The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells

Global cancer statistics

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Global cancer statistics, 2012

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Cancer statistics, 2015

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Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

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Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis

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Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications

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Dietary polyphenols and their biological significance

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Bioavailability of the polyphenols: Status and controversies

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Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action

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Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents

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Multitargeted cancer prevention by quercetin

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The flavonoid quercetin in disease prevention and therapy: Facts and fancies

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Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

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Simultaneous Determination of All Polyphenols in Vegetables, Fruits, and Teas

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Flavones: An important scaffold for medicinal chemistry

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Tea and Health: Studies in Humans

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Reversal of Hypermethylation and Reactivation of p16INK4a, RARβ, and MGMT Genes by Genistein and Other Isoflavones from Soy

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Dietary polyphenolic phytochemicals—promising cancer chemopreventive agents in humans? A review of their clinical properties

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USDA Database for the Flavonoid Content of Selected Foods Release 3.1

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Determination of Flavonoids in Plant Material by HPLC with Diode-Array and Electro-Array Detections

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Designing a broad-spectrum integrative approach for cancer prevention and treatment

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Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature

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Characterization of protein–polyphenol interactions

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Flavonoid-membrane interactions: possible consequences for biological effects of some polyphenolic compounds1

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Flavonoids in Vegetable Foods Commonly Consumed in Brazil and Estimated Ingestion by the Brazilian Population

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Flavonoids, Flavonoid Subclasses and Breast Cancer Risk: A Meta-Analysis of Epidemiologic Studies

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Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer

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Quercetin: A potential drug to reverse multidrug resistance

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Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study

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Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2′-deoxycytidine

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Association between Soy Isoflavone Intake and Breast Cancer Risk for Pre- and Post-Menopausal Women: A Meta-Analysis of Epidemiological Studies

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Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries

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Bioavailability of Apigenin from Apiin-Rich Parsley in Humans

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Epigenetic activities of flavonoids in the prevention and treatment of cancer

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Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation

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Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway

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Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway

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Delphinidin, an anthocyanidin in pigmented fruits and vegetables, induces apoptosis and cell cycle arrest in human colon cancer HCT116 cells

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Quercetin induces cytochrome‐c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, in cervical carcinoma: signal cascade and drug‐DNA interaction

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Plant Phytochemicals as Epigenetic Modulators: Role in Cancer Chemoprevention

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Intakes of Selected Nutrients, Foods, and Phytochemicals and Prostate Cancer Risk in Western New York

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Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells

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Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models

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Hesperetin Induced G1-Phase Cell Cycle Arrest in Human Breast Cancer MCF-7 Cells: Involvement of CDK4 and p21

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Intermolecular binding of blueberry pectin-rich fractions and anthocyanin

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Lignin and polyphenols as allelochemicals

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Genistein—A dietary compound inducing hormonal and metabolic changes

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The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways

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Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort

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Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT

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Anticarcinogenesis by dietary phytochemicals: Cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-κB and AP-1 in abnormal cancer cells

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Flavonoid intake and ovarian cancer risk in a population‐based case‐control study

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Flavonoids Influence Epigenetic-Modifying Enzyme Activity: Structure-Function Relationships and the Therapeutic Potential for Cancer

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Essential requirement of reduced glutathione (GSH) for the anti-oxidant effect of the flavonoid quercetin

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Dietary Flavonoid Intake, Black Tea Consumption, and Risk of Overall and Advanced Stage Prostate Cancer

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Hesperetin Induces the Apoptosis of Gastric Cancer Cells via Activating Mitochondrial Pathway by Increasing Reactive Oxygen Species

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Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

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Naringenin up‐regulates the expression of death receptor 5 and enhances TRAIL‐induced apoptosis in human lung cancer A549 cells

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Cancer-linked targets modulated by curcumin.

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Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro

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Dietary Flavonoids and Gastric Cancer Risk in a Korean Population

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Epigallocatechin-3-gallate (EGCG) downregulates gelatinase-B (MMP-9) by involvement of FAK/ERK/NFκB and AP-1 in the human breast cancer cell line MDA-MB-231

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Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA)

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EGCG Inhibits the Invasion of Highly Invasive CL1-5 Lung Cancer Cells through Suppressing MMP-2 Expression via JNK Signaling and Induces G2/M Arrest

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Inhibition of mackerel (Scomber scombrus) muscle lipoxygenase by green tea polyphenols

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Natural polyphenols as proteasome modulators and their role as anti‐cancer compounds

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Modulation of signaling pathways in prostate cancer by green tea polyphenols

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Daidzein causes cytochrome c-mediated apoptosis via the Bcl-2 family in human hepatic cancer cells

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Quercetin-3-O-glucuronide inhibits noradrenaline-promoted invasion of MDA-MB-231 human breast cancer cells by blocking β2-adrenergic signaling

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Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study

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Genistein Affects Histone Modifications on Dickkopf-Related Protein 1 (DKK1) Gene in SW480 Human Colon Cancer Cell Line

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The polyphenol (−)-epicatechin gallate disrupts the secretion of virulence-related proteins by Staphylococcus aureus

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Apigenin Protects Endothelial Cells from Lipopolysaccharide (LPS)-Induced Inflammation by Decreasing Caspase-3 Activation and Modulating Mitochondrial Function

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Genistein exhibits anti-cancer effects via down-regulating FoxM1 in H446 small-cell lung cancer cells

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Apoptotic effect of genistein on human colon cancer cells via inhibiting the nuclear factor-kappa B (NF-κB) pathway

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Aryl hydrocarbon receptor-dependent apoptotic cell death induced by the flavonoid chrysin in human colorectal cancer cells

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Molecular Mechanism Underlying Hesperetin-induced Apoptosis by in silico Analysis and in Prostate Cancer PC-3 Cells

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Isoflavone consumption and risk of breast cancer: a dose-response meta-analysis of observational studies.

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The Risk of Lung Cancer Related to Dietary Intake of Flavonoids

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Luteolin is effective in the non‐small cell lung cancer model with L 858 R / T 790 M EGF receptor mutation and erlotinib resistance

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