dauchet, L., Amouyel, P., Hercberg, S., & Dallongeville, J. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.10.2588 · Cited by 1,204 · see citing works
Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk
Ríboli, E., & Norat, T. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.559s · Cited by 1,173 · see citing works
Fruit and vegetable consumption and stroke: meta-analysis of cohort studies
He, F. J., Nowson, C. A., & MacGregor, G. A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68069-0 · Cited by 1,108 · see citing works
Markers of the Validity of Reported Energy Intake
Livingstone, M. B. E., & Black, A. E. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.3.895s · Cited by 1,081 · see citing works
Nutritional epidemiology
(1990) · Choice Reviews Online · doi:10.5860/choice.27-5795 · Cited by 1,049 · see citing works
Low-Fat Dietary Pattern and Risk of Invasive Breast Cancer: The Women's Health Initiative Randomized Controlled Dietary Modification Trial
Prentice, R. L., Caan, B., Chlebowski, R. T., Patterson, R., Kuller, L. H., Ockene, J. K., Margolis, K. L., Limacher, M. C., Manson, J. E., Parker, L. M., et al. (2006) · JAMA · doi:10.1001/jama.295.6.629 · Cited by 828 · see citing works
Plant-based foods and prevention of cardiovascular disease: an overview
Hu, F. B. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.544s · Cited by 700 · see citing works
Validation of dietary assessment methods in the UK arm of EPIC using weighed records, and 24-hour urinary nitrogen and potassium and serum vitamin C and carotenoids as biomarkers
Bingham, S. (1997) · International Journal of Epidemiology · doi:10.1093/ije/26.suppl_1.s137 · Cited by 634 · see citing works
Effects of fruit and vegetable consumption on plasma antioxidant concentrations and blood pressure: a randomised controlled trial
John, J., Ziébland, S., Yudkin, P. L., Roe, L., & Neil, H. (2002) · The Lancet · doi:10.1016/s0140-6736(02)98858-6 · Cited by 526 · see citing works
A new recommended dietary allowance of vitamin C for healthy young women
Levine, M., Wang, Y., Padayatty, S. J., & Morrow, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171318198 · Cited by 496 · see citing works
Select Flavonoids and Whole Juice From Purple Grapes Inhibit Platelet Function and Enhance Nitric Oxide Release
Freedman, J. E., Parker, C., Li, L., Perlman, J. A., Frei, B. B., Ivanov, V. O., Deak, L. R., Iafrati, M. D., & Folts, J. D. (2001) · Circulation · doi:10.1161/01.cir.103.23.2792 · Cited by 476 · see citing works
Biomarkers in nutritional epidemiology: applications, needs and new horizons
Jenab, M., Slimani, N., Bictash, M., Ferrari, P., & Bingham, S. A. (2009) · Human Genetics · doi:10.1007/s00439-009-0662-5 · Cited by 448 · see citing works
Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol
Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., & Jula, A. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.2.323 · Cited by 445 · see citing works
Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection
Brown, M. J., Ferruzzi, M. G., Nguyen, M. L., Cooper, D. A., Eldridge, A. L., Schwartz, S. J., & White, W. S. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.396 · Cited by 376 · see citing works
Mediterranean Dietary Pattern in a Randomized Trial
de Lorgeril, M., Salen, P., Martin, J., Monjaud, I., Boucher, P., & Mamelle, N. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.11.1181 · Cited by 364 · see citing works
Quantification of Carotenoid and Tocopherol Antioxidants inZeamays
Kurilich, A. C., & Juvik, J. A. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf981029d · Cited by 357 · see citing works
Human plasma carotenoid response to the ingestion of controlled diets high in fruits and vegetables
Yeum, K., Booth, S. L., Sadowski, J., Liu, C., Tang, G., Krinsky, N., & Russell, R. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.4.594 · Cited by 356 · see citing works
Carotenoid Absorption from Salad and Salsa by Humans Is Enhanced by the Addition of Avocado or Avocado Oil
Unlu, N. Z., Bohn, T., Clinton, S. K., & Schwartz, S. J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.3.431 · Cited by 330 · see citing works
The Food Matrix of Spinach Is a Limiting Factor in Determining the Bioavailability of β-Carotene and to a Lesser Extent of Lutein in Humans
Castenmiller, J. J. M., West, C. E., Linssen, J. P. H., Hof, K. H. V. H., & Voragen, A. G. J. (1999) · Journal of Nutrition · doi:10.1093/jn/129.2.349 · Cited by 318 · see citing works
Plasma carotenoid response to chronic intake of selected foods and β-carotene supplements in men
Micozzi, M. S., Brown, E., Edwards, B., Bieri, J. G., Taylor, P., Khachik, F., Beecher, G. R., & Smith, J. C. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/55.6.1120 · Cited by 315 · see citing works
The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers
Duthie, S. J., Jenkinson, A. M., Crozier, A., Mullen, W., Pirie, L. P., Kyle, J., Yap, L. S., Christen, P., & Duthie, G. G. (2005) · European Journal of Nutrition · doi:10.1007/s00394-005-0572-9 · Cited by 306 · see citing works
Supplementation with cactus pear (Opuntia ficus-indica) fruit decreases oxidative stress in healthy humans: a comparative study with vitamin C
Tesoriere, L., Butera, D., Pintaudi, A. M., Allegra, M., & Livrea, M. A. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.391 · Cited by 292 · see citing works
Prospective Study of Fruit and Vegetable Intake and Risk of Prostate Cancer
Kirsh, V. A., Peters, U., Mayne, S. T., Subar, A. F., Chatterjee, N., Johnson, C. C., & Hayes, R. B. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm065 · Cited by 291 · see citing works
Plasma carotenoids as biomarkers of vegetable and fruit intake.
Campbell, D. R., Gross, M., Martini, M. C., Grandits, G., Slavin, J. L., & Potter, J. D. (1994) · PubMed · Cited by 282 · see citing works
Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status
Young, J. F., Nielsen, S. E., Haraldsdóttir, J., Daneshvar, B., Lauridsen, S. T., Knuthsen, P., Crozier, A., Sandström, B., & Dragsted, L. O. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.1.87 · Cited by 279 · see citing works
The Medi-RIVAGE study: reduction of cardiovascular disease risk factors after a 3-mo intervention with a Mediterranean-type diet or a low-fat diet
Vincent-Baudry, S., Defoort, C., Gerber, M., Bernard, M., Verger, P., Helal, O., Portugal, H., Planells, R., Grolier, P., Amiot, M. J., et al. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.964 · Cited by 274 · see citing works
Bioavailability of β-Carotene Is Lower in Raw than in Processed Carrots and Spinach in Women
Rock, C. L., Lovalvo, J. L., Emenhiser, C., Ruffin, M. T., Flatt, S. W., & Schwartz, S. J. (1998) · Journal of Nutrition · doi:10.1093/jn/128.5.913 · Cited by 270 · see citing works
Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake
de Vries, J. H. M., Hollman, P. C. H., Meyboom, S., Buysman, M. N. C. P., Zock, P. L., van Staveren, W. A., & Katan, M. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.1.60 · Cited by 270 · see citing works
A randomized trial of the effect of a plant-based dietary pattern on additional breast cancer events and survival:
Pierce, J. P., Faerber, S., Wright, F. A., Rock, C. L., Newman, V. A., Flatt, S. W., Kealey, S., Jones, V. E., Caan, B. J., Gold, E. B., et al. (2002) · Controlled Clinical Trials · doi:10.1016/s0197-2456(02)00241-6 · Cited by 246 · see citing works
Bioavailability of lutein from vegetables is 5 times higher than that of β-carotene
Hof, K. H. V. H., Brouwer, I. A., West, C. E., Haddeman, E., Steegers‐Theunissen, R. P. M., van Dusseldorp, M., Weststrate, J. A., Eskes, T. K. A. B., & HAUTVAST, J. G. A. J. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.70.2.261 · Cited by 243 · see citing works
Daily consumption of Indian spinach (Basella alba) or sweet potatoes has a positive effect on total-body vitamin A stores in Bangladeshi men
Haskell, M. J., Jamil, K. M., Hassan, F., Peerson, J. M., Hossain, M., Fuchs, G. J., & Brown, K. H. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.3.705 · Cited by 240 · see citing works
Fruit juice consumption modulates antioxidative status, immune status and DNA damage
Bub, A., Watzl, B., Blockhaus, M., Briviba, K., Liegibel, U., Müller, H., Pool-Zobel, B. L., & Rechkemmer, G. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00255-3 · Cited by 233 · see citing works
Effect of increased vegetable and fruit consumption on markers of oxidative cellular damage
Thompson, H. J., Heimendinger, J., Haegele, A. D., SEDLACEK, S. M., Gillette, C. D., O'neill, C., Wolfe, P., & Conry, C. M. (1999) · Carcinogenesis · doi:10.1093/carcin/20.12.2261 · Cited by 222 · see citing works
A 4-wk intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy, nonsmoking men
Watzl, B., Kulling, S. E., Möseneder, J., Barth, S. W., & Bub, A. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.1052 · Cited by 220 · see citing works
Fruits and Vegetables Increase Plasma Carotenoids and Vitamins and Decrease Homocysteine in Humans
Broekmans, W. M. R., Klöpping-Ketelaars, I. A. A., Schuurman, C. R. W. C., Verhagen, H., van den Berg, H., Kok, F. J., & van Poppel, G. (2000) · Journal of Nutrition · doi:10.1093/jn/130.6.1578 · Cited by 218 · see citing works
Consequences of Revised Estimates of Carotenoid Bioefficacy for Dietary Control of Vitamin A Deficiency in Developing Countries
West, C. E., Eilander, A., & Lieshout, M. V. (2002) · Journal of Nutrition · doi:10.1093/jn/132.9.2920s · Cited by 213 · see citing works
Plasma carotenoids as biomarkers of intake of fruits and vegetables: ecological-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Al‐Delaimy, W. K., Slimani, N., Ferrari, P., Key, T. J., Spencer, E. A., Johansson, I., Johansson, G., Mattisson, I., Wirfält, E., Sieri, S., et al. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602253 · Cited by 212 · see citing works
Consumption of Watermelon Juice Increases Plasma Concentrations of Lycopene and β-Carotene in Humans
