Immune regulation by microbiome metabolites

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070 · see citing works

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T _reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048 · see citing works

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works

Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism

Morrison, D. J., & Preston, T. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1134082 · Cited by 3,781 · see citing works

Gut microbiota, metabolites and host immunity

Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409 · see citing works

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241 · see citing works

A classification of glycosyl hydrolases based on amino acid sequence similarities.

Henrissat, B. (1991) · Biochemical Journal · doi:10.1042/bj2800309 · Cited by 3,188 · see citing works

Formation of propionate and butyrate by the human colonic microbiota

Louis, P., & Flint, H. J. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13589 · Cited by 3,028 · see citing works

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

Wahlstrom, A. M., Sayin, S. I., Marschall, H., & Bäckhed, F. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.005 · Cited by 2,903 · see citing works

Gut microbiota functions: metabolism of nutrients and other food components

Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., & Tuohy, K. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1445-8 · Cited by 2,878 · see citing works

The gut microbiota, bacterial metabolites and colorectal cancer

Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,836 · see citing works

Review article: the role of butyrate on colonic function

HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03562.x · Cited by 2,721 · see citing works

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409 · see citing works

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.12.007 · Cited by 2,368 · see citing works

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature · doi:10.1038/nature12347 · Cited by 2,219 · see citing works

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.

Chang, P. V., Hao, L., Offermanns, S., & Medzhitov, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322269111 · Cited by 2,175 · see citing works

Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers

Peng, L., Li, Z.-R., Green, R. S., Holzmanr, I. R., & Lin, J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.104638 · Cited by 2,130 · see citing works

Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium

Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094 · see citing works

Regulation of short-chain fatty acid production

Macfarlane, S., & Macfarlane, G. T. (2003) · Proceedings of the Nutrition Society · doi:10.1079/pns2002207 · Cited by 1,939 · see citing works

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

Buffie, C. G., Bucci, V., Stein, R. R., McKenney, P. T., Ling, L., Gobourne, A., No, D., Liu, H., Kinnebrew, M., Viale, A., et al. (2015) · Nature · doi:10.1038/nature13828 · Cited by 1,872 · see citing works

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

Quintana, F. J., Basso, A. S., Iglesias, A. H., Korn, T., Farez, M. F., Bettelli, E., Caccamo, M., Oukka, M., & Weiner, H. L. (2008) · Nature · doi:10.1038/nature06880 · Cited by 1,865 · see citing works

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739 · see citing works

Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation

Le Poul, E., Loison, C., Struyf, S., Springael, J.-Y., Lannoy, V., Decobecq, M.-E., Brezillon, S., Dupriez, V., Vassart, G., Van Damme, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301403200 · Cited by 1,651 · see citing works

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

Wang, H., Chen, J., Hollister, K., Sowers, L. C., & Forman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80348-2 · Cited by 1,636 · see citing works

A G Protein-coupled Receptor Responsive to Bile Acids

Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628 · see citing works

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterström, R. H., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80900-9 · Cited by 1,534 · see citing works

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Lamas, B., Richard, M. L., Leducq, V., Pham, H.-P., Michel, M.-L., Da Costa, G., Bridonneau, C., Jegou, S., Hoffmann, T. W., Natividad, J. M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4102 · Cited by 1,482 · see citing works

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

Park, J., Kim, M., Kang, S. G., Jannasch, A. H., Cooper, B., Patterson, J., & Kim, C. H. (2015) · Mucosal Immunology · doi:10.1038/mi.2014.44 · Cited by 1,307 · see citing works

The P2X7 Receptor in Infection and Inflammation

Di Virgilio, F., Dal Ben, D., Sarti, A. C., Giuliani, A. L., & Falzoni, S. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.020 · Cited by 1,267 · see citing works

Identification of a nuclear receptor that is activated by farnesol metabolites

Forman, B. M., Goode, E., Chen, J., Oro, A. E., Bradley, D. J., Perlmann, T., Noonan, D. J., Burka, L. T., McMorris, T., Lamph, W. W., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90530-8 · Cited by 1,210 · see citing works

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L.-X., Rey, F., Wang, T., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215927110 · Cited by 1,191 · see citing works

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

Kim, M. H., Kang, S. G., Park, J. H., Yanagisawa, M., & Kim, C. H. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.056 · Cited by 1,127 · see citing works

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4

Venkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A. P., Qiu, Z., Maher, L., Redinbo, M. R., Phillips, R. S., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.014 · Cited by 1,066 · see citing works

<i>Ruminococcus bromii</i> is a keystone species for the degradation of resistant starch in the human colon

Ze, X., Duncan, S. H., Louis, P., & Flint, H. J. (2012) · The ISME Journal · doi:10.1038/ismej.2012.4 · Cited by 1,060 · see citing works

Identification of membrane-type receptor for bile acids (M-BAR)

Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H., & Tanaka, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02550-0 · Cited by 993 · see citing works

Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation

Kasubuchi, M., Hasegawa, S., Hiramatsu, T., Ichimura, A., & Kimura, I. (2015) · Nutrients · doi:10.3390/nu7042839 · Cited by 904 · see citing works

Gut Microbial Metabolites Fuel Host Antibody Responses

Kim, M., Qie, Y., Park, J., & Kim, C. H. (2016) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2016.07.001 · Cited by 893 · see citing works

Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System

Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876 · see citing works

Identification of a human nuclear receptor defines a new signaling pathway for CYP 3 A induction

Bertilsson, G., Heidrich, J., Svensson, K., Åsman, M., Jendeberg, L., Sydow‐Báckman, M., OHLSSON, R. I., Postlind, H., Blomquist, P., & Berkenstam, A. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12208 · Cited by 873 · see citing works

P2X receptors as cell-surface ATP sensors in health and disease

Khakh, B. S., & North, R. A. (2006) · Nature · doi:10.1038/nature04886 · Cited by 854 · see citing works

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

Guo, C., Xie, S., Chi, Z., Zhang, J., Liu, Y., Zhang, L., Zheng, M., Zhang, X., Xia, D., Ke, Y., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.09.008 · Cited by 838 · see citing works

GPR109A Is a G-protein–Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

Thangaraju, M., Cresci, G. A., Liu, K., Ananth, S., Gnanaprakasam, J. P., Browning, D. D., Mellinger, J. D., Smith, S. B., Digby, G. J., Lambert, N. A., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4466 · Cited by 789 · see citing works

Diversity of human colonic butyrate‐producing bacteria revealed by analysis of the butyryl‐CoA:acetate CoA‐transferase gene

Louis, P., Young, P., Holtrop, G., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.02066.x · Cited by 783 · see citing works

Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study

Murri, M., Leiva, I., Gómez‐Zumaquero, J. M., Tinahones, F. J., Cardona, F., Soriguer, F., & Queipo‐Ortuño, M. I. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-46 · Cited by 767 · see citing works

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

Apetoh, L., Quintana, F. J., Pot, C., Joller, N., Xiao, S., Kumar, D., Burns, E. J., Sherr, D. H., Weiner, H. L., & Kuchroo, V. K. (2010) · Nature Immunology · doi:10.1038/ni.1912 · Cited by 725 · see citing works

Gut microbiota-derived short-chain Fatty acids, T cells, and inflammation

Kim, C. H., Park, J., & Kim, M. (2014) · Immune Network · doi:10.4110/in.2014.14.6.277 · Cited by 704 · see citing works

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Mariño, E., Richards, J. L., McLeod, K. H., Stanley, D., Yap, Y. A., Knight, J., McKenzie, C., Kranich, J., Oliveira, A. C., Rossello, F. J., et al. (2017) · Nature Immunology · doi:10.1038/ni.3713 · Cited by 686 · see citing works

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

Tan, J., McKenzie, C. I., Vuillermin, P., Goverse, G., Vinuesa, C. G., Mebius, R. E., Macia, L., & Mackay, C. R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.047 · Cited by 666 · see citing works

Remaining mysteries of molecular biology: the role of polyamines in the cell

Miller-Fleming, L., Olin-Sandoval, V., Campbell, K., & Ralser, M. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.06.020 · Cited by 658 · see citing works

The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: Implications for epithelial protection

Burger-van Paassen, N., Vincent, A., Puiman, P. J., van der Sluis, M., Bouma, J., Boehm, G., van Goudoever, J. B., van Seuningen, I., & Renes, I. B. (2009) · Biochemical Journal · doi:10.1042/bj20082222 · Cited by 611 · see citing works

Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases

Nikolaus, S., Schulte, B., Al-Massad, N., Thieme, F., Schulte, D. M., Bethge, J., Rehman, A., Tran, F., Aden, K., Häsler, R., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.08.028 · Cited by 611 · see citing works

Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.

Henrissat, B., Callebaut, I., Fabrega, S., Lehn, P., Mornon, J., & Davies, G. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.7090 · Cited by 599 · see citing works

Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Bjeldanes, L. F., Kim, J. Y., Grose, K. R., Bartholomew, J. C., & Bradfield, C. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9543 · Cited by 588 · see citing works

Metabolism of Cholesterol and Bile Acids by the Gut Microbiota

Gérard, P. (2013) · Pathogens · doi:10.3390/pathogens3010014 · Cited by 580 · see citing works

Amino acid metabolism in intestinal bacteria: links between gut ecology and host health

Dai, Z. (2010) · Frontiers in bioscience · doi:10.2741/3820 · Cited by 563 · see citing works

Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2

Zheng, L., Kelly, C. J., Battista, K. D., Schaefer, R., Lanis, J. M., Alexeev, E. E., Wang, R. X., Onyiah, J. C., Kominsky, D. J., & Colgan, S. P. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700105 · Cited by 549 · see citing works

The Effects of Short-Chain Fatty Acids on Human Colon Cancer Cell Phenotype Are Associated with Histone Hyperacetylation

Hinnebusch, B. F., Meng, S., Wu, J. T., Archer, S. Y., & Hodin, R. A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.5.1012 · Cited by 546 · see citing works

Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids

Nilsson, N. E., Kotarsky, K., Owman, C., & Olde, B. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00488-1 · Cited by 540 · see citing works

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

Kimura, A., Naka, T., Nohara, K., Fujii‐Kuriyama, Y., & Kishimoto, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804231105 · Cited by 540 · see citing works

Short-Chain Fatty Acids in the Human Colon: Relation to Gastrointestinal Health and Disease

Mortensen, P. B., & Clausen, M. R. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609094568 · Cited by 513 · see citing works

Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion

Andrade‐Oliveira, V., Amano, M. T., Corrêa-Costa, M., Castoldi, Â., Felizardo, R. J. F., de Almeida, D. C., Bassi, Ê. J., Moraes‐Vieira, P. M., Hiyane, M. I., Rodas, A. C. D., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014030288 · Cited by 504 · see citing works

Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora

Miller, T. L., & Wolin, M. J. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.5.1589-1592.1996 · Cited by 481 · see citing works

The bile acid TGR5 membrane receptor: from basic research to clinical application

Duboc, H., Taché, Y., & Hofmann, A. F. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.10.021 · Cited by 473 · see citing works

Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells

Belcheva, A., Irrazabal, T., Robertson, S. J., Streutker, C., Maughan, H., Rubino, S., Moriyama, E. H., Copeland, J. K., Surendra, A., Kumar, S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.051 · Cited by 473 · see citing works

Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences

Blachier, F., Mariotti, F., Huneau, J. F., & Tomé, D. (2007) · Amino Acids · doi:10.1007/s00726-006-0477-9 · Cited by 452 · see citing works

The effect of short-chain fatty acids on human monocyte-derived dendritic cells

Nastasi, C., Candela, M., Bonefeld, C. M., Geisler, C., Hansen, M., Krejsgaard, T., Biagi, E., Andersen, M. H., Brigidi, P., Ødum, N., et al. (2015) · Scientific Reports · doi:10.1038/srep16148 · Cited by 414 · see citing works

Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition

Kishino, S., Takeuchi, M., Park, S.-B., Hirata, A., Kitamura, N., Kunisawa, J., Kiyono, H., Iwamoto, R., Isobe, Y., Arita, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312937110 · Cited by 395 · see citing works

THE BACTERIAL PHOSPHOENOL-PYRUVATE: GLYCOSE PHOSPHOTRANSFERASE SYSTEM

Meadow, N. D., Fox, D. K., & Roseman, S. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.002433 · Cited by 386 · see citing works

Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways

Schauber, J. (2003) · Gut · doi:10.1136/gut.52.5.735 · Cited by 383 · see citing works

Aryl hydrocarbon receptor Controls Monocyte Differentiation into dendritic Cells versus Macrophages

Goudot, C., Coillard, A., Villani, A.-C., Gueguen, P., Cros, A., Sarkizova, S., Tang-Huau, T.-L., Bohec, M., Baulande, S., Hacohen, N., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.016 · Cited by 382 · see citing works

Complex Carbohydrate Utilization by the Healthy Human Microbiome

Cantarel, B. L., Lombard, V., & Henrissat, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0028742 · Cited by 378 · see citing works

G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation

Sina, C., Gavrilova, O., Förster, M., Till, A., Derer, S., Hildebrand, F., Rabe, B., Chalaris, A., Scheller, J., Rehmann, A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900063 · Cited by 377 · see citing works

Potentiation by specific short-chain fatty acids of differentiation and apoptosis in human colonic carcinoma cell lines.

Heerdt, B. G., Houston, M. A., & Augenlicht, L. H. (1994) · PubMed · Cited by 357 · see citing works

Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease

Fennema, D., Phillips, I. R., & Shephard, E. A. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.116.070615 · Cited by 355 · see citing works

Microbiome-modulated metabolites at the interface of host immunity

Blacher, E., Levy, M., Tatirovsky, E., & Elinav, E. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601247 · Cited by 354 · see citing works

The cellulosome concept as an efficient microbial strategy for the degradation of insoluble polysaccharides

Shoham, Y., Lamed, R., & Bayer, E. A. (1999) · Trends in Microbiology · doi:10.1016/s0966-842x(99)01533-4 · Cited by 339 · see citing works

Activation of the Ah Receptor by Tryptophan and Tryptophan Metabolites

Heath‐Pagliuso, S., Rogers, W. J., Tullis, K. M., Seidel, S. D., Cenijn, P. H., Brouwer, A., & Denison, M. S. (1998) · Biochemistry · doi:10.1021/bi980087p · Cited by 331 · see citing works

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

Biagioli, M., Carino, A., Cipriani, S., Francisci, D., Marchianò, S., Scarpelli, P., Sorcini, D., Zampella, A., & Fiorucci, S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700183 · Cited by 327 · see citing works

Decreased dietary fiber intake and structural alteration of gut microbiota in patients with advanced colorectal adenoma

Chen, H.-M., Yu, Y.-N., Wang, J.-L., Lin, Y.-W., Kong, X., Yang, C.-Q., Yang, L., Liu, Z.-J., Yuan, Y.-Z., Liu, F., et al. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.046607 · Cited by 321 · see citing works

SLC5A8 , a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers

Li, H., Myeroff, L. L., Smiraglia, D. J., Romero, M. F., Pretlow, T. P., Kasturi, L., Lutterbaugh, J., Rerko, R. M., Casey, G., Issa, J. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1430846100 · Cited by 295 · see citing works

SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor

Vinolo, M. A. R., Ferguson, G. J., Kulkarni, S., Damoulakis, G., Anderson, K. E., Bohlooly‐Y, M., Stephens, L., Hawkins, P. T., & Curi, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021205 · Cited by 292 · see citing works

Metabolism of Linoleic Acid by Human Gut Bacteria: Different Routes for Biosynthesis of Conjugated Linoleic Acid

Devillard, E., McIntosh, F. M., Duncan, S. H., & Wallace, R. J. (2007) · Journal of Bacteriology · doi:10.1128/jb.01359-06 · Cited by 285 · see citing works

Autocrine regulation of T‐cell activation by ATP release and P2X 7 receptors

Yip, L., Woehrle, T., Corriden, R., Hirsh, M., Chen, Y., Inoue, Y., Ferrari, V., Insel, P. A., & JUNGER, W. G. (2009) · The FASEB Journal · doi:10.1096/fj.08-126458 · Cited by 284 · see citing works

Microflora‐associated characteristics in faeces from allergic and nonallergic infants

Böttcher, M. F., Nordin, E. K., Sandin, A., Midtvedt, T., & Björkstén, B. (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00982.x · Cited by 256 · see citing works

New Trends in Aryl Hydrocarbon Receptor Biology

Mulero‐Navarro, S., & Fernández‐Salguero, P. M. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00045 · Cited by 254 · see citing works

BIOHYDROGENATION OF UNSATURATED FATTY ACIDS BY RUMEN BACTERIA

Polan, C. E., McNeill, J. J., & Tove, S. B. (1964) · Journal of Bacteriology · doi:10.1128/jb.88.4.1056-1064.1964 · Cited by 251 · see citing works

Aiolos promotes TH17 differentiation by directly silencing Il2 expression

Quintana, F. J., Jin, H., Burns, E. J., Nadeau, M., Yeste, A., Kumar, D., Rangachari, M., Zhu, C. Y., Xiao, S., Seavitt, J., et al. (2012) · Nature Immunology · doi:10.1038/ni.2363 · Cited by 250 · see citing works

Expression and activation of the farnesoid X receptor in the vasculature

Bishop‐Bailey, D., Walsh, D. T., & Warner, T. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400046101 · Cited by 242 · see citing works

Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD

Preter, V. D., Machiels, K., Joossens, M., Arijs, I., Matthys, C., Vermeire, S., Rutgeerts, P. J., & Verbeke, K. (2014) · Gut · doi:10.1136/gutjnl-2013-306423 · Cited by 239 · see citing works

Butyrate Attenuates Inflammation and Lipolysis Generated by the Interaction of Adipocytes and Macrophages

Ohira, H., Fujioka, Y., Katagiri, C., Mamoto, R., Aoyama-Ishikawa, M., Amako, K., Izumi, Y., Nishiumi, S., Yoshida, M., Usami, M., et al. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.15065 · Cited by 238 · see citing works

Contribution of the microflora to proteolysis in the human large intestine

Macfarlane, G. T., Allison, C., Gibson, S. A. W., & Cummings, J. H. (1988) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1988.tb02427.x · Cited by 237 · see citing works

Biogenic amine production by Lactobacillus

Arena, M. E., & de Nadra, M. C. M. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2001.01223.x · Cited by 232 · see citing works

Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-κB target gene expression

Shah, Y. M., Ma, X., Morimura, K., Kim, I., & Gonzalez, F. J. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00528.2006 · Cited by 231 · see citing works

TGR 5 signalling inhibits the production of pro‐inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease

Yoneno∥, K., Hisamatsu, T., Shimamura, K., Kamada, N., Ichikawa, R., Kitazume, M. T., Mori, M., Uo, M., Namikawa, Y., Matsuoka, K., et al. (2013) · Immunology · doi:10.1111/imm.12045 · Cited by 229 · see citing works

Distinct fecal and oral microbiota composition in human type 1 diabetes, an observational study

de Groot, P. F., Belzer, C., Aydin, Ö., Levin, E., Levels, J. H. M., Aalvink, S., Boot, F., Holleman, F., van Raalte, D. H., Scheithauer, T. P. M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188475 · Cited by 208 · see citing works

Diet-derived short chain fatty acids stimulate intestinal epithelial cells to induce mucosal tolerogenic dendritic cells

Goverse, G., Molenaar, R., Macia, L., Tan, J., Erkelens, M. N., Konijn, T., Knippenberg, M., Cook, E. C. L., Hanekamp, D., Veldhoen, M., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600165 · Cited by 200 · see citing works

Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission

Hamer, H. M., Jonkers, D. M. A. E., Vanhoutvin, S. A. L. W., Troost, F. J., Rijkers, G. T., de Bruı̈ne, A. P., Bast, A., Venema, K., & Brummer, R. J. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2010.04.002 · Cited by 195 · see citing works

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

Guo, C., Xie, S., Chi, Z., Zhang, J., Liu, Y., Zhang, L., Zheng, M., Zhang, X., Xia, D., Ke, Y., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.009 · Cited by 175 · see citing works

Stimulatory effect of short chain fatty acids on the epithelial cell proliferation in rat large intestine

Sakata, T., & Engelhardt, W. V. (1983) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(83)90631-x · Cited by 172 · see citing works

Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment

Hayes, C. S., Shicora, A. C., Keough, M. P., Snook, A. E., Burns, M. R., & Gilmour, S. K. (2013) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0120-t · Cited by 166 · see citing works

Chronically Elevated Levels of Short-Chain Fatty Acids Induce T Cell–Mediated Ureteritis and Hydronephrosis

