Effect of n-3 fatty acids on metabolism of apoB100-containing lipoprotein in type 2 diabetic subjects
Open accessAbstract
The effect of long-chain n-3 PUFA on the metabolism of apoB100-containing lipoprotein in diabetic subjects is not fully understood. The objective of the present study was to determine the effect of a daily intake of 1080mg EPA and 720mg DHA for diabetic subjects on the kinetics of apoB100-containing lipoprotein in the fasting state. A kinetic study was undertaken to determine the mechanisms involved in the effects of n-3 fatty acids in terms of a decrease in triacylglycerol level in type 2 diabetic patients. We have studied the effect of fish oils on the metabolism of apoB100 endogenously labelled by [5,5,5–2H3]-leucine in type 2 diabetic patients in the fasting state. The kinetic parameters of apoB100 in VLDL, intermediate-density lipoprotein and LDL were determined by compartmental modelling in five diabetic subjects before and 8 weeks after n-3 fatty acid treatment. Treatment did not change the plasma cholesterol level (0·801 (sd 0·120)v. 0·793 (sd 0·163) mmol/l) but lowered the plasma triacylglycerol level (1·776 (sd 0·280) v.1·356 (sd 0·595) mmol/l; p<0·05). Treated patients showed a decrease in VLDL apoB100 concentration (0·366 (sd 0·030) v.0·174 (sd 0·036) g/l; v<0·05) related to a decrease in VLDL 1 production (1·49 (sd 0·23) v.0·44 (sd 0·19) mg/kg per h; p<0·05) and an increase in the VLDL conversion rate (0·031 (sd 0·024)v.0·052 (sd 0·040) per h; p<0·05), with no change in fractional catabolic rates. Treatment led to a higher direct production of intermediate-density lipoprotein (0·02 (sd 0·01) v 0·24 (sd 0·12) mg/kg per h; p<0·05). In conclusion, the present study, conducted in the fasting state, showed that supplementation with n-3 fatty acids in type 2 diabetic patients induced beneficial changes in the metabolism of apoB100-containing lipoprotein.
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OM3FA supplementation partly corrects the underlying disorder responsible for atherogenic dyslipidemia in patients with type 2 diabetes by reducing hepatic production of VLDL1.
“This study shows that OM3FA supplementation partly corrects for the underlying disorder responsible for the atherogenic dyslipidemia in patients with type 2 diabetes by reducing hepatic production of VLDL1.”
A reduction in large VLDL1 production is the most likely explanation for the larger LDL particles after treatment with OM3FAs.
“A reduction in large VLDL1 production [30] is the most likely explanation for the larger LDL particles after treatment with OM3FAs.”
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- Authors
- Ouguerram, K., Maugeais, C., Gardette, J., Magot, T., & Krempf, M.
- Affiliations
- Inserm (FR)
- F. Hoffmann-La Roche AG (CH)
- Corresponding author
- Ouguerram, K.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2006-01
- Volume
- 96
- Issue
- 1
- Pages
- 100-106
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2118132337
- Cited by
- 31
- References
- 48
- Citations by year
- 2025: 4 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- Funders
- Les Laboratories Pierre Fabre
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- omega-3 fatty acids, omega-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid, fish oil supplementation, type 2 diabetes, lipoprotein kinetics, intermediate density lipoprotein, triglycerides, serum cholesterol, fractional catabolic rate, fractional synthesis rate, compartmental modeling
- MeSH terms
- Adolescent, Adult, Aged, Apolipoproteins B, Diabetes Mellitus, Type 2, Dietary Proteins, Docosahexaenoic Acids, Fish Oils, Humans, Lipoproteins, Lipoproteins, LDL, Lipoproteins, VLDL, Middle Aged, Models, Biological, Triglycerides, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Apolipoprotein B-100, Lipoproteins, IDL
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