The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Measurement and meaning of salivary cortisol: A focus on health and disease in children: Review
Open accessAbstract
Measurement of salivary cortisol can provide important information about hypothalamic-pituitary-adrenal (HPA) axis activity under normal conditions and in response to stress. However, there are many variables relating to the measurement of cortisol in saliva which may introduce error and therefore may render difficult the comparison and interpretation of data between, and within, laboratories. This review addresses the effects of gender, age, time and location of sampling, units of measurement, assay conditions and compliance with the protocol, all of which have the potential to impact upon the precision, accuracy and reliability of salivary cortisol measurements in the literature. Some of these factors are applicable to both adults and children, but the measurement of salivary cortisol in children introduces aspects of unique variability which demand special attention. The specific focus of this review is upon the somewhat neglected area of methodological variability of salivary cortisol measurement in children. In addition to these methodological issues, the review highlights the use of salivary cortisol measurements to provide information about HPA axis dysfunction associated with psycho- and patho-physiological conditions in children. Novel applications for salivary cortisol measurements in future research into HPA axis activity in children are also discussed.
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Citations
Cites
Social regulation of the cortisol levels in early human development
Gunnar, M. R., & Donzella, B. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00045-2 · Cited by 1,088
The effects of sex and hormonal status on the physiological response to acute psychosocial stress
Kajantie, E., & Phillips, D. I. W. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.07.002 · Cited by 1,035
The awakening cortisol response: methodological issues and significance
Clow, A., Thorn, L., Evans, P., & Hucklebridge, F. (2004) · Stress · doi:10.1080/10253890410001667205 · Cited by 856
Essex, M. J., Klein, M. H., Cho, E., & Kalin, N. H. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01553-6 · Cited by 698
Attenuated free cortisol response to psychosocial stress in children with atopic dermatitis
Buske-Kirschbaum, A., Jobst, S., Wustmans, A., Kirschbaum, C., Rauh, W., & Hellhammer, D. (1997) · Psychosomatic Medicine · doi:10.1097/00006842-199707000-00012 · Cited by 696
Child's stress hormone levels correlate with mother's socioeconomic status and depressive state
Lupien, S. J., King, S., Meaney, M. J., & McEwen, B. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00965-3 · Cited by 532 · cited 2×
“Morning basal cortisol levels were also elevated in children aged 6–10 years whose mothers were depressed (Lupien et al. 2000; Ashman et al. 2002); morning, evening and total cortisol levels were higher in pre-school children (n ¼ 56, age 3.5–4.5 years) whose mothers were suffering from job…”
BackgroundInfluentialSalivary cortisol levels in children adopted from Romanian orphanages
GUNNAR, M. R., MORISON, S. J., CHISHOLM, K., & SCHUDER, M. (2001) · Development and Psychopathology · doi:10.1017/s095457940100311x · Cited by 517
Vamvakopoulos, N. C., & Chrousos, G. P. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116782 · Cited by 422
KLIMES–DOUGAN, B., HASTINGS, P. D., GRANGER, D. A., USHER, B. A., & ZAHN–WAXLER, C. (2001) · Development and Psychopathology · doi:10.1017/s0954579401003157 · Cited by 352
Ahnert, L., Gunnar, M. R., Lamb, M. E., & Barthel, M. (2004) · Child Development · doi:10.1111/j.1467-8624.2004.00698.x · Cited by 334 · cited 2×
“Cortisol levels increased in infants aged 15 months during the maternal separation phase following the start of childcare and had returned to baseline 6 months later (Ahnert et al. 2004).”
BackgroundStress hormone levels of children of depressed mothers
ASHMAN, S. B., DAWSON, G., PANAGIOTIDES, H., YAMADA, E., & WILKINSON, C. W. (2002) · Development and Psychopathology · doi:10.1017/s0954579402002080 · Cited by 310
Foster Children’s Diurnal Production of Cortisol: An Exploratory Study
Dozier, M., Manni, M., Gordon, M. K., Peloso, E., Gunnar, M. R., Stovall-McClough, K. C., Eldreth, D., & Levine, S. (2006) · Child Maltreatment · doi:10.1177/1077559505285779 · Cited by 259 · cited 1×
“Children aged 20–60 months undergoing fostering exhibited a flatter diurnal cortisol slope from morning to evening, with lower morning levels (Dozier et al. 2006).”
BackgroundCortisol circadian rhythms and response to stress in children with autism
Corbett, B. A., Mendoza, S., Abdullah, M., Wegelin, J. A., & Levine, S. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.05.011 · Cited by 258 · cited 1×
“Similar findings have been reported in a study of 6–11-year-old children who provided salivary samples in the home environment (Corbett et al. 2006).”
ResultHypothalamic-pituitary-adrenocortical axis regulation
Jacobson, L. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.01.003 · Cited by 248
Luby, J. L., Heffelfinger, A., Mrakotsky, C., Brown, K., Hessler, M., & Spitznagel, E. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1248 · Cited by 184
Straub, R. H., Paimela, L., Peltomaa, R., Schölmerich, J., & Leirisalo‐Repo, M. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10177 · Cited by 183
Free cortisol awakening responses are influenced by awakening time
Federenko, I., Wüst, S., Hellhammer, D. H., Dechoux, R., Kumsta, R., & Kirschbaum, C. (2004) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00021-0 · Cited by 173 · cited 1×
“Design of future studies to investigate any disruption of the ACR in pathological conditions should take into account the reported effects of awakening time on the ACR (Federenko et al. 2004).”
BackgroundThe Psychobiology of Children Exposed to Marital Violence
Saltzman, K. M., Holden, G. W., & Holahan, C. J. (2005) · Journal of Clinical Child & Adolescent Psychology · doi:10.1207/s15374424jccp3401_12 · Cited by 159
Circadian Rhythm of Salivary Cortisol, 17α-Hydroxyprogesterone, and Progesterone in Healthy Children
Gröschl, M., Rauh, M., & Dörr, H.-G. (2003) · Clinical Chemistry · doi:10.1373/49.10.1688 · Cited by 145 · cited 6×
“The circadian pattern of cortisol secretion develops early in breastfed infants, generally not being present before 4 weeks (Groschl et al. 2003) but becoming apparent between 2 and 20 weeks post-partum, with no apparent gender dimorphism in early or late development during this period (Santiago et…”
BackgroundResultInfluentialJansen, L. M., Gispen-de Wied, C. C., van der Gaag, R.-J., & van Engeland, H. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300046 · Cited by 118
Cortisol and behavior in fragile X syndrome
Hessl, D., Glaser, B., Dyer-Friedman, J., Blasey, C., Hastie, T., Gunnar, M., & Reiss, A. L. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00087-7 · Cited by 115
Salivary cortisol for screening of Cushing's syndrome in children.
Martinelli, C. E., Sader, S. L., Oliveira, E. B., Daneluzzi, J. C., & Moreira, A. C. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00749.x · Cited by 114
Feder, A., Coplan, J. D., Goetz, R. R., Mathew, S. J., Pine, D. S., Dahl, R. E., Ryan, N. D., Greenwald†, S., & Weissman, M. M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.05.005 · Cited by 103 · cited 2×
“Whilst there is a small but growing body of evidence that has included children when looking at the ACR (Pruessner et al. 1997; Wust et al. 2000; Bartels et al. 2003; Buske-Kirschbaum et al. 2003; Kudielka and Kirschbaum 2003; Feder et al. 2004; Rosmalen et al. 2005), these studies have used heterogeneous samples with…”
BackgroundA defect in cortisol production in rheumatoid arthritis: why are we still looking?
Jessop, D. S., & Harbuz, M. S. (2005) · Rheumatology · doi:10.1093/rheumatology/keh644 · Cited by 49
Self-citation
Cited by
Salivary cortisol as a biomarker in stress research
Hellhammer, D. H., Wüst, S., & Kudielka, B. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.026 · Cited by 1,925
Kudielka, B. M., Hellhammer, D. H., & Wüst, S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.004 · Cited by 963
Oberle, E., & Schonert-Reichl, K. A. (2016) · Social Science & Medicine · doi:10.1016/j.socscimed.2016.04.031 · Cited by 524
Kudielka, B. M., & Wüst, S. (2010) · Stress · doi:10.3109/10253890902874913 · Cited by 424
Anxiety of children and adolescents who stutter: A review
Smith, K. A., Iverach, L., O’Brian, S., Kefalianos, E., & Reilly, S. (2014) · Journal of Fluency Disorders · doi:10.1016/j.jfludis.2014.01.003 · Cited by 126
Metadata
- Authors
- Jessop, D. S., & Turner-Cobb, J. M.
- Venue
- Stress
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 11
- Issue
- 1
- Pages
- 1-14
- ISSN
- 1025-3890 (ISSN-L)
- 1607-8888
- OpenAlex
- W2090971231
- Cited by
- 286
- References
- 24
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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