Precision medicine in the allergy clinic: the application of component resolved diagnosis

Panaitescu, Carmen; Haidar, Laura; Buzan, Maria Roxana; Grijincu, Manuela; Spanu, Daniela Elena; Cojanu, Catalina; Laculiceanu, Alexandru; Bumbacea, Roxana; Agache, Ioana

doi:10.1080/1744666x.2022.2034501

Cited by 13

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Precision medicine in the allergy clinic: the application of component resolved diagnosis

Panaitescu, Carmen, Haidar, Laura, Buzan, Maria Roxana, Grijincu, Manuela, Spanu, Daniela Elena, Cojanu, Catalina, Laculiceanu, Alexandru, Bumbacea, Roxana, Agache, Ioana·2022·Expert Review of Clinical Immunology

DOI 10.1080/1744666x.2022.2034501

Open this paper in CoChat — free account

Abstract

Introduction A precise diagnosis is key for the optimal management of allergic diseases and asthma. In vivo or in vitro diagnostic methods that use allergen extracts often fail to identify the molecules eliciting the allergic reactions. Areas covered Component-resolved diagnosis (CRD) has solved most of the limitations of extract-based diagnostic procedures and is currently valuable tool for the precision diagnosis in the allergy clinic, for venom and food allergy, asthma, allergic rhinitis, and atopic dermatitis. Its implementation in daily practice facilitates: a) the distinction between genuine multiple sensitizations and cross-reactive sensitization in polysensitized patients; b) the prediction of a severe, systemic reaction in food or insect venom allergy; c) the optimal selection of allergen immunotherapy based on the patient sensitization profile. This paper describes its main advantages and disadvantages, cost-effectiveness and future perspectives. Expert opinion The diagnostic strategy based on CRD is part of the new concept of precision immunology, which aims to improve the management of allergic diseases.

Integrity signals

Registry

Crossref · 10.1080/1744666x.2022.2034501

Cites

9 of 9 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Public Health Burden and Epidemiology of Atopic Dermatitis
Silverberg, J. I. (2017) · Dermatologic Clinics · doi:10.1016/j.det.2017.02.002 · Cited by 400
Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3-galactose
Mullins, R. J., James, H., Platts-Mills, T. A. E., & Commins, S. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.02.038 · Cited by 260
Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber
Werfel, T., Heratizadeh, A., Niebuhr, M., Kapp, A., Roesner, L. M., Karch, A., Erpenbeck, V. J., Lösche, C., Jung, T., Krug, N., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.04.015 · Cited by 171
Evolution pathways of IgE responses to grass and mite allergens throughout childhood
Custovic, A., Sonntag, H.-J., Buchan, I. E., Belgrave, D., Simpson, A., & Prosperi, M. C. F. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.03.041 · Cited by 159
Skin Prick Test Extracts for Dog Allergy Diagnosis Show Considerable Variations Regarding the Content of Major and Minor Dog Allergens
Curin, M., Reininger, R., Swoboda, I., Focke, M., Valenta, R., & Spitzauer, S. (2011) · International Archives of Allergy and Immunology · doi:10.1159/000321113 · Cited by 107
Machine learning to identify pairwise interactions between specific IgE antibodies and their association with asthma: a cross-sectional analysis within a population-based birth cohort
Fontanella, S., Frainay, C., Murray, C. S., Simpson, A., & Custovic, A. (2018) · PLoS Medicine · doi:10.1371/journal.pmed.1002691 · Cited by 91 · cited 1×
“Artificial intelligence-aided interpretation of the results, such as pairings between IgE antibodies to individual allergenic molecules (components), rather than IgE responses to ‘informative’ molecules, can be used to predict the increased risk of asthma [207].”
Background
Keep the cat, change the care pathway: a transformational approach to managing Fel d 1, the major cat allergen
Satyaraj, E., Wedner, H. J., & Bousquet, J. (2019) · Allergy · doi:10.1111/all.14013 · Cited by 78
Evolution of IgE responses to multiple allergen components throughout childhood
Howard, R., Belgrave, D., Papastamoulis, P., Simpson, A., Rattray, M., & Custovic, A. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.11.064 · Cited by 75
Molecular diagnosis in cat allergy
Popescu, F.-D., Ganea, C. S., Panaitescu, C., & Vieru, M. (2021) · World Journal of Methodology · doi:10.5662/wjm.v11.i3.46 · Cited by 25
Self-citation

Show all 9 references

Research works printed but not linked: 206

10.1016/j.jaci.2017.03.050 · DOI
Agache I, 2018, Zurich Switzerland, 152, 66
10.1016/j.aller.2011.11.004 · DOI
10.1111/cea.12349 · DOI · Paper page
10.1016/j.jaci.2009.10.009 · DOI
10.1016/j.jaci.2007.11.004 · DOI
10.3390/jcm9113688 · DOI
10.1183/13993003.02094-2020 · DOI
10.1111/all.14061 · DOI
10.1111/all.12305 · DOI
10.1016/j.jaci.2017.11.003 · DOI
10.5588/ijtld.14.0170 · DOI
10.1001/jamanetworkopen.2018.5630 · DOI
10.1111/j.1398-9995.2004.00526.x · DOI
10.1080/14737167.2020.1819793 · DOI
10.1016/j.jaip.2018.08.032 · DOI
10.1016/j.anai.2021.01.003 · DOI
10.1159/000151243 · DOI
10.1016/j.aller.2018.05.008 · DOI
10.1172/JCI124611 · DOI
10.1016/j.waojou.2019.100091 · DOI · Paper page
10.1111/pai.12563 · DOI · Paper page
10.1016/j.mam.2021.101027 · DOI
10.1111/all.14582 · DOI
10.1016/j.molimm.2018.03.013 · DOI
10.1177/0004563219877434 · DOI
10.1016/j.alit.2016.07.002 · DOI
10.1186/s13601-017-0158-7 · DOI
10.3389/fimmu.2020.594978 · DOI
10.5662/wjm.v8.i3.17 · DOI · Paper page
10.1034/j.1398-9995.2001.056006478.x · DOI
10.1067/mai.2000.108434 · DOI
10.1016/j.aller.2018.03.002 · DOI
10.1016/j.jaci.2018.10.048 · DOI
10.1016/j.jaci.2017.04.028 · DOI
10.1016/j.ymeth.2003.08.018 · DOI
10.1007/s40629-015-0046-4 · DOI
10.1111/j.1398-9995.2005.00963.x · DOI · Paper page
10.1111/j.1398-9995.2011.02630.x · DOI
10.1111/all.13262 · DOI
10.3389/fimmu.2020.579409 · DOI
10.1097/ACI.0000000000000574 · DOI
10.1111/j.1365-2222.2009.03347.x · DOI
10.3389/fimmu.2020.01815 · DOI · Paper page
10.1111/cea.12057 · DOI
10.1111/all.12850 · DOI
10.1111/all.13000 · DOI
10.1007/s40629-020-00119-5 · DOI
10.1080/21645515.2017.1323603 · DOI
10.1067/mai.2001.120013 · DOI
10.1097/ACI.0000000000000390 · DOI
10.1111/j.1398-9995.2012.02847.x · DOI
10.1111/j.1398-9995.2011.02667.x · DOI
10.1016/j.jaci.2016.04.024 · DOI
10.7754/Clin.Lab.2015.150816 · DOI
10.1016/j.anai.2015.01.010 · DOI
10.18176/jiaci.0053 · DOI
10.1007/s11882-017-0707-0 · DOI
10.1371/journal.pone.0062009 · DOI
10.1016/j.jaci.2017.11.003 · DOI
10.1542/peds.2011-0204 · DOI · Paper page
10.1016/j.jaip.2020.04.020 · DOI · Paper page
Muraro A, 2021, Allergy
10.1111/all.12429 · DOI · Paper page
10.1111/all.12272 · DOI
10.1016/j.waojou.2021.100530 · DOI
10.1111/all.13399 · DOI
10.1016/S0091-6749(97)70309-9 · DOI
10.1016/S0091-6749(97)70045-9 · DOI
10.1016/S1081-1206(10)62121-7 · DOI
10.1016/S0091-6749(96)80436-2 · DOI
10.1002/mnfr.200900582 · DOI
10.1111/j.1398-9995.1996.tb04639.x · DOI
10.1111/pai.12283 · DOI
10.1016/j.jaci.2008.05.043 · DOI
10.1186/1476-7961-10-1 · DOI
10.1046/j.1365-2222.2001.01167.x · DOI
10.1016/j.jaci.2008.06.040 · DOI
10.1586/14737159.2015.1041927 · DOI
10.1016/j.jaci.2008.06.016 · DOI
10.1016/S0091-6749(94)70054-0 · DOI
10.1111/pai.12299 · DOI
10.1111/pai.12644 · DOI
Shanti KN, 1993, J Immunol, 151, 5354, 10.4049/jimmunol.151.10.5354 · DOI
10.2147/JAA.S142476 · DOI
10.1002/mnfr.200400015 · DOI
10.1007/s12016-013-8363-1 · DOI
10.4049/jimmunol.168.9.4576 · DOI
10.1111/j.1399-3038.2007.00674.x · DOI
10.3389/fimmu.2014.00179 · DOI
10.1111/j.1398-9995.2009.02162.x · DOI
10.1016/j.jaip.2019.03.031 · DOI
10.1016/j.anai.2015.08.003 · DOI
10.1111/j.1399-3038.2005.00302.x · DOI
10.1007/s40629-014-0019-z · DOI
10.1016/j.jaci.2007.05.026 · DOI
10.1016/j.jaci.2010.03.029 · DOI
10.1016/j.jaci.2009.10.008 · DOI
10.1016/j.jaci.2012.05.019 · DOI
10.1016/j.jaci.2009.06.008 · DOI
10.1016/j.jaci.2008.09.034 · DOI
10.1016/j.jaci.2013.04.028 · DOI
10.1016/j.jaip.2015.06.002 · DOI
10.1016/j.jaci.2003.09.030 · DOI
10.1016/j.jaci.2013.02.024 · DOI
10.1016/j.jaip.2014.03.013 · DOI
10.1159/000365050 · DOI
10.1016/S0022-3476(05)81788-3 · DOI
10.1111/cea.12267 · DOI
10.1111/pai.12610 · DOI
10.1016/S0091-6749(99)70411-2 · DOI
10.1046/j.1365-2222.2003.01592.x · DOI
10.1159/000327549 · DOI
10.1016/S0923-1811(03)00156-7 · DOI
10.1074/jbc.M311340200 · DOI
10.1067/mai.2001.118602 · DOI
10.1111/cea.12393 · DOI
10.3390/medicina55080498 · DOI
10.1371/journal.pone.0040945 · DOI
10.1111/j.1365-2222.2011.03915.x · DOI
10.1111/all.12671 · DOI
10.1111/cea.12515 · DOI
10.1016/j.jaip.2015.02.001 · DOI
10.1016/j.waojou.2019.100080 · DOI · Paper page
10.1016/j.anai.2015.01.006 · DOI
10.1111/cei.12721 · DOI
Lloyd M, 2015, Current Allergy Clinical Immunology, 28, 104
10.1111/all.12666 · DOI · Paper page
10.23822/EurAnnACI.1764-1489.108 · DOI
10.1159/000065172 · DOI · Paper page
10.1007/s11882-016-0668-8 · DOI
10.2500/aap.2021.42.200129 · DOI
10.1007/s11882-018-0816-4 · DOI
10.1186/s13601-020-00331-0 · DOI
10.1586/1744666X.2015.1062365 · DOI
10.1159/000453034 · DOI
10.3892/etm.2021.9957 · DOI
10.1186/s12948-019-0112-4 · DOI
10.1016/S1473-3099(17)30483-8 · DOI
10.1111/cea.12713 · DOI
10.1016/j.diagmicrobio.2011.09.007 · DOI
10.1111/j.1398-9995.2006.00994.x · DOI
10.2217/imt-2015-0027 · DOI
10.1007/s12016-009-8177-3 · DOI · Paper page
Biedermann T, 2019, Allergy, 74, 1237, 10.1111/all.13758 · DOI · Paper page
10.1067/mai.2003.1683 · DOI
10.1159/000069013 · DOI
10.1111/j.1472-9733.2008.00126.x · DOI
10.1111/all.13338 · DOI
10.2332/allergolint.11-OA-0372 · DOI
10.1159/000487997 · DOI
10.1016/S0091-6749(98)70384-7 · DOI
10.1074/jbc.M115.702001 · DOI
10.1016/j.ymeth.2013.06.014 · DOI
10.1016/j.anai.2014.06.009 · DOI
10.1111/j.1365-3024.2011.01288.x · DOI
10.1016/j.jaci.2014.10.012 · DOI
10.1016/j.anai.2016.07.004 · DOI
10.4049/jimmunol.1202288 · DOI
10.1159/000065179 · DOI
10.1038/jid.2014.271 · DOI
10.1016/j.amjoto.2011.07.004 · DOI
10.1016/j.envint.2016.01.003 · DOI
10.2147/JAA.S130459 · DOI
10.1080/13693780600902250 · DOI
10.1159/000370220 · DOI
10.1016/j.jaad.2017.04.019 · DOI
10.1016/j.jdermsci.2010.02.008 · DOI
10.1159/000250435 · DOI
10.1111/j.1365-2222.2004.02090.x · DOI · Paper page
10.1016/j.jaci.2014.08.026 · DOI
10.1111/all.13391 · DOI
10.1159/000336388 · DOI
10.3390/vetsci4030038 · DOI
10.1016/j.jaci.2015.09.052 · DOI · Paper page
10.1111/pai.12198 · DOI · Paper page
10.1111/j.1398-9995.2012.02797.x · DOI
10.1016/S0091-6749(99)70395-7 · DOI
10.1111/cea.13555 · DOI
10.3390/jof7030183 · DOI
10.3390/ijms22105286 · DOI
10.3389/fped.2019.00369 · DOI
10.1016/j.jaci.2012.05.053 · DOI
10.1016/j.jaci.2016.08.014 · DOI · Paper page
10.1111/pai.12200 · DOI
10.1111/j.1365-2222.2008.03031.x · DOI
10.1159/000337654 · DOI
Lepage-Nefkens I, 2015, The Diagnosis And Treatment of Allergic Rhinitis In The Netherlands Value Heal, 18, A359
10.3342/ceo.2015.8.4.385 · DOI
10.1111/all.13553 · DOI
10.1111/cea.13788 · DOI
10.1111/j.1398-9995.2012.02808.x · DOI
10.1016/j.anai.2015.09.018 · DOI
10.1007/s40521-016-0084-2 · DOI
10.1111/cea.12635 · DOI
10.1016/j.jaci.2015.03.024 · DOI
10.1016/j.jaci.2020.02.031 · DOI
10.1111/j.1398-9995.2007.01620.x · DOI · Paper page
10.1016/j.jaci.2019.01.050 · DOI · Paper page
10.1016/j.jaci.2008.09.017 · DOI

200 of 206 shown

Sorted by citations

Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges
Haidar, L., Bănărescu, C. F., Uța, C., Moldovan, S. I., Zimbru, E.-L., Zimbru, R.-I., Ciurariu, E., Georgescu, M., & Panaitescu, C. (2024) · Applied Sciences · doi:10.3390/app15010066 · Cited by 21
Self-citation

See all 13

Authors: Panaitescu, C., Haidar, L., Buzan, M. R., Grijincu, M., Spanu, D. E., Cojanu, C., Laculiceanu, A., Bumbacea, R., & Agache, I.
Affiliations: Department of Functional Sciences, Physiology, Center of Immuno-Physiology and Biotechnologies (Cifbioteh), “Victor Babeș” University of Medicine and Pharmacy Timișoara, Timisoara, Romania
Transylvania University Brasov - Faculty of Medicine, Brasov
Department of Allergy, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania
ORCID: Panaitescu, Carmen
Haidar, Laura
Laculiceanu, Alexandru
Bumbacea, Roxana
Agache, Ioana
Venue: Expert Review of Clinical Immunology
Publisher: Informa UK Limited
Published: 2022-02-01
Volume: 18
Issue: 2
Pages: 145-162
ISSN: 1744-666X
1744-8409
DOI: 10.1080/1744666x.2022.2034501
Cited by: 13
References: 9
Language: en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page: CoChat. (2026). Citation check: Precision medicine in the allergy clinic: the application of component resolved diagnosis. https://app.cochat.ai/papers/10.1080/1744666x.2022.2034501
The paper: Panaitescu, C., Haidar, L., Buzan, M. R., Grijincu, M., Spanu, D. E., Cojanu, C., Laculiceanu, A., Bumbacea, R., & Agache, I. (2022). Precision medicine in the allergy clinic: the application of component resolved diagnosis. Expert Review of Clinical Immunology. https://doi.org/10.1080/1744666x.2022.2034501

Precision medicine in the allergy clinic: the application of component resolved diagnosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks

How to cite