Vitamin D bioavailability: state of the art

Borel, P.; Caillaud, D.; Cano, N. J.

doi:10.1080/10408398.2012.688897

Cited by 378Vitamin D Research StudiesNutrition and Health StudiesAntioxidant Activity and Oxidative Stress

Vitamin D bioavailability: state of the art

Open access

Borel, P., Caillaud, D., Cano, N. J.·2015·Critical Reviews in Food Science and Nutrition

DOI 10.1080/10408398.2012.688897

Open this paper in CoChat — free account

Abstract

There has been renewed interest in vitamin D since numerous recent studies have suggested that besides its well-established roles in bone metabolism and immunity, vitamin D status is inversely associated with the incidence of several diseases, e.g., cancers, cardio-vascular diseases, and neurodegenerative diseases. Surprisingly, there is very little data on factors that affect absorption of this fat-soluble vitamin, although it is acknowledged that dietary vitamin D could help to fight against the subdeficient vitamin D status that is common in several populations. This review describes the state of the art concerning the fate of vitamin D in the human upper gastrointestinal tract and on the factors assumed to affect its absorption efficiency. The main conclusions are: (i) ergocalciferol (vitamin D2), the form mostly used in supplements and fortified foods, is apparently absorbed with similar efficiency to cholecalciferol (vitamin D3, the main dietary form), (ii) 25-hydroxyvitamin D (25OHD), the metabolite produced in the liver, and which can be found in foods, is better absorbed than the nonhydroxy vitamin D forms cholecalciferol and ergocalciferol, (iii) the amount of fat with which vitamin D is ingested does not seem to significantly modify the bioavailability of vitamin D3, (iv) the food matrix has apparently little effect on vitamin D bioavailability, (v) sucrose polyesters (Olestra) and tetrahydrolipstatin (orlistat) probably diminish vitamin D absorption, and (vi) there is apparently no effect of aging on vitamin D absorption efficiency. We also find that there is insufficient, or even no data on the following factors suspected of affecting vitamin D bioavailability: (i) effect of type and amount of dietary fiber, (ii) effect of vitamin D status, and (iii) effect of genetic variation in proteins involved in its intestinal absorption. In conclusion, further studies are needed to improve our knowledge of factors affecting vitamin D absorption efficiency. Clinical studies with labeled vitamin D, e.g., deuterated or (13)C, are needed to accurately and definitively assess the effect of various factors on its bioavailability.

Integrity signals

Registry

Crossref · 10.1080/10408398.2012.688897

Cites

104 of 104 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Vitamin D supplements containing either vitamin D2 or D3 have similar bioavailability as dietary-derived vitamin D.
“Further, vitamin D supplements containing either vitamin D2 or D3, which have similar bioavailability as dietary-derived vitamin D [287], have become more popular and are commonly consumed [267].”
From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [287]

Decreased bioavailability of vitamin D in obesity
Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.690 · Cited by 3,204 · see citing works
Vitamin D2Is Much Less Effective than Vitamin D3in Humans
Armas, L. A. G., Hollis, B. W., & Heaney, R. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0360 · Cited by 1,124 · see citing works
Genome-wide association study of circulating vitamin D levels
Ahn, J., Yu, K. F., Stolzenberg‐Solomon, R. Z., Simon, K. C., McCullough, M. L., Gallicchio, L. M., Jacobs, E. J., Ascherio, A., Helzlsouer, K. J., Jacobs, K. B., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq155 · Cited by 810 · see citing works
Vitamin D2 Is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 25-Hydroxyvitamin D
Holick, M. F., Biancuzzo, R. M., Chen, T. C., Klein, E. K., Young, A., Bibuld, D., Reitz, R. E., Salameh, W. A., Ameri, A., & Tannenbaum, A. D. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2308 · Cited by 770 · see citing works
Volumetric Dilution, Rather Than Sequestration Best Explains the Low Vitamin D Status of Obesity
Drincic, A., Armas, L. A. G., van Diest, E. E., & Heaney, R. P. (2012) · Obesity · doi:10.1038/oby.2011.404 · Cited by 662 · see citing works
Vitamin D and its Major Metabolites: Serum Levels after Graded Oral Dosing in Healthy Men
Barger-Lux, M. J., Heaney, R. P., Dowell, S. T., Chen, T. C., & Holick, M. F. (1998) · Osteoporosis International · doi:10.1007/s001980050058 · Cited by 356 · see citing works
THE FUNCTION OF BILE SALTS IN FAT ABSORPTION. THE SOLVENT PROPERTIES OF DILUTE MICELLAR SOLUTIONS OF CONJUGATED BILE SALTS
Hofmann, A. (1963) · Biochemical Journal · doi:10.1042/bj0890057 · Cited by 353 · see citing works
Short and Long-Term Variations in Serum Calciotropic Hormones after a Single Very Large Dose of Ergocalciferol (Vitamin D2) or Cholecalciferol (Vitamin D3) in the Elderly
Romagnoli, E., Mascia, M. L., Cipriani, C., Fassino, V., Mazzei, F., D'Erasmo, E., Carnevale, V., Scillitani, A., & Minisola, S. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0350 · Cited by 331 · see citing works
Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health
Tangpricha, V., Koutkia, P., Rieke, S. M., Chen, T. C., Perez, A. A., & Holick, M. F. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.6.1478 · Cited by 298 · see citing works
Class B Scavenger Receptor-Mediated Intestinal Absorption of Dietary β-Carotene and Cholesterol
van Bennekum, A., Werder, M., Thuahnai, S. T., Han, C.-H., Duong, P., Williams, D. L., Wettstein, P., Schulthess, G., Phillips, M. C., & Hauser, H. (2005) · Biochemistry · doi:10.1021/bi0484320 · Cited by 290 · see citing works
Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings
Staggers, J. E., Hernell, O., Stafford, R. J., & Carey, M. C. (1990) · Biochemistry · doi:10.1021/bi00460a011 · Cited by 289 · see citing works
Lutein transport by Caco-2 TC-7 cells occurs partly by a facilitated process involving the scavenger receptor class B type I (SR-BI)
Reboul, E., Abou, L., Mikail, C., Ghiringhelli, O., ANDRÉ, M., Portugal, H., Dominique Jourdheuil-rahmani, A., Amiot, M. J., Lairon, D., & Borel, P. (2005) · Biochemical Journal · doi:10.1042/bj20040554 · Cited by 277 · see citing works
Scavenger Receptor Class B Type I (SR-BI) Is Involved in Vitamin E Transport across the Enterocyte
Reboul, E., Klein, A., Biétrix, F., Gleize, B., Malezet‐Desmoulins, C., Schneider, M., Margotat, A., Lagrost, L., Collet, X., & Borel, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509042200 · Cited by 252 · see citing works
ISX is a retinoic acid-sensitive gatekeeper that controls intestinal β,β-carotene absorption and vitamin A production
Lobo, G. P., Hessel, S., Eichinger, A., Noy, N., Moise, A. R., Wyss, A., Palczewski, K., & Von Lintig, J. (2010) · The FASEB Journal · doi:10.1096/fj.09-150995 · Cited by 248 · see citing works
A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations
McGrath, J. J., Saha, S., Burne, T. H. J., & Eyles, D. W. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.03.073 · Cited by 240 · see citing works
Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women
Sinotte, M., Diorio, C., Bérubé, S., Pollak, M., & Brisson, J. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26445 · Cited by 240 · see citing works
Proteins involved in uptake, intracellular transport and basolateral secretion of fat-soluble vitamins and carotenoids by mammalian enterocytes
Reboul, E., & Borel, P. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.07.001 · Cited by 237 · see citing works
Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis
Orton, S. M., Morris, A. P., Herrera, B. M., Ramagopalan, S. V., Lincoln, M. R., Chao, M. J., Vieth, R., Sadovnick, A. D., & Ebers, G. C. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.441 · Cited by 231 · see citing works
Vitamin D absorption in healthy subjects and in patients with intestinal malabsorption syndromes
Lo, C., Paris, P., Clemens, T. L., Nolan, J. M., & Holick, M. F. (1985) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/42.4.644 · Cited by 216 · see citing works
Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation
Fu, L., Yun, F., Oczak, M., Wong, B. Y. L., Vieth, R., & Cole, D. E. C. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.03.008 · Cited by 214 · see citing works
Vitamin D intestinal absorption is not a simple passive diffusion: Evidences for involvement of cholesterol transporters
Reboul, E., Goncalves, A., Coméra, C., Bott, R., Nowicki, M., Landrier, J., Dominique Jourdheuil-rahmani, A., Dufour, C., Collet, X., & Borel, P. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000553 · Cited by 212 · see citing works
Effects of Orlistat on Fat‐Soluble Vitamins in Obese Adolescents
McDuffie, J. R., Calis, K. A., Booth, S. L., Uwaifo, G. I., & Yanovski, J. A. (2002) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.22.11.814.33627 · Cited by 202 · see citing works
Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. II. Action on cholesterol esters and lipid-soluble vitamin esters
Lombardo, D., & Guy, O. (1980) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(80)90050-9 · Cited by 196 · see citing works
Absorption of vitamin D3-3H in control subjects and patients with intestinal malabsorption.
Thompson, G. R., Lewis, B. L., & Booth, C. C. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105327 · Cited by 194 · see citing works
COMPARISON OF ORAL 25-HYDROXYCHOLECALCIFEROL, VITAMIN D, AND ULTRAVIOLET LIGHT AS DETERMINANTS OF CIRCULATING 25-HYDROXYVITAMIN D
Stamp, T. C. B., Haddad, J. G., & Twigg, C. A. (1977) · The Lancet · doi:10.1016/s0140-6736(77)92553-3 · Cited by 190 · see citing works
Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults
Biancuzzo, R. M., Young, A., Bibuld, D., Cai, M. H., Winter, M. R., Klein, E. K., Ameri, A., Reitz, R. E., Salameh, W. A., Chen, T. C., et al. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27972 · Cited by 185 · see citing works
Cholesterol reduction by different plant stanol mixtures and with variable fat intake
Gylling, H., & Miettinen, T. A. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90053-7 · Cited by 176 · see citing works
Evaluation of Ergocalciferol or Cholecalciferol Dosing, 1,600 IU Daily or 50,000 IU Monthly in Older Adults
Binkley, N., Gemar, D., Engelke, J. A., Gangnon, R. E., Ramamurthy, R., Krueger, D. C., & Drezner, M. K. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0015 · Cited by 175 · see citing works
Dietary carotenoids and their role in combating vitamin A deficiency: a review of the literature.
de Pee, S., & West, C. E. (1996) · PubMed · Cited by 171 · see citing works
Safety of long-term consumption of plant sterol esters-enriched spread
Hendriks, H., Brink, E. J., Meijer, G. W., Princen, H. M. G., & Ntanios, F. Y. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601598 · Cited by 164 · see citing works
Changes in gastrointestinal function attributed to aging
Russell, R. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/55.6.1203s · Cited by 164 · see citing works
Serum Vitamin D2and Vitamin D3Metabolite Concentrations and Absorption of Vitamin D2in Elderly Subjects*
Clemens, T. L., ZHOUf, X.-Y., MYLES, M., Endres, D. B., & LINDSAY, R. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-3-656 · Cited by 158 · see citing works
Genetic variations involved in interindividual variability in carotenoid status
Borel, P. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100322 · Cited by 157 · see citing works
Vitamin D2 Formation and Bioavailability from Agaricus bisporus Button Mushrooms Treated with Ultraviolet Irradiation
Koyyalamudi, S. R., Jeong, S., Song, C. H., Cho, K. Y., & Pang, G. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf803908q · Cited by 152 · see citing works
Lycopene Absorption in Human Intestinal Cells and in Mice Involves Scavenger Receptor Class B Type I but Not Niemann-Pick C1-Like 1
Moussa, M., Landrier, J., Reboul, E., Ghiringhelli, O., Coméra, C., Collet, X., Fröhlich, K., Böhm, V., & Borel, P. (2008) · Journal of Nutrition · doi:10.1093/jn/138.8.1432 · Cited by 151 · see citing works
Niemann-Pick C1-Like 1 Mediates α-Tocopherol Transport
Narushima, K., Takada, T., Yamanashi, Y., & Suzuki, H. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.043034 · Cited by 149 · see citing works
Intestinal Cholecalciferol Absorption in the Elderly and in Younger Adults
Barragry, J. M., France, M. W., Corless, D., Gupta, S. P., Switala, S., Boucher, B. J., & Cohen, R. D. (1978) · Clinical Science · doi:10.1042/cs0550213 · Cited by 136 · see citing works
Bread Fortified with Cholecalciferol Increases the Serum 25-HydroxyvitaminD Concentration in Women as Effectively as a Cholecalciferol Supplement
Natri, A.-M., Salo, P., Vikstedt, T., Palssa, A., Huttunen, M. M., Kärkkäinen, M. U. M., Salovaara, H. O., Piironen, V. I., Jakobsen, J., & Lamberg-Allardt, C. J. E. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.123 · Cited by 136 · see citing works
Heritability and seasonal variability of vitamin D concentrations in male twins
Karohl, C., Su, S., Kumari, M., Tangpricha, V., Veledar, E., Vaccarino, V., & Raggi, P. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.30176 · Cited by 134 · see citing works
Quantification of the "SLAMENGHI" factors for carotenoid bioavailability and bioconversion.
West, C. E., & Castenmiller, J. J. M. (1998) · PubMed · Cited by 132 · see citing works
Emulsification and lipolysis of triacylglycerols are altered by viscous soluble dietary fibres in acidic gastric medium in vitro
Pasquier, B., Armand, M., Castelain, C., Guillon, F., Borel, P., Lafont, H., & Lairon, D. (1996) · Biochemical Journal · doi:10.1042/bj3140269 · Cited by 125 · see citing works
Vitamin D-3 intestinal absorption in vivo: influence of fatty acids, bile salts, and perfusate pH on absorption.
Hollander, D., Muralidhara, K. S., & Zimmerman, A. (1978) · Gut · doi:10.1136/gut.19.4.267 · Cited by 124 · see citing works
Diminished and erratic absorption of ergocalciferol in adult cystic fibrosis patients
Lark, R. K., Lester, G. E., Ontjes, D. A., Blackwood, A. D., Hollis, B. W., Hensler, M. M., & Aris, R. M. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.3.602 · Cited by 116 · see citing works
Bioavailability of vitamin D2 from UV-B-irradiated button mushrooms in healthy adults deficient in serum 25-hydroxyvitamin D: a randomized controlled trial
Urbain, P., Singler, F., Ihorst, G., Biesalski, H.-K., & Bertz, H. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.53 · Cited by 111 · see citing works
Treatment and Prevention of Vitamin D Insufficiency in Cystic Fibrosis Patients: Comparative Efficacy of Ergocalciferol, Cholecalciferol, and UV Light
Khazai, N. B., Judd, S. E., Jeng, L., Wolfenden, L. L., Stecenko, A. A., Ziegler, T. R., & Tangpricha, V. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2012 · Cited by 109 · see citing works
Vitamin D in the New Millennium
Wimalawansa, S. J. (2012) · Current Osteoporosis Reports · doi:10.1007/s11914-011-0094-8 · Cited by 106 · see citing works
Use of a novel vitamin D bioavailability test demonstrates that vitamin D absorption is decreased in patients with quiescent crohnʼs disease1,2,3
Farraye, F. A., Nimitphong, H., Stucchi, A. F., Dendrinos, K. G., Boulanger, A., Vijjeswarapu, A., Tanennbaum, A., Biancuzzo, R. M., Chen, T. C., & Holick, M. F. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21595 · Cited by 103 · see citing works
Loss-of-Function Mutation in Carotenoid 15,15´-Monooxygenase Identified in a Patient with Hypercarotenemia and Hypovitaminosis A
Lindqvist, A., Sharvill, J., Sharvill, D., & Andersson, S. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2346 · Cited by 103 · see citing works
Serum concentration of vitamin D metabolites during treatment with vitamin D2 and D3 in normal premenopausal women.
Tjellesen, L., Hummer, L., Christiansen, C., & Rødbro, P. (1986) · PubMed · Cited by 102 · see citing works
Evaluation of vehicle substances on vitamin D bioavailability: A systematic review
Grossmann, R. E., & Tangpricha, V. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900578 · Cited by 102 · see citing works
Intestinal absorption of cholecalciferol and 25-hydroxycholecalciferol in patients with both Crohn's disease and intestinal resection
Leichtmann, G. A., Bengoa, J., Bolt, M., & Sitrin, M. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.3.548 · Cited by 101 · see citing works
Plasma Vitamin D and 25OHD Responses of Young and Old Men to Supplementation with Vitamin D3
Harris, S. S., & Dawson‐Hughes, B. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719235 · Cited by 101 · see citing works
The Bioavailability of Vitamin D from Fortified Cheeses and Supplements Is Equivalent in Adults
Wagner, D., Sidhom, G., Whiting, S. J., Rousseau, D., & Vieth, R. (2008) · Journal of Nutrition · doi:10.1093/jn/138.7.1365 · Cited by 99 · see citing works
Reduced plasma half-life of radio-labelled 25-hydroxyvitamin D3in subjects receiving a high-fibre diet
Batchelor, A., & Compston, J. E. (1983) · British Journal Of Nutrition · doi:10.1079/bjn19830027 · Cited by 97 · see citing works
Retinol, vitamin D, carotenes and α-tocopherol in serum of a moderately hypercholesterolemic population consuming sitostanol ester margarine
Gylling, H., Puska, P., Vartiainen, E. A., & Miettinen, T. A. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00078-7 · Cited by 90 · see citing works
Pancreatic lipase and pancreatic lipase-related protein 2, but not pancreatic lipase-related protein 1, hydrolyze retinyl palmitate in physiological conditions
Reboul, E., Berton, A., Moussa, M., Kreuzer, C., Crenon, I., & Borel, P. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.12.013 · Cited by 90 · see citing works
Self-citation
Bioavailability of vitamin D from wild edible mushrooms (Cantharellus tubaeformis) as measured with a human bioassay
Outila, T. A., Mattila, P. H., Piironen, V. I., & Lamberg-Allardt, C. J. E. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.1.95 · Cited by 87 · see citing works
Cholesterol-Lowering Effect of Stanol Ester in a US Population of Mildly Hypercholesterolemic Men and Women: A Randomized Controlled Trial
Nguyen, T. T., Dale, L. C., von Bergmann, K., & Croghan, I. T. (1999) · Mayo Clinic Proceedings · doi:10.4065/74.12.1198 · Cited by 86 · see citing works
d-α-Tocopheryl Polyethylene Glycol-1000 Succinate Enhances the Absorption of Vitamin D in Chronic Cholestatic Liver Disease of Infancy and Childhood
Argào, E. A., Heubi, J. E., Hollis, B. W., & Tsang, R. C. (1992) · Pediatric Research · doi:10.1203/00006450-199202000-00011 · Cited by 84 · see citing works
Studies on the in vivo absorption of micellar solutions of tocopherol and tocopheryl acetate in the rat: demonstration and partial characterization of a mucosal esterase localized to the endoplasmic reticulum of the enterocyte.
Mathias, P. M., Harries, J. T., Peters, T. J., & Muller, D. P. R. (1981) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37355-7 · Cited by 84 · see citing works
Membrane stabilization of vitamin E; interactions of α-tocopherol with phospholipids in bilayer liposomes
Urano, S., Iida, M., Otani, I., & Matsuo, M. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90807-2 · Cited by 83 · see citing works
Type of Dietary Fat Is Associated with the 25-Hydroxyvitamin D3 Increment in Response to Vitamin D Supplementation
Niramitmahapanya, S., Harris, S. S., & Dawson‐Hughes, B. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1518 · Cited by 81 · see citing works
Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterols
Korpela, R., Tuomilehto, J. O., Högström, P., Seppo, L., Piironen, V. I., Salo-Väänänen, P., Toivo, J., Lamberg-Allardt, C. J. E., Kärkkäinen, M., Outila, T. A., et al. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602362 · Cited by 80 · see citing works
The absorption and transport of lipids by the small intestine
Tso, P., & Fujimoto, K. (1991) · Brain Research Bulletin · doi:10.1016/0361-9230(91)90145-a · Cited by 78 · see citing works
The effect of a very high daily plant stanol ester intake on serum lipids, carotenoids, and fat-soluble vitamins
Gylling, H. K., Hallikainen, M., Nissinen, M. J., & Miettinen, T. A. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.08.005 · Cited by 78 · see citing works
Taking vitamin D with the largest meal improves absorption and results in higher serum levels of 25-hydroxyvitamin D
Mulligan, G. B., & Licata, A. A. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.67 · Cited by 73 · see citing works
Bone disease in chronic childhood cholestasis. I. vitamin D absorption and metabolism†
Heubi, J. E., Hollis, B. W., SPECKER, B. L., & Tsang, R. C. (1989) · Hepatology · doi:10.1002/hep.1840090216 · Cited by 72 · see citing works
Vitamin D absorption: consequences of gastric bypass surgery
Aarts, E. O., van Groningen, L. F. J., Horst, R. L., Telting, D., van Sorge, A., Janssen, I. M. C., & de Boer, H. (2011) · European Journal of Endocrinology · doi:10.1530/eje-10-1126 · Cited by 72 · see citing works
Bioavailability of vitamin D.
van den Berg, H. (1997) · PubMed · Cited by 72 · see citing works
Bioavailability of Vitamin D from Fortified Process Cheese and Effects on Vitamin D Status in the Elderly
Johnson, J. L., Mistry, V. V., Vukovich, M. D., Hogie-Lorenzen, T., Hollis, B. W., & SPECKER, B. L. (2005) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(05)72907-6 · Cited by 69 · see citing works
Phytosterols can impair vitamin D intestinal absorption in vitro and in mice
Goncalves, A., Gleize, B., Bott, R., Nowicki, M., Amiot, M. J., Lairon, D., Borel, P., & Reboul, E. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100055 · Cited by 66 · see citing works
Intestinal absorption of cholecalciferol and 25-hydroxycholecalciferol in chronic cholestatic liver disease
Sitrin, M. D., & Bengoa, J. M. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/46.6.1011 · Cited by 60 · see citing works
Intestinal absorption of vitamin D sterols: Differential absorption into lymph and portal blood in the rat
Maislos, M., Silver, J., & FAINARU, M. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90268-7 · Cited by 56 · see citing works
Bioavailability of vitamin D2 from irradiated mushrooms: an in vivo study
Jasinghe, V. J., Perera, C. O., & Barlow, P. J. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051416 · Cited by 51 · see citing works
Absorption of a pharmacological dose of vitamin D3 from two different lipid vehicles in man: Comparison of peanut oil and a medium chain triglyceride
Holmberg, I., Aksnes, L., Berlin, T., Lindbäck, B., Zemgals, J., & Lindeke, B. (1990) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.2510110908 · Cited by 50 · see citing works
Bioavailability and Efficacy of Vitamin D2 from UV-Irradiated Yeast in Growing, Vitamin D-Deficient Rats
Hohman, E. E., Martin, B. R., Lachcik, P. J., Gordon, D. T., Fleet, J. C., & Weaver, C. M. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf104679c · Cited by 49 · see citing works
Comparison of the Appearance of Radiolabelled Vitamin D3 and 25-Hydroxy-Vitamin D3 in the Chylomicron Fraction of Plasma after Oral Administration in Man
Compston, J. E., Merrett, A. L., Hammett, F., & Magill, P. J. (1981) · Clinical Science · doi:10.1042/cs0600241 · Cited by 46 · see citing works
Mechanism and site of small intestinal uptake of vitamin D3 in pharmacological concentrations
Hollander, D., & Truscott, T. C. (1976) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/29.9.970 · Cited by 43 · see citing works
Bone Disease in Chronic Childhood Cholestasis II. Better Absorption of 25-OH Vitamin D than Vitamin D in Extrahepatic Biliary Atresia
Heubi, J. E., Hollis, B. W., & Tsang, R. C. (1990) · Pediatric Research · doi:10.1203/00006450-199001000-00006 · Cited by 43 · see citing works
Postprandial chylomicron and plasma vitamin E responses in healthy older subjects compared with younger ones
Borel, P., MEKKI, N., Boirie‌, Y., Partier, A., Grolier, P., Alexandre-Gouabau, M. C., Beaufrère, B., Armand, M., Lairon, D., & Azaı̈s-Braesco, V. (1997) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1997.1960744.x · Cited by 42 · see citing works
Different actions of vitamin D2 and D3 on bone metabolism in patients treated with phenobarbitone/phenytoin
Tjellesen, L., Gotfredsen, A., & Christiansen, C. (1985) · Calcified Tissue International · doi:10.1007/bf02554866 · Cited by 42 · see citing works
Olestra's Effect on Vitamins D and E in Humans Can Be Offset by Increasing Dietary Levels of These Vitamins , ,
Schlagheck, T. G., Kesler, J. M., Jones, M. B., Zorich, N. L., Dugan, L. D., Davidson, M. H., & Peters, J. C. (1997) · Journal of Nutrition · doi:10.1093/jn/127.8.1666s · Cited by 41 · see citing works
Effects of aging on the microclimate pH of the rat jejunum
Ikuma, M., Hanai, H., Kaneko, E., Hayashi, H., & Hoshi, T. (1996) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)00261-8 · Cited by 41 · see citing works
13-Week Oral Toxicity Study with Stanol Esters in Rats
Turnbull, D., Whittaker, M. H., Frankos, V. H., & Jonker, D. (1999) · Regulatory Toxicology and Pharmacology · doi:10.1006/rtph.1999.1291 · Cited by 34 · see citing works
Sunlight is an important determinant of vitamin D serum concentrations in cystic fibrosis
Robberecht, E., Vandewalle, S., Wehlou, C., Kaufman, J.-M., & Schepper, J. D. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.280 · Cited by 34 · see citing works
Fat Soluble Vitamins in Liposomes: Studies on Incorporation Efficiency and Bile Salt Induced Vesicle Disintegration
Kirilenko, V., & Gregoriadis, G. C. (1993) · Journal of drug targeting · doi:10.3109/10611869308996095 · Cited by 34 · see citing works
A randomised comparison of increase in serum 25-hydroxyvitamin D concentration after 4 weeks of daily oral intake of 10 μg cholecalciferol from multivitamin tablets or fish oil capsules in healthy young adults
Holvik, K., Madar, A. A., Meyer, H. E., Lofthus, C. M., & Stene, L. C. (2007) · British Journal Of Nutrition · doi:10.1017/s000711450773074x · Cited by 34 · see citing works
Effect of High- versus Low-Fat Meal on Serum 25-Hydroxyvitamin D Levels after a Single Oral Dose of Vitamin D: A Single-Blind, Parallel, Randomized Trial
Raimundo, F. V., Faulhaber, G. A. M., Menegatti, P. K., Marques, L. D. S., & Furlanetto, T. W. (2011) · International Journal of Endocrinology · doi:10.1155/2011/809069 · Cited by 31 · see citing works
Effect of age on the intestinal absorption of vitamin D3-palmitate and nonesterified vitamin D2 in the term human infant
Hollis, B. W., Lowery, J. W., Pittard, W. B., Guy, D., & Hansen, J. W. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636338 · Cited by 30 · see citing works
Aqueous solubilisation of vitamin D3 in normal man.
Rautureau, M., & Rambaud, J. C. (1981) · Gut · doi:10.1136/gut.22.5.393 · Cited by 25 · see citing works
Rickets in Asian immigrants.
Compston, J. E. (1979) · BMJ · doi:10.1136/bmj.2.6190.612-b · Cited by 23 · see citing works
Vitamin D2 impairs utilization of vitamin D3 in high-yielding dairy cows in a cross-over supplementation regimen
Hymøller, L., & Jensen, S. K. (2011) · Journal of Dairy Science · doi:10.3168/jds.2010-4111 · Cited by 22 · see citing works
Optimization and validation of assays to estimate pancreatic esterase activity using well-characterized micellar solutions of cholesteryl oleate and tocopheryl acetate
Mathias, P. M., Harries, J. T., & Muller, D. P. R. (1981) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34754-4 · Cited by 18 · see citing works
Different metabolism of vitamin D2 and vitamin D3 in epileptic patients on carbamazepine
Tjellesen, L., Christiansen, C., Rødbro, P., & Hummer, L. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1985.tb03217.x · Cited by 17 · see citing works
Influence of aging on vitamin D absorption and unstirred water layer dimensions in the rat.
Hollander, D., & Tarnawski, H. (1984) · PubMed · Cited by 16 · see citing works
Bioavailability of vitamin D3 in non-oily capsules: the role of formulated compounds and implications for intermittent replacement
Coelho, I. M. G., de Andrade, L. D., Saldanha, L., Diniz, E. T., Griz, L., & Bandeira, F. A. F. (2010) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302010000200022 · Cited by 15 · see citing works
Bile salt deficiency and the absorption of vitamin D metabolites. In vivo study in the rat.
Maislos, M., & Shany, S. (1987) · PubMed · Cited by 13 · see citing works
Improvement of the absorption of 3H-Cholecalciferol by formation of its cyclodextrin complex.
Szejtli, J., Gerloczy, A., & Fonagy, A. (1983) · PubMed · Cited by 12 · see citing works
Differences in outcomes between cholecalciferol and ergocalciferol supplementation in veterans with inflammatory bowel disease
Youssef, D. A., Bailey, B. A., Atia, A. N., Elabbassi, A. M., Manning, T. G., & Peiris, A. N. (2012) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2011.00798.x · Cited by 10 · see citing works
Effects of aging process on digestive functions.
Vellas, B. J., Balas, D., & Albaréde, J. L. (1991) · PubMed · Cited by 10 · see citing works
Changes in the concentrations of vitamin D and its metabolites in the plasma of healthy subjects orally given physiological doses of vitamin D2 by multivitamin or vitamin D preparations.
MATSUOKA, M., Otsuka, H., 増田, 園., Okano, T., Kobayashi, T., Takeuchi, T., & Itokawa, Y. (1989) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.35.253 · Cited by 9 · see citing works
Polimorfismos reguladores y su participación en la patogenia de enfermedades complejas en la era posgenómica
Hernández‐Romano, J., Martínez-Barnetche, J., & Valverde-Garduño, V. (2009) · Salud Pública de México · doi:10.1590/s0036-36342009000900011 · Cited by 7 · see citing works
Effect of Fish Oil on Vitamin D Absorption
Korkor, A. B., & Bretzmann, C. M. (2009) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.11.010 · Cited by 5 · see citing works
[Effect of varying vitamin D status in the body on intestinal absorption and metabolism of vitamin D in the rat liver].
Апуховская, Л. И., Nl, K., Antonenko, L. V., Omel'chenko, L. I., & La, D. (1990) · PubMed · Cited by 2 · see citing works

Flagged first, then by citations

Sorted by citations

Vitamin D: Nutrient, Hormone, and Immunomodulator
Sassi, F., Tamone, C., & D’Amelio, P. (2018) · Nutrients · doi:10.3390/nu10111656 · Cited by 780 · see citing works
Nanotechnology Approaches for Increasing Nutrient Bioavailability
Jafari, S. M., & McClements, D. J. (2017) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2016.12.008 · Cited by 387 · see citing works
Consensus statement on vitamin D status assessment and supplementation: Whys, whens, and hows
Giustina, A., Bilezikian, J. P., Adler, R. A., Banfi, G., Bikle, D. D., Binkley, N. C., Bollerslev, J., Bouillon, R., Brandi, M. L., Casanueva, F. F., et al. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae009 · Cited by 392 · see citing works
Nanoemulsion delivery systems for oil-soluble vitamins: Influence of carrier oil type on lipid digestion and vitamin D3 bioaccessibility
Öztürk, B., Argın, S., Özilgen, M., & McClements, D. J. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.04.065 · Cited by 329 · see citing works
Vitamin D and cardiovascular disease prevention
Pilz, S., Verheyen, N., Grübler, M. R., Tomaschitz, A., & März, W. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.73 · Cited by 331 · see citing works
Dietary reference values for vitamin D
EFSA Panel on Dietetic Products, N. A. A. (. (2016) · EFSA Journal · doi:10.2903/j.efsa.2016.4547 · Cited by 318 · see citing works
Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment
Dominguez, L. J., Farruggia, M., Veronese, N., & Barbagallo, M. (2021) · Metabolites · doi:10.3390/metabo11040255 · Cited by 301 · see citing works
Encapsulation of vitamin D3 in pickering emulsions stabilized by nanofibrillated mangosteen cellulose: Impact on in vitro digestion and bioaccessibility
Winuprasith, T., Khomein, P., Mitbumrung, W., Suphantharika, M., Nitithamyong, A., & McClements, D. J. (2018) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.04.047 · Cited by 263 · see citing works
Vitamin D Deficiency and Oral Health: A Comprehensive Review
Botelho, J., Machado, V., Proença, L., Delgado, A. S., & Mendes, J. J. (2020) · Nutrients · doi:10.3390/nu12051471 · Cited by 258 · see citing works
Vitamin D: sources, physiological role, biokinetics, deficiency, therapeutic use, toxicity, and overview of analytical methods for detection of vitamin D and its metabolites
Janoušek, J., Pilařová, V., Macáková, K., Nomura, A., Veiga-Matos, J., da Silva, D. D., Remião, F., Saso, L., Malá‐Ládová, K., Malý, J., et al. (2022) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2022.2070595 · Cited by 235 · see citing works
Dietary reference values for vitamin K
EFSA Panel on Dietetic Products, N. A. A. (., Turck, D., Bresson, J., Burlingame, B., Dean, T., Fairweather‐Tait, S. J., Heinonen, M., Hirsch‐Ernst, K. I., Mangelsdorf, I., McArdle, H. J., et al. (2017) · EFSA Journal · doi:10.2903/j.efsa.2017.4780 · Cited by 222 · see citing works
Vitamin D Metabolism and Guidelines for Vitamin D Supplementation
Ramasamy, I. (2020) · Clinical Biochemist Reviews · doi:10.33176/aacb-20-00006 · Cited by 202 · see citing works
Vitamin D microencapsulation and fortification: Trends and technologies
Maurya, V. K., Bashir, K., & Aggarwal, M. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105489 · Cited by 185 · see citing works
Calcium, vitamin D, vitamin K2, and magnesium supplementation and skeletal health
Capozzi, A., Scambia, G., & Lello, S. (2020) · Maturitas · doi:10.1016/j.maturitas.2020.05.020 · Cited by 181 · see citing works
Ionizing Radiation as a Source of Oxidative Stress—The Protective Role of Melatonin and Vitamin D
Nuszkiewicz, J., Woźniak, A., & Szewczyk-Golec, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165804 · Cited by 156 · see citing works
Immune Modulatory Effects of Vitamin D on Viral Infections
Siddiqui, M., Manansala, J. S., Abdulrahman, H. A., Nasrallah, G. K., Smatti, M. K., Younes, N., Thani, A. A. A., & Yassine, H. M. (2020) · Nutrients · doi:10.3390/nu12092879 · Cited by 136 · see citing works
Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis
Machado, V., Lobo, S., Proença, L., Mendes, J. J., & Botelho, J. (2020) · Nutrients · doi:10.3390/nu12082177 · Cited by 130 · see citing works
Vitamin D and Obesity/Adiposity—A Brief Overview of Recent Studies
Bennour, I., Haroun, N., Sicard, F., Mounien, L., & Landrier, J. (2022) · Nutrients · doi:10.3390/nu14102049 · Cited by 114 · see citing works
Vitamin D and autoimmune diseases
Montes, R. I., Melguizo‐Rodríguez, L., Ruíz, C., & Costela-Ruiz, V. J. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116744 · Cited by 111 · see citing works
UV-irradiated mushrooms as a source of vitamin D 2 : A review
Taofiq, O., Fernandes, Â. S. F., Barros, L., Barreiro, M. F., & Ferreira, I. C. F. R. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.10.008 · Cited by 109 · see citing works
Nutraceutical nanodelivery; an insight into the bioaccessibility/bioavailability of different bioactive compounds loaded within nanocarriers
Dima, C. V., Assadpour, E., Dima, Ş., & Jafari, S. M. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1792409 · Cited by 99 · see citing works
Drug Delivery Systems for Vitamin D Supplementation and Therapy
Główka, E., Stasiak, J., & Lulek, J. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11070347 · Cited by 97 · see citing works
Culinary–medicinal mushrooms: a review of organic compounds and bioelements with antioxidant activity
Podkowa, A., Kryczyk‐Poprawa, A., Opoka, W., & Muszyńska, B. (2020) · European Food Research and Technology · doi:10.1007/s00217-020-03646-1 · Cited by 101 · see citing works
Comparative bioavailability of vitamins in human foods sourced from animals and plants
Chungchunlam, S. M. S., & Moughan, P. J. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2241541 · Cited by 98 · see citing works
A Combination of Single-Nucleotide Polymorphisms Is Associated with Interindividual Variability in Dietary β-Carotene Bioavailability in Healthy Men
Borel, P., Desmarchelier, C., Nowicki, M., & Bott, R. (2015) · Journal of Nutrition · doi:10.3945/jn.115.212837 · Cited by 89 · see citing works
Vitamin D Incorporation in Foods: Formulation Strategies, Stability, and Bioaccessibility as Affected by the Food Matrix
Lavelli, V., D’Incecco, P., & Pellegrino, L. (2021) · Foods · doi:10.3390/foods10091989 · Cited by 89 · see citing works
Vitamin D modulates adipose tissue biology: possible consequences for obesity?
Landrier, J., Karkeni, E., Marcotorchino, J., Bonnet, L., & Tourniaire, F. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115004164 · Cited by 85 · see citing works
Cardiac tissue oxidative stress and inflammation after vitamin D administrations in high fat- diet induced obese rats
Farhangi, M. A., Nameni, G., Hajiluian, G., & Mesgari-Abbasi, M. (2017) · BMC Cardiovascular Disorders · doi:10.1186/s12872-017-0597-z · Cited by 81 · see citing works
Preventing Bacterial Translocation in Patients with Leaky Gut Syndrome: Nutrition and Pharmacological Treatment Options
Twardowska, A., Makaro, A., Binienda, A., Fichna, J., & Sałaga, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063204 · Cited by 78 · see citing works
Impact of an indigestible oil phase (mineral oil) on the bioaccessibility of vitamin D3 encapsulated in whey protein-stabilized nanoemulsions
Tan, Y., Liu, J., Zhou, H., Mundo, J. L. M., & McClements, D. J. (2019) · Food Research International · doi:10.1016/j.foodres.2019.02.031 · Cited by 77 · see citing works
The influence of lipid droplet size on the oral bioavailability of vitamin D 2 encapsulated in emulsions: an in vitro and in vivo study
Salvia‐Trujillo, L., Fumiaki, B., Park, Y., & McClements, D. J. (2017) · Food & Function · doi:10.1039/c6fo01565d · Cited by 77 · see citing works
Functional effects of vitamin D: From nutrient to immunomodulator
Meza-Meza, M. R., Ruiz-Ballesteros, A. I., & la Cruz-Mosso, U. D. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1862753 · Cited by 74 · see citing works
Vitamin D3 Reduces Tissue Damage and Oxidative Stress Caused by Exhaustive Exercise
Ke, C.-Y., Yang, F., Wu, W.-T., Chung, C.-H., Lee, R.-P., Yang, W.-T., Subeq, Y., & Liao, K. (2016) · International Journal of Medical Sciences · doi:10.7150/ijms.13746 · Cited by 74 · see citing works
Cow’s Milk and Immune Function in the Respiratory Tract: Potential Mechanisms
Perdijk, O., van Splunter, M. E., Savelkoul, H. F. J., Brugman, S., & van Neerven, R. J. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00143 · Cited by 71 · see citing works
Scientific opinion on the tolerable upper intake level for vitamin D, including the derivation of a conversion factor for calcidiol monohydrate
EFSA Panel on Nutrition, N. F. A. F. (., Turck, D., Bohn, T., Castenmiller, J. J. M., Henauw, S. D., Hirsch‐Ernst, K. I., Knutsen, H. K., Maciuk, A., Mangelsdorf, I., McArdle, H. J., et al. (2023) · EFSA Journal · doi:10.2903/j.efsa.2023.8145 · Cited by 72 · see citing works
GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract
Walther, B., Lett, A. M., Bordoni, A., Tomás‐Cobos, L., Nieto, J. A., Dupont, D., Danesi, F., Shahar, D. R., Echaniz, A., Re, R., et al. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900677 · Cited by 69 · see citing works
Vitamin D in Osteosarcopenic Obesity
di Filippo, L., LORENZO, R. D., Giustina, A., Rovere, P. Q., & Conte, C. (2022) · Nutrients · doi:10.3390/nu14091816 · Cited by 70 · see citing works
Oxidative Stress as a Possible Target in the Treatment of Toxoplasmosis: Perspectives and Ambiguities
Szewczyk‐Golec, K., Pawłowska, M., Wesołowski, R., Wróblewski, M., & Mila-Kierzenkowska, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115705 · Cited by 67 · see citing works
Update of the tolerable upper intake level for vitamin D for infants
EFSA Panel on Dietetic Products, N. A. A. (. N. P., Turck, D., Bresson, J., Burlingame, B., Dean, T., Fairweather‐Tait, S. J., Heinonen, M., Hirsch‐Ernst, K. I., Mangelsdorf, I., McArdle, H. J., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5365 · Cited by 63 · see citing works
Vitamin D deficiency and its treatment in cystic fibrosis
Daley, T. C., Hughan, K. S., Rayas, M. S., Kelly, A. T., & Tangpricha, V. (2019) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2019.08.022 · Cited by 61 · see citing works
Bioavailability and release of bioactive components from nanocapsules
Jafari, S. M., Katouzian, I., Rajabi, H., & Ganje, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809436-5.00013-6 · Cited by 55 · see citing works
Engineering oral delivery of hydrophobic bioactives in real-world scenarios
Sarkar, A., & Mackie, A. R. (2020) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2020.03.009 · Cited by 54 · see citing works
Food synergies for improving bioavailability of micronutrients from plant foods
Nair, K. M., & Augustine, L. F. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.09.115 · Cited by 51 · see citing works
Vitamin D deficiency and glycemic control among patients with type 2 diabetes mellitus in Jazan City, Saudi Arabia
Darraj, H. A., Badedi, M., Poore, K. R., Hummadi, A. A., Khawaji, A. A., Solan, Y., Zakri, I., Sabai, A. I., Darraj, M. A., Mutawwam, D. A., et al. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s203700 · Cited by 49 · see citing works
The Evolving Role of Natural Compounds in the Medical Treatment of Uterine Fibroids
Ciebiera, M., Ali, M. K., Prince, L., Jackson-Bey, T., Atabiekov, I., Zgliczyński, S., & Al-Hendy, A. A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051479 · Cited by 49 · see citing works
Natural health products, dietary minerals and over-the-counter medications as add-on therapies to antidepressants in the treatment of major depressive disorder: a review
Döme, P., Tombor, L., Lazáry, J., Gonda, X., & Rihmer, Z. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.12.015 · Cited by 49 · see citing works
Vitamin D3 Protects Mice from Diquat‐Induced Oxidative Stress through the NF‐κB/Nrf2/HO‐1 Signaling Pathway
Zhang, H., Liu, Y., Fang, X., Gu, L., Luo, C., Chen, L., & Wang, Q. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6776956 · Cited by 48 · see citing works
Association between Vitamin D Levels and Nonalcoholic Fatty Liver Disease: Potential Confounding Variables
Pacifico, L., Osborn, J. F., Bonci, E., Pierimarchi, P., & Chiesa, C. (2018) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557518666181025153712 · Cited by 46 · see citing works
Vitamin D: Current Challenges between the Laboratory and Clinical Practice
Máčová, L., & Bičı́ková, M. (2021) · Nutrients · doi:10.3390/nu13061758 · Cited by 46 · see citing works
Effects of vitamin D supplementation in endometriosis: a systematic review
Kalaitzopoulos, D. R., Samartzis, N., Daniilidis, A., Leeners, B., Makieva, S., Nirgianakis, K., Dedes, I., Metzler, J. M., Imesch, P., & Lempesis, I. G. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-022-01051-9 · Cited by 51 · see citing works
Female Athlete Triad and Relative Energy Deficiency in Sport (REDs): Nutritional Management
Grabia, M., Perkowski, J., Socha, K., & Markiewicz‐Żukowska, R. (2024) · Nutrients · doi:10.3390/nu16030359 · Cited by 59 · see citing works
Nutritional Considerations for the Vegan Athlete
West, S., Monteyne, A. J., van der Heijden, I., Stephens, F. B., & Wall, B. T. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.04.012 · Cited by 42 · see citing works
“dietary-derived vitamin D [287], have becomemore popular and are commonly consumed [267].”
Background
Formulation and characterization of zein/chitosan complex particles stabilized Pickering emulsion with the encapsulation and delivery of vitamin D3
Shah, B. R., Xu, W., & Mráz, J. (2021) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11190 · Cited by 42 · see citing works
Impact of Vitamin D on Immunopathology of Hashimoto’s Thyroiditis: From Theory to Practice
Lebiedziński, F., & Lisowska, K. A. (2023) · Nutrients · doi:10.3390/nu15143174 · Cited by 41 · see citing works
Bioavailability by design — Vitamin D3 liposomal delivery vehicles
Dałek, P., Drabik, D., Wołczańska, H., Foryś, A., Jagas, M., Jędruchniewicz, N., Przybyło, M., Witkiewicz, W., & Langner, M. (2022) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2022.102552 · Cited by 40 · see citing works
Nutritional interventions in depression: The role of vitamin D and omega-3 fatty acids in neuropsychiatric health
Raza, M. L., Hassan, S. T., Jamil, S., Fatima, W., & Fatima, M. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.01.009 · Cited by 40 · see citing works
Vitamin D history part III: the “modern times”—new questions for orthopaedic practice: deficiency, cell therapy, osteomalacia, fractures, supplementation, infections
Hernigou, P., Sitbon, J. M., Dubory, A., & Aurégan, J.-C. (2019) · International Orthopaedics · doi:10.1007/s00264-019-04334-w · Cited by 42 · see citing works
Vitamin D deficiency is highly prevalent in malnourished inpatients and associated with higher mortality
Merker, M., Amsler, A., Pereira, R., Bolliger, R., Tribolet, P., Braun, N., Hoess, C., Pavlicek, V., Bilz, S., Sigrist, S., et al. (2019) · Medicine · doi:10.1097/md.0000000000018113 · Cited by 18 · see citing works
Fabrication, stability and rheological properties of zein/chitosan particles stabilized Pickering emulsions with antioxidant activities of the encapsulated vit-D3
Shah, B. R., Xu, W., & Mráz, J. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.09.159 · Cited by 39 · see citing works
Vitamin D: recent advances, associated factors, and its role in combating non-communicable diseases
Deepika, D., Kumari, A., Singh, S., Ahmad, M. F., Chaki, D., Poria, V., Kumar, S., Saini, N., Yadav, N., Sangwan, N. S., et al. (2025) · npj Science of Food · doi:10.1038/s41538-025-00460-5 · Cited by 38 · see citing works
Update on the management of vitamins and minerals in cystic fibrosis
Sankararaman, S., Hendrix, S. J., & Schindler, T. (2022) · Nutrition in Clinical Practice · doi:10.1002/ncp.10899 · Cited by 37 · see citing works
Influence of Proteins on the Absorption of Lipophilic Vitamins, Carotenoids and Curcumin – A Review
Iddir, M., Vahid, F., Merten, D., Larondelle, Y., & Bohn, T. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200076 · Cited by 36 · see citing works
Controlling Chronic Diseases and Acute Infections with Vitamin D Sufficiency
Wimalawansa, S. J. (2023) · Nutrients · doi:10.3390/nu15163623 · Cited by 36 · see citing works
Reduced-fat Gouda-type cheese enriched with vitamin D3 effectively prevents vitamin D deficiency during winter months in postmenopausal women in Greece
Μanios, Y., Moschonis, G., Mavrogianni, C., van den Heuvel, E. G. H. M., Singh‐Povel, C. M., Kiely, M. E., & Cashman, K. D. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1277-y · Cited by 36 · see citing works
Challenges to Quantify Total Vitamin Activity: How to Combine the Contribution of Diverse Vitamers?
Jakobsen, J., Melse‐Boonstra, A., & Rychlik, M. (2019) · Current Developments in Nutrition · doi:10.1093/cdn/nzz086 · Cited by 37 · see citing works
Naturally enhanced eggs as a source of vitamin D: A review
Barnkob, L. L., Argyraki, A., & Jakobsen, J. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.05.018 · Cited by 36 · see citing works
The Association between Serum Vitamin D Levels and Helicobacter pylori Presence and Eradication
Shafrir, A., Shauly‐Aharonov, M., Katz, L. H., Paltiel, O., Pickman, Y., & Ackerman, Z. (2021) · Nutrients · doi:10.3390/nu13010278 · Cited by 36 · see citing works
Compositional determinants of fruit and vegetable quality and nutritional value
Vicente, A. R., Manganaris, G. Α., Darré, M., Ortiz, C. M., Sozzi, G. O., & Crisosto, C. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822845-6.00019-1 · Cited by 35 · see citing works
The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis
Zhu, S., Wang, Y., Luo, F., Liu, J., Xiu, L., Qin, J., Wang, T., Yu, N. H., Wu, H., & Zou, T. (2019) · BioMed Research International · doi:10.1155/2019/7643542 · Cited by 35 · see citing works
Effectiveness of Vitamin D Supplementation on Disease Course in Inflammatory Bowel Disease Patients: Systematic Review With Meta-Analysis
Valvano, M., Magistroni, M., Cesaro, N., Carlino, G., Monaco, S., Fabiani, S., Vinci, A., Vernia, F., Viscido, A., & Latella, G. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac253 · Cited by 35 · see citing works
A reassessment of the vitamin D requirements of modern broiler genotypes
Sakkas, P., Smith, S. K., Hill, T. R., & Kyriazakis, I. (2018) · Poultry Science · doi:10.3382/ps/pey350 · Cited by 34 · see citing works
Vitamin D status and vitamin D deficiency risk factors among pregnancy of Shanghai in China
Yang, C., Wu, J., Ge, S., & Sun, W. (2021) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-021-03889-0 · Cited by 34 · see citing works
Post-thyroidectomy hypocalcemia: Is a routine preferable over a selective supplementation?
Sessa, L., Crea, C. D., Zotta, F., Cerviere, M. P., Gallucci, P., Pennestrì, F., Princi, P., Revelli, L., Arcuri, G., Bellantone, R. D. A., et al. (2021) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2021.10.015 · Cited by 34 · see citing works
Nutrients and amyloid β status in the brain: A narrative review
Díaz, G., Lengelé, L., Sourdet, S., Soriano, G., & Barreto, P. D. S. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101728 · Cited by 33 · see citing works
Fortification by design: A rational approach to designing vitamin D delivery systems for foods and beverages
Maurya, V. K., Shakya, A., Bashir, K., Jan, K., & McClements, D. J. (2022) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13066 · Cited by 33 · see citing works
Vitamin D Enhancement of Adipose Biology: Implications on Obesity-Associated Cardiometabolic Diseases
Lee, M. (2025) · Nutrients · doi:10.3390/nu17030586 · Cited by 40 · see citing works
Vitamin D deficiency and childhood obesity: interactions, implications, and recommendations
Peterson, C. A. (2015) · Nutrition and Dietary Supplements · doi:10.2147/nds.s52024 · Cited by 32 · see citing works
A Combination of Single-Nucleotide Polymorphisms Is Associated with Interindividual Variability in Cholecalciferol Bioavailability in Healthy Men
Desmarchelier, C., Borel, P., Goncalves, A., Kopec, R. E., Nowicki, M., Morange, S., Lesavre, N., Portugal, H., & Reboul, E. (2016) · Journal of Nutrition · doi:10.3945/jn.116.237115 · Cited by 32 · see citing works
Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk
Somoza-Moncada, M. M., Turrubiates‐Hernández, F. J., Muñóz-Valle, J. F., Gutiérrez-Brito, J. A., Díaz-Pérez, S. A., Arelis, A. A., & Hernández‐Bello, J. (2023) · Nutrients · doi:10.3390/nu15071765 · Cited by 36 · see citing works
Simulation of Physicochemical and Pharmacokinetic Properties of Vitamin D3 and Its Natural Derivatives
Deb, S., Reeves, A. A., & Lafortune, S. (2020) · Pharmaceuticals · doi:10.3390/ph13080160 · Cited by 31 · see citing works
The future is bright: Biofortification of common foods can improve vitamin D status
Neill, H. R., Gill, C. I. R., McDonald, E. J., McRoberts, W. C., & Pourshahidi, L. K. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1950609 · Cited by 31 · see citing works
Vitamin d-fortified bread: Systematic review of fortification approaches and clinical studies
Souza, S. V. D. S., Borges, N., & Vieira, E. F. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.131325 · Cited by 31 · see citing works
25-Hydroxyvitamin D, 1,25-Dihydroxyvitamin D, and Peripheral Bone Densitometry in Adults with Celiac Disease
Ciacci, C., Bilancio, G., Russo, I., Iovino, P., Cavallo, P., Santonicola, A., Bucci, C., Círillo, M., & Zingone, F. (2020) · Nutrients · doi:10.3390/nu12040929 · Cited by 30 · see citing works
Shift Work and Serum Vitamin D Levels: A Systematic Review and Meta-Analysis
Martelli, M., Salvio, G., Santarelli, L., & Bracci, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19158919 · Cited by 32 · see citing works
A cholecalciferol-loaded emulsion stabilized by a pea protein isolate–inulin complex and its application in 3D food printing
Lim, W. S., Lim, N., Kim, Y. J., Woo, J. H., Park, H. J., & Lee, M. H. (2023) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2023.111811 · Cited by 29 · see citing works
Encapsulation of Vitamins Using Nanoliposome: Recent Advances and Perspectives
Mohammadi, M. A., Farshi, P., Ahmadi, P., Ahmadi, A., Yousefi, M., Ghorbani, M., & Hosseini, S. M. (2021) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2023.005 · Cited by 29 · see citing works
Efficiency of Vitamin D Supplementation in Healthy Adults is Associated with Body Mass Index and Baseline Serum 25-Hydroxyvitamin D Level
Žmitek, K., Hribar, M., Hristov, H., & Pravst, I. (2020) · Nutrients · doi:10.3390/nu12051268 · Cited by 28 · see citing works
Vitamin D-Related Single Nucleotide Polymorphisms as Risk Biomarker of Cardiovascular Disease
González‐Rojo, P., Pérez-Ramírez, C., Gálvez-Navas, J. M., Pineda-Lancheros, L. E., Rojo-Tolosa, S., Ramírez-Tortosa, M. C., & Morales, A. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158686 · Cited by 28 · see citing works
Association between vitamin D deficiency and benign paroxysmal positional vertigo (BPPV) incidence and recurrence: a systematic review and meta-analysis
Wood, H. B., Kluk, K., & BinKhamis, G. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-077986 · Cited by 27 · see citing works
Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release
Diego‐Taboada, A., Sathyapalan, T., Courts, F. L., Lorch, M., Almutairi, F. M., Burke, B. P., Harris, K., Kruusmägi, M., Walther, T., Booth, J., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.017 · Cited by 27 · see citing works
Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds
Shegani, A., Kealey, S., Luzi, F., Basagni, F., Machado, J. D. M., Ekici, S. D., Ferocino, A., Gee, A. D., & Bongarzone, S. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00398 · Cited by 27 · see citing works
The effects of vitamin D-fortified foods on circulating 25(OH)D concentrations in adults: a systematic review and meta-analysis
Nikooyeh, B., & Neyestani, T. R. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521002816 · Cited by 26 · see citing works
Insights Into the Role of Vitamin D as a Biomarker in Stem Cell Transplantation
Ros‐Soto, J., Anthias, C., Madrigal, J. A., & Snowden, J. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00966 · Cited by 26 · see citing works
Neuroprotective Roles of Vitamin D: Bridging the Gap Between Mechanisms and Clinical Applications in Cognitive Decline
Liu, Y., Zhong, Z., Xie, J., Ni, B., & Wu, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157146 · Cited by 25 · see citing works
Zein coated calcium carbonate nanoparticles for the targeted controlled release of model antibiotic and nutrient across the intestine
Gautam, M., Santhiya, D., & Dey, N. (2020) · Materials Today Communications · doi:10.1016/j.mtcomm.2020.101394 · Cited by 25 · see citing works
Comparative Bioavailability Study of a New Vitamin D3 Orodispersible Film Versus a Marketed Oral Solution in Healthy Volunteers
Radicioni, M. M., Caverzasio, C., Rovati, S., Giori, A. M., Cupone, I. E., Marra, F., & Mautone, G. (2022) · Clinical Drug Investigation · doi:10.1007/s40261-021-01113-7 · Cited by 24 · see citing works
Role of Vitamin D in Cognitive Function in Chronic Kidney Disease
Cheng, Z., Lin, J., & Qian, Q. (2016) · Nutrients · doi:10.3390/nu8050291 · Cited by 23 · see citing works
Dietary vitamin D improves performance and bone mineralisation, but increases parasite replication and compromises gut health in Eimeria-infected broilers
Sakkas, P., Oikeh, I., Blake, D. P., Smith, S. K., & Kyriazakis, I. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519001375 · Cited by 23 · see citing works
Vitamin D deficiency exacerbates hepatic oxidative stress and inflammation during acetaminophen-induced acute liver injury in mice
Wang, Y., Geng, X.-P., Wang, M., Wang, H., Zhang, C., He, X., Liang, S.-M., Xu, D., & Chen, X. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107716 · Cited by 23 · see citing works
Recommendation and Roadmap of Mass Vaccination against Coronavirus Disease 2019 Pandemic in Bangladesh as a Lower-Middle-Income Country.
Hossain, M. J., Rahman, S. M. A., Emran, T. B., Mitra, S., Islam, M. R., & Dhama, K. (2021) · PubMed Central · doi:10.22092/ari.2021.356357.1824 · Cited by 25 · see citing works

Factors influencing the absorption of vitamin D in GIT: an overview
Maurya, V. K., & Aggarwal, M. (2017) · Journal of Food Science and Technology · doi:10.1007/s13197-017-2840-0 · Cited by 160 · see citing works
Absorption and metabolism of vitamin D in health and in gastrointestinal tract diseases
Pigarova, E. A., Dzeranova, L. K., & Yatsenko, D. A. (2022) · Obesity and metabolism · doi:10.14341/omet12835 · Cited by 8 · see citing works
Factors affecting the bioavailability of vitamin D
Vodolazkaya, A. N., Орлова, С. В., Batysheva, T. T., Никитина, Е. А., Balashova, V. B., & Prokopenko, E. V. (2023) · Medical alphabet · doi:10.33667/2078-5631-2023-29-55-60 · Cited by 2 · see citing works
Intestinal absorption of vitamin D: a systematic review
Silva, M. C., & Furlanetto, T. W. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux034 · Cited by 154 · see citing works
Intestinal absorption of vitamin D: from the meal to the enterocyte
Reboul, E. (2014) · Food & Function · doi:10.1039/c4fo00579a · Cited by 95 · see citing works

Authors: Borel, P., Caillaud, D., & Cano, N. J.
Affiliations: Inserm (FR)
Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
Université Clermont Auvergne (FR)
Corresponding author: Borel, P.
ORCID: Borel, P.
Caillaud, D.
Cano, N. J.
Venue: Critical Reviews in Food Science and Nutrition
Publisher: Informa UK Limited
Published: 2013-10-02
Volume: 55
Issue: 9
Pages: 1193-1205
ISSN: 1040-8398 (ISSN-L)
1549-7852
DOI: 10.1080/10408398.2012.688897
OpenAlex: W2029625174
Cited by: 378
References: 104
Citations by year: 2026: 30 · 2025: 48 · 2024: 47 · 2023: 55 · 2022: 41 · 2021: 42 · 2020: 31 · 2019: 25 · 2018: 25 · 2017: 13 · 2016: 12 · 2015: 7 · 2014: 2
FWCI: 5.22
Type: journal article
Language: en
Open access: green
inserm.hal.science
Licence: other-oa
Locations: Critical Reviews in Food Science and Nutrition (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords: vitamin D bioavailability, vitamin D absorption, upper gastrointestinal tract, vitamin D3, vitamin D2, 25-hydroxyvitamin D, fat-soluble vitamins, dietary fat, food matrix, olestra, orlistat, aging, dietary fiber, intestinal absorption, vitamin D status
MeSH terms: Orlistat, Aging, Biological Availability, Cholecalciferol, Ergocalciferols, Fatty Acids, Food, Fortified, Humans, Intestinal Absorption, Lactones, Risk Factors, Sucrose, Vitamin D, Dietary Supplements

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Vitamin D bioavailability: state of the art

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks