The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women
Open accessAbstract
A consensus view of soyabean phyto-oestrogens in clinical interventions in post-menopausal women is presented that is based on data from the EU-funded project Phytohealth. The phyto-oestrogens, primarily genistein and daidzein, were given as soyabean-protein isolates, whole-soyabean foods or extracts, supplements or pure compounds. A comprehensive literature search was conducted with well-defined inclusion or exclusion criteria. For areas for which substantial research exists only placebo-controlled double-blind randomised controlled trials (RCT) conducted on healthy post-menopausal women were included. For emerging areas all available human studies in post-menopausal women were reviewed. In order to make cross comparisons between studies the doses of isoflavones were calculated as aglycone equivalents. There is a suggestion, but no conclusive evidence, that isoflavones from the sources studied so far have a beneficial effect on bone health. The consumption of whole-soyabean foods and soyabean-protein isolates has some beneficial effects on lipid markers of cardiovascular risk. The consumption of isolated isoflavones does not affect blood lipid levels or blood pressure, although it may improve endothelial function. For menopausal symptoms there is currently limited evidence that soyabean-protein isolates, soyabean foods or red-clover (Trifolium pratense L.) extract are effective but soyabean isoflavone extracts may be effective in reducing hot flushes. There are too few RCT studies to reach conclusions on the effects of isoflavones on breast cancer, colon cancer, diabetes or cognitive function. The health benefits of soyabean phyto-oestrogens in healthy post-menopausal women are subtle and even some well-designed studies do not show protective effects. Future studies should focus on high-risk post-menopausal women, especially in the areas of diabetes, CVD, breast cancer and bone health.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582
Diet, lifestyle, and the risk of type 2 diabetes mellitus in women.
Hu, F. B., Manson, J. E., Stampfer, M. J., Colditz, G., Liu, S., Solomon, C. G., & Willett, W. C. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010492 · Cited by 2,901
Meta-Analysis of the Effects of Soy Protein Intake on Serum Lipids
Anderson, J. W., Johnstone, B. M., & Cook-Newell, M. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508033330502 · Cited by 2,048
Collins, R., Armitage, J., Parish, S., Sleight, P., & Peto, R. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12475-0 · Cited by 492
Kreijkamp-Kaspers, S., Kok, L., Grobbee, D. E., de Haan, E. H. F., Aleman, A., Lampe, J. W., & van der Schouw, Y. T. (2004) · JAMA · doi:10.1001/jama.292.1.65 · Cited by 438
Weggemans, R. M., & Trautwein, E. A. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601628 · Cited by 265
Van Patten, C. L., Olivotto, I. A., Chambers, G. K., Gelmon, K. A., Hislop, T. G., Templeton, E., Wattie, A., & Prior, J. C. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.6.1449 · Cited by 265
Grace, P. B., Taylor, J. I., Low, Y.-L., Luben, R. N., Mulligan, A. A., Botting, N. P., Dowsett, M., Welch, A. A., Khaw, K.-T., Wareham, N. J., et al. (2004) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.698.13.5 · Cited by 264
Dietary phytoestrogens and breast cancer risk
Keinan-Boker, L., van Der Schouw, Y. T., Grobbee, D. E., & Peeters, P. H. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.2.282 · Cited by 199
Atkinson, C., Warren, R. M., Sala, E., Dowsett, M., Dunning, A. M., Healey, C. S., Runswick, S., Day, N. E., & Bingham, S. A. (2004) · Breast Cancer Research · doi:10.1186/bcr773 · Cited by 151
Cited by
The pros and cons of phytoestrogens
Patisaul, H. B., & Jefferson, W. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.03.003 · Cited by 746
Craig, W. J. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.26736n · Cited by 597
Minor components of pulses and their potential impact on human health
Campos-Vega, R., Loarca-Piña, G., & Oomah, B. D. (2010) · Food Research International · doi:10.1016/j.foodres.2009.09.004 · Cited by 530
Mayo, B., Vázquez, L., & Flórez, A. B. (2019) · Nutrients · doi:10.3390/nu11092231 · Cited by 416
Legume and soy food intake and the incidence of type 2 diabetes in the Shanghai Women's Health Study
Villegas, R., Gao, Y.-T., Yang, G., Li, H.-L., Elasy, T. A., Zheng, W., & Shu, X. O. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.162 · Cited by 393
Metadata
- Authors
- Cassidy, A., Albertazzi, P., Nielsen, I. L., Hall, W., Williamson, G., Tetens, I., Atkins, S., Cross, H., Manios, Y., Wolk, A., Steiner, C., & Branca, F.
- Venue
- Proceedings of the Nutrition Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2006-02
- Volume
- 65
- Issue
- 1
- Pages
- 76-92
- ISSN
- 0029-6651 (ISSN-L)
- 1475-2719
- OpenAlex
- W2000177216
- Cited by
- 257
- References
- 11
- FWCI
- 20.62
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women. https://app.cochat.ai/papers/10.1079/pns2005476
- The paper
- Cassidy, A., Albertazzi, P., Nielsen, I. L., Hall, W., Williamson, G., Tetens, I., Atkins, S., Cross, H., Manios, Y., Wolk, A., Steiner, C., & Branca, F. (2006). Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women. Proceedings of the Nutrition Society. https://doi.org/10.1079/pns2005476
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