Edwards, A. J., Wiley, E. R., Brown, E. D., Clevidence, B. A., Vinyard, B. T., Collins, J. K., Perkins-Veazie, P. M., & Baker, R. A. (2003) · Journal of Nutrition · doi:10.1093/jn/133.4.1043 · Cited by 207 · see citing works
Moderate Intervention with Carotenoid-Rich Vegetable Products Reduces Lipid Peroxidation in Men
Bub, A., Watzl, B., Delincée, H., Adam, S., Wever, J., Müller, H., Rechkemmer, G., & Abrahamse, L. (2000) · Journal of Nutrition · doi:10.1093/jn/130.9.2200 · Cited by 200 · see citing works
Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women
Moon, J., Nakata, R., Oshima, S., Inakuma, T., & Terao, J. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.2.r461 · Cited by 199 · see citing works
The 6-a-day study: effects of fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers
Dragsted, L. O., Pedersen, A. T., Hermetter, A., Basu, S., Hansen, M., Ravn‐Haren, G., Kall, M. A., Breinholt, V. M., Castenmiller, J. J. M., Stagsted, J., et al. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.1060 · Cited by 194 · see citing works
Comparison of nutrients in the food composition tables available in the nine European countries participating in EPIC
Deharveng, G., Charrondière, U. R., Slimani, N., Southgate, D. A. T., & Ríboli, E. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600677 · Cited by 191 · see citing works
Protection by quercetin and quercetin-rich fruit juice against induction of oxidative DNA damage and formation of BPDE-DNA adducts in human lymphocytes
Wilms, L. C., Hollman, P. C. H., Boots, A. W., & Kleinjans, J. C. S. (2005) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2005.01.006 · Cited by 176 · see citing works
Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Al-Delaimy, W. K., Ferrari, P., Slimani, N., Pala, V, Johansson, I., Nilsson, S., Mattisson, I., Wirfalt, E., Galasso, R., Palli, D., et al. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602252 · Cited by 176 · see citing works
Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods
Mennen, L. I., Sapinho, D., Ito, H., Bertrais, S., Galan, P., Hercberg, S., & Scalbert, A. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061808 · Cited by 174 · see citing works
Absorption and antioxidant effects of quercetin from onions, in man
McAnlis, G., McEneny, J., Pearce, J., & Young, I. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600682 · Cited by 167 · see citing works
Self-citation
Implementation of a 4-y, high-fiber, high-fruit-and-vegetable, low-fat dietary intervention: results of dietary changes in the Polyp Prevention Trial
Lanza, E., Schatzkin, A. G., Daston, C., Corle, D. K., Freedman, L. S., Ballard-Barbash, R. R., Caan, B. J., Lance, P., Marshall, J. R., Iber, F. L., et al. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.3.387 · Cited by 167 · see citing works
Randomised controlled trial of effect of fruit and vegetable consumption on plasma concentrations of lipids and antioxidants
Zino, S., Skeaff, M., Williams, S., & Mann, J. (1997) · BMJ · doi:10.1136/bmj.314.7097.1787 · Cited by 166 · see citing works
Biochemical Indicators of Dietary Intake
van Dam, R. M., & Hunter, D. (2012) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199754038.003.0008 · Cited by 163 · see citing works
An anthocyanin/polyphenolic‐rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands
Weisel, T., Baum, M., Eisenbrand, G., Dietrich, H., Will, F., Stockis, J., Kulling, S. E., Rüfer, C. E., Johannes, C., & Janzowski, C. (2006) · Biotechnology Journal · doi:10.1002/biot.200600004 · Cited by 163 · see citing works
Behavioural counselling to increase consumption of fruit and vegetables in low income adults: randomised trial
Steptoe, A., Perkins-Porras, L., McKay, C., Rink, E., Hilton, S., & Cappuccio, F. P. (2003) · BMJ · doi:10.1136/bmj.326.7394.855 · Cited by 162 · see citing works
Dietary Intake of Fruits and Vegetables Improves Microvascular Function in Hypertensive Subjects in a Dose-Dependent Manner
McCall, D. O., McGartland, C. P., McKinley, M. C., Patterson, C. C., Sharpe, P., McCance, D. R., Young, I. S., & Woodside, J. V. (2009) · Circulation · doi:10.1161/circulationaha.108.831297 · Cited by 161 · cited 1× · see citing works
“All but five of the studies in this section were conducted in healthy participants; the others focused on myocardial infarction patients ( Singh et al , 1995 ), hypertensive patients ( McCall et al , 2009 ), subjects at risk of cardiovascular disease ( Erlund et al.”
ResultSelf-citation
Consumption of Brussels sprouts results in elevated α-class glutathione S-transferase levels in human blood plasma
Bogaards, J. J. P., Verhagen, H., Willems, M. I., van Poppel, G., & van BLADEREN, P. J. (1994) · Carcinogenesis · doi:10.1093/carcin/15.5.1073 · Cited by 160 · see citing works
Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults
Gill, C. I., Haldar, S., Boyd, L. A., Bennett, R. N., Whiteford, J., Butler, M., Pearson, J. R., Bradbury, I., & Rowland, I. R. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.504 · Cited by 158 · see citing works
Effect of orange juice intake on vitamin C concentrations and biomarkers of antioxidant status in humans
Sánchez‐Moreno, C., Cano, M. P., de Ancos, B., Plaza, L., Olmedilla‐Alonso, B., Granado, F., & Martin-Marco, A. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.454 · Cited by 153 · see citing works
Carotenoid Intakes, Assessed by Dietary Questionnaire, Are Associated with Plasma Carotenoid Concentrations in an Elderly Population
Tucker, K. L., Chen, H., Vogel, S., Wilson, P. W. F., Schaefer, E. J., & Lammi‐Keefe, C. J. (1999) · Journal of Nutrition · doi:10.1093/jn/129.2.438 · Cited by 151 · see citing works
Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables
Erlund, I., Silaste, M.-L., Alfthan, G., Rantala, M., Kesäniemi, Y. A., & Aro, A. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601409 · Cited by 151 · see citing works
Carotenoids and provitamin A activity of carrot (Daucus carota L.) cultivars
Heinonen, M. I. (1990) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00093a005 · Cited by 149 · see citing works
Serum beta-carotene and vitamin C as biomarkers of vegetable and fruit intakes in a community-based sample of French adults
Drewnowski, A., Rock, C. L., Henderson, S., Shore, A., Fischler, C., Galan, P., Preziosi, P., & Herçberg, S. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.6.1796 · Cited by 148 · see citing works
Increasing vegetable and fruit intake: randomized intervention and monitoring in an at-risk population.
Smith‐Warner, S. A., Elmer, P. J., Tharp, T. M., Fosdick, L., Randall, B. L., Gross, M. D., Wood, J., & Potter, J. D. (2000) · PubMed · Cited by 144 · see citing works
A vegetable/fruit concentrate with high antioxidant capacity has no effect on biomarkers of antioxidant status in male smokers
van den Berg, R., van Vliet, T., Broekmans, W. M. R., Cnubben, N. H. P., Vaes, W. H. J., Roza, L., Haenen, G. R. M. M., Bast, A., & van den Berg, H. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.6.1714 · Cited by 144 · cited 1× · see citing works
“Studies were also excluded if the intervention used fruit juice diluted with water rather than pure fruit juice as this is not classified as contributing to fruit and vegetable intake ( van den Berg et al, 2001 ; Bub et al.”
Background
Participant characteristics associated with errors in self-reported energy intake from the Women’s Health Initiative food-frequency questionnaire
Horner, N. K., Patterson, R. E., Neuhouser, M. L., Lampe, J. W., Beresford, S. A. A., & Prentice, R. L. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.4.766 · Cited by 141 · see citing works
Effects of kiwi fruit consumption on platelet aggregation and plasma lipids in healthy human volunteers
Duttaroy, A. K., & Jørgensen, A. (2004) · Platelets · doi:10.1080/09537100410001710290 · Cited by 140 · see citing works
Changes in plasma antioxidant status following consumption of diets high or low in fruit and vegetables or following dietary supplementation with an antioxidant mixture
Record, I. R., Dreosti, I. E., & McInerney, J. K. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2000292 · Cited by 138 · see citing works
No effect of 600 grams fruit and vegetables per day on oxidative DNA damage and repair in healthy nonsmokers.
Møller, P., Vogel, U. B., Pedersen, A. T., Dragsted, L. O., Sandström, B., & Loft, S. H. (2003) · PubMed · Cited by 134 · see citing works
Citrus fruit supplementation reduces lipoprotein oxidation in young men ingesting a diet high in saturated fat: presumptive evidence for an interaction between vitamins C and E in vivo
Harats, D., Chevion, S., Nahir, M. A., Norman, Y., Sagee, O., & Berry, E. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.2.240 · Cited by 115 · see citing works
Telephone Counseling Intervention Increases Intakes of Micronutrient- and Phytochemical-Rich Vegetables, Fruit and Fiber in Breast Cancer Survivors
Pierce, J. P., Newman, V. A., Flatt, S. W., Faerber, S., Rock, C. L., Natarajan, L., HOLLENBACH, K. A., Wasserman, L. M., Kealey, S., Caan, B. J., et al. (2004) · Journal of Nutrition · doi:10.1093/jn/134.2.452 · Cited by 114 · see citing works
Is plasma vitamin C an appropriate biomarker of vitamin C intake? A systematic review and meta-analysis
Dehghan, M., Akhtar‐Danesh, N., McMillan, C. R., & Thabane, L. (2007) · Nutrition Journal · doi:10.1186/1475-2891-6-41 · Cited by 114 · see citing works
Feasibility of a randomized trial of a high‐vegetable diet to prevent breast cancer recurrence
Pierce, J. P., Faerber, S., Wright, F. A., Newman, V. A., Flatt, S. W., Kealey, S., Rock, C. L., Hryniuk, W. M., & Greenberg, E. R. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514589 · Cited by 108 · see citing works
Effects of consumption of Brussels sprouts on plasma and urinary glutathione S-transferase class-α and -π in humans
Nijhoff, W. A., MULDER, T. P. J., Verhagen, H., van Poppel, G., & Peters, W. H. M. (1995) · Carcinogenesis · doi:10.1093/carcin/16.4.955 · Cited by 108 · see citing works
A pilot study on the use of plasma carotenoids and ascorbic acid as markers of compliance to a high fruit and vegetable dietary intervention.