Park, J., Goergen, C. J., HogenEsch, H., & Kim, C. H. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502046 · Cited by 166 · see citing works

Acetate and Butyrate Are the Major Substrates for De Novo Lipogenesis in Rat Colonic Epithelial Cells

Zambell, K. L., Fitch, M. D., & Fleming, S. E. (2003) · Journal of Nutrition · doi:10.1093/jn/133.11.3509 · Cited by 164 · see citing works

Bile acids induce monocyte differentiation toward interleukin‐12 hypo‐producing dendritic cells via a TGR5‐dependent pathway

Ichikawa, R., Takayama, T., Yoneno∥, K., Kamada, N., Kitazume, M. T., Higuchi, H., Matsuoka, K., 渡辺, 光., Itoh, H., Kanai∥, T., et al. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03554.x · Cited by 163 · see citing works

The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages

Nakajima, A., Nakatani, A., Hasegawa, S., Irie, J., Ozawa, K., Tsujimoto, G., Suganami, T., Itoh, H., & Kimura, I. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179696 · Cited by 153 · see citing works

Expression of the Human Aryl Hydrocarbon Receptor Complex in Yeast

Miller, C. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32824 · Cited by 146 · see citing works

Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-κB

Venkatraman, A., Ramakrishna, B., Velayudhan, S. R., Kumar, N. S. N., Pulimood, A. B., & Patra, S. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00307.2002 · Cited by 138 · see citing works

Dietary fructooligosaccharides up-regulate immunoglobulin A response and polymeric immunoglobulin receptor expression in intestines of infant mice

Nakamura, Y., NOSAKA, S., Suzuki, M., NAGAFUCHI, S., Takahashi, T., Yajima, T., Takenouchi‐Ohkubo, N., Iwase, T., & Moro, I. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02487.x · Cited by 135 · see citing works

Dietary Indoles Suppress Delayed-Type Hypersensitivity by Inducing a Switch from Proinflammatory Th17 Cells to Anti-Inflammatory Regulatory T Cells through Regulation of MicroRNA

Singh, N. P., Singh, U. P., Rouse, M. D., Zhang, J., Chatterjee, S., Nagarkatti, P. S., & Nagarkatti, M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501727 · Cited by 134 · see citing works

Deoxycholic Acid Triggers NLRP3 Inflammasome Activation and Aggravates DSS-Induced Colitis in Mice

Zhao, S., Gong, Z., Zhou, J., Tian, C., Gao, Y., Xu, C., Chen, Y., Cai, W., & Wu, J. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00536 · Cited by 116 · see citing works

HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability

Krishnan, M., Singh, A. B., Smith, J. J., Sharma, A. K., Chen, X., Eschrich, S. A., Yeatman, T. J., Beauchamp, R. D., & Dhawan, P. (2009) · Oncogene · doi:10.1038/onc.2009.324 · Cited by 114 · see citing works

The Bile Acid Sensor FXR Is Required for Immune-Regulatory Activities of TLR-9 in Intestinal Inflammation

Renga, B., Mencarelli, A., Cipriani, S., D’Amore, C., Carino, A., Bruno, A. M., Francisci, D., Zampella, A., Distrutti, E., & Fiorucci, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054472 · Cited by 106 · see citing works

Regulation of humoral immunity by gut microbial products

Kim, M., & Kim, C. H. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1299311 · Cited by 104 · see citing works

Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator–dependent system in gut

Ito, S., Chen, C., Satoh, J., Yim, S., & Gonzalez, F. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31647 · Cited by 96 · see citing works

Faecal short chain fatty acid pattern and allergy in early childhood

Sandin, A., Bråbäck, L., Norin, E. L., & Björkstén, B. (2009) · Acta Paediatrica · doi:10.1111/j.1651-2227.2008.01215.x · Cited by 90 · see citing works

SPERMINE DIFFERENTIALLY REGULATES THE PRODUCTION OF INTERLEUKIN-12 P40 AND INTERLEUKIN-10 AND SUPPRESSES THE RELEASE OF THE T HELPER 1 CYTOKINE INTERFERON-γ

Haskó, G., Kuhel, D. G., Marton, A., Németh, Z. H., Deitch, E. A., & Szabó, C. (2000) · Shock · doi:10.1097/00024382-200014020-00012 · Cited by 90 · see citing works

A Rat Model of Chronic Postinflammatory Visceral Pain Induced by Deoxycholic Acid

Traub, R. J., Tang, B., Ji, Y., Pandya, S., Yfantis, H. G., & Sun, Y. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.08.051 · Cited by 83 · see citing works

Pharmacological potential of biogenic amine–polyamine interactions beyond neurotransmission

Sánchez‐Jiménez, F., Ruiz-Pérez, M. V., Urdiales, J. L., & Medina, M. Á. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12109 · Cited by 70 · see citing works

Short-chain fatty acid enemas fail to decrease colonic hypersensitivity and inflammation in TNBS-induced colonic inflammation in rats

Tarrerias, L. A., Millecamps, M., Alloui, A., Beaughard, C., Kemeny, L. J., Bourdu, S., Bommelaer, G., Eschalier, A., Dapoigny, M. C., & Ardid, D. (2002) · Pain · doi:10.1016/s0304-3959(02)00234-8 · Cited by 66 · see citing works

In Vitro Production of Short-Chain Fatty Acids by Bacterial Fermentation of Dietary Fiber Compared with Effects of Those Fibers on Hepatic Sterol Synthesis in Rats

Stark, A. H., & Madar, Z. (1993) · Journal of Nutrition · doi:10.1093/jn/123.12.2166 · Cited by 58 · see citing works

Dietary fibers stimulate colonic cell proliferation by different mechanisms at different sites

Zhang, J., & Lupton, J. R. (1994) · Nutrition and Cancer · doi:10.1080/01635589409514352 · Cited by 53 · see citing works

Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7

Hashimoto‐Hill, S., Friesen, L., Kim, M., & Kim, C. H. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.109 · Cited by 52 · see citing works

Unique dietary-related mouse model of colitis

Bernstein, H., Holubec, H., Bernstein, C., Ignatenko, N. A., Gerner, E. W., Dvorak, K., Besselsen, D. G., Ramsey, L., DallʼAgnol, M., Blohm-Mangone, K. A., et al. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000209789.14114.63 · Cited by 50 · see citing works

Cellular expression of a sodium-dependent monocarboxylate transporter (Slc5a8) and the MCT family in the mouse kidney

Yanase, H., Takebe, K., Nio‐Kobayashi, J., Takahashi‐Iwanaga, H., & Iwanaga, T. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0490-z · Cited by 48 · see citing works

Regulation of intracellular pH gradients by identified Na/H exchanger isoforms and a short-chain fatty acid

Gonda, T. A., Maouyo, D., Rees, S. E., & Montrose, M. H. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.1.g259 · Cited by 46 · see citing works

Ah receptor mediating induction of aryl hydrocarbon hydroxylase: detection in human lung by binding of 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin.

Roberts, E. A., Golas, C. L., & Okey, A. B. (1986) · PubMed · Cited by 45 · see citing works

Propionate-initiated changes in intracellular pH in rabbit colonocytes

DeSoignie, R. C., & Sellin, J. H. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90158-9 · Cited by 42 · see citing works

n‐Butyrate Anergized Effector CD4+ T Cells Independent of Regulatory T cell Generation or Activity

FONTENELLE, B. M., & Gilbert, K. M. (2012) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2012.02740.x · Cited by 32 · see citing works

The polyamine spermine promotes survival and activation of human eosinophils

Ilmarinen, P., Moilanen, E., Erjefalt, J. S., & Kankaanranta, H. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.12.1922 · Cited by 20 · see citing works

Elevated Epidermal Ornithine Decarboxylase Activity Suppresses Contact Hypersensitivity

Keough, M. P., Hayes, C. S., DeFeo, K., & Gilmour, S. K. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.263 · Cited by 17 · see citing works

An Increase in Histone Acetylation and IL-2 Antagonizing the Immunoinhibitory Effect Are Necessary for Augmentation by Butyrate of in Vitro Anti-TNP Antibody Production.

Okamura, T., Gohda, E., Kohge, T., & Yamamoto, I. (1999) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.22.1288 · Cited by 6 · see citing works

Untitled work

Kalina (2002) · doi:10.1002/1521-4141(200209)32:9

The role of short-chain fatty acids in immunity, inflammation and metabolism

Yao, Y., Cai, X. T., Fei, W., Ye, Y., Zhao, M., & Zheng, C. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1854675 · Cited by 776 · see citing works

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

Yang, W., & Cong, Y. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00661-4 · Cited by 701 · see citing works

Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

Ferrere, G., Tidjani Alou, M., Liu, P., Goubet, A.-G., Fidelle, M., Kepp, O., Durand, S., Iebba, V., Fluckiger, A., Daillère, R., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.145207 · Cited by 533 · see citing works

Secondary bile acids and short chain fatty acids in the colon: a focus on colonic microbiome, cell proliferation, inflammation, and cancer

Zeng, H., Umar, S., Rust, B., Lazarova, D., & Bordonaro, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051214 · Cited by 480 · see citing works

Complex regulatory effects of gut microbial short-chain fatty acids on immune tolerance and autoimmunity

Kim, C. H. (2023) · Cellular &amp; Molecular Immunology · doi:10.1038/s41423-023-00987-1 · Cited by 420 · see citing works

Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids

Kim, C. H. (2021) · Cellular &amp; Molecular Immunology · doi:10.1038/s41423-020-00625-0 · Cited by 404 · see citing works

Gut microbiome in HCC – Mechanisms, diagnosis and therapy

Schwabe, R. F., & Greten, T. F. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2019.08.016 · Cited by 370 · see citing works

The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: impact via gut microbiota and direct effects on immune cells

Beukema, M., Faas, M. M., & de Vos, P. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0449-2 · Cited by 337 · see citing works

Biological Function of Short-Chain Fatty Acids and Its Regulation on Intestinal Health of Poultry

Liu, L., Li, Q., Yang, Y., & Guo, A. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.736739 · Cited by 318 · see citing works

Immunological Effects of Human Milk Oligosaccharides

Triantis, V., Bode, L., & van Neerven, R. J. J. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00190 · Cited by 309 · see citing works

Dual Role of Indoles Derived From Intestinal Microbiota on Human Health

Ye, X., Li, H., Anjum, K., Zhong, X., Miao, S., Zheng, G., Liu, W., & Li, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.903526 · Cited by 282 · see citing works

Inflammation: the incubator of the tumor microenvironment

Denk, D., & Greten, F. R. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.07.002 · Cited by 279 · see citing works

Immunotherapy in Melanoma: Recent Advances and Future Directions

Knight, A., Karapetyan, L., & Kirkwood, J. M. (2023) · Cancers · doi:10.3390/cancers15041106 · Cited by 269 · see citing works

Leaky Gut: Effect of Dietary Fiber and Fats on Microbiome and Intestinal Barrier

Usuda, H., Okamoto, T., & Wada, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147613 · Cited by 258 · see citing works

The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases

Hosseinkhani, F., Heinken, A., Thiele, I., Lindenburg, P. W., Harms, A. C., & Hankemeier, T. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1882927 · Cited by 244 · see citing works

The Dietary Fiber Pectin: Health Benefits and Potential for the Treatment of Allergies by Modulation of Gut Microbiota

Blanco‐Pérez, F., Steigerwald, H., Schülke, S., Vieths, S., Toda, M., & Scheurer, S. (2021) · Current Allergy and Asthma Reports · doi:10.1007/s11882-021-01020-z · Cited by 218 · see citing works

Gut metabolomics profiling of non-small cell lung cancer (NSCLC) patients under immunotherapy treatment

Botticelli, A., Vernocchi, P., Marini, F., Quagliariello, A., Cerbelli, B., Reddel, S., Del Chierico, F., Di Pietro, F., Giusti, R., Tomassini, A., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02231-0 · Cited by 209 · see citing works

The Impact of Mushroom Polysaccharides on Gut Microbiota and Its Beneficial Effects to Host: A Review

Yin, C., Noratto, G. D., Fan, X., Chen, Z., Yao, F., Shi, D., & Gao, H. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116942 · Cited by 216 · see citing works

The Effects of Nutrition on the Gastrointestinal Microbiome of Cats and Dogs: Impact on Health and Disease

Wernimont, S. M., Radosevich, J., Jackson, M. I., Ephraim, E., Badri, D. V., MacLeay, J. M., Jewell, D. E., & Suchodolski, J. S. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01266 · Cited by 220 · see citing works

Bidirectional regulatory potentials of short-chain fatty acids and their G-protein-coupled receptors in autoimmune neuroinflammation

Park, J., Wang, Q., Wu, Q., Mao‐Draayer, Y., & Kim, C. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-45311-y · Cited by 197 · see citing works

Effects of dietary components on intestinal permeability in health and disease

Khoshbin, K., & Camilleri, M. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00245.2020 · Cited by 197 · see citing works

Interactions between polysaccharides and gut microbiota: A metabolomic and microbial review

Zhang, D., Liu, J., Cheng, H., Wang, H., Tan, Y., Feng, W., & Peng, C. Y. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111653 · Cited by 200 · see citing works

Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing

Conway, J., & Duggal, N. A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101323 · Cited by 194 · see citing works

Metabolites of microbiota response to tryptophan and intestinal mucosal immunity: A therapeutic target to control intestinal inflammation

Zhang, J., Zhu, S., Ma, N., Johnston, L. J., Wu, C., & Ma, X. (2020) · Medicinal Research Reviews · doi:10.1002/med.21752 · Cited by 181 · see citing works

Gut Microbiota Modulate CD8 T Cell Responses to Influence Colitis-Associated Tumorigenesis

Yu, A. I., Zhao, L., Eaton, K. A., Ho, S., Chen, J., Poe, S., Becker, J. T., Gonzalez, A., McKinstry, D., Hasso, M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.035 · Cited by 173 · see citing works

The metabolites of lactic acid bacteria: classification, biosynthesis and modulation of gut microbiota

Tang, H., Huang, W., & Yao, Y. (2023) · Microbial Cell · doi:10.15698/mic2023.03.792 · Cited by 169 · see citing works

Perinatal and Early-Life Nutrition, Epigenetics, and Allergy

Acevedo, N., Alhamwe, B. A., Caraballo, L. R., Ding, M., Ferrante, A., Garn, H., Garssen, J., Hii, C. S. T., Irvine, J., Llinás-Caballero, K., et al. (2021) · Nutrients · doi:10.3390/nu13030724 · Cited by 172 · see citing works

The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota

Bermudez-Martin, P., Becker, J. A. J., Caramello, N., Fernández, S. P., Campos, R. C., Canaguier, J., Barbosa, S., Martínez-Gili, L., Myridakis, A., Dumas, M., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01103-z · Cited by 164 · see citing works

Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs

Zhao, X., Jiang, L., Fang, X., Guo, Z., Wang, X., Shi, B., & Meng, Q. (2022) · Microbiome · doi:10.1186/s40168-022-01303-1 · Cited by 157 · see citing works

Indolepropionic Acid, a Metabolite of the Microbiome, Has Cytostatic Properties in Breast Cancer by Activating AHR and PXR Receptors and Inducing Oxidative Stress

Sári, Z., Mikó, E., Kovàcs, T., Jankó, L., Csonka, T., Lente, G., Sebő, É., Tóth, J., Tóth, D., Árkosy, P., et al. (2020) · Cancers · doi:10.3390/cancers12092411 · Cited by 153 · see citing works

The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling

Sipos, A., Ujlaki, G., Mikó, E., Maka, E., Szabó, J., Uray, K., Krasznai, Z. T., & Bai, P. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00295-2 · Cited by 150 · see citing works

Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)

Sun, J., Chen, S., Zang, D., Sun, H., Sun, Y., & Chen, J. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5632 · Cited by 143 · see citing works

Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants

Li, A., Acevedo‐Rocha, C. G., D’Amore, L., Chen, J., Peng, Y., Garcia‐Borràs, M., Gao, C., Zhu, J., Rickerby, H., Osuna, S., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202003139 · Cited by 140 · see citing works

Dietary fiber metabolites regulate innate lymphoid cell responses

Sepahi, A., Liu, Q., Friesen, L., & Kim, C. H. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0312-8 · Cited by 141 · see citing works

Molecules Produced by Probiotics and Intestinal Microorganisms with Immunomodulatory Activity

Delgado, S., Sánchez, B., Margollés, A., Ruas‐Madiedo, P., & Ruíz, L. (2020) · Nutrients · doi:10.3390/nu12020391 · Cited by 139 · see citing works

Inflammaging as a target for healthy ageing

Dugan, B., Conway, J., & Duggal, N. A. (2023) · Age and Ageing · doi:10.1093/ageing/afac328 · Cited by 142 · see citing works

Immunological Tolerance and Function: Associations Between Intestinal Bacteria, Probiotics, Prebiotics, and Phages

Vitetta, L., Vitetta, G., & Hall, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02240 · Cited by 134 · see citing works

Short-chain fatty acids, secondary bile acids and indoles: gut microbial metabolites with effects on enteroendocrine cell function and their potential as therapies for metabolic disease

Masse, K. E., & Lu, V. B. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1169624 · Cited by 120 · see citing works

Gut Microbiome and Space Travelers’ Health: State of the Art and Possible Pro/Prebiotic Strategies for Long-Term Space Missions

Turroni, S., Magnani, M., Pukar, K. C., Lesnik, P., Vidal, H., & Heer, M. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.553929 · Cited by 120 · see citing works

Fecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice

Bonomo, R. R., Cook, T. M., Gavini, C. K., White, C. R., Jones, J. R., Bovo, E., Zima, A. V., Brown, I. A., Dugas, L. R., Zakharian, E., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2006065117 · Cited by 114 · see citing works

Regulation of common neurological disorders by gut microbial metabolites

Park, J., & Kim, C. H. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00703-x · Cited by 120 · see citing works

Role for diet in normal gut barrier function: developing guidance within the framework of food-labeling regulations

Camilleri, M., Lyle, B. J., Madsen, K. L., Sonnenburg, J. L., Verbeke, K., & Wu, G. D. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00063.2019 · Cited by 111 · see citing works

The Gut-liver Axis in Immune Remodeling: New insight into Liver Diseases

Yang, X., Lu, D., Zhuo, J., Lin, Z., Yang, M., & Xu, X. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.46405 · Cited by 109 · see citing works

The early life education of the immune system: Moms, microbes and (missed) opportunities

Jain, N. (2020) · Gut microbes · doi:10.1080/19490976.2020.1824564 · Cited by 106 · see citing works

Gut microbial metabolites SCFAs and chronic kidney disease

Meng, H., Wei, W., Zhang, Y., Xiang, Z., Peng, D., Kasimumali, A., & Rong, S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04974-6 · Cited by 112 · see citing works

Recent advances in utilization of pectins in biomedical applications: a review focusing on molecular structure-directing health-promoting properties

Zhang, S., Waterhouse, G. I. N., Xu, F., He, Z., Du, Y., Lian, Y., Wu, P., & Sun‐Waterhouse, D. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1988897 · Cited by 104 · see citing works

The cancer-immune dialogue in the context of stress

Ma, Y., & Kroemer, G. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00949-8 · Cited by 110 · see citing works

A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption

Jang, H. R., Park, H., Kang, D., Chung, H., Nam, M. H., Lee, Y., Park, J., & Lee, H. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0293-4 · Cited by 102 · see citing works

A systematic review and critical evaluation of inflammatory cytokine associations in hidradenitis suppurativa

Frew, J. W., Hawkes, J. E., & Krueger, J. G. (2018) · F1000Research · doi:10.12688/f1000research.17267.1 · Cited by 91 · see citing works

The Role of Gut Microbiota in Some Liver Diseases: From an Immunological Perspective

Wang, L., Cao, Z.-M., Zhang, L., Li, J.-M., & Lv, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.923599 · Cited by 87 · see citing works

Sustained Dysbiosis and Decreased Fecal Short-Chain Fatty Acids after Traumatic Brain Injury and Impact on Neurologic Outcome

Opeyemi, O., Rogers, M. B., Firek, B., Janesko‐Feldman, K. L., Vagni, V., Mullett, S. J., Wendell, S. G., Nelson, B. P., New, L. A., Mariño, E., et al. (2021) · Journal of Neurotrauma · doi:10.1089/neu.2020.7506 · Cited by 83 · see citing works

The microbiome in asthma

Kozik, A. J., & Huang, Y. J. (2018) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2018.12.005 · Cited by 82 · see citing works

Topical, systemic and biologic therapies in hidradenitis suppurativa: pathogenic insights by examining therapeutic mechanisms

Frew, J. W., Hawkes, J. E., & Krueger, J. G. (2019) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622319830646 · Cited by 82 · see citing works

The Power of Psychobiotics in Depression: A Modern Approach through the Microbiota–Gut–Brain Axis: A Literature Review

Dziedzic, A., Maciak, K., Bliźniewska-Kowalska, K. M., Gałecka, M., Kobierecka, W., & Saluk, J. (2024) · Nutrients · doi:10.3390/nu16071054 · Cited by 89 · see citing works

Flammulina velutipes polysaccharide counteracts cadmium-induced gut injury in mice via modulating gut inflammation, gut microbiota and intestinal barrier

Hao, R., Zhou, X., Zhao, X., Lv, X., Zhu, X., Gao, N., Jiang, Y., Wu, M., Sun‐Waterhouse, D., & Li, D. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.162910 · Cited by 80 · see citing works

The role of the microbiota in the management of intensive care patients

Szychowiak, P., Villageois-Tran, K., Patrier, J., Timsit, J., & Ruppé, É. (2022) · Annals of Intensive Care · doi:10.1186/s13613-021-00976-5 · Cited by 81 · see citing works

Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis

Park, D. H., Kim, J. W., Park, H., & Hahm, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084228 · Cited by 76 · see citing works

Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions

Tesei, D., Jewczynko, A., Lynch, A., & Urbaniak, C. (2022) · Life · doi:10.3390/life12040495 · Cited by 75 · see citing works

Structure-function effects of different pectin chemistries and its impact on the gastrointestinal immune barrier system

Tang, X., & de Vos, P. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2290230 · Cited by 75 · see citing works

Gut Microbiome in Retina Health: The Crucial Role of the Gut-Retina Axis

Scuderi, G., Troiani, E., & Minnella, A. M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.726792 · Cited by 70 · see citing works

Gut microbiota bridges the iron homeostasis and host health

Xiao, L., Tang, R., Wang, J., Wan, D., Yin, Y., & Xie, L. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2302-5 · Cited by 70 · see citing works

Integrated Multi‐Cohort Analysis of the Parkinson's Disease Gut Metagenome

Boktor, J. C., Sharon, G., Metman, L. V., Hall, D. A., Engen, P. A., Zreloff, Z. J., Hakim, D., Bostick, J. W., Ousey, J. A., Lange, D., et al. (2023) · Movement Disorders · doi:10.1002/mds.29300 · Cited by 68 · see citing works

Food, gut barrier dysfunction, and related diseases: A new target for future individualized disease prevention and management

Liang, L., Saunders, C., & Sanossian, N. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3229 · Cited by 74 · see citing works

Oncobiosis and Microbial Metabolite Signaling in Pancreatic Adenocarcinoma

Kiss, B., Mikó, E., Sebő, É., Tóth, J., Ujlaki, G., Szabó, J., Uray, K., Bai, P., & Árkosy, P. (2020) · Cancers · doi:10.3390/cancers12051068 · Cited by 66 · see citing works

Pathogen Colonization Resistance in the Gut and Its Manipulation for Improved Health

Pickard, J. M., & Núñez, G. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.03.003 · Cited by 64 · see citing works

Decreased expression of G-protein-coupled receptors GPR43 and GPR109a in psoriatic skin can be restored by topical application of sodium butyrate

Krejner, A., Bruhs, A., Mrowietz, U., Wehkamp, U., Schwarz, T., & Schwarz, A. (2018) · Archives of Dermatological Research · doi:10.1007/s00403-018-1865-1 · Cited by 62 · see citing works

Gold‐Doped Covalent Organic Framework Reveals Specific Serum Metabolic Fingerprints as Point of Crohn's Disease Diagnosis

Yang, C., Yu, H., Hu, X., Chen, H., Wu, H., Deng, C., & Sun, N. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202105478 · Cited by 62 · see citing works

Metabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects

Mintoff, D., Benhadou, F., Pace, N. P., & Frew, J. W. (2021) · International Journal of Dermatology · doi:10.1111/ijd.15910 · Cited by 61 · see citing works

Microbiota-dependent indole production stimulates the development of collagen-induced arthritis in mice

Seymour, B. J., Trent, B. J., Allen, B. E., Berlinberg, A. J., Tangchittsumran, J., Jubair, W. K., Chriswell, M. E., Liu, S., Ornelas, A., Stahly, A., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci167671 · Cited by 65 · see citing works

The Interaction of Microbiome and Pancreas in Acute Pancreatitis

Zhang, C., Li, G., Lu, T., Liu, L., Sui, Y., Bai, R., Li, L., & Sun, B. (2023) · Biomolecules · doi:10.3390/biom14010059 · Cited by 61 · see citing works

Characterizations of multi-kingdom gut microbiota in immune checkpoint inhibitor-treated hepatocellular carcinoma

Zhu, C., Zhang, C., Wang, S., Xun, Z., Zhang, D., Lan, Z., Zhang, L., Chao, J., Liang, Y., Pu, Z., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-008686 · Cited by 60 · see citing works

Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora

Tsutsumi, R., Yamasaki, Y., Takeo, J., Miyahara, H., Sebe, M., Bando, M., Tanba, Y., Izumi-Mishima, Y., Takeji, K., Ueshima, N., et al. (2021) · Translational research · doi:10.1016/j.trsl.2021.03.016 · Cited by 59 · see citing works

Overview of the rules of the microbial engagement in the gut microbiome: a step towards microbiome therapeutics

Yadav, M., & Chauhan, N. S. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14883 · Cited by 59 · see citing works

Anti-Infective, Anti-Inflammatory, and Immunomodulatory Properties of Breast Milk Factors for the Protection of Infants in the Pandemic From COVID-19

Quitadamo, P. A., Comegna, L., & Cristalli, P. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2020.589736 · Cited by 60 · see citing works

Babies, Bugs, and Barriers: Dietary Modulation of Intestinal Barrier Function in Early Life

Wells, J. M., Gao, Y., de Groot, N., Vonk, M. M., Ulfman, L. H., & van Neerven, R. J. J. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122221-103916 · Cited by 58 · see citing works

Gut Microbiota and Autoimmune Diseases: Mechanisms, Treatment, Challenges, and Future Recommendations

Heravi, F. S. (2024) · Current Clinical Microbiology Reports · doi:10.1007/s40588-023-00213-6 · Cited by 65 · see citing works

Indoxylsulfate, a Metabolite of the Microbiome, Has Cytostatic Effects in Breast Cancer via Activation of AHR and PXR Receptors and Induction of Oxidative Stress

Sári, Z., Mikó, E., Kovàcs, T., Boratkó, A., Ujlaki, G., Jankó, L., Kiss, B., Uray, K., & Bai, P. (2020) · Cancers · doi:10.3390/cancers12102915 · Cited by 57 · see citing works

Unraveling the role of the microbiome in chronic rhinosinusitis

Psaltis, A. J., Mackenzie, B. W., Cope, E. K., & Ramakrishnan, V. R. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.02.022 · Cited by 56 · see citing works

Microbial Metabolite Dysbiosis and Colorectal Cancer

Niekamp, P., & Kim, C. H. (2023) · Gut and Liver · doi:10.5009/gnl220260 · Cited by 56 · see citing works

An organismal understanding of C. elegans innate immune responses, from pathogen recognition to multigenerational resistance

Tran, T. D., & Luallen, R. J. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.03.005 · Cited by 51 · see citing works

AMON: annotation of metabolite origins via networks to integrate microbiome and metabolome data

Shaffer, M., Thurimella, K., Quinn, K. D., Doenges, K., Zhang, X., Bokatzian, S. S., Reisdorph, N. A., & Lozupone, C. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-3176-8 · Cited by 50 · see citing works

The involvement of oncobiosis and bacterial metabolite signaling in metastasis formation in breast cancer

Kovàcs, T., Mikó, E., Ujlaki, G., Yousef, H., Csontos, V., Uray, K., & Bai, P. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10013-3 · Cited by 52 · see citing works

Tryptophan Supplementation Increases the Production of Microbial-Derived AhR Agonists in an In Vitro Simulator of Intestinal Microbial Ecosystem

Koper, J. E. B., Troise, A. D., Loonen, L. M. P., Vitaglione, P., Capuano, E., Fogliano, V., & Wells, J. M. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c04145 · Cited by 50 · see citing works

Microbiota-derived short-chain fatty acids functions in the biology of B lymphocytes: From differentiation to antibody formation

Qu, S., Gao, Y., Ma, J., & Yan, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115773 · Cited by 51 · see citing works

Anti-inflammatory properties of polysaccharides from edible fungi on health-promotion: a review

Yin, Z., Zhang, J., Qin, J., Guo, L., Guo, Q., Kang, W., Ma, C., & Chen, L. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1447677 · Cited by 50 · see citing works

The gut microbiota-bile acid axis in cholestatic liver disease

Sun, D.-Y., Xie, C., Zhao, Y., Liao, J.-M., Li, S.-S., Zhang, Y.-N., Wang, D.-D., Hua, K., Gu, Y.-C., Du, J.-B., et al. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00830-x · Cited by 53 · see citing works

Role of gut microbes in acute lung injury/acute respiratory distress syndrome

Ren, Z., Zheng, Z., & Feng, X. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2440125 · Cited by 48 · see citing works

Regulation of Microbiota by Vitamin D Receptor: A Nuclear Weapon in Metabolic Diseases

Bakke, D., Chatterjee, I., Agrawal, A., Dai, Y. D., & Sun, J. (2018) · Nuclear Receptor Research · doi:10.11131/2018/101377 · Cited by 48 · see citing works

Intermittent Fasting Enhances Right Ventricular Function in Preclinical Pulmonary Arterial Hypertension

Prisco, S. Z., Eklund, M., Moutsoglou, D., Prisco, A. R., Khoruts, A., Weir, E. K., Thenappan, T., & Prins, K. W. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.022722 · Cited by 47 · see citing works

HMOs modulate immunoregulation and gut microbiota in a β-lactoglobulin-induced allergic mice model

Liu, T., Chen, P., Munir, M., Liu, L., Li, C., Li, A., & Fu, H. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103993 · Cited by 46 · see citing works

Microbes, metabolites and (synaptic) malleability, oh my! T he effect of the microbiome on synaptic plasticity

Glinert, A., Turjeman, S., Elliott, E., & Koren, O. (2021) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12812 · Cited by 45 · see citing works

Microbial metabolite butyrate promotes induction of IL-10+IgM+ plasma cells

Föh, B., Buhre, J. S., Lunding, H. B., Moreno‐Fernandez, M. E., König, P., Sina, C., Divanovic, S., & Ehlers, M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0266071 · Cited by 45 · see citing works

Diet-microbiota associations in gastrointestinal research: a systematic review

Duncanson, K., Williams, G. M., Hoedt, E. C., Collins, C. E., Keely, S., & Talley, N. J. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2350785 · Cited by 46 · see citing works

Yin and Yang: A disrupted skin microbiome and an aberrant host immune response in hidradenitis suppurativa

Schell, S. L., Schneider, A. M., & Nelson, A. M. (2021) · Experimental Dermatology · doi:10.1111/exd.14398 · Cited by 46 · see citing works

Microbial‐derived indoles inhibit neutrophil myeloperoxidase to diminish bystander tissue damage

Alexeev, E. E., Dowdell, A. S., Henen, M. A., Lanis, J. M., Lee, J. S., Cartwright, I. M., Schaefer, R. E. M., Ornelas, A., Onyiah, J. C., Vögeli, B., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202100027r · Cited by 44 · see citing works

Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease

Kayongo, A., Robertson, N. M., Siddharthan, T., Ntayi, M. L., Ndawula, J. C., Sande, O. J., Bagaya, B. S., Kirenga, B., Mayanja‐Kizza, H., Joloba, M. L., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1085551 · Cited by 46 · see citing works

Role of the microbiome in regulation of the immune system

Kim, S., Ndwandwe, C., Devotta, H., Kareem, L., Yao, L., & O’Mahony, L. (2025) · Allergology International · doi:10.1016/j.alit.2024.12.006 · Cited by 44 · see citing works

Microbiome-Gut-Mucosal-Immune-Brain Axis and Autism Spectrum Disorder (ASD): A Novel Proposal of the Role of Gut Microbiome in ASD Aetiology

De Sales-Millán, A., Aguirre-Garrido, J. F., González-Cervantes, R. M., & Velázquez-Aragón, J. A. (2023) · doi:10.20944/preprints202305.1223.v1 · Cited by 44 · see citing works

Short Chain Fatty Acids Prevent Glyoxylate-Induced Calcium Oxalate Stones by GPR43-Dependent Immunomodulatory Mechanism

Jin, X., Jian, Z., Chen, X., Ma, Y., Ma, H., Liu, Y., Gong, L., Xiang, L., Zhu, S., Shu, X., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.729382 · Cited by 43 · see citing works

Alternative Splicing of Pre-mRNA in the Control of Immune Activity

Su, Z., & Huang, D. (2021) · Genes · doi:10.3390/genes12040574 · Cited by 43 · see citing works

Role of microbial metabolites in regulating host immunity

Tadepally, H. D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821406-0.00004-7

Microbial metabolites and immune modulation

Ghasemi, H. (2024) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.22034/jpcm.2024.496202.1197 · Cited by 1 · see citing works

Metabolites: messengers between the microbiota and the immune systemPreprint

Levy, M., Thaiss, C. A., & Elinav, E. (2016) · Genes & Development · doi:10.1101/gad.284091.116 · Cited by 438 · see citing works

Microbiome-modulated metabolites at the interface of host immunity

Blacher, E., Levy, M., Tatirovsky, E., & Elinav, E. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601247 · Cited by 354 · see citing works

Microbiome, metabolites and host immunity

Levy, M., Blacher, E., & Elinav, E. (2016) · Current Opinion in Microbiology · doi:10.1016/j.mib.2016.10.003 · Cited by 488 · see citing works