The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Kaempferol Inhibits Angiogenesis and VEGF Expression Through Both HIF Dependent and Independent Pathways in Human Ovarian Cancer Cells
Open accessAbstract
Ovarian cancer is 1 of the most significant malignancies in the Western world, and the antiangiogenesis strategy has been postulated for prevention and treatment of ovarian cancers. Kaempferol is a natural flavonoid present in many fruits and vegetables. The antiangiogenesis potential of kaempferol and its underlying mechanisms were investigated in two ovarian cancer cell lines, OVCAR-3 and A2780/CP70. Kaempferol mildly inhibits cell viability but significantly reduces VEGF gene expression at mRNA and protein levels in both ovarian cancer cell lines. In chorioallantoic membranes of chicken embryos, kaempferol significantly inhibits OVCAR-3-induced angiogenesis and tumor growth. HIF-1alpha, a regulator of VEGF, is downregulated by kaempferol treatment in both ovarian cancer cell lines. Kaempferol also represses AKT phosphorylation dose dependently at 5 to 20 muM concentrations. ESRRA is a HIF-independent VEGF regulator, and it is also downregulated by kaempferol in a dose-dependent manner. Overall, this study demonstrated that kaempferol is low in cytotoxicity but inhibits angiogenesis and VEGF expression in human ovarian cancer cells through both HIF-dependent (Akt/HIF) and HIF-independent (ESRRA) pathways and deserves further studies for possible application in angio prevention and treatment of ovarian cancers.
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Cites
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Cited by
Loh, C.-Y., Chai, J., Tang, T., Wong, W., Sethi, G., Shanmugam, M., Chong, P., & Looi, C. (2019) · Cells · doi:10.3390/cells8101118 · Cited by 1,315
Kaempferol: A Key Emphasis to Its Anticancer Potential
Imran, M., Salehi, B., Sharifi-Rad, J., Aslam Gondal, T., Saeed, F., Imran, A., Shahbaz, M., Tsouh Fokou, P. V., Umair Arshad, M., Khan, H., et al. (2019) · Molecules · doi:10.3390/molecules24122277 · Cited by 819
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Lokman, N. A., Elder, A. S. F., Ricciardelli, C., & Oehler, M. K. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13089959 · Cited by 358
Kim, T. W., Lee, S. Y., Kim, M., Cheon, C., & Ko, S.-G. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0930-1 · Cited by 304
Metadata
- Authors
- Luo, H., Rankin, G. O., Liu, L., Daddysman, M. K., Jiang, B.-H., & Chen, Y. C.
- Venue
- Nutrition and Cancer
- Publisher
- Informa UK Limited
- Published
- 2009-07-17
- Volume
- 61
- Issue
- 4
- Pages
- 554-563
- ISSN
- 0163-5581 (ISSN-L)
- 1532-7914
- OpenAlex
- W2011984268
- Cited by
- 196
- References
- 5
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Luo, H., Rankin, G. O., Liu, L., Daddysman, M. K., Jiang, B.-H., & Chen, Y. C. (2009). Kaempferol Inhibits Angiogenesis and VEGF Expression Through Both HIF Dependent and Independent Pathways in Human Ovarian Cancer Cells. Nutrition and Cancer. https://doi.org/10.1080/01635580802666281
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