A preliminary feasibility study of varenicline for smoking cessation in bipolar disorder
Open accessAbstract
Our review of studies examining smoking cessation interventions among persons with bipolar disorders (George, Wu, & Weinberger, 2012, this issue) shows the need for safe and efficacious smoking ces...
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Only four published smoking cessation treatment trials in smokers with bipolar disorder were identified: one very small open pilot study with bupropion, two open pilot studies with varenicline, and two studies using varenicline either alone or in combination with CBT.
“We identified only four published smoking cessation treatment trials in smokers with BD: one very small open pilot study with bupropion (70), two open pilot studies with varenicline (71, 72), and 2 studies using varenicline either alone (73) or in combination with CBT (74).”
From The detrimental effects of smoking on the course and outcome in adults with bipolar disorder—A narrative review (2023) · cites this paper as [72]
The TO THE EDITOR section identifies this as a pilot study of varenicline in smokers with bipolar disorder, but explicitly describes its design as double-blind, randomized, and placebo-controlled—not open-label. The paper therefore contradicts the claim if it is being cited as one of the open pilot studies; it does not establish the citing document’s total count of published trials. (LLM, conf=0.84)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredAll four identified smoking cessation treatment trials in smokers with bipolar disorder were in favor of the specific treatment.
“All studies were in favor of the specific treatment.”
From The detrimental effects of smoking on the course and outcome in adults with bipolar disorder—A narrative review (2023) · cites this paper as [72]
In “TO THE EDITOR” (page not supplied), the authors report that their varenicline trial reduced smoking and that an earlier bupropion trial showed promise. The paper does not assess four treatment trials or conclude that all four favored their respective treatments; it says only one earlier study had been published at the time. (LLM, conf=0.88)
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Self-citation
- Authors
- Wu, B. S., Weinberger, A. H., Mancuso, E., Wing, V. C., Haji-Khamneh, B., Levinson, A. J., & George, T. P.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Yale University (US)
- Venue
- Journal of Dual Diagnosis
- Publisher
- Informa UK Limited
- Published
- 2012-04
- Volume
- 8
- Issue
- 2
- Pages
- 131-132
- ISSN
- 1550-4263 (ISSN-L)
- 1550-4271
- PMC
- PMC3435104
- OpenAlex
- W2095330365
- Cited by
- 40
- References
- 8
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 9 · 2014: 5 · 2013: 6 · 2012: 4
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Dual Diagnosis (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pfizer
- Health Canada
- Canadian Institutes of Health Research
- National Institute on Drug Abuse (R01DA013672, K02DA016611, K12DA000167)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- varenicline, smoking cessation, bipolar disorder, nicotine dependence, feasibility, smoking cessation interventions, dual diagnosis
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