Is Insomnia a Risk Factor for Decreased Influenza Vaccine Response?
Open accessAbstract
Healthy young adult college students (N = 133) with Insomnia (n = 65) or No Insomnia (n = 68) were compared on influenza serum antibody levels pre- and four weeks postvaccination. Volunteers underwent structured clinical interviews for sleep disorders to ensure insomnia diagnoses, as well as psychiatric interviews, physical examinations, and drug testing to ensure comorbid health problems were not potential confounds. There were significant time (both groups had increases in antibody levels pre- to postvaccination) and group (Insomnia group had lower HI antibody levels overall) main effects, but the time × group interaction was nonsignificant. Exploratory analyses did find significant PSQI x Time (p < .001) and Insomnia Status × Time (p = .002) interaction effects. Results indicate insomnia may be a risk factor for lowered immunity to the influenza virus.
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Treatment of RA patients with IL-6 or TNF blockers improved sleep.
“As described in section IID2, treatment of RA patients with IL-6 or TNF blockers improved sleep (196, 283, 535).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [535]
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- Authors
- Taylor, D. J., Kelly, K., Kohut, M. L., & Song, K.-S.
- Affiliations
- University of North Texas (US)
- Iowa State University (US)
- Corresponding author
- Taylor, Daniel J.
- Venue
- Behavioral Sleep Medicine
- Publisher
- Informa UK Limited
- Published
- 2016-04-14
- Volume
- 15
- Issue
- 4
- Pages
- 270-287
- ISSN
- 1540-2002 (ISSN-L)
- 1540-2010
- PMC
- PMC5554442
- OpenAlex
- W2341996269
- Cited by
- 69
- References
- 59
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 2 · 2023: 13 · 2022: 17 · 2021: 7 · 2020: 7 · 2019: 10 · 2018: 1
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioral Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R15A1085558)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- insomnia, influenza vaccine response, humoral immunity, hemagglutination inhibition antibodies, sleep quality, university students, vaccine immunogenicity, sleep disorders
- MeSH terms
- Antibodies, Viral, Female, Humans, Influenza, Human, Influenza Vaccines, Sleep Initiation and Maintenance Disorders, Male, Risk Factors, Students, Racial Groups, Young Adult, Healthy Volunteers
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