A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Disorder
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Weinberger, Andrea H. PhD; Vessicchio, Jennifer C. LCSW; Sacco, Kristi A. PsyD; Creeden, Cerissa L. BA; Chengappa, K.N. Roy MD; George, Tony P. MD, FRCPC Author Information
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Only four published smoking cessation treatment trials in smokers with bipolar disorder were identified: one very small open pilot study with bupropion, two open pilot studies with varenicline, and two studies using varenicline either alone or in combination with CBT.
“We identified only four published smoking cessation treatment trials in smokers with BD: one very small open pilot study with bupropion (70), two open pilot studies with varenicline (71, 72), and 2 studies using varenicline either alone (73) or in combination with CBT (74).”
From The detrimental effects of smoking on the course and outcome in adults with bipolar disorder—A narrative review (2023) · cites this paper as [70]
The citation to this paper is attached to the description of a very small bupropion pilot study. The study was small, with five participants, but the Discussion explicitly calls it a placebo-controlled trial—not an open pilot study. No page numbers are provided in our copy. (LLM, conf=0.88)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredAll four identified smoking cessation treatment trials in smokers with bipolar disorder were in favor of the specific treatment.
“All studies were in favor of the specific treatment.”
From The detrimental effects of smoking on the course and outcome in adults with bipolar disorder—A narrative review (2023) · cites this paper as [70]
In “To the Editors” (page not available), one bupropion-treated participant had confirmed abstinence at the end of treatment, while none of the placebo-treated participants quit. The Discussion calls bupropion potentially promising, but this paper reports one small trial; it does not establish that all four identified trials favored their treatments. (LLM, conf=0.87)
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Self-citation
- Authors
- Weinberger, A. H., Vessicchio, J. C., Sacco, K. A., Creeden, C. L., Chengappa, K. N. R., & George, T. P.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- University of Pittsburgh (US)
- Corresponding author
- Weinberger, Andrea H.
- Vessicchio, Jennifer C.
- Sacco, Kristi A.
- Creeden, Cerissa L.
- Venue
- Journal of Clinical Psychopharmacology
- Published
- 2008-10
- Volume
- 28
- Issue
- 5
- Pages
- 584-587
- ISSN
- 0271-0749 (ISSN-L)
- PMC
- PMC3684621
- OpenAlex
- W2028915490
- Cited by
- 47
- References
- 17
- Citations by year
- 2023: 3 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 1 · 2015: 7 · 2014: 5 · 2013: 4 · 2012: 9
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01-DA-1-3672, R01DA013672, K02-DA-16611, K02DA016611, K12DA000167)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- bupropion, sustained-release formulation, smoking cessation, bipolar disorder, nicotine dependence
- MeSH terms
- Bipolar Disorder, Delayed-Action Preparations, Female, Humans, Male, Middle Aged, Pilot Projects, Smoking Cessation, Bupropion, Antidepressive Agents, Second-Generation
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