Marchand, L. L., Hankin, J. H., Carter, F. S., Essling, C., Luffey, D., Franke, A. A., Wilkens, L. R., Cooney, R. V., & Kolonel, L. N. (1994) · PubMed · Cited by 108 · see citing works
Influence of Increased Fruit and Vegetable Intake on Plasma and Lipoprotein Carotenoids and LDL Oxidation in Smokers and Nonsmokers
Chopra, M., O'Neill, M. E., Keogh, N., Wortley, G. M., Southon, S., & Thurnham, D. I. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.11.1818 · Cited by 107 · see citing works
Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables
Watzl, B., Bub, A., Brandstetter, B. R., & Rechkemmer, G. (1999) · British Journal Of Nutrition · doi:10.1017/s0007114599001634 · Cited by 106 · see citing works
Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage:repair balance in human lymphocytes
ASTLEY, S. B., Elliott, R. M., Archer, D. B., & Southon, S. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20031001 · Cited by 101 · see citing works
A critical assessment of some biomarker approaches linked with dietary intake
Crews, H., Alink, G., Andersen, R., Braesco, V., Holst, B., Maiani, G., Ovesen, L., Scotter, M., Solfrizzo, M., van den Berg, R., et al. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2001337 · Cited by 99 · see citing works
Flavonoids in human urine as biomarkers for intake of fruits and vegetables.
Nielsen, S. E., Freese, R., Kleemola, P., & Mutanen, M. L. (2002) · PubMed · Cited by 97 · see citing works
The Bioavailability to Humans of Ascorbic Acid from Oranges, Orange Juice and Cooked Broccoli Is Similar to That of Synthetic Ascorbic Acid
Mangels, A. R., Block, G., Frey, C. M., Patterson, B. H., Taylor, P. R., Norkus, E. P., & Levander, O. A. (1993) · The Journal of Nutrition · doi:10.1093/jn/123.6.1054 · Cited by 96 · see citing works
Supplementation of a Low-Carotenoid Diet with Tomato or Carrot Juice Modulates Immune Functions in Healthy Men
Watzl, B., Bub, A., Briviba, K., & Rechkemmer, G. (2003) · Annals of Nutrition and Metabolism · doi:10.1159/000072397 · Cited by 94 · see citing works
Plasma concentrations of carotenoids in healthy volunteers after intervention with carotenoid-rich foods
Müller, H., Bub, A., Watzl, B., & Rechkemmer, G. (1999) · European Journal of Nutrition · doi:10.1007/s003940050044 · Cited by 94 · see citing works
Responsiveness of carotenoids to a high vegetable diet intervention designed to prevent breast cancer recurrence.
Rock, C. L., Flatt, S. W., Wright, F. A., Faerber, S., Newman, V. A., Kealey, S., & Pierce, J. P. (1997) · PubMed · Cited by 94 · see citing works
Plasma carotenoids as biomarkers of vegetable intake: the University of Minnesota Cancer Prevention Research Unit Feeding Studies.
Martini, M. C., Campbell, D. R., Gross, M., Grandits, G., Potter, J. D., & Slavin, J. L. (1995) · PubMed · Cited by 89 · see citing works
A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: Results from a randomized controlled feeding study
MILLERIII, E., Erlinger, T. P., Sacks, F. M., Svetkey, L. P., Charleston, J. B., LIN, P., & Appel, L. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.04.001 · Cited by 89 · see citing works
Bioavailability of Quercetin From Berries and the Diet
Erlund, I., Freese, R., Marniemi, J., Hakala, P., & Alfthan, G. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5401_3 · Cited by 89 · see citing works
Oxidative DNA damage in circulating mononuclear blood cells after ingestion of blackcurrant juice or anthocyanin-rich drink
Möller, P., Loft, S. H., Alfthan, G., & Freese, R. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.02.020 · Cited by 85 · see citing works
A Home-Based Nutrition Intervention to Increase Consumption of Fruits, Vegetables, and Calcium-Rich Foods in Community Dwelling Elders
Bernstein, M., Nelson, M. E., Tucker, K. L., Layne, J. E., Johnson, E. J., Nuernberger, A., Castañeda, C., Judge, J. O., Büchner, D. M., & Singh, M. F. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90315-9 · Cited by 85 · see citing works
Bioavailability of Carotenoids and Tocopherols from Broccoli: In Vivo and in Vitro Assessment
Granado, F., Olmedilla‐Alonso, B., Herrero, C., Pérez-Sacristán, B., Blanco, I., & Blázquez, S. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623101110 · Cited by 84 · see citing works
Six carotenoids in plasma used to assess recommended intake of fruits and vegetables in a controlled feeding study
Brevik, A., Andersen, L. F., Karlsen, A. S., Trygg, K. U., Blomhoff, R., & Drevon, C. A. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601945 · Cited by 84 · see citing works
8-Isoprostane F2α excretion is reduced in women by increased vegetable and fruit intake
Thompson, H. J., Heimendinger, J., SEDLACEK, S. M., Haegele, A. D., Diker, A., O’Neill, C. C., Meinecke, B., Wolfe, P., Zhu, Z., & Jiang, W. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.4.768 · Cited by 84 · see citing works
The contribution of plant foods to the vitamin A supply of lactating women in Vietnam: a randomized controlled trial
Khẩn, N. C., West, C. E., de Pee, S., Bosch, D., Ha, D. T. P., Hulshof, P. J. M., Khoi, H. H., Verhoef, H., & HAUTVAST, J. G. A. J. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1112 · Cited by 83 · see citing works
Mediterranean vegetable soup consumption increases plasma vitamin C and decreases F2-isoprostanes, prostaglandin E2 and monocyte chemotactic protein-1 in healthy humans
Sánchez‐Moreno, C., Cano, M. P., de Ancos, B., Plaza, L., Olmedilla‐Alonso, B., Granado, F., & Martin-Marco, A. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.07.001 · Cited by 82 · see citing works
Consumption of High-Pressurized Vegetable Soup Increases Plasma Vitamin C and Decreases Oxidative Stress and Inflammatory Biomarkers in Healthy Humans
Sánchez‐Moreno, C., Cano, M. P., de Ancos, B., Plaza, L., Olmedilla‐Alonso, B., Granado, F., & Martín, A. (2004) · Journal of Nutrition · doi:10.1093/jn/134.11.3021 · Cited by 81 · see citing works
The Effect of Cruciferous and Leguminous Sprouts on Genotoxicity, In vitro and In vivo
Gill, C. I. R., Haldar, S., Porter, S., Matthews, S., Sullivan, S., Coulter, J., McGlynn, H., & Rowland, I. R. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.1199.13.7 · Cited by 80 · see citing works
High intakes of vegetables, berries, and apples combined with a high intake of linoleic or oleic acid only slightly affect markers of lipid peroxidation and lipoprotein metabolism in healthy subjects,,
Freese, R., Alfthan, G., Jauhiainen, M., Basu, S., Erlund, I., Salminen, I., Aro, A., & Mutanen, M. L. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.950 · Cited by 80 · see citing works
Supplementation with Fruit and Vegetable Soups and Beverages Increases Plasma Carotenoid Concentrations but Does Not Alter Markers of Oxidative Stress or Cardiovascular Risk Factors
Paterson, E., Gordon, M. H., Niwat, C., George, T. W., Parr, L., Waroonphan, S., & Lovegrove, J. A. (2006) · Journal of Nutrition · doi:10.1093/jn/136.11.2849 · Cited by 79 · see citing works
Plasma Carotenoids Are Biomarkers of Long-Term High Vegetable Intake in Women with Breast Cancer
McEligot, A. J., Rock, C. L., Flatt, S. W., Newman, V. A., Faerber, S., & Pierce, J. P. (1999) · Journal of Nutrition · doi:10.1093/jn/129.12.2258 · Cited by 75 · see citing works
Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers
Wilms, L. C., Boots, A. W., de Boer, V. C. J., Maas, L. M., Pachen, D. M. F. A., Gottschalk, R. W. H., Ketelslegers, H. B., Godschalk, R., Haenen, G. R. M. M., van Schooten, F., et al. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm145 · Cited by 73 · see citing works
No difference in platelet activation or inflammation markers after diets rich or poor in vegetables, berries and apple in healthy subjects
Freese, R., Vaarala, O., Turpeinen, A. M., & Mutanen, M. L. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0456-4 · Cited by 71 · see citing works
Racial Differences in Urinary Potassium Excretion
Turban, S., Miller, E. R., Ange, B. A., & Appel, L. J. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007101142 · Cited by 68 · see citing works
Plasma carotenoid levels in Dutch men and women, and the relation with vegetable and fruit consumption
Jansen, M., van Kappel, A. L., Ocké, M., Veer, P. V., Boshuizen, H. C., Ríboli, E., & Bueno-de-Mesquita, H. B. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601981 · Cited by 67 · see citing works
The effect of an increased intake of vegetables and fruit on weight loss, blood pressure and antioxidant defense in subjects with sleep related breathing disorders
Svendsen, M., Blomhoff, R., Holme, I., & Tonstad, S. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602652 · Cited by 67 · see citing works
Dietary Botanical Diversity Affects the Reduction of Oxidative Biomarkers in Women due to High Vegetable and Fruit Intake
Thompson, H. J., Heimendinger, J., Diker, A., O'Neill, C., Haegele, A. D., Meinecke, B., Wolfe, P., SEDLACEK, S. M., Zhu, Z., & Jiang, W. (2006) · Journal of Nutrition · doi:10.1093/jn/136.8.2207 · Cited by 67 · see citing works
Variability of Serum Carotenoids in Response to Controlled Diets Containing Six Servings of Fruits and Vegetables per Day
Bowen, P. E., Garg, V. K., Stacewicz‐Sapuntzakis, M., Yelton, L. A., & SCHREINER, R. S. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb26182.x · Cited by 65 · see citing works
Serum β-carotene response to supplementation with raw carrots, carrot juice or purified β-carotene in healthy non-smoking women
Törrönen, R., Lehmusaho, M., Häkkinen, S. H., Hänninen, O., & Mykkänen, H. M. (1996) · Nutrition Research · doi:10.1016/0271-5317(96)00035-8 · Cited by 64 · see citing works
In Vivo Investigation of Changes in Biomarkers of Oxidative Stress Induced by Plant Food Rich Diets
Thompson, H. J., Heimendinger, J., Gillette, C. D., SEDLACEK, S. M., Haegele, A. D., O’Neill, C. C., & Wolfe, P. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050493x · Cited by 62 · see citing works
Lack of Effect of a Low-Fat, High-Fruit, -Vegetable, and -Fiber Diet on Serum Prostate-Specific Antigen of Men Without Prostate Cancer: Results From a Randomized Trial
Shike, M., Latkany, L., Riedel, E., Fleisher, M., Schatzkin, A. G., Lanza, E., Corle, D. K., Begg, C. B., & the Polyp Prevention Trial Study Group (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.02.040 · Cited by 62 · see citing works
Plasma micronutrient status is improved after a 3-month dietary intervention with 5 daily portions of fruits and vegetables: implications for optimal antioxidant levels
Polidori, M. C., Carrillo, J.-C., Verde, P. E., Sies, H., Siegrist, J., & Stahl, W. (2009) · Nutrition Journal · doi:10.1186/1475-2891-8-10 · Cited by 60 · see citing works
The effects of dietary advice and vouchers on the intake of fruit and fruit juice by pregnant women in a deprived area: a controlled trial
Burr, M. L., Trembeth, J., Jones, K., Geen, J., Lynch, L., & Roberts, Z. (2007) · Public Health Nutrition · doi:10.1017/s1368980007249730 · Cited by 59 · see citing works
Quality of life and self-rated health in relation to changes in fruit and vegetable intake and in plasma vitamins C and E in a randomised trial of behavioural and nutritional education counselling
Steptoe, A., Perkins-Porras, L., Hilton, S. R., Rink, E., & Cappuccio, F. P. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041177 · Cited by 59 · see citing works
Spinach Cultigen Variation for Tissue Carotenoid Concentrations Influences Human Serum Carotenoid Levels and Macular Pigment Optical Density Following a 12-Week Dietary Intervention
Kopsell, D. A., Lefsrud, M. G., Kopsell, D. E., Wenzel, A. J., Gerweck, C., & Curran-Celentano, J. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0614802 · Cited by 54 · see citing works
Increases in Plasma Carotenoid Concentrations in Response to a Major Dietary Change in the Women's Healthy Eating and Living Study
Pierce, J. P., Natarajan, L., Sun, S., Al‐Delaimy, W. K., Flatt, S. W., Kealey, S., Rock, C. L., Thomson, C. A., Newman, V. A., Ritenbaugh, C., et al. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0928 · Cited by 54 · see citing works
Consumption of Brussels sprouts protects peripheral human lymphocytes against 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) and oxidative DNA‐damage: results of a controlled human intervention trial
Hoelzl, C., Glatt, H. R., Meinl, W., Sontag, G., Haidinger, G., Kundi, M., Simic, T. P., Chakraborty, A., Bichler, J., Ferk, F., et al. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700406 · Cited by 53 · see citing works
Relative validity of fruit and vegetable intake estimated by the food frequency questionnaire used in the Danish National Birth Cohort*
Mikkelsen, T. B., Olsen, S. F., Rasmussen, S. E., & Osler, M. (2006) · Scandinavian Journal of Public Health · doi:10.1080/14034940600975625 · Cited by 52 · see citing works
Effects of enhanced consumption of fruit and vegetables on plasma antioxidant status and oxidative resistance of LDL in smokers supplemented with fish oil
Roberts, W. G., Gordon, M. H., & Walker, A. F. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601692 · Cited by 50 · see citing works
Lutein and β-carotene from lutein-containing yellow carrots are bioavailable in humans
Molldrem, K. L., Li, J., Simon, P. W., & Tanumihardjo, S. A. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.1.131 · Cited by 49 · see citing works
Orange Juice Ingestion and Supplemental Vitamin C Are Equally Effective at Reducing Plasma Lipid Peroxidation in Healthy Adult Women
Johnston, C. S., Dancho, C. L., & Strong, G. M. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719330 · Cited by 49 · see citing works
Effect of Antioxidant-Rich Foods on Plasma Ascorbic Acid, Cardiac Enzyme, and Lipid Peroxide Levels in Patients Hospitalized with Acute Myocardial Infarction
Singh, R. B., Niaz, M. A., AGARWAL, P., Beegom, R., & Rastogi, S. S. (1995) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(95)00215-4 · Cited by 48 · see citing works
Dietary Supplementation With Orange and Carrot Juice in Cigarette Smokers Lowers Oxidation Products in Copper–Oxidized Low–Density Lipoproteins
Abbey, M., Noakes, M., & Nestel, P. J. (1995) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(95)00183-2 · Cited by 48 · see citing works
Urinary Total Flavonoid Excretion but Not 4-Pyridoxic Acid or Potassium Can Be Used as a Biomarker for the Intake of Fruits and Vegetables
Krogholm, K. S., Haraldsdóttir, J., Knuthsen, P., & Rasmussen, S. E. (2004) · Journal of Nutrition · doi:10.1093/jn/134.2.445 · Cited by 47 · see citing works
Dietary Modification and Moderate Antioxidant Supplementation Differentially Affect Serum Carotenoids, Antioxidant Levels and Markers of Oxidative Stress in Older Humans
Peterman, J. N., Schmidt, M. C., Askew, E. W., Bernstein, P. S., & Tress, M. S. V. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3117 · Cited by 46 · see citing works
Plasma concentration response to drinks containing β-carotene as carrot juice or formulated as a water dispersible powder
Thürmann, P., Steffen, J., Zwernemann, C., Aebischer, C. P., Cohn, W., Wendt, G., & Schalch, W. (2002) · European Journal of Nutrition · doi:10.1007/s00394-002-0381-3 · Cited by 44 · see citing works
High Vegetable and Fruit Diet Intervention in Premenopausal Women with Cervical Intraepithelial Neoplasia
Rock, C. L., MOSKOWITZ, A., HUIZAR, B., Saenz, C. C., CLARK, J. T., Daly, T., Chin, H. G., Behling, C. A., & Ruffin, M. T. (2001) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(01)00286-3 · Cited by 42 · see citing works
Biomarkers in COPD: time for a deep breath
Stockley, R. A. (2007) · Thorax · doi:10.1136/thx.2007.084228 · Cited by 42 · see citing works
Strategies to Increase Vegetable or Reduce Energy and Fat Intake Induce Weight Loss in Adults
Tanumihardjo, S. A., Valentine, A. R., Zhang, Z., Whigham, L. D., Lai, H.-C., & Atkinson, R. L. (2009) · Experimental Biology and Medicine · doi:10.3181/0810-rm-293 · Cited by 41 · see citing works
No Differences in DNA Damage and Antioxidant Capacity Between Intervention Groups of Healthy, Nonsmoking Men Receiving 2, 5, or 8 Servings/Day of Vegetables and Fruit
Briviba, K., Bub, A., Möseneder, J., Schwerdtle, T., Hartwig, A., Kulling, S. E., & Watzl, B. (2008) · Nutrition and Cancer · doi:10.1080/01635580701621346 · Cited by 41 · see citing works
The Bioavailability of β-Carotene in Stir- or Deep-Fried Vegetables in Men Determined by Measuring the Serum Response to a Single Ingestion
Huang, C.-J., Tang, Y., Chen, C., Chen, M.-L., Chu, C.-H., & Hseu, C.-T. (2000) · Journal of Nutrition · doi:10.1093/jn/130.3.534 · Cited by 40 · see citing works
Effect of dietary advice to increase fruit and vegetable consumption on plasma flavonol concentrations: results from a randomised controlled intervention trial: Table 1
Huxley, R., Lean, M. E. J., Crozier, A., John, J. H., & Neil, H. A. W. (2004) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2003.014274 · Cited by 40 · see citing works
Partial resistance of low density lipoprotein to oxidation in vivo after increased intake of berries.
Marniemi, J., Hakala, P., Mäki, J., & Ahotupa, M. O. (2000) · PubMed · Cited by 38 · see citing works
Ascorbic acid, HDL, and total plasma cholesterol in the elderly.
Jacques, P. F., Hartz, S. C., McGandy, R. B., Jacob, R. A., & Russell, R. M. (1987) · Journal of the American College of Nutrition · doi:10.1080/07315724.1987.10720177 · Cited by 38 · see citing works
The Men's Eating and Living (MEAL) Study: A Cancer and Leukemia Group B Pilot Trial of Dietary Intervention for the Treatment of Prostate Cancer
Parsons, J. K., Newman, V. A., Mohler, J. L., Pierce, J. P., Paskett, E. D., & Marshall, J. R. (2008) · Urology · doi:10.1016/j.urology.2007.11.050 · Cited by 38 · see citing works
Vitamin A potency of carrot and spinach carotenes in human metabolic studies.
Hussein, L., & El-Tohamy, M. (1990) · PubMed · Cited by 37 · see citing works
Effects of High Fruit-Vegetable and/or Low-Fat Intervention on Plasma Micronutrient Levels
Djurić, Z., Ren, J., Mekhovich, O., Venkatranamoorthy, R., & Heilbrun, L. K. (2006) · Journal of the American College of Nutrition · doi:10.1080/07315724.2006.10719530 · Cited by 37 · see citing works
Fruit and vegetables and cardiovascular risk profile: a diet controlled intervention study
Broekmans, W. M. R., Klöpping-Ketelaars, W. A. A., Kluft, C., van den Berg, H., Kok, F. J., & van Poppel, G. (2001) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601192 · Cited by 35 · see citing works
Urinary Excretion of Flavonoids Reflects Even Small Changes in the Dietary Intake of Fruits and Vegetables
Brevik, A., Rasmussen, S. E., Drevon, C. A., & Andersen, L. F. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.843.13.5 · Cited by 35 · see citing works
13C Natural Abundance in Serum Retinol Acts as a Biomarker for Increases in Dietary Provitamin A
Howe, J. A., Valentine, A. R., Hull, A. K., & Tanumihardjo, S. A. (2008) · Experimental Biology and Medicine · doi:10.3181/0806-rm-199 · Cited by 34 · see citing works
Potassium Excretion in Healthy Japanese Women Was Increased by a Dietary Intervention Utilizing Home-Parcel Delivery of Okinawan Vegetables
Tuekpe, M. K.-N., Todoriki, H., Sasaki, S., Zheng, K., & Ariizumi, M. (2006) · Hypertension Research · doi:10.1291/hypres.29.389 · Cited by 32 · see citing works
A population-based dietary intervention trial in a high-risk area for stomach cancer and stroke: changes in intakes and related biomarkers
Takashashi, Y., Sasaki, S., Takahashi, M., Okubo, S., Hayashi, M., & Tsugane, S. (2003) · Preventive Medicine · doi:10.1016/s0091-7435(03)00164-6 · Cited by 32 · see citing works
Fruit and vegetables: think variety, go ahead, eat!
Padayatty, S. J., & Levine, M. N. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.5 · Cited by 31 · see citing works
Serum carotenoids and retinol of human subjects consuming carrot juice
Kim, H., Simpson, K. L., & Gerber, L. E. (1988) · Nutrition Research · doi:10.1016/s0271-5317(88)80113-1 · Cited by 26 · see citing works
Telephone Counseling Promotes Dietary Change in Healthy Adults: Results of a Pilot Trial
Newman, V. A., Flatt, S. W., & Pierce, J. P. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.05.007 · Cited by 25 · see citing works
A Randomized Trial of an Intervention to Increase Fruit and Vegetable Intake in Curatively Treated Patients with Early-Stage Head and Neck Cancer
Cartmel, B., Bowen, D. J., Ross, D., Johnson, E., & Mayne, S. T. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0191 · Cited by 22 · see citing works
Molecular Biomarkers Workshop: a European Strategy for Developing Lung Cancer Molecular Diagnostics in High Risk Populations
Field, J. K., Brambilla, C., Hirsch, F. R., Hittelman, W. N., Hogan, M., Marshall, D. A., Mulshine, J. L., Rabbitts, P. H., Sutedja, T. G., Watson, A. J. M., et al. (2001) · Lung Cancer · doi:10.1016/s0169-5002(00)00236-1 · Cited by 19 · see citing works
Adherence to the Polyp Prevention Trial Dietary Intervention Is Associated with a Behavioral Pattern of Adherence to Nondietary Trial Requirements and General Health Recommendations1,2
Wanke, K. L., Daston, C., Slonim, A., Albert, P. S., Snyder, K., Schatzkin, A. G., & Lanza, E. (2007) · Journal of Nutrition · doi:10.1093/jn/137.2.391 · Cited by 17 · see citing works
Measurement of ceruloplasmin in chick plasma by o-dianisidine oxidation
Kim, Y. S., & Combs, G. F. (1988) · Nutrition Research · doi:10.1016/s0271-5317(88)80032-0 · Cited by 10 · see citing works
Fruits and stir-fried vegetables increase plasma carotenoids in young adults.
Lin, Y. J., Chien, Y. W., Yang, S. H., & Cheng, H.-H. (2007) · PubMed · Cited by 10 · see citing works
Effects on Plasma Ascorbic Acid and Coronary Risk Factors of Adding Guava Fruit to the Usual Diet in Hypertensives with Mild to Moderate
Singh, R. B., Rastogi, S. S., DDPHN, R. S., Niaz, M. A., MD, N. K. S., & Madhu, S. V. (1997) · Journal of Nutritional & Environmental Medicine · doi:10.1080/13590849762754 · Cited by 8 · see citing works

Flagged first, then by citations

2 of the 150 references couldn’t be matched to a known paper.

Sorted by citations

The food metabolome: a window over dietary exposure
Scalbert, A., Brennan, L., Manach, C., Andres-Lacueva, C., Dragsted, L. O., Draper, J., Rappaport, S. M., van der Hooft, J. J., & Wishart, D. S. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.076133 · Cited by 519 · see citing works
The Health Potential of Fruits and Vegetables Phytochemicals: Notable Examples
Rodríguez‐Casado, A. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.755149 · Cited by 267 · see citing works
Validation of biomarkers of food intake—critical assessment of candidate biomarkers
Dragsted, L. O., Gao, Q., Scalbert, A., Vergères, G., Kolehmainen, M., Manach, C., Brennan, L., Afman, L. A., Wishart, D. S., Andrés‐Lacueva, C., et al. (2018) · Genes & Nutrition · doi:10.1186/s12263-018-0603-9 · Cited by 232 · see citing works
Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review
Elvira-Torales, L. I., García‐Alonso, J., & Periago, M. J. (2019) · Antioxidants · doi:10.3390/antiox8070229 · Cited by 222 · see citing works
Let them eat fruit! The effect of fruit and vegetable consumption on psychological well-being in young adults: A randomized controlled trial
Conner, T. S., Brookie, K. L., Carr, A. C., Mainvil, L. A., & Vissers, M. C. M. (2017) · PLOS ONE · doi:10.1371/journal.pone.0171206 · Cited by 207 · see citing works
Dietary fiber intake and risk of colorectal cancer and incident and recurrent adenoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Kunzmann, A. T., Coleman, H. G., Huang, W., Kitahara, C. M., Cantwell, M. M., & Berndt, S. I. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.113282 · Cited by 202 · see citing works
Mass spectrometry-based metabolomics for the discovery of biomarkers of fruit and vegetable intake: citrus fruit as a case study
Pujos-Guillot, E., Hubert, J., Martin, J.-F., Lyan, B., Quintana, M., Claude, S., Chabanas, B., Rothwell, J. A., Bennetau-Pelissero, C., Scalbert, A., et al. (2013) · Journal of Proteome Research · doi:10.1021/pr300997c · Cited by 166 · see citing works
Correlations between Fruit, Vegetables, Fish, Vitamins, and Fatty Acids Estimated by Web-Based Nonconsecutive Dietary Records and Respective Biomarkers of Nutritional Status.
Lassale, C., Castetbon, K., Laporte, F., Deschamps, V., Vernay, M., Camilleri, G. M., Faure, P., Hercberg, S., Galan, P., & Kesse-Guyot, E. (2016) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2015.09.017 · Cited by 150 · see citing works
Association of plasma biomarkers of fruit and vegetable intake with incident type 2 diabetes: EPIC-InterAct case-cohort study in eight European countries
Zheng, J., Sharp, S. J., Imamura, F., Chowdhury, R., Gundersen, T. E., Steur, M., Sluijs, I., van der Schouw, Y. T., Agudo, A., Aune, D., et al. (2020) · BMJ · doi:10.1136/bmj.m2194 · Cited by 166 · see citing works
Persimmon (Diospyros kaki) fruit: hidden phytochemicals and health claims
Butt, M. S., Sultan, M. T., Aziz, M., Naz, A., Ahmed, W., Kumar, N., & Imran, M. (2015) · EXCLI journal · doi:10.17179/excli2015-159 · Cited by 127 · see citing works
Carotenoids and health in older people
Woodside, J. V., McGrath, A. J., Lyner, N., & McKinley, M. C. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.10.012 · Cited by 116 · see citing works
Self-citation
Nutritional biomarkers for objective dietary assessment
Kuhnle, G. (2012) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5631 · Cited by 108 · see citing works
Skin and plasma carotenoid response to a provided intervention diet high in vegetables and fruit: uptake and depletion kinetics , , ,
Jahns, L., Johnson, L. K., Mayne, S. T., Cartmel, B., Picklo, M. J., Ermakov, I. V., Gellermann, W., & Whigham, L. D. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.086900 · Cited by 109 · see citing works
Hippuric Acid in 24-Hour Urine Collections Is a Potential Biomarker for Fruit and Vegetable Consumption in Healthy Children and Adolescents,
Krupp, D., Doberstein, N., Shi, L., & Remer, T. (2012) · Journal of Nutrition · doi:10.3945/jn.112.159319 · Cited by 106 · see citing works
Food subsidy programs and the health and nutritional status of disadvantaged families in high income countries: a systematic review
Black, A. P., Brimblecombe, J. K., Eyles, H. C., Morris, P. S., Vally, H., & O’Dea, K. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-1099 · Cited by 103 · see citing works
Food intake biomarkers for apple, pear, and stone fruit
Ulaszewska, M., Vázquez-Manjarrez, N., Garcia‐Aloy, M., Llorach, R., Mattivi, F., Dragsted, L. O., Praticò, G., & Manach, C. (2018) · Genes & Nutrition · doi:10.1186/s12263-018-0620-8 · Cited by 92 · see citing works
Fruits and vegetables: measuring intake and encouraging increased consumption
Woodside, J. V., Young, I. S., & McKinley, M. C. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112003059 · Cited by 90 · see citing works
Self-citation
Flavonoids from Fruit and Vegetables: A Focus on Cardiovascular Risk Factors
Toh, J. Y., Tan, V. M. H., Lim, P. C. Y., Lim, S. T., & Chong, M. F. (2013) · Current Atherosclerosis Reports · doi:10.1007/s11883-013-0368-y · Cited by 89 · see citing works
Nutritional Cognitive Neuroscience: Innovations for Healthy Brain Aging
Zamroziewicz, M. K., & Barbey, A. K. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00240 · Cited by 78 · see citing works
Biomarkers in nutrition: new frontiers in research and application
Combs, G. F., Trumbo, P. R., McKinley, M. C., Milner, J. A., Studenski, S. A., Kimura, T., Watkins, S. M., & Raiten, D. J. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12069 · Cited by 76 · see citing works
Self-citation
Carotenoids as biomarkers of fruit and vegetable intake in men and women
Couillard, C., Lemieux, S., Vohl, M., Couture, P., & Lamarche, B. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516003056 · Cited by 75 · see citing works
METABOLOMICS IN THE IDENTIFICATION OF BIOMARKERS OF DIETARY INTAKE
O’Gorman, A., Gibbons, H., & Brennan, L. (2013) · Computational and Structural Biotechnology Journal · doi:10.5936/csbj.201301004 · Cited by 72 · see citing works
Food intake biomarkers for green leafy vegetables, bulb vegetables, and stem vegetables: a review
Brouwer-Brolsma, E. M., Brandl, B., Buso, M. E. C., Skurk, T., & Manach, C. (2020) · Genes & Nutrition · doi:10.1186/s12263-020-00667-z · Cited by 71 · see citing works
Effect of fruit and vegetable intake on oxidative stress and inflammation in COPD: a randomised controlled trial
Baldrick, F. R., Elborn, J. S., Woodside, J. V., Treacy, K., Bradley, J. M., Patterson, C. C., Schock, B. C., Ennis, M., Young, I. S., & McKinley, M. C. (2011) · European Respiratory Journal · doi:10.1183/09031936.00086011 · Cited by 65 · see citing works
Self-citation
Criterion-Related Validity of Spectroscopy-Based Skin Carotenoid Measurements as a Proxy for Fruit and Vegetable Intake: A Systematic Review
Radtke, M. D., Pitts, S. J., Jahns, L., Firnhaber, G. C., Loofbourrow, B. M., Zeng, A., & Scherr, R. E. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa054 · Cited by 64 · see citing works
Use of biomarkers to assess fruit and vegetable intake
Woodside, J. V., Draper, J., Lloyd, A., & McKinley, M. C. (2017) · Proceedings of The Nutrition Society · doi:10.1017/s0029665117000325 · Cited by 64 · see citing works
Self-citation
Role of fruits, nuts, and vegetables in maintaining cognitive health
Miller, M. G., Thangthaeng, N., Poulose, S. M., & Shukitt‐Hale, B. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.12.014 · Cited by 60 · see citing works
Evaluating the relationship between plasma and skin carotenoids and reported dietary intake in elementary school children to assess fruit and vegetable intake
Nguyen, L. M., Scherr, R. E., Linnell, J. D., Ermakov, I. V., Gellermann, W., Jahns, L., Keen, C. L., Miyamoto, S., Steinberg, F. M., Young, H. M., et al. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.02.015 · Cited by 55 · see citing works
The association between a biomarker score for fruit and vegetable intake and incident type 2 diabetes: the EPIC-Norfolk study
Cooper, A., Sharp, S. J., Luben, R., Khaw, K., Wareham, N. J., & Forouhi, N. G. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.246 · Cited by 54 · see citing works
The development and effectiveness of an ecological momentary intervention to increase daily fruit and vegetable consumption in low-consuming young adults
Brookie, K. L., Mainvil, L. A., Carr, A. C., Vissers, M. C. M., & Conner, T. S. (2016) · Appetite · doi:10.1016/j.appet.2016.09.015 · Cited by 55 · see citing works
A Dietary Biomarker Approach Captures Compliance and Cardiometabolic Effects of a Healthy Nordic Diet in Individuals with Metabolic Syndrome
Marklund, M., Magnúsdóttir, Ó. K., Rosqvist, F., Cloetens, L., Landberg, R., Kolehmainen, M., Brader, L., Hermansen, K., Poutanen, K. S., Herzig, K., et al. (2014) · Journal of Nutrition · doi:10.3945/jn.114.193771 · Cited by 50 · see citing works
Nutritional impacts of a fruit and vegetable subsidy programme for disadvantaged Australian Aboriginal children
Black, A. P., Vally, H., Morris, P. S., Daniel, M., Esterman, A., Karschimkus, C. S., & O’Dea, K. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513001700 · Cited by 47 · see citing works
Fruit and vegetable intakes and risk of colorectal cancer and incident and recurrent adenomas in the PLCO cancer screening trial
Kunzmann, A. T., Coleman, H. G., Huang, W., Cantwell, M. M., Kitahara, C. M., & Berndt, S. I. (2015) · International Journal of Cancer · doi:10.1002/ijc.29922 · Cited by 44 · see citing works
Fruit and vegetable intake and cardiovascular risk factors in people with newly diagnosed type 2 diabetes
Lamb, M. J. E., Griffin, S. J., Sharp, S. J., & Cooper, A. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.180 · Cited by 42 · see citing works
Biomarkers of intake for tropical fruits
Vázquez-Manjarrez, N., Ulaszewska, M., Garcia‐Aloy, M., Mattivi, F., Praticò, G., Dragsted, L. O., & Manach, C. (2020) · Genes & Nutrition · doi:10.1186/s12263-020-00670-4 · Cited by 41 · see citing works
Diet Quality, Carotenoid Status, and Body Composition in NCAA Division I Athletes
Jontony, N., Hill, E. B., Taylor, C. A., Boucher, L. C., O'Brien, V., Weiss, R., & Spees, C. (2020) · American Journal of Health Behavior · doi:10.5993/ajhb.44.4.6 · Cited by 39 · see citing works
Dietary antioxidant capacity is associated with improved serum antioxidant status and decreased serum C-reactive protein and plasma homocysteine concentrations
Yang, M., Chung, S., Floegel, A., Song, W. O., Koo, S. I., & Chun, O. K. (2013) · European Journal of Nutrition · doi:10.1007/s00394-012-0491-5 · Cited by 38 · see citing works
Comparative validity of vitamin C and carotenoids as indicators of fruit and vegetable intake: a systematic review and meta-analysis of randomised controlled trials
Pennant, M. E., Steur, M., Moore, C. S., Butterworth, A. S., & Johnson, L. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515003165 · Cited by 37 · see citing works
Dose-Response Effect of Fruit and Vegetables on Insulin Resistance in People at High Risk of Cardiovascular Disease
Wallace, I. R., McEvoy, C. T., Hunter, S. J., Hamill, L. L., Ennis, C. N., Bell, P. M., Patterson, C. C., Woodside, J. V., Young, I. S., & McKinley, M. C. (2013) · Diabetes Care · doi:10.2337/dc13-0718 · Cited by 36 · see citing works
Self-citation
Prediction of fruit and vegetable intake from biomarkers using individual participant data of diet-controlled intervention studies
Souverein, O. W., de Vries, J. H. M., Freese, R., Watzl, B., Bub, A., Miller, E. R., Castenmiller, J. J. M., Pasman, W. J., Hof, K. H. V. H., Chopra, M., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515000355 · Cited by 35 · see citing works
Using the Veggie Meter in Elementary Schools to Objectively Measure Fruit and Vegetable Intake: A Pilot Study
Martinelli, S., Acciai, F., Tasevska, N., & Ohri‐Vachaspati, P. (2021) · Methods and Protocols · doi:10.3390/mps4020033 · Cited by 33 · see citing works
Orange proteomic fingerprinting: From fruit to commercial juices
Lerma-García, M. J., D’Amato, A., Simó‐Alfonso, E. F., Righetti, P. G., & Fasoli, E. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.10.009 · Cited by 33 · see citing works
Correlates of the difference in plasma carotenoid concentrations between men and women
Allore, T., Lemieux, S., Vohl, M., Couture, P., Lamarche, B., & Couillard, C. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518003045 · Cited by 31 · see citing works
Validation of the Brazilian Healthy Eating Index-Revised Using Biomarkers in Children and Adolescents
Toffano, R. B. D., Hillesheim, E., Mathias, M. G., Coelho‐Landell, C. D. A., Salomão, R. G., Almada, M. O. R. D. V., Camarneiro, J. M., Barros, T., Camelo‐Junior, J. S., Rezzi, S., et al. (2018) · Nutrients · doi:10.3390/nu10020154 · Cited by 30 · see citing works
Carotenoids and alkylresorcinols as objective biomarkers of diet quality when assessing the validity of a web-based food record tool and a food frequency questionnaire in a middle-aged population
Nybacka, S., Lindroos, A. K., Wirfält, E., Leanderson, P., Landberg, R., Ericson, U., Larsson, I., Lemming, E. W., Bergström, G. M. L., Hedblad, B., et al. (2016) · BMC Nutrition · doi:10.1186/s40795-016-0094-2 · Cited by 29 · see citing works
Skin carotenoid status and plasma carotenoids: biomarkers of dietary carotenoids, fruits and vegetables for middle-aged and older Singaporean adults
Toh, D. W. K., Loh, W. W., Sutanto, C. N., Yao, Y., & Kim, J. E. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521000143 · Cited by 28 · see citing works
Assessment of Fruit and Vegetables Intake with Biomarkers in Children and Adolescents and Their Level of Validation: A Systematic Review
Li, Y., Muli, S., Huybrechts, I., Nöthlings, U., Ahrens, W., Scalbert, A., & Floegel, A. (2022) · Metabolites · doi:10.3390/metabo12020126 · Cited by 28 · see citing works
Optimization of Conditions for Extraction of Polyphenols and the Determination of the Impact of Cooking on Total Polyphenolic, Antioxidant, and Anticholinesterase Activities of Potato
Laib, I., & Barkat, M. (2018) · Foods · doi:10.3390/foods7030036 · Cited by 29 · see citing works
Integrating (Nutri-)Metabolomics into the One Health Tendency—The Key for Personalized Medicine Advancement
Hotea, I., Sîrbu, C. B., Plotuna, A.-M., Tîrziu, E., Badea, C., Berbecea, A. A., Dragomirescu, M., & Radulov, I. (2023) · Metabolites · doi:10.3390/metabo13070800 · Cited by 26 · see citing works
The Potential of Multi-Biomarker Panels in Nutrition Research: Total Fruit Intake as an Example
McNamara, A. E., Walton, J., Flynn, A., Nugent, A. P., McNulty, B. A., & Brennan, L. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.577720 · Cited by 24 · see citing works
Sensitivity of Pressure-Mediated Reflection Spectroscopy to Detect Changes in Skin Carotenoids in Adults Without Obesity in Response to Increased Carotenoid Intake: A Randomized Controlled Trial
Casperson, S. L., Roemmich, J. N., Larson, K., Hess, J., Palmer, D. G., & Jahns, L. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.01.002 · Cited by 24 · see citing works
Factors associated with serum/plasma concentrations of vitamins A, C, E and carotenoids in older people throughout Europe: the EUREYE study
Woodside, J. V., Young, I. S., Gilchrist, S. E. C. M., Vioqué, J., Chakravarthy, U., de Jong, P. T. V. M., Rahu, M., Seland, J. H., Soubrane, G., Tomazzoli, L., et al. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0456-8 · Cited by 23 · see citing works
Self-citation
Combining vitamin C and carotenoid biomarkers better predicts fruit and vegetable intake than individual biomarkers in dietary intervention studies
McGrath, A. J., Hamill, L. L., Cardwell, C. R., Draffin, C. R., Neville, C. E., Appleton, K. M., McEneny, J., McKinley, M. C., Young, I. S., & Woodside, J. V. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0953-7 · Cited by 23 · see citing works
Self-citation
Validation of Diet ID™ in Predicting Nutrient Intake Compared to Dietary Recalls, Skin Carotenoid Scores, and Plasma Carotenoids in University Students
Radtke, M. D., Chodur, G., Bissell, M. C. S., Kemp, L. C., Medici, V., Steinberg, F. M., & Scherr, R. E. (2023) · Nutrients · doi:10.3390/nu15020409 · Cited by 23 · see citing works
Strong and Bitter Vegetables from Traditional Cultivars and Cropping Methods Improve the Health Status of Type 2 Diabetics: A Randomized Control Trial
Thorup, A. C. S., Kristensen, H. L., Kidmose, U., Lambert, M. N. T., Christensen, L. P., Fretté, X. C., Clausen, M. R., Hansen, S. M., & Jeppesen, P. B. (2021) · Nutrients · doi:10.3390/nu13061813 · Cited by 21 · see citing works
Suppressive effects of lycopene and β-carotene on the viability of the human esophageal squamous carcinoma cell line EC109
Ngoc, N. B., Lv, P., & Zhao, W. (2018) · Oncology Letters · doi:10.3892/ol.2018.8175 · Cited by 19 · see citing works
Biomarker-based validity of a food frequency questionnaire estimating intake in Brazilian children and adolescents
Hillesheim, E., Toffano, R. B. D., de Barros, T. T., Salomão, R. G., Mathias, M. G., Coelho‐Landell, C. D. A., Almada, M. O. R. D. V., Camarneiro, J. M., Camelo‐Junior, J. S., Ued, F. D. V., et al. (2020) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2020.1786026 · Cited by 16 · see citing works
PPARγ-dependent pathway in the growth-inhibitory effects of K562 cells by carotenoids in combination with rosiglitazone
Zhao, H., Gu, H., Zhang, H., Li, J., & Zhao, W. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.09.005 · Cited by 16 · see citing works
Associations between self-reported vegetable and fruit intake assessed with a new web-based 24-h dietary recall and serum carotenoids in free-living adults: a relative validation study
Lafrenière, J., Couillard, C., Lamarche, B., Laramée, C., Vohl, M., & Lemieux, S. (2019) · Journal of Nutritional Science · doi:10.1017/jns.2019.23 · Cited by 15 · see citing works
Simple and sensitive dilute-and-shoot analysis of carotenoids in human plasma
Bukowski, M. R., Voeller, K., & Jahns, L. (2018) · Journal of Chromatography B · doi:10.1016/j.jchromb.2018.07.020 · Cited by 14 · see citing works
The Food Exposome
Scalbert, A., Huybrechts, I., & Gunter, M. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-89321-1_8 · Cited by 13 · see citing works
Protective effect of provitamin A dietary carotenoid intake on overweight/obesity and their relation to inflammatory and oxidative stress biomarkers – a case-control study
Koós, N., Vahid, F., & Bohn, T. (2024) · Food & Function · doi:10.1039/d3fo05648a · Cited by 11 · see citing works
Relationship between Serum Antioxidative Vitamin Concentrations and Type 2 Diabetes in Japanese Subjects
Yamada, C., Kishimoto, N., Urata, N., Kimura, M., Toyoda, M., Masuda, Y., Takashimizu, S., Ishii, N., Akira, K. U. B. O., & Nishizaki, Y. (2020) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.66.289 · Cited by 10 · see citing works
Genetically Predicted Vegetable Intake and Cardiovascular Diseases and Risk Factors: An Investigation with Mendelian Randomization
Feng, Q., Grant, A. J., Yang, Q., Burgess, S., Bešević, J., Conroy, M. C., Omiyale, W., Sun, Y., Allen, N. E., & Lacey, B. (2023) · Nutrients · doi:10.3390/nu15173682 · Cited by 11 · see citing works
Dietary Data in the Malmö Offspring Study–Reproducibility, Method Comparison and Validation against Objective Biomarkers
Hellstrand, S., Ottosson, F. A., Smith, E., Brunkwall, L., Ramne, S., Sonestedt, E., Nilsson, P. M., Melander, O., Orho‐Melander, M., & Ericson, U. (2021) · Nutrients · doi:10.3390/nu13051579 · Cited by 10 · see citing works
Using metabolomics to evaluate food intake
Manach, C., Brennan, L., & Dragsted, L. O. (2014) · Elsevier eBooks · doi:10.1016/b978-1-78242-084-2.00009-5 · Cited by 10 · see citing works
High folate levels in Aboriginal children after subsidised fruit and vegetables and mandatory folic acid fortification
Black, A. P., Vally, H., Morris, P., Daniel, M., Esterman, A., Smith, F., & O’Dea, K. (2014) · Australian and New Zealand Journal of Public Health · doi:10.1111/1753-6405.12235 · Cited by 10 · see citing works
Genetic and Common Environmental Contributions to Familial Resemblances in Plasma Carotenoid Concentrations in Healthy Families
Tremblay, B. L., Guénard, F., Lamarche, B., Përusse, L., & Vohl, M. (2018) · Nutrients · doi:10.3390/nu10081002 · Cited by 9 · see citing works
Urinary Biomarkers in Screening for the Usual Intake of Fruit and Vegetables, and Sodium, Potassium, and the Sodium-to-Potassium Ratio: Required Number and Accuracy of Measurements
Suzuki, A., Takachi, R., Ishihara, J., Maruya, S., Ishii, Y., Kito, K., Nakamura, K., Tanaka, J., Yamaji, T., Iso, H., et al. (2024) · Nutrients · doi:10.3390/nu16030442 · Cited by 6 · see citing works
Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause–Specific Mortality and All–Cause Mortality: A National Prospective Cohort Study
Pu, L., Zhang, R., Wang, X., Zhao, T., Sun, H., & Han, L. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.874943 · Cited by 6 · see citing works
Exposure to (Poly)phenol Metabolites after a Fruit and Vegetable Supplement Intake: A Double-Blind, Cross-Over, Randomized Trial
Romain, C., Bresciani, L., Muralidharan, J., Mena, P. R., Chung, L. H., Alcaráz, P. E., Rio, D. D., & Cases, J. (2022) · Nutrients · doi:10.3390/nu14224913 · Cited by 5 · see citing works
Odd Chain Fatty Acids Are Not Robust Biomarkers for Dietary Intake of Fiber
Wu, Y., Posma, J. M., Holmes, E. C., Frost, G. S., Chambers, E. S., & García‐Pérez, I. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100316 · Cited by 5 · see citing works
Preparation and Quality Evaluation of Functional Persimmon (Diospyros kaki) Juice for Diabetic Patients.
Ahmad, M. A. M. (2022) · Agricultural Sciences Journal · doi:10.56520/asj.v4i2.88 · Cited by 5 · see citing works
Analysis, Presentation, and Interpretation of Dietary Data
Johnson, R. K., Kerr, D. A., & Schap, T. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802928-2.00008-4 · Cited by 5 · see citing works
Derivation and Validation of a Total Fruit and Vegetable Intake Prediction Model to Identify Targets for Biomarker Discovery Using the UK National Diet and Nutrition Survey
Owen, E., Patel, S., Flannery, O., Dew, T. P., & O’Connor, L. M. (2021) · Journal of Nutrition · doi:10.1093/jn/nxaa406 · Cited by 4 · see citing works
Inferring food intake from multiple biomarkers using a latent variable model
D’Angelo, S., Brennan, L., & Gormley, I. C. (2021) · The Annals of Applied Statistics · doi:10.1214/21-aoas1478 · Cited by 4 · see citing works
multiMarker: software for modelling and prediction of continuous food intake using multiple biomarkers measurements
D’Angelo, S., Gormley, I. C., McNamara, A. E., & Brennan, L. (2021) · BMC Bioinformatics · doi:10.1186/s12859-021-04394-z · Cited by 4 · see citing works
Design, methods and baseline characteristics of the Beijing Hospital Atherosclerosis Study: a prospective dynamic cohort study
Zhang, W., Yang, R., Xue, Y., Wang, S., Wang, X., Mu, H., Tang, Y., Li, X., Wang, M., Yang, C., et al. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-2834 · Cited by 4 · see citing works
An Evidence-Based Systematic Review of Lutein by the Natural Standard Research Collaboration
Ulbricht, C. E. (2015) · Journal of Dietary Supplements · doi:10.3109/19390211.2014.988577 · Cited by 4 · see citing works
Mushroom Extract Protects against Hydrogen Peroxide-Induced Toxicity in Hepatic and Neuronal Human Cultured Cells
Guizani, N., & Waly, M. I. (2012) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2012.1069.1074 · Cited by 3 · see citing works
Vegetable Signatures Derived from Human Urinary Metabolomic Data in Controlled Feeding Studies
Lynn, K., Cheng, M., Yang, H., Liang, Y.-J., Kang, M.-J., Chen, F.-L., Shiao, M., & Pan, W. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00470 · Cited by 3 · see citing works
Adherence to a healthy dietary pattern is associated with greater anti-oxidant capacity and improved glycemic control in Iraqi patients with type 2 diabetes
Ashor, A. W., Al-Rammahi, T. M. M., Abdulrazzaq, V. M., & Siervo, M. (2022) · Mediterranean Journal of Nutrition and Metabolism · doi:10.3233/mnm-210016 · Cited by 3 · see citing works
The associations between the response efficacy and objective and subjective change in physical activity and diet in the Information and Risk Modification trial
Wou, C., Šilarova, B., Griffin, S. J., & Usher‐Smith, J. A. (2018) · Public Health · doi:10.1016/j.puhe.2018.09.006 · Cited by 3 · see citing works
Practical Guide to Nutritional Assessment in CKD
Lambert, K., Anderson, C. E., Hassan, H. I. C., Mullan, A., Sabatino, A., & Shroff, R. C. (2025) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.0000000818 · Cited by 2 · see citing works
Alkylresorcinol Metabolites Candidate Biomarkers for Whole Grain Wheat and Rye Intake
Marklund, M. (2012) · Cited by 2 · see citing works
Assays for Carotenoids: Linking Breastmilk and Maternal Intakes
Hamułka, J., Hallmann, E., & Zielinska-Pukos, M. A. (2022) · Biomarkers in disease · doi:10.1007/978-3-031-07389-2_16 · Cited by 2 · see citing works
Vegetable intake and metabolic risk factors: A Mendelian randomization studyPreprint
Feng, Q., & Bešević, J. (2022) · medRxiv · doi:10.1101/2022.03.21.22272720 · Cited by 2 · see citing works
Reproducibility and Validity of Plant-Based Dietary Indices in the Cancer Prevention Study-3 Diet Assessment Substudy
Cousineau, B., Mitchell, E. L., Hodge, R. A., Vaccarino, V., Alvarez, J. A., Flanders, W. D., Stein, A. D., Mitchell, D. C., McCullough, M. L., & Hartman, T. J. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.11.017 · Cited by 1 · see citing works
Les caroténoïdes sériques comme biomarqueurs : une stratégie pour améliorer la validité de l’évaluation alimentaire
Lafrenière, J., Couillard, C., Lamarche, B., & Lemieux, S. (2017) · Canadian Journal of Dietetic Practice and Research · doi:10.3148/cjdpr-2017-030 · Cited by 1 · see citing works
Higher dietary vegetable and fruit intake along with their biomarkers is inversely associated with all-cause mortality among cancer survivors
Jiang, M., & Zhang, C. (2025) · Nutrition Research · doi:10.1016/j.nutres.2025.02.001 · Cited by 1 · see citing works
Review article: PERSIMMON (DIOSPYROS KAKI) FRUIT: HIDDEN PHYTOCHEMICALS AND HEALTH CLAIMS
Butt, M. S., Sultan, M. T., Aziz, M., Naz, A., Ahmed, W., Kumar, N., & Imran, M. (2015) · Cited by 1 · see citing works
Analysis, Presentation, and Interpretation of Dietary Data
Kerr, D. A., Schap, T. E., & Johnson, R. K. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-391884-0.00007-x · Cited by 1 · see citing works
Vegetable intake and cardiovascular risk: genetic evidence from Mendelian randomizationPreprint
Feng, Q., Grant, A. J., Yang, Q., Burgess, S., Bešević, J., Conroy, M. C., Omiyale, W., Sun, Y., Allen, N. E., & Lacey, B. (2022) · medRxiv · doi:10.1101/2022.03.21.22272719 · Cited by 1 · see citing works
Single Nucleotide Polymorphisms in DNA Repair and Oxidative Stress Genes, and Their Interaction with Antioxidants on Prostate Cancer Aggressiveness
Antwi, S. O. (2014) · Scholar Commons (University of South Carolina)
Exposing the position of dairy products on health in the context of obesity and gut health: implications for research and practice
Nolan‐Clark, D. (2012) · Research Online (University of Wollongong)
Prevention of Age-Related Diseases: Effects of Antioxidant Supplements
Stahl, W. (2015) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-319-19096-9_21
Dietary patterns in Norwegian women aged 50-69 years
Markussen, M. S. (2016) · NORA - Norwegian Open Research Archives
A role for nutrition in healthy brain aging
Zamroziewicz, M. K. (2017) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
"5 am Tag" gilt auch zur Diabetesprävention
Müssig, K. (2020) · Info Diabetologie · doi:10.1007/s15034-020-2190-2
Nutritional biomarkers in aging research
Davinelli, S., & Scapagnini, G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822569-1.00016-0

Use of biomarkers to assess fruit and vegetable intake
Woodside, J. V., Draper, J., Lloyd, A., & McKinley, M. C. (2017) · Proceedings of The Nutrition Society · doi:10.1017/s0029665117000325 · Cited by 64 · see citing works
Self-citation
Combining vitamin C and carotenoid biomarkers better predicts fruit and vegetable intake than individual biomarkers in dietary intervention studies
McGrath, A. J., Hamill, L. L., Cardwell, C. R., Draffin, C. R., Neville, C. E., Appleton, K. M., McEneny, J., McKinley, M. C., Young, I. S., & Woodside, J. V. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0953-7 · Cited by 23 · see citing works
Self-citation
Fruits and vegetables: measuring intake and encouraging increased consumption
Woodside, J. V., Young, I. S., & McKinley, M. C. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112003059 · Cited by 90 · see citing works
Self-citation
A Novel Combined Biomarker including Plasma Carotenoids, Vitamin C, and Ferric Reducing Antioxidant Power Is More Strongly Associated with Fruit and Vegetable Intake than the Individual Components
Jin, Y., Gordon, M. H., Alimbetov, D., Chong, M. F., George, T. W., Spencer, J. P. E., Kennedy, O. B., Tuohy, K. M., Minihane, A. M., & Lovegrove, J. A. (2014) · Journal of Nutrition · doi:10.3945/jn.114.192856 · Cited by 16 · see citing works
Comparative validity of vitamin C and carotenoids as indicators of fruit and vegetable intake: a systematic review and meta-analysis of randomised controlled trials
Pennant, M. E., Steur, M., Moore, C. S., Butterworth, A. S., & Johnson, L. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515003165 · Cited by 37 · see citing works

Authors: Baldrick, F. R., Woodside, J. V., Elborn, J. S., Young, I. S., & McKinley, M. C.
Affiliations: Queen's University Belfast (GB)
ORCID: Woodside, Jayne V.
Elborn, J. Stuart
Young, Ian S.
McKinley, Michelle C.
Venue: Critical Reviews in Food Science and Nutrition
Publisher: Informa UK Limited
Published: 2011-10
Volume: 51
Issue: 9
Pages: 795-815
ISSN: 1040-8398 (ISSN-L)
1549-7852
DOI: 10.1080/10408398.2010.482217
OpenAlex: W2041984497
Cited by: 109
References: 150
Citations by year: 2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 12 · 2021: 10 · 2020: 10 · 2019: 2 · 2018: 11 · 2017: 5 · 2016: 7 · 2015: 12 · 2014: 9 · 2013: 9 · 2012: 9
FWCI: 1.36
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Food Science and Nutrition (publishedVersion)
PubMed (publishedVersion)
Research Portal (Queen's University Belfast) (submittedVersion)
Funders: Economic and Social Research Council (ES/G007438/1)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords: fruit and vegetable intake, biomarkers, dietary assessment, dietary intervention studies, compliance monitoring, carotenoids, vitamin C
MeSH terms: Ascorbic Acid, Beverages, Energy Intake, Carotenoids, Diet, Feeding Behavior, Fruit, Humans, Vegetables, Lutein, Biomarkers, Xanthophylls, Zeaxanthins, Cryptoxanthins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Biomarkers of fruit and vegetable intake in human intervention studies: a systematic review

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks