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Cited by 10Cardiovascular Issues in PregnancyGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesReproductive Health and Technologies

Wish to conceive and concerns to develop cardiovascular complications during pregnancy in patients with Turner syndrome

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van Hagen, Iris M., Duijnhouwer, Anthonie L., Ten Kate-Booij, Marianne J., Dykgraaf, Ramon H. M., Duvekot, Johannes J., Utens, Elisabeth M. W. J., Roos-Hesselink, Jolien W.·2017·Journal of Psychosomatic Obstetrics & Gynecology
DOI 10.1080/0167482x.2016.1216961
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Abstract

INTRODUCTION: Turner syndrome (TS) is associated with subfertility and infertility. Nevertheless, an increasing number of women become pregnant through oocyte donation. The wish to conceive may be negatively influenced by the fear of cardiovascular complications. The aim was to investigate the wish to conceive and the concerns about cardiovascular complications during pregnancy in women with TS. METHODS: The patient association for TS invited all members of ≥18 years old (n = 344) to complete a specifically developed, disease-specific questionnaire, including questions about fertility, wish to conceive, attempts and concerns. Results were compared with previously published results of this questionnaire in women with congenital heart disease. RESULTS: The questionnaire was completed by 89 women (median age 30.1 years, Q1-Q3 = 22.9-39.4). Of them, 51% had 45, X0-monosomy and 38% had ≥1 cardiac abnormality. Seventeen women (19%) had attempted to become pregnant and 12 of them succeeded to become pregnant. Women who had not undertaken attempts to conceive (81%), considered themselves mainly too young or had no partner. Of the total sample, 58% were concerned about the influence of pregnancy on their cardiovascular status. This was higher (75%) in the sample of women with TS and cardiac abnormalities, than in women with congenital heart disease from a previously published cohort (21%), (p < .001). There were no differences in concerns about pregnancy complications between women with TS who respectively had or had not attempted to become pregnant. DISCUSSION: Women with TS, especially those with cardiac abnormalities, show serious concerns about the risks pregnancy may have. Patients should be timely counseled and specifically asked about their concerns. Psychosocial care should be provided when necessary.

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  • Many individuals with TS endorse a desire for biological children and pregnancy.

    “For example, though many individuals with TS endorse a desire for biological children and pregnancy, concern about the negative impact of pregnancy on cardiovascular health may cause some individuals with TS to forgo fertility preservation options.566,567”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [567]

  • Concern about the negative impact of pregnancy on cardiovascular health may cause some individuals with TS to forgo fertility preservation options.

    “For example, though many individuals with TS endorse a desire for biological children and pregnancy, concern about the negative impact of pregnancy on cardiovascular health may cause some individuals with TS to forgo fertility preservation options.566,567”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [567]

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Research works printed but not linked: 2

  1. Stochholm K, Juul S, Juel K, et al. Prevalence, inci- dence, diagnostic delay, and mortality in Turner syn- drome. J Clin Endocrinol Metab 2006;91:3897-902.
  2. Practice Committee of American Society for Reproductive M. Increased maternal cardiovascular mortality associated with pregnancy in women with Turner syndrome. Fertil Steril 2012;97:282-4.

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Authors
van Hagen, I. M., Duijnhouwer, A. L., Ten Kate-Booij, M. J., Dykgraaf, R. H. M., Duvekot, J. J., Utens, E. M. W. J., & Roos-Hesselink, J. W.
Affiliations
  • Department of Cardiology, Erasmus University Medical Center, Rotterdam, The Netherlands;
  • Radboud University Medical Center (NL)
  • Department of Obstetrics and gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands;
  • Erasmus MC (NL)
ORCID
Venue
Journal of Psychosomatic Obstetrics & Gynecology
Publisher
Informa UK Limited
Published
2016-09-01
Volume
38
Issue
1
Pages
45-52
ISSN
  • 0167-482X (ISSN-L)
  • 1743-8942
DOI
10.1080/0167482x.2016.1216961
OpenAlex
W2508432932
Cited by
10
References
33
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2020: 1 · 2018: 1 · 2017: 1
FWCI
0.55
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Psychosomatic Obstetrics & Gynecology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
  • Pure Amsterdam UMC (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • UvA-DARE (University of Amsterdam) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Issues in Pregnancy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Keywords
Turner syndrome, pregnancy, cardiovascular complications, infertility, subfertility, oocyte donation, congenital heart disease, patient concerns, psychosocial care, patient counseling, 45,X monosomy
MeSH terms
Adult, Cross-Sectional Studies, Female, Humans, Health Knowledge, Attitudes, Practice, Pregnancy, Pregnancy Complications, Cardiovascular, Risk, Turner Syndrome, Young Adult

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