Regulation of humoral immunity by gut microbial products
Open accessAbstract
The intestinal tract provides ideal niches for several different microbial species, which are collectively called the gut microbiota. A key host immune effector that controls the microbiota and prevents mucosal infection is IgA. Gut microbiota-derived factors are largely classified into molecular pattern recognition receptor ligands and nutrient-derived metabolites including short-chain fatty acids and adenosine triphosphate. Along with host-derived factors such as retinoic acid, various cytokines and cytokine-like molecules, gut microbial products profoundly shape B cell responses. Gut microbial products can directly regulate B cell activation and differentiation. They can also indirectly affect B cells through epithelial cells, T cells, and myeloid cell subsets. We highlight the various direct and indirect mechanisms by which microbial products regulate humoral immunity.
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Gut microbiota-derived antigens bind to various receptors on B cells to mediate B cell activation and differentiation.
“Gut microbiota-derived antigens bind to various receptors on B cells to mediate B cell activation and differentiation [44].”
From Gut microbiota-mediated immunomodulation in tumor (2021) · cites this paper as [44]
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- Authors
- Kim, M., & Kim, C. H.
- Affiliations
- Purdue University West Lafayette (US)
- Corresponding author
- Kim, Chang H.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2017-02-28
- Volume
- 8
- Issue
- 4
- Pages
- 392-399
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC5570419
- OpenAlex
- W2594759176
- Cited by
- 104
- References
- 44
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 18 · 2023: 10 · 2022: 12 · 2021: 12 · 2020: 12 · 2019: 9 · 2018: 5 · 2017: 5
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Gut Microbes (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI121302, R01AI080769)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- gut microbiota, humoral immunity, IgA, B cell activation, B cell differentiation, short-chain fatty acids, adenosine triphosphate, retinoic acid, pattern recognition receptors, mucosal immunity, epithelial cells, T cells, myeloid cells, cytokines
- MeSH terms
- Gastrointestinal Microbiome, Animals, B-Lymphocytes, Bacteria, Epithelial Cells, Fatty Acids, Volatile, Humans, Intestines, T-Lymphocytes, Immunity, Humoral
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