The Role of the Gut Microbiome in Multiple Sclerosis Risk and Progression : Towards Characterization of the “MS Microbiome.”
Open accessAbstract
Multiple sclerosis (MS) is the prototypic complex disease, in which both genes and the environment contribute to its pathogenesis. To date, > 200 independent loci across the genome have been associated with MS risk. However, these only explain a fraction of the total phenotypic variance, suggesting the possible presence of additional genetic factors, and, most likely, also environmental factors. New DNA sequencing technologies have enabled the sequencing of all kinds of microorganisms, including those living in and around humans (i.e., microbiomes). The study of bacterial populations inhabiting the gut is of particular interest in autoimmune diseases owing to their key role in shaping immune responses. In this review, we address the potential crosstalk between B cells and the gut microbiota, a relevant scenario in light of recently approved anti-B-cell therapies for MS. In addition, we review recent efforts to characterize the gut microbiome in patients with MS and discuss potential challenges and future opportunities. Finally, we describe the international MS microbiome study, a multicenter effort to study a large population of patients with MS and their healthy household partners to define the core MS microbiome, how it is shaped by disease-modifying therapies, and to explore potential therapeutic interventions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Multiple sclerosis patients with active disease have an altered microbiota compared to patients in the remission phase, who have a microbiota more similar to healthy controls.
“Interestingly, even MS patients with active disease have an altered microbiota compared to patients in the remission phase, which in turn have a microbiota more similar to healthy controls (25, 134–138).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [138]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Turnbaugh, P. J., Ley, R. E., Hamady, M., Fraser-Liggett, C. M., Knight, R., & Gordon, J. I. (2007) · Nature · doi:10.1038/nature06244 · Cited by 6,091 · see citing works
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554 · see citing works
Compston, A., & Coles, A. J. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61620-7 · Cited by 4,459 · see citing works
Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622 · see citing works
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000322 · Cited by 3,058 · cited 1× · see citing works
“Another major potential confounder for studies on the gut microbiome is diet, whose influence on the gut bacterial composition is arguably stronger than that of genetics [60].”
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872 · see citing works
Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment
Iida, N., Dzutsev, A., Stewart, C. A., Smith, L., Bouladoux, N., Weingarten, R. A., Molina, D. A., Salcedo, R., Back, T., Cramer, S., et al. (2013) · Science · doi:10.1126/science.1240527 · Cited by 2,251 · see citing works
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
MetaHIT consortium, Forslund, K., Hildebrand, F., Nielsen, T., Falony, G., Le Chatelier, E., Sunagawa, S., Prifti, E., Vieira-Silva, S., Gudmundsdottir, V., et al. (2015) · Nature · doi:10.1038/nature15766 · Cited by 2,116 · see citing works
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094 · see citing works
The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide
Viaud, S., Saccheri, F., Mignot, G., Yamazaki, T., Daillère, R., Hannani, D., Enot, D. P., Pfirschke, C., Engblom, C., Pittet, M. J., et al. (2013) · Science · doi:10.1126/science.1240537 · Cited by 2,050 · see citing works
Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis
Hauser, S. L., Bar-Or, A., Comi, G., Giovannoni, G., Hartung, H.-P., Hemmer, B., Lublin, F., Montalban, X., Rammohan, K. W., Selmaj, K., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1601277 · Cited by 2,021 · see citing works
Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis
Montalban, X., Hauser, S. L., Kappos, L., Arnold, D. L., Bar-Or, A., Comi, G., de Seze, J., Giovannoni, G., Hartung, H.-P., Hemmer, B., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1606468 · Cited by 1,905 · see citing works
The microbiota in adaptive immune homeostasis and disease
Honda, K., & Littman, D. R. (2016) · Nature · doi:10.1038/nature18848 · Cited by 1,846 · see citing works
Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study
(2007) · New England Journal of Medicine · doi:10.1056/nejmoa073493 · Cited by 1,746 · see citing works
Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin
Yednock, T. A., Cannon, C., Fritz, L. C., Sánchez‐Madrid, F., Steinman, L., & Karin, N. (1992) · Nature · doi:10.1038/356063a0 · Cited by 1,737 · see citing works
Hughes, R. A., & Cornblath, D. R. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67665-9 · Cited by 1,679 · see citing works
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
International Multiple Sclerosis Genetics Consortium, Patsopoulos, N. A., Baranzini, S. E., Santaniello, A., Shoostari, P., Cotsapas, C., Wong, G., Beecham, A. H., James, T., Replogle, J., et al. (2019) · Science · doi:10.1126/science.aav7188 · Cited by 1,471 · see citing works
Self-citationAlterations of the human gut microbiome in multiple sclerosis
Jangi, S., Gandhi, R., Cox, L. M., Li, N., von Glehn, F., Yan, R., Patel, B., Mazzola, M. A., Liu, S., Glanz, B. L., et al. (2016) · Nature Communications · doi:10.1038/ncomms12015 · Cited by 1,307 · see citing works
Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease
Palm, N. W., de Zoete, M. R., Cullen, T. W., Barry, N. A., Stefanowski, J., Hao, L., Degnan, P. H., Hu, J., Peter, I., Zhang, W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.006 · Cited by 1,286 · see citing works
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
Berer, K., Mues, M., Koutrolos, M., Rasbi, Z. A., Boziki, M., Johner, C., Wekerle, H., & Krishnamoorthy, G. (2011) · Nature · doi:10.1038/nature10554 · Cited by 1,251 · see citing works
Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis
Olsson, T. P., Barcellos, L. F., & Alfredsson, L. S. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.187 · Cited by 1,184 · see citing works
Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor
Smith, M. I., Yatsunenko, T., Manary, M. J., Trehan, I., Mkakosya, R., Cheng, J., Kau, A. L., Rich, S. S., Concannon, P., Mychaleckyj, J. C., et al. (2013) · Science · doi:10.1126/science.1229000 · Cited by 1,173 · see citing works
Shen, P., Roch, T., Lampropoulou, V., O’Connor, R. A., Stervbo, U., Hilgenberg, E., Ries, S., Dang, V. D., Jaimes, Y., Daridon, C., et al. (2014) · Nature · doi:10.1038/nature12979 · Cited by 1,048 · see citing works
Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis
Kappos, L., Antel, J. P., Comi, G., Montalbán, X., O'Connor, P. W., Polman, C. H., Haas, T., Korn, A., Karlsson, G., & Radue, E. W. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052643 · Cited by 1,047 · see citing works
Cekanaviciute, E., Yoo, B. B., Runia, T. F., Debelius, J. W., Singh, S., Nelson, C., Kanner, R., Bencosme, Y., Lee, Y. K., Hauser, S. L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711235114 · Cited by 1,040 · see citing works
Self-citationMultiple sclerosis: a complicated picture of autoimmunity
McFarland, H. F., & Martin, R. (2007) · Nature Immunology · doi:10.1038/ni1507 · Cited by 985 · see citing works
Berer, K., Gerdes, L. A., Cekanaviciute, E., Jia, X., Xiao, L., Xia, Z., Liu, C., Klotz, L., Stauffer, U., Baranzini, S. E., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711233114 · Cited by 933 · see citing works
Self-citationMultiple sclerosis patients have a distinct gut microbiota compared to healthy controls
Chen, J., Chia, N., Kalari, K. R., Yao, J. Z., Novotna, M., Paz Soldan, M. M., Luckey, D. H., Marietta, E. V., Jeraldo, P. R., Chen, X., et al. (2016) · Scientific Reports · doi:10.1038/srep28484 · Cited by 933 · see citing works
Miyake, S., Kim, S., Suda, W., Oshima, K., Nakamura, M., Matsuoka, T., Chihara, N., Tomita, A., Sato, W., Kim, S.-W., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137429 · Cited by 809 · see citing works
Goodman, A. L., Kallstrom, G., Faith, J. J., Reyes, A., Moore, A. M., Dantas, G. A., & Gordon, J. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102938108 · Cited by 779 · see citing works
The human microbiome: Our second genome
Grice, E. A., & Segre, J. A. (2012) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-090711-163814 · Cited by 759 · see citing works
Intestinal microbiota in human health and disease: the impact of probiotics
Gerritsen, J., Smidt, H., Rijkers, G. T., & de Vos, W. M. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0229-7 · Cited by 724 · see citing works
Experimental and analytical tools for studying the human microbiome
Kuczynski, J., Lauber, C. L., Walters, W. A., Parfrey, L. W., Clemente, J. C., Gevers, D., & Knight, R. D. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3129 · Cited by 705 · see citing works
The role of peripheral immune cells in the CNS in steady state and disease
Prinz, M., & Priller, J. (2017) · Nature Neuroscience · doi:10.1038/nn.4475 · Cited by 657 · see citing works
Derrien, M., van Baarlen, P., Hooiveld, G. J. E. J., Norin, E. L., Müller, M. M., & de Vos, W. M. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00166 · Cited by 582 · see citing works
Campbell, R. D., & Trowsdale, J. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90234-c · Cited by 579 · see citing works
McNulty, N. P., Yatsunenko, T., Hsiao, A., Faith, J. J., Muegge, B. D., Goodman, A. L., Henrissat, B., Oozeer, R., Cools-Portier, S., Gobert, G., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002701 · Cited by 544 · see citing works
Predicting a Human Gut Microbiota’s Response to Diet in Gnotobiotic Mice
Faith, J. J., McNulty, N. P., Rey, F. E., & Gordon, J. I. (2011) · Science · doi:10.1126/science.1206025 · Cited by 536 · see citing works
Depletion of Murine Intestinal Microbiota: Effects on Gut Mucosa and Epithelial Gene Expression
Reikvam, D. H., Erofeev, A. S., Sandvik, A., Grcic, V., Jahnsen, F. L., Gaustad, P., McCoy, K. D., Macpherson, A. J., Meza‐Zepeda, L. A., & Johansen, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017996 · Cited by 531 · see citing works
Ganesh, B. P., Klopfleisch, R., Loh, G., & Blaut, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074963 · Cited by 522 · see citing works
Nayfach, S., Rodriguez-Mueller, B., Garud, N., & Pollard, K. S. (2016) · Genome Research · doi:10.1101/gr.201863.115 · Cited by 470 · see citing works
Regulatory B cells are induced by gut microbiota–driven interleukin-1β and interleukin-6 production
Rosser, E. C., Oļeiņika, K., Tonon, S., Doyle, R., Bosma, A., Carter, N. A., Harris, K., Jones, S. A., Klein, N. J., & Mauri, C. (2014) · Nature Medicine · doi:10.1038/nm.3680 · Cited by 452 · see citing works
Gut microbiota in multiple sclerosis: possible influence of immunomodulators
Cantarel, B. L., Waubant, E., Chehoud, C., Kuczynski, J., DeSantis, T. Z., Warrington, J., Venkatesan, A., Fraser, C. M., & Mowry, E. M. (2015) · Journal of Investigative Medicine · doi:10.1097/jim.0000000000000192 · Cited by 409 · see citing works
Kau, A. L., Planer, J. D., Liu, J., Rao, S. M., Yatsunenko, T., Trehan, I., MANARY, M. J., Liu, T., Stappenbeck, T. S., Maleta, K. M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa4877 · Cited by 366 · see citing works
Voices from within: gut microbes and the CNS
Forsythe, P., & Kunze, W. A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1028-z · Cited by 336 · see citing works
The Human Microbiome and Cancer
Rajagopala, S. V., Vashee, S., Oldfield, L. M., Suzuki, Y., Venter, J. C., Telenti, A., & Nelson, K. E. (2017) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-16-0249 · Cited by 322 · see citing works
Viladomiu, M., Kivolowitz, C., Abdulhamid, A., Dogan, B., Victorio, D., Castellanos, J. G., Woo, V., Teng, F., Tran, N. L., Sczesnak, A., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf9655 · Cited by 314 · see citing works
Gacias, M., Gaspari, S., Santos, P.-M. G., Tamburini, S., Andrade, M., Zhang, F., Shen, N., Tolstikov, V., Kiebish, M. A., Dupree, J. L., et al. (2016) · eLife · doi:10.7554/elife.13442 · Cited by 308 · see citing works
Microbial colonization influences early B-lineage development in the gut lamina propria
Wesemann, D. R., Portuguese, A. J., Meyers, R. M., Gallagher, M. P., Cluff-Jones, K., Magee, J. M., Panchakshari, R. A., Rodig, S. J., Kepler, T. B., & Alt, F. W. (2013) · Nature · doi:10.1038/nature12496 · Cited by 286 · see citing works
B cells and antibodies in multiple sclerosis pathogenesis and therapy
Krumbholz, M., Derfuss, T. J., Hohlfeld, R., & Meinl, E. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.203 · Cited by 266 · see citing works
Galili, U. (2013) · Immunology · doi:10.1111/imm.12110 · Cited by 225 · see citing works
Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk
Rhead, B. L., Bäärnhielm, M., Gianfrancesco, M. A., Mok, A., Shao, X., Quach, H., Shen, L., Schaefer, C. A., Link, J., Gyllenberg, A., et al. (2016) · Neurology Genetics · doi:10.1212/nxg.0000000000000097 · Cited by 217 · see citing works
Rumah, K. R., Linden, J. R., Fischetti, V. A., & Vartanian, T. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076359 · Cited by 204 · see citing works
Gut microbiota composition and relapse risk in pediatric MS: A pilot study
Tremlett, H. L., Fadrosh, D. W., Faruqi, A. A., Hart, J., Roalstad, S., Graves, J. S., Lynch, S. V., Waubant, E. L., Aaen, G. S., Belman, A. L., et al. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.02.042 · Cited by 175 · see citing works
High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice
Okai, S., Usui, F., Yokota, S., Hori-i, Y., Hasegawa, M., Nakamura, T., Kurosawa, M., Okada, S., Yamamoto, K., Nishiyama, E., et al. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.103 · Cited by 171 · see citing works
DNA Extraction for Streamlined Metagenomics of Diverse Environmental Samples
Marotz, C. A., Amir, A., Humphrey, G. C., Gaffney, J., Gogul, G., & Knight, R. D. (2017) · BioTechniques · doi:10.2144/000114559 · Cited by 166 · see citing works
Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens
Cree, B., Spencer, C. M., Varrin‐Doyer, M., Baranzini, S. E., & Zamvil, S. S. (2016) · Annals of Neurology · doi:10.1002/ana.24718 · Cited by 156 · see citing works
Self-citationBuscarinu, M. C., Cerasoli, B., Annibali, V., Policano, C., Lionetto, L., Capi, M., Mechelli, R., Romano, S., Fornasiero, A., Mattei, G., et al. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458516652498 · Cited by 147 · see citing works
Do antibodies select a healthy microbiota?
Kubinak, J. L., & Round, J. L. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.114 · Cited by 133 · see citing works
Cytomegalovirus seropositivity is negatively associated with multiple sclerosis
Sundqvist, E., Bergström, T. B., Daialhosein, H., Nyström, M., Sundström, P., Hillert, J. A., Alfredsson, L. S., Kockum, I. S., & Olsson, T. P. (2013) · Multiple Sclerosis Journal · doi:10.1177/1352458513494489 · Cited by 131 · see citing works
Smoking is a major preventable risk factor for multiple sclerosis
Hedström, A. K., Olsson, T. P., & Alfredsson, L. S. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458515609794 · Cited by 106 · see citing works
Regulation of humoral immunity by gut microbial products
Kim, M., & Kim, C. H. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1299311 · Cited by 104 · see citing works
Brain Autoimmunity and Intestinal Microbiota: 100 Trillion Game Changers
Wekerle, H. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.03.008 · Cited by 101 · see citing works
The Charcot Lecture | Beating MS: A story of B cells, with twists and turns
Hauser, S. L. (2014) · Multiple Sclerosis Journal · doi:10.1177/1352458514561911 · Cited by 100 · see citing works
The Human Microbiome and the Missing Heritability Problem
Sandoval‐Motta, S., Aldana, M., Martínez‐Romero, E., & Frank, A. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00080 · Cited by 89 · see citing works
Hughes, L. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00274-1 · Cited by 86 · see citing works
Metagenomics and the global ocean survey: what's in it for us, and why should we care?
Nealson, K. H., & Venter, J. C. (2007) · The ISME Journal · doi:10.1038/ismej.2007.43 · Cited by 61 · see citing works
Influence of the Gut Microbiome on Autoimmunity in the Central Nervous System
Colpitts, S. L., & Kasper, L. H. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601438 · Cited by 61 · see citing works
Environmental factors and their interactions with risk genotypes in MS susceptibility
Hedström, A. K., Alfredsson, L. S., & Olsson, T. P. (2016) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000329 · Cited by 36 · see citing works
Ringeisen, B. R., Rincon, K., Fitzgerald, L. A., Fulmer, P. A., & Wu, P. (2014) · Methods in Ecology and Evolution · doi:10.1111/2041-210x.12303 · Cited by 30 · see citing works
Berre, L. L., Rousse, J., Gourraud, P., Imbert‐Marcille, B., Salama, A., Evanno, G., Sémana, G., Nicot, A. B., Dugast, E., Guérif, P., et al. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.05.006 · Cited by 26 · see citing works
Anti-cancer therapies affected by gut microbiota
Greenhill, C. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.238 · Cited by 19 · see citing works
Role of astrocytes and microglia in central nervous system inflammation
Rothhammer, V., & Quintana, F. J. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0521-5 · Cited by 18 · see citing works
Flagged first, then by citations
1 of the 76 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Wallin, M. T., Culpepper, W. J., Nichols, E., Bhutta, Z. A., Gebrehiwot, T. T., Hay, S. I., Khalil, I. A., Krohn, K. J., Liang, X., Naghavi, M., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30443-5 · Cited by 1,108 · see citing works
The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821 · see citing works
Microbiota-Brain-Gut Axis and Neurodegenerative Diseases
Quigley, E. M. M. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0802-6 · Cited by 804 · see citing works
Zhou, X., Baumann, R., Gao, X., Mendoza, M., Singh, S., Sand, I. K., Xia, Z., Cox, L. M., Chitnis, T., Yoon, H., et al. (2022) · Cell · doi:10.1016/j.cell.2022.08.021 · Cited by 319 · see citing works
Self-citationThe gut microbiota–brain axis in neurological disorder
Ullah, H., Arbab, S., Tian, Y., Liu, C., Chen, Y., Li, Q., Khan, M. I. U., Hassan, I. U., & Li, K. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1225875 · Cited by 279 · see citing works
Gut microbiota–specific IgA + B cells traffic to the CNS in active multiple sclerosis
Pröbstel, A., Zhou, X., Baumann, R., Wischnewski, S., Kutza, M., Rojas, O. L., Sellrie, K., Bischof, A., Kim, K., Ramesh, A., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abc7191 · Cited by 226 · see citing works
Self-citationThe role of the gut microbiota in multiple sclerosis
Correale, J., Hohlfeld, R., & Baranzini, S. E. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00697-8 · Cited by 207 · see citing works
Self-citationThe intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics
Camara-Lemarroy, C. R., Metz, L. M., Meddings, J. B., Sharkey, K. A., & Yong, V. W. (2018) · Brain · doi:10.1093/brain/awy131 · Cited by 188 · see citing works
Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases
Opazo, M. C., Ortega-Rocha, E. M., Coronado-Arrázola, I., Bonifaz, L. C., Boudin, H., Neunlist, M., Bueno, S. M., Kalergis, A. M., & Riedel, C. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00432 · Cited by 179 · see citing works
Fecal microbiota transplantation associated with 10 years of stability in a patient with SPMS
Makkawi, S., Camara-Lemarroy, C. R., & Metz, L. M. (2018) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000459 · Cited by 144 · see citing works
The Gut–CNS Axis in Multiple Sclerosis
Kadowaki, A., & Quintana, F. J. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.06.002 · Cited by 92 · see citing works
Microbiome in Multiple Sclerosis: Where Are We, What We Know and Do Not Know
Boziki, M. K., Kesidou, E., Theotokis, P., Mentis, A. A., Karafoulidou, E., Melnikov, M., Sviridova, A. A., Rogovskii, V., Boyко, A., & Grigoriadis, N. (2020) · Brain Sciences · doi:10.3390/brainsci10040234 · Cited by 90 · see citing works
Alterations of the Fecal Microbiota in Chinese Patients With Multiple Sclerosis
Ling, Z., Cheng, Y., Yan, X., Shao, L., Liu, X., Zhou, D., Zhang, L., Yu, K., & Zhao, N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.590783 · Cited by 90 · see citing works
Bianchimano, P., Britton, G. J., Wallach, D. S., Smith, E. M., Cox, L. M., Liu, S., Iwanowski, K., Weiner, H. L., Faith, J. J., Clemente, J. C., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01364-2 · Cited by 81 · see citing works
Cui, Y., Yu, H., Bu, Z., Wen, L., Yan, L.-L., & Feng, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.894298 · Cited by 79 · see citing works
Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome
Camara-Lemarroy, C. R., Metz, L. M., & Yong, V. W. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i37.4217 · Cited by 75 · see citing works
Impact of gut microbiota on gut‐distal autoimmunity: a focus on T cells
Sprouse, M. L., Bates, N. A., Felix, K. M., & Wu, H.-J. J. (2018) · Immunology · doi:10.1111/imm.13037 · Cited by 75 · see citing works
Ghaffari, S., Abbasi, A., Somi, M. H., Moaddab, S. Y., Nikniaz, L., Kafil, H. S., & Leylabadlo, H. E. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2045894 · Cited by 74 · see citing works
Origins and immunopathogenesis of autoimmune central nervous system disorders
Ramanathan, S., Brilot, F., Irani, S. R., & Dale, R. C. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00776-4 · Cited by 71 · see citing works
Gut Microbiome in Anesthesiology and Pain Medicine
Minerbi, A., & Shen, S. (2022) · Anesthesiology · doi:10.1097/aln.0000000000004204 · Cited by 73 · see citing works
Revisiting the Hygiene Hypothesis in the Context of Autoimmunity
Bach, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.615192 · Cited by 66 · see citing works
Role of environmental factors in multiple sclerosis
Zarghami, A., Li, Y., Claflin, S. B., van der Mei, I. A. F., & Taylor, B. V. (2021) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2021.1978843 · Cited by 64 · see citing works
Khan, Z., Mehan, S., Gupta, G. D., & Narula, A. S. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.04.004 · Cited by 62 · see citing works
Gut microbiome and multiple sclerosis: New insights and perspective
Amini, M. E., Shomali, N., Bakhshi, A., Rezaei, S., Hemmatzadeh, M., Hosseinzadeh, R., Eslami, S., Babaie, F., Aslani, S., Torkamandi, S., et al. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107024 · Cited by 53 · see citing works
Impact of Microbiome–Brain Communication on Neuroinflammation and Neurodegeneration
Stolzer, I., Scherer, E., Süß, P., Rothhammer, V., Winner, B., Neurath, M. F., & Günther, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914925 · Cited by 47 · see citing works
Gut microbiome is associated with multiple sclerosis activity in children
Horton, M. K., McCauley, K. E., Fadrosh, D. W., Fujimura, K. E., Graves, J. S., Ness, J., Wheeler, Y., Gorman, M., Benson, L. A., Weinstock‐Guttman, B., et al. (2021) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51441 · Cited by 50 · see citing works
B-cell-depletion reverses dysbiosis of the microbiome in multiple sclerosis patients
Troci, A., Zimmermann, O. L., Esser, D., Krampitz, P., May, S., Franke, A., Berg, D., Leypoldt, F., Stürner, K. H., & Bang, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-07336-8 · Cited by 46 · see citing works
Strategies for Neuroprotection in Multiple Sclerosis and the Role of Calcium
Enders, M., Heider, T., Ludwig, A., & Küerten, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051663 · Cited by 45 · see citing works
Species differences in immune‐mediated CNS tissue injury and repair: A (neuro)inflammatory topic
Healy, L. M., Yaqubi, M., Ludwin, S. K., & Antel, J. P. (2019) · Glia · doi:10.1002/glia.23746 · Cited by 41 · see citing works
New drugs for multiple sclerosis: new treatment algorithms
Cree, B., Hartung, H., & Barnett, M. H. (2022) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001063 · Cited by 39 · see citing works
Cencicchio, M. A., Montini, F., Palmieri, V., Massimino, L., Conte, M. L., Finardi, A., Mandelli, A., Asnicar, F., Pavlović, R., Drago, D., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102028 · Cited by 40 · see citing works
Abdollahpour, I., Jakimovski, D., Shivappa, N., Hébert, J. R., Vahid, F., Nedjat, S., Mansournia, M. A., & Weinstock‐Guttman, B. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.02.033 · Cited by 38 · see citing works
Current understanding of the human microbiome in glioma
Liang, J., Li, T., Zhao, J., Wang, C., & Sun, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.781741 · Cited by 37 · see citing works
Multiple Sclerosis and Microbiome
Preiningerova, J. L., Zakostelska, Z. J., Srinivasan, A., Tichá, V., Kovářová, I., Kleinová, P., Tlaskalová-Hogenová, H., & Havrdová, E. (2022) · Biomolecules · doi:10.3390/biom12030433 · Cited by 39 · see citing works
A Distinct Microbiome Signature in Posttreatment Lyme Disease Patients
Morrissette, M., Pitt, N., González, A., Strandwitz, P., Caboni, M., Rebman, A. W., Knight, R. D., Donofrio, A. E., Aucott, J. N., Soloski, M. J., et al. (2020) · mBio · doi:10.1128/mbio.02310-20 · Cited by 37 · see citing works
Aznar, M. D. G., Guerrero, M. D. V., Ramos, J., Madueño, S. E., Bravo, M. M., Ruiz, R. L., & García, M. B. (2022) · BMC Neurology · doi:10.1186/s12883-022-02913-w · Cited by 34 · see citing works
Leyrolle, Q., Decoeur, F., Brière, G., Amadieu, C., Quadros, A. R. A. D. A., Voytyuk, I., Lacabanne, C., Benmamar‐Badel, A., Bourel, J., Aubert, A., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00793-7 · Cited by 33 · see citing works
Environmental factors related to multiple sclerosis progression
Gouider, R., Souissi, A., Mrabet, S., Gharbi, A., Abida, Y., Kacem, I., & Gargouri, A. (2024) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2024.123161 · Cited by 30 · see citing works
The Microbiome and Neurologic Disease: Past and Future of a 2-Way Interaction
Ochoa‐Repáraz, J., & Kasper, L. H. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0604-9 · Cited by 28 · see citing works
Diebold, M., Meola, M., Purushothaman, S., Siewert, L. K., Pössnecker, E., Roloff, T. C., Lindberg, R. L. P., Kühle, J., Kappos, L., Derfuss, T., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2147055 · Cited by 26 · see citing works
Self-citationMultiple Sclerosis: B Cells Take Center Stage
Pröbstel, A., & Hauser, S. L. (2018) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000000642 · Cited by 25 · see citing works
Self-citationA Gut Feeling: The Importance of the Intestinal Microbiota in Psychiatric Disorders
Ochoa‐Repáraz, J., Ramelow, C. C., & Kasper, L. H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.510113 · Cited by 22 · see citing works
Nemati, M. H., Yazdanpanah, E., Kazemi, R., Orooji, N., Dadfar, S., Oksenych, V., & Haghmorad, D. (2025) · Biology · doi:10.3390/biology14040435 · Cited by 21 · see citing works
Davoody, S., Halimi, H., Zali, A., Houri, H., & Brand, S. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107032 · Cited by 19 · see citing works
Normal gut microbiome in NMDA receptor encephalitis
Herken, J., Bang, C., Rühlemann, M. C., Finke, C., Klag, J., Franke, A., & Prüß, H. (2019) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000632 · Cited by 16 · see citing works
Badihian, N., Riahi, R., Goli, P., Badihian, S., Poursafa, P., & Kelishadi, R. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102823 · Cited by 15 · see citing works
Gut microbiome changes in anti-N-methyl-D-aspartate receptor encephalitis patients
Jingya, W., Zhang, X., Yang, F., Shi, X., Wang, X., Chen, R., Du, F., Shi, M., & Jiang, W. (2022) · BMC Neurology · doi:10.1186/s12883-022-02804-0 · Cited by 14 · see citing works
Gut Microorganisms and Neurological Disease Perspectives
Faruqui, N. A., Prium, D. H., Mowna, S. A., Ullah, M. A., Araf, Y., Sarkar, B., Zohora, U. S., & Rahman, M. S. (2021) · Future Neurology · doi:10.2217/fnl-2020-0026 · Cited by 14 · see citing works
Zancan, V., Nasello, M., Bigi, R., Reniè, R., Buscarinu, M. C., Mechelli, R., Ristori, G., Salvetti, M., & Bellucci, G. (2024) · Microorganisms · doi:10.3390/microorganisms12071476 · Cited by 14 · see citing works
Therapeutic targeting of gut‐originating regulatory B cells in neuroinflammatory diseases
Neziraj, T., Siewert, L. K., Pössnecker, E., & Pröbstel, A. (2023) · European Journal of Immunology · doi:10.1002/eji.202250033 · Cited by 13 · see citing works
Self-citationAlexander, T., Snowden, J. A., Burman, J., Chang, H., Papa, N. D., Farge, D., Lindsay, J. O., Malard, F., Muraro, P. A., Nitti, R., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.722436 · Cited by 12 · see citing works
Damavandi, A. R., Mirmosayyeb, O., Ebrahimi, N., Zalpoor, H., Khalilian, P., Yahiazadeh, S., Eskandari, N., Rahdar, A., Kumar, P. S., & Pandey, S. (2022) · Applied Nanoscience · doi:10.1007/s13204-022-02698-x · Cited by 12 · see citing works
Microbiota, diet, and the gut–brain axis in multiple sclerosis and stroke
Díaz-Marugán, L., Kantsjö, J. B., Rutsch, A., & Ronchi, F. (2023) · European Journal of Immunology · doi:10.1002/eji.202250229 · Cited by 14 · see citing works
Pérez-Muñoz, M. E., Sugden, S., Harmsen, H. J. M., Hart, B. A. ‘., Laman, J. D., & Walter, J. (2021) · iScience · doi:10.1016/j.isci.2021.102709 · Cited by 12 · see citing works
Update on novel multiple sclerosis treatments: from dismal defeat to scintillating success
Cree, B., & Hartung, H. (2025) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001363 · Cited by 11 · see citing works
Association of multiple sclerosis with stroke: A comprehensive review
Marsool, M. D. M., Prajjwal, P., John, J., Keluskar, H. S., Sivarajan, V. V., Kundiri, K. A., Lam, J. R., Chavda, S., Atew, H. G., Marsool, A. D. M., et al. (2024) · Health Science Reports · doi:10.1002/hsr2.1837 · Cited by 10 · see citing works
Multiple sclerosis and faecal microbiome transplantation: are you going to eat that?
Wing, A. C., & Kremenchutzky, M. (2018) · Beneficial Microbes · doi:10.3920/bm2018.0029 · Cited by 10 · see citing works
Mokhtarzade, M., Shamsi, M. M., Abolhasani, M., Bakhshi, B., Sahraian, M. A., shalamzari, M. H., & Soudi, S. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.103639 · Cited by 9 · see citing works
Bingöl, F. G., Koçyiğit, E., Çelik, E., Ağagündüz, D., & Budán, F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125464 · Cited by 7 · see citing works
Darchiashvili, S., Kulkarni, R., Tandon, R., Deak, P., Nguyen, K. L., & Jain, P. (2024) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2024-0007 · Cited by 7 · see citing works
Multiple sclerosis and the intestine: Chasing the microbial offender
Peters, A., Gerdes, L. A., & Wekerle, H. (2024) · Immunological Reviews · doi:10.1111/imr.13357 · Cited by 7 · see citing works
Role of Gut Microbiota in Human Health and Diseases
Narayanan, A., Latika, A., Nair, A. S., Ajeesh, P., Kumar, N. S., & Babu, M. (2020) · Current Nutrition & Food Science · doi:10.2174/1573401316999200930130101 · Cited by 7 · see citing works
A diet-dependent enzyme from the human gut microbiome promotes Th17 cell accumulation and colitisPreprint
Alexander, M., Ang, Q. Y., Nayak, R. R., Bustion, A. E., Upadhyay, V., Pollard, K. S., & Turnbaugh, P. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/766899 · Cited by 6 · see citing works
Mikrobiota und Multiple Sklerose
Gerdes, L. A., Yoon, H., & Peters, A. (2020) · Der Nervenarzt · doi:10.1007/s00115-020-01012-w · Cited by 4 · see citing works
Forging the microbiome to help us live long and prosper
Rock, R. R., & Turnbaugh, P. J. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002087 · Cited by 5 · see citing works
Milk and multiple sclerosis: A possible link?
Morin, C. R., Baeva, M.-E., Hollenberg, M. D., & Brain, M. C. (2024) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2024.105477 · Cited by 5 · see citing works
Szablewski, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00065-6 · Cited by 5 · see citing works
Complex Interactions of Obesity, Dairy Food Intake and Genetics of Lactase
Szilagyi, A. (2018) · Journal of Obesity and Chronic Diseases · doi:10.17756/jocd.2018-017 · Cited by 4 · see citing works
Influence of the Microbiota Through the Gut-Brain Axis in Neurological Diseases
Guarnotta, V., Mandarino, F. V., Fasulo, E., Maida, M. F., Laterza, L., Sferrazza, S., Raimondo, D., & Sinagra, E. (2024) · Integrated science · doi:10.1007/978-3-031-73061-0_20 · Cited by 3 · see citing works
Sriwastava, S., Beard, K., Amatya, S., Shrestha, K., Jaiswal, S., & Lisak, R. P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95343-6.00014-5 · Cited by 3 · see citing works
Prospects for the use of polyphenols in multiple sclerosis
Lopatina, A., Kukushkina, A. D., Melnikov, M., & Rogovskii, V. (2022) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202212207236 · Cited by 3 · see citing works
Relación de la microbiota intestinal con enfermedades autoinmunes
Peláez, J. P. M., Garate, B. P. O., & Aguinsaca, K. F. P. (2023) · Revista Vive · doi:10.33996/revistavive.v6i16.213 · Cited by 5 · see citing works
Microbiota-Brain-Gut Axis and Neurodegenerative Disorders
Abughazaleh, S. J., Euers, L. A., & Quigley, E. M. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00031-0 · Cited by 3 · see citing works
A importância da nutrição integrativa em pacientes com doenças autoimunes
Damasceno, S. M. F., Fernandes, R., & de Almeida, S. G. (2023) · Research Society and Development · doi:10.33448/rsd-v12i6.42156 · Cited by 3 · see citing works
«Gut-brain» axis and multiple sclerosis
Omarova, М. А., & Boyko, A. N. (2023) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2023-6-122-127 · Cited by 2 · see citing works
Silent Intruders: The Gut Virome in Brain Aging and Cognitive Decline
Silvestro, S., Midiri, A., Biondo, C., Casilli, S., Borrello, L., Zummo, S., & Mancuso, G. (2026) · Pathogens · doi:10.3390/pathogens15020180 · Cited by 2 · see citing works
Gut microbiota modification as an option in multiple sclerosis management
Zwiernik, B., Arłukowicz, T., Mycko, M. P., & Zwiernik, J. (2020) · Polish Annals of Medicine · doi:10.29089/2020.20.00133 · Cited by 2 · see citing works
Calvo‐Barreiro, L., Clerico, M., & Espejo, C. (2021) · Multiple Sclerosis Journal · doi:10.1177/13524585211016723 · Cited by 2 · see citing works
Prognostic markers of multiple sclerosis
Alifirova, V. M., Kamenskikh, E. M., Koroleva, E. S., Колоколова, Е. В., & Petrakovich, A. M. (2022) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202212202122 · Cited by 2 · see citing works
Effects of Pregnancy and Hormones on T cell Immune Regulation in Multiple Sclerosis
Hellberg, S. (2019) · Linköping University medical dissertations · doi:10.3384/diss.diva-161091 · Cited by 1 · see citing works
Regulatory roles of the microbiome in arthritis, fibromyalgia, and multiple sclerosis
Vázquez-Chinea, L. J., Johnson, S. N., & Lipski, E. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822