Prevalence and effectiveness of psychiatric treatments for patients with IBD: A systematic literature review
Abstract
Objectives Higher prevalence of psychiatric disorders, such as anxiety and depression, has been found in people with Crohn's disease and Ulcerative Colitis compared to the general population. Nowadays, international guidelines advocate psychotherapy and psycho-pharmacological treatments as playing an important role in IBD care. The main goal of this systematic literature review was summarize the evidence on the utilization and effectiveness of treatments for depression and anxiety in persons with IBD.Methods A systematic literature review was conducted using three different electronic databases: MEDLINE, PsychINFO, and EMBASE to identify studies reporting the prevalence and efficacy of psycho-pharmacological and psychotherapeutic treatments for IBD. A quality appraisal was conducted using several scales as appropriate for each study design. A narrative synthesis was also performed.Results Forty-three studies were included. Although a high rate of psychoactive drug use was found in people with IBD, a low proportion of IBD patients have access to psychiatric referral. 1/3 of the studies found that psychotherapy was effective for improving the quality of life, perception of stress, anxiety and depression as well as disease. Antidepressants proved effective in reducing disease activity, gastrointestinal symptoms, anxiety and depression.Conclusion Our results suggest that psychiatric treatment should be implemented in IBD care. However, further studies are needed to confirm the findings of our systematic review.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Antidepressants are beneficial for relieving chronic pain, especially in patients with emotional disorders.
“Antidepressants are beneficial for relieving chronic pain, especially in patients with emotional disorders (113).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [113]
A systematic literature review has shown that 1/3 of the included 43 studies supported the effectiveness of psychotherapy on the quality of life and disease activity.
“A systematic literature review has shown that 1/3 of the included 43 studies supported the effectiveness of psychotherapy on the quality of life and disease activity (113).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [113]
Cites
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859 · see citing works
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & the PRISMA Group* (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00135 · Cited by 37,554 · see citing works
Moher, D., Jadad, A. R., Nichol, G., Penman, M., Tugwell, P., & Walsh, S. (1995) · Controlled Clinical Trials · doi:10.1016/0197-2456(94)00031-w · Cited by 1,308 · see citing works
Assche, G. V., Dignass, A. U., Reinisch, W., van der Woude, C. J., Sturm, A., Vos, M. D., Guslandi, M., Oldenburg, B., Dotan, I., Marteau, P. R., et al. (2009) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2009.09.009 · Cited by 891 · see citing works
Mikocka-Walus, A., Knowles, S. R., Keefer, L., & Graff, L. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000620 · Cited by 567 · see citing works
Mittermaier, C., Dejaco, C., Waldhoer, T., Oefferlbauer-Ernst, A., Miehsler, W., Beier, M., Tillinger, W., Gangl, A., & Moser, G. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000106907.24881.f2 · Cited by 532 · see citing works
Assche, G. V., Dignass, A. U., Bokemeyer, B., Danese, S., Gionchetti, P., Moser, G., Beaugerie, L., Gomollón, F., Häuser, W., Herrlinger, K. R., et al. (2012) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2012.09.005 · Cited by 461 · see citing works
Feltz-Cornelis, C. M. V. D., Nuyen, J., Stoop, C. H., Chan, J. C. N., Jacobson, A. M., Katon, W. J., Snoek, F. J., & Sartorius, N. (2010) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2010.03.011 · Cited by 339 · see citing works
Fuller-Thomson, E., & Sulman, J. (2006) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200608000-00005 · Cited by 292 · see citing works
Wong, W. C., Cheung, C. S., & Hart, G. J. (2008) · Emerging Themes in Epidemiology · doi:10.1186/1742-7622-5-23 · Cited by 257 · see citing works
Goodhand, J. R., Wahed, M., Mawdsley, J. E., Farmer, A. D., Aziz, Q., & Rampton, D. S. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22916 · Cited by 234 · see citing works
Elsenbruch, S., Langhorst, J., Popkirowa, K., Müller, T., Luedtke, R., Franken, U., Paul, A., Spahn, G., Michalsen, A., Janssen, O., et al. (2005) · Psychotherapy and Psychosomatics · doi:10.1159/000086318 · Cited by 181 · see citing works
Psychiatric illness in patients with inflammatory bowel disease.
Andrews, H., Barczak, P., & Allan, R. N. (1987) · Gut · doi:10.1136/gut.28.12.1600 · Cited by 180 · see citing works
Duffy, L. C., Zielezny, M. A., Marshall, J. R., Byers, T. E., Weiser, M. M., Phillips, J. F., Calkins, B. M., Ogra, P. L., & Graham, S. (1991) · Behavioral Medicine · doi:10.1080/08964289.1991.9937553 · Cited by 176 · see citing works
Dignass, A. U., Preiß, J., Aust, D., Autschbach, F., Ballauff, A., Barretton, G., Bokemeyer, B., Fichtner‐Feigl, S., Hagel, S., Herrlinger, K. R., et al. (2011) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0031-1281666 · Cited by 175 · see citing works
Influence of inflammatory bowel disease on different dimensions of quality of life
Casellas, F., López-Vivancos, J., Badia, X. C., Vilaseca, J., & Malagelada, J. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200105000-00017 · Cited by 167 · see citing works
Walker, E. A., Gelfand, M. D., Gelfand, A. N., Creed, F., & Katon, W. J. (1996) · General Hospital Psychiatry · doi:10.1016/0163-8343(96)00036-9 · Cited by 144 · see citing works
Jedel, S., Hoffman, A., Merriman, P., Swanson, B., Voigt, R., Rajan, K. B., Shaikh, M., Li, H., & Keshavarzian, A. (2014) · Digestion · doi:10.1159/000356316 · Cited by 143 · see citing works
Psychological treatment may reduce the need for healthcare in patients with Crohnʼs disease
Deter, H., Keller, W., von Wietersheim, J., Jantschek, G., Duchmann, R., & Zeitz, M. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20068 · Cited by 137 · see citing works
Gut-directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis
Keefer, L., Taft, T. H., Kiebles, J. L., Martinovich, Z., Barrett, T. A., & Palsson, O. S. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12449 · Cited by 132 · see citing works
Goodhand, J., Greig, F. I. S., Koodun, Y., Mcdermott, A., Wahed, M., Langmead, L., & Rampton, D. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21846 · Cited by 131 · see citing works
Berrill, J. W., Sadlier, M., Hood, K., & Green, J. T. (2014) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2014.01.018 · Cited by 123 · see citing works
A stress management programme for Crohn’s disease
García-Vega, E., & Fernández, C. (2003) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(03)00146-3 · Cited by 114 · see citing works
Boye, B., Lundin, K. E. A., Jantschek, G., Leganger, S., Mokleby, K., Tangen, T., Jantschek, I., Pripp, A. H., Wojniusz, S., Dahlstroem, A., et al. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21575 · Cited by 113 · see citing works
Larsson, K., Sundberg Hjelm, M., Karlbom, U., Nordin, K., Anderberg, U. M., & Lööf, L. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310003309 · Cited by 106 · see citing works
Psychotherapy for inflammatory bowel disease: a review and update
McCombie, A. M., Mulder, R. T., & Gearry, R. B. (2013) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2013.02.004 · Cited by 105 · see citing works
Gerbarg, P. L., Jacob, V. E., Stevens, L., Bosworth, B. P., Chabouni, F., DeFilippis, E. M., Warren, R., Trivellas, M., Patel, P. V., Webb, C. D., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000568 · Cited by 103 · see citing works
Rubin, G. P., Hungin, A. P. S., Chinn, D. J., & Dwarakanath, D. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.1873.x · Cited by 100 · see citing works
McCombie, A., Gearry, R., Andrews, J., Mulder, R., & Mikocka-Walus, A. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000567 · Cited by 100 · see citing works
Vidal, À., Gómez‐Gil, E., Sans, M., Portella, M. J., Salamero, M., Pique, J. M., & Panés, J. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20388 · Cited by 98 · see citing works
Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease
Iskandar, H. N., Cassell, B., Kanuri, N., Gyawali, C. P., Gutierrez, A., Dassopoulos, T., Ciorba, M. A., & Sayuk, G. S. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000049 · Cited by 96 · see citing works
M., M., U., B., N., N., R., O., & V., S. M. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310003110 · Cited by 94 · see citing works
Langhorst, J., Mueller, T., Luedtke, R., Franken, U., Paul, A., Michalsen, A., Schedlowski, M., Dobos, G. J., & Elsenbruch, S. (2007) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520601101682 · Cited by 94 · see citing works
Jantschek, G. (1998) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365529850172386 · Cited by 92 · see citing works
Antidepressants in Inflammatory Bowel Disease: A Systematic Review
Macer, B. J. D., Prady, S. L., & Mikocka-Walus, A. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001059 · Cited by 92 · see citing works
Fatigue management in patients with IBD: a randomised controlled trial
Vogelaar, L., Spijker, A. V., Timman, R., van Tilburg, A. J. P., Bac, D., Vogelaar, T., Kuipers, E. J., Busschbach, J. J. V., & van der Woude, C. J. (2013) · Gut · doi:10.1136/gutjnl-2013-305191 · Cited by 91 · see citing works
Smith, G. D., Watson, R. A., Roger, D., McRorie, E., Hurst, N. P., Luman, W., & Palmer, K. R. (2002) · Journal of Advanced Nursing · doi:10.1046/j.1365-2648.2002.02159.x · Cited by 89 · see citing works
Schoultz, M., Atherton, I., & Watson, A. J. M. (2015) · Trials · doi:10.1186/s13063-015-0909-5 · Cited by 87 · see citing works
Mikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A., & Andrews, J. M. (2015) · BMC Gastroenterology · doi:10.1186/s12876-015-0278-2 · Cited by 86 · see citing works
Mizrahi, M. C., Reicher-Atir, R., Levy, S., Haramati, S., Wengrower, D., Israeli, E., & Goldin, E. (2012) · Psychology & Health · doi:10.1080/08870446.2012.691169 · Cited by 83 · see citing works
Neilson, K., Ftanou, M., Monshat, K., Salzberg, M., Bell, S., Kamm, M. A., Connell, W., Knowles, S. R., Sevar, K., Mancuso, S. G., et al. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000629 · Cited by 80 · see citing works
Mikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A., & Andrews, J. M. (2017) · International Journal of Behavioral Medicine · doi:10.1007/s12529-016-9580-9 · Cited by 78 · see citing works
Group‐based intervention program in inflammatory bowel disease patients: Effects on quality of life
Oxelmark, L., Magnusson, A., Löfberg, R., & Hillerås, P. K. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20061 · Cited by 76 · see citing works
Vogelaar, L., Spijker, A. V., Vogelaar, T., Busschbach, J. J. V., Visser, M. S., Kuipers, E. J., & van der Woude, C. J. (2011) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2011.06.001 · Cited by 70 · see citing works
Does psychological counseling alter the natural history of inflammatory bowel disease?
Wahed, M., Corser, M., Goodhand, J., & Rampton, D. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21098 · Cited by 69 · see citing works
Yanartas, Ö., Kani, H. T., Bicakci, E., Kilic, I., Banzragch, M., Acikel, C., Atug, O., Kuscu, K., Imeryuz, N., & Akin, H. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s106039 · Cited by 69 · see citing works
Effect of psychotherapy and relaxation on the psychosocial and somatic course of Crohn's disease
Keller, W., Pritsch, M., von Wietersheim, J., Scheib, P., Osborn, W., Balck, F. B., Dilg, R., Schmelz-Schumacher, E., Doppl, W., Jantschek, G., et al. (2004) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(03)00122-3 · Cited by 67 · see citing works
Supportive-Expressive Group Psychotherapy for Persons with Inflammatory Bowel Disease
Maunder, R., & Esplen, M. J. (2001) · The Canadian Journal of Psychiatry · doi:10.1177/070674370104600706 · Cited by 65 · see citing works
The burden of comedication among patients with inflammatory bowel disease
Buckley, J. P., Kappelman, M. D., Allen, J. K., Van Meter, S. A., & Cook, S. F. (2013) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000435442.07237.a4 · Cited by 59 · see citing works
Sharbafchi, M. R., Daghaghzadeh, H., Naji, F., Afshar, H., Feizi, A., Maroufi, M., Tabatabaeeyan, M., Adibi, P., & Tavakoli, H. (2015) · Journal of Research in Medical Sciences · doi:10.4103/1735-1995.165969 · Cited by 57 · see citing works
Treatment of Inflammatory Bowel Disease:A Role for Hypnotherapy?
Miller, V., & Whorwell, P. J. (2008) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207140802041884 · Cited by 56 · see citing works
Relapse-Precipitating Life Events and Feelings in Patients with Inflammatory Bowel Disease
von Wietersheim, J., Köhler, T. C., & Feiereis, H. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000288617 · Cited by 53 · see citing works
Behavioral interventions may prolong remission in patients with inflammatory bowel disease
Keefer, L., Kiebles, J. L., Martinovich, Z., Cohen, E., Denburg, A. N. V., & Barrett, T. A. (2010) · Behaviour Research and Therapy · doi:10.1016/j.brat.2010.12.005 · Cited by 51 · see citing works
Quality-of-Life Measurement in Patients with Inflammatory Bowel Disease Receiving Social Support
de Oliveira, S. M. A., Zaltman, C., Elia, C., Vargens, R. W., Leal, A. R. S., Barros, R., & Fogaça, H. S. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20071 · Cited by 49 · see citing works
Perianal disease is associated with psychiatric co-morbidity in Crohn’s disease in remission
Maconi, G., Gridavilla, D., Viganò, C. A., Sciurti, R., Asthana, A. K., Furfaro, F., Re, F., Ardizzone, S., & Ba, G. (2014) · International Journal of Colorectal Disease · doi:10.1007/s00384-014-1935-6 · Cited by 45 · see citing works
The Potential Role of a Self-Management Intervention for Ulcerative Colitis
Keefer, L., Kiebles, J. L., Kwiatek, M. A., Palsson, O. S., Taft, T., Martinovich, Z., & Barrett, T. A. (2011) · Biological Research For Nursing · doi:10.1177/1099800410397629 · Cited by 43 · see citing works
Walter, J. G., Kahn, S. A., Noe, J. D., Schurman, J. V., Miller, S. A., & Greenley, R. N. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000657 · Cited by 43 · see citing works
Sibaja, M. Á. D., Moreno, M. I. C., & Hesse, B. M. (2007) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082007001000006 · Cited by 42 · see citing works
Mikocka-Walus, A. A., Gordon, A. L., Stewart, B. J., & Andrews, J. M. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2011.06.006 · Cited by 34 · see citing works
Mikocka-Walus, A., Gordon, A. L., Stewart, B. J., & Andrews, J. (2012) · BMC Gastroenterology · doi:10.1186/1471-230x-12-93 · Cited by 31 · see citing works
De Ronchi, D., Bellini, F., Cremante, G., Ujkaj, M., Tarricone, I., Selleri, R., Quartesan, R., Piselli, M., & Scudellari, P. (2006) · AIDS Care · doi:10.1080/09540120500307842 · Cited by 24 · see citing works
Reusch, A., Weiland, R., Gerlich, C., Dreger, K., Derra, C., Mainos, D., Tuschhoff, T., Berding, A., Witte, C. E., Kaltz, B., et al. (2016) · Health Education Research · doi:10.1093/her/cyw042 · Cited by 21 · see citing works
Mikocka‐Walus, A. A., & Andrews, J. M. (2013) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2013.09.002 · Cited by 18 · see citing works
Mikocka-Walus, A., & Andrews, J. M. (2016) · Gastroenterology Nursing · doi:10.1097/sga.0000000000000182 · Cited by 16 · see citing works
‘Just to get it off my chest’: Patients' views on psychotherapy in inflammatory bowel disease
Mikocka‐Walus, A. A., Gordon, A. L., Stewart, B. J. R., & Andrews, J. M. (2012) · Counselling and Psychotherapy Research · doi:10.1080/14733145.2012.730540 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Stress triggers flare of inflammatory bowel disease in children and adults
Sun, Y., Li, L., Xie, R., Wang, B., Jiang, K., & Cao, H. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00432 · Cited by 171 · see citing works
The role of stress in the mosaic of autoimmunity: An overlooked association
Sharif, Κ., Watad, ., Coplan, L., Lichtbroun, B., Krosser, A., Lichtbroun, M., Bragazzi, N. L., Amital, H., Afek, A. B., & Shoenfeld, Y. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.04.005 · Cited by 111 · see citing works
The gut–brain axis in irritable bowel syndrome and inflammatory bowel disease
Ancona, A., Petito, C., Iavarone, I., Petito, V., Galasso, L., Leonetti, A., Turchini, L., Belella, D., Ferrarese, D., Addolorato, G., et al. (2020) · Digestive and Liver Disease · doi:10.1016/j.dld.2020.11.026 · Cited by 111 · see citing works
Antidepressants in inflammatory bowel disease
Mikocka-Walus, A., Ford, A. C., & Drossman, D. A. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0259-y · Cited by 93 · see citing works
Dubinsky, M. C., Dotan, I., Rubin, D. T., Bernauer, M. J., Patel, D. A., Cheung, R. Y., Modesto, I., Latymer, M., & Keefer, L. (2021) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2021.1911644 · Cited by 92 · see citing works
Enns, M. W., Bernstein, C. N., Kroeker, K., Graff, L. A., Walker, J. R., Lix, L. M., Hitchon, C. A., El-Gabalawy, R. M., Fisk, J. D., Marrie, R. A., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198975 · Cited by 89 · see citing works
Depression and Anxiety Disorders in Patients With Inflammatory Bowel Disease
Hu, S., Chen, Y., Chen, Y., & Wang, C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.714057 · Cited by 91 · see citing works
Irving, P., Barrett, K., Nijher, M., & de Lusignan, S. (2021) · Evidence-Based Mental Health · doi:10.1136/ebmental-2020-300223 · Cited by 63 · see citing works
New pathway ameliorating ulcerative colitis: focus on Roseburia intestinalis and the gut–brain axis
Xu, F., Cheng, Y., Ruan, G., Fan, L.-Q., Tian, Y., Xiao, Z., Chen, D., & Wei, Y. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848211004469 · Cited by 49 · see citing works
Depressive symptoms predict clinical recurrence of inflammatory bowel disease
Jordi, S. B. U., Lang, B. M., Auschra, B., von Känel, R., Biedermann, L., Greuter, T., Schreiner, P., Rogler, G., Krupka, N., Sulz, M. C., et al. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab136 · Cited by 41 · see citing works
Validation of the PHQ-9 for Suicidal Ideation in Persons with Inflammatory Bowel Disease
Litster, B., Bernstein, C. N., Graff, L. A., Walker, J. R., Fisk, J. D., Patten, S. B., Bolton, J. M., Sareen, J., El-Gabalawy, R. M., & Marrie, R. A. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy032 · Cited by 39 · see citing works
Viganò, C. A., Beltrami, M., Bosi, M. F., Zanello, R., Valtorta, M., & Maconi, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00324 · Cited by 42 · see citing works
Cooney, R., Tang, D., Barrett, K., & Russell, R. K. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad169 · Cited by 39 · see citing works
Butter, M., Weiler, S., Biedermann, L., Scharl, M. M., Rogler, G., Bischoff-Ferrari, H. A., & Misselwitz, B. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.01.015 · Cited by 38 · see citing works
Ning, L., Wang, X., Xuan, B., Ma, Y., Yan, Y., Gao, Z., Tong, T., Cui, Z., Chen, H., Li, X., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1145070 · Cited by 30 · see citing works
Luo, H., Sun, Y., Li, Y., Lv, H., Sheng, L., Wang, L., & Qian, J. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.07.013 · Cited by 25 · see citing works
Dober, M., Mikocka-Walus, A., Evans, S., Beswick, L., Emerson, C., & Olive, L. (2021) · Psychotherapy Research · doi:10.1080/10503307.2020.1813915 · Cited by 25 · see citing works
Sick Leave and Disability Pension in Prevalent Patients With Crohn’s Disease
Everhov, A. H., Khalili, H., Askling, J., Myrelid, P., Ludvigsson, J. F., Halfvarson, J., Nordenvall, C. A. M., Söderling, J. K., Olén, O., & Neovius, M. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy123 · Cited by 24 · see citing works
Psychosocial burden of inflammatory bowel disease in adolescents and young adults
Halloran, J., McDERMOTT, B. M., Ewais, T., Begun, J., Karatela, S., d’Emden, H., Corias, C., & Denny, S. (2020) · Internal Medicine Journal · doi:10.1111/imj.15034 · Cited by 23 · see citing works
Li, Q., He, X., Gao, F., Fan, Y., Zhao, B., Ma, Q., Yan, B., Wang, W., Ma, X., & Yang, J. (2022) · Schizophrenia · doi:10.1038/s41537-022-00244-w · Cited by 22 · see citing works
Ewais, T., Begun, J., Kenny, M. A., Chuang, K., Barclay, J. L., Hay, K. E., & Kisely, S. R. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-025568 · Cited by 16 · see citing works
Psychological Comorbidity and Intervention in Inflammatory Bowel Disease
Kredentser, M. S., Graff, L. A., & Bernstein, C. N. (2020) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001463 · Cited by 17 · see citing works
Löwe, B., Nestoriuc, Y., Andresen, V., Vettorazzi, E., Zapf, A., Hübener, S., Maehder, K., Peters, L., & Lohse, A. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-059529 · Cited by 11 · see citing works
A Phenome-Wide Analysis of Healthcare Costs Associated with Inflammatory Bowel Diseases
Cai, W., Cagan, A., He, Z., & Ananthakrishnan, A. N. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06329-9 · Cited by 15 · see citing works
Ba, D. M., Yadav, S. K., Liu, G., LESLIE, D. L., Vrana, K. E., & Coates, M. D. (2024) · Scientific Reports · doi:10.1038/s41598-024-51282-6 · Cited by 11 · see citing works
Gao, Z., Wang, P., Hong, J., Yan, Y., Tong, T., Wu, B., Hu, J., & Wang, Z. (2022) · Health and Quality of Life Outcomes · doi:10.1186/s12955-022-01969-z · Cited by 11 · see citing works
Tiles-Sar, N., Neuser, J., de Sordi, D., Rücker, G., Baltes, A., Preiß, J., Moser, G., & Timmer, A. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-056982 · Cited by 10 · see citing works
The burden of early life stress in chronic inflammatory bowel diseases
Minjoz, S., Sinniger, V., Hot, P., Bonaz, B. L., & Sonia Pellissier, A. (2023) · Journal of Health Psychology · doi:10.1177/13591053231173918 · Cited by 10 · see citing works
Comment on “Prevalence of Anxiety and Depression in Patients with Inflammatory Bowel Disease”
Lai, W., & Cai, S. (2018) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2018/6747630 · Cited by 10 · see citing works
Lontai, L., Elek, L. P., Balogh, F., Angyal, D., Pajkossy, P., Gönczi, L., Lakatos, P. L., & Iliás, Á. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13072002 · Cited by 9 · see citing works
Wang, J., Wang, Y., Zhu, Y., Cui, C., Feng, T., Huang, Q., Liu, S., & Wu, Q. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14723 · Cited by 9 · see citing works
Vincenzo, F. D., D’Onofrio, A. M., GAUDIO, A. D., Chiera, E., Ferrajoli, G. F., Pesaresi, F., Simonetti, A., Mazza, M., Kotzalidis, G. D., Pettorruso, M., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136514 · Cited by 9 · see citing works
Hedayat, K. M., & Lapraz, J.-C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816964-3.00011-0 · Cited by 8 · see citing works
Skvarc, D., Evans, S., Cheah, S., Cranney, M., German, B., Orr, R., Emerson, C., Olive, L., Beswick, L., Massuger, W., et al. (2022) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2022.101616 · Cited by 4 · see citing works
The Spectrum of Psychiatric Comorbidity in Individuals With Inflammatory Bowel Disease
Cadogan, K., Marrie, R. A., Graff, L. A., El-Gabalawy, R. M., Enns, M. W., Bolton, J. M., Sareen, J., & Bernstein, C. N. (2025) · Crohn s & Colitis 360 · doi:10.1093/crocol/otaf035 · Cited by 4 · see citing works
Adolescent IBD: recent data and practical management
Green, Z., Ashton, J. J., & Beattie, R. M. (2025) · Frontline Gastroenterology · doi:10.1136/flgastro-2024-102940 · Cited by 4 · see citing works
Factors affecting antidepressant use by patients requiring home parenteral nutrition
Cloutier, A., Deutsch, L., Miller, B., Leahy, G., Ablett, J., Healey, A., Twist, K., Teubner, A., Abraham, A., Taylor, M., et al. (2021) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2090 · Cited by 4 · see citing works
Nadeem, A. J., Donohue, S. R., Shah, F. Z., Perez, J. A., Harper, E., Sinh, P., Padival, R., Cooper, G. S., Katz, J., Cominelli, F., et al. (2024) · Crohn s & Colitis 360 · doi:10.1093/crocol/otae066 · Cited by 3 · see citing works
Dobre, M., Manuc, T. E., Mănuc, M., Matei, I.-C., Dobre, A.-M., Dragne, A.-D., Maffioletti, E., Pelisenco, I. A., & Milanesi, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157321 · Cited by 5 · see citing works
Uhlenbusch, N., Manthey, C. F., Nestoriuc, Y., Andresen, V., Lohse, A. W., & Löwe, B. (2022) · PPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie · doi:10.1055/a-1785-5496 · Cited by 2 · see citing works
He, J. Z., Hirschtritt, M. E., Wei, J. C., Ramalingam, N. D., Kahane, S. M., Velayos, F. S., & Hassid, B. G. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad190 · Cited by 2 · see citing works
Emotional dysfunction and inflammatory bowel disease
Li, S., & Wu, Q. (2019) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v27.i12.727 · Cited by 1 · see citing works
Hanani, A. A., Shaer, H., Nairat, M., Zeer, R., Abdo, Q., & Damiri, B. (2024) · Cogent Psychology · doi:10.1080/23311908.2024.2369411 · Cited by 1 · see citing works
The role of mastery in Crohn’s disease: a cross-sectional study
Gattoni, M. F., Previtali, E., Leone, S., Amore, A., & Volpato, E. (2025) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848251314796 · Cited by 2 · see citing works
Ozen, M. B., Gazioğlu, I., Özgün, Ö., Güner, H., Semiz, G., & Şen, A. (2025) · Drug Research · doi:10.1055/a-2551-2418 · Cited by 1 · see citing works
Seyedian, S. S., Nazarinasab, M., Nematpour, S., & Esfahanian, N. (2019) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_236_18 · Cited by 1 · see citing works
Development of a dual flow microfluidic device for the study of barrier systems
Baldwin, L. (2020) · Repository@Hull (Worktribe) (University of Hull) · Cited by 1 · see citing works
Letter to the Editor: Missed Meals While Hospitalized for UC
Kane, S. V. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izx091
McGeer, R., Ascott, A., Eccles, J., Smith, M. A., Page, L., Hills, E., Jones, A. S. C., & Gregory, J. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjx180.499
Laparoscopic surgical treatment for ulcerative colitis
Tajti, J. (2019) · doi:10.14232/phd.10096
Chronisch entzündliche Darmerkrankungen
Brechmann, T. (2022) · Springer Reference Medizin · doi:10.1007/978-3-662-61937-7_68-1
Chronisch entzündliche Darmerkrankungen
Brechmann, T. (2025) · Springer Reference Medizin · doi:10.1007/978-3-662-60980-4_68
Advances in research on comorbidities in inflammatory bowel disease
Zhou, S., & yang, Y. (2026) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v34.i5.385
- Authors
- Tarricone, I., Regazzi, M. G., Bonucci, G., Rizzello, F., Carini, G., Muratori, R., Poggioli, G., & Campieri, M.
- Affiliations
- University of Bologna (IT)
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Corresponding author
- Tarricone, Ilaria
- Venue
- Journal of Psychosomatic Research
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 101
- Pages
- 68-95
- ISSN
- 0022-3999 (ISSN-L)
- OpenAlex
- W2736761101
- Cited by
- 53
- References
- 65
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 10
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychosomatic Research (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Funders
- Marmara Üniversitesi
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- inflammatory bowel disease, Crohn's disease, ulcerative colitis, depression, anxiety, psychiatric comorbidity, psychotherapy, antidepressants, psychiatric referral, treatment effectiveness, quality of life, stress
- MeSH terms
- Adult, Colitis, Ulcerative, Crohn Disease, Female, Humans, Male, Psychotherapy, Quality of Life, Inflammatory Bowel Diseases, Prevalence, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
