Cited by 94Inflammatory Bowel DiseaseMindfulness and Compassion InterventionsAnorectal Disease Treatments and Outcomes

Effects of a Comprehensive Lifestyle Modification Program on Quality-of-Life in Patients with Ulcerative Colitis: A Twelve-Month Follow-Up

Langhorst, Jost, Mueller, Twyla, Luedtke, Rainer, Franken, Ulla, Paul, Anna, Michalsen, Andreas, Schedlowski, Manfred, Dobos, Gustav J. +1 more·2007·Scandinavian Journal of Gastroenterology

Abstract

OBJECTIVE: To analyze the effects of a comprehensive lifestyle modification program on health-related quality-of-life, psychological distress, and clinical parameters in patients with ulcerative colitis (UC) 3- and 12 months after completion of the program. MATERIAL AND METHODS: Sixty patients with UC in clinical remission or with low disease activity were randomly assigned to an intervention group or a usual-care control group. Comprehensive lifestyle modification consisted of a structured 60-h training program over a period of 10 weeks which included stress management training, psychoeducational elements, and self-care strategies. Quality-of-life, psychological distress, and clinical disease activity were assessed with standardized questionnaires (Inflammatory Bowel Disease Questionnaire (IBDQ); the MOS Short-Form 36 (SF-36); the Brief Symptom Inventory (BSI), and the Colitis Activity Index (CAI)) at baseline, and 3 months and 12 months after comprehensive lifestyle modification. RESULTS: Three months after comprehensive lifestyle modification, patients in the intervention group showed significantly greater improvement in the SF-36 scale physical function (p=0.0175), and a significantly greater reduction in anxiety scores, measured with the BSI (p=0.0294). Use of relaxation techniques was a significant predictor of improvement in the psychological sum score after 3 months of therapy (p=0.034). Though 80% of patients with an initial IBDQ score <170 in the intervention group showed an improvement of >16 points after 3 months, no significant effects of the intervention were found on the IBDQ scales, or on clinical disease parameters, including CAI scores, self-assessed disease activity, hospitalizations, or medical consultations. CONCLUSIONS: These results are consistent with possible short-term benefits of a comprehensive lifestyle modification program on some aspects of quality-of-life and emotional well-being, but no effects were discernable 12 months after completion of therapy. Comprehensive lifestyle modification had no effect on clinical disease variables. The generalizability of these data is limited because of the inclusion of patients with a relatively low disease activity who were interested in integrative medicine.

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Crossref · 10.1080/00365520601101682

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Authors
Langhorst, J., Mueller, T., Luedtke, R., Franken, U., Paul, A., Michalsen, A., Schedlowski, M., Dobos, G. J., & Elsenbruch, S.
Affiliations
  • Kliniken Essen-Mitte (DE)
  • ETH Zurich (CH)
  • Essen University Hospital (DE)
Corresponding author
Langhorst, Jost
Venue
Scandinavian Journal of Gastroenterology
Published
2007-01
Volume
42
Issue
6
Pages
734-745
ISSN
  • 0036-5521 (ISSN-L)
  • 1502-7708
OpenAlex
W2048545464
Cited by
94
References
49
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 8 · 2017: 12 · 2016: 1 · 2015: 4 · 2014: 7 · 2013: 3 · 2012: 9
FWCI
1.43
Type
journal article
Language
en
Open access
closed
Locations
  • Scandinavian Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Health Sciences › Medicine › Surgery › Anorectal Disease Treatments and Outcomes
Keywords
ulcerative colitis, lifestyle modification, health-related quality of life, psychological distress, anxiety, stress management training, psychoeducation, self-care strategies, relaxation techniques, integrative medicine, disease activity, inflammatory bowel disease
MeSH terms
Adult, Colitis, Ulcerative, Female, Follow-Up Studies, Humans, Life Style, Male, Middle Aged, Quality of Life, Self Care, Stress, Psychological

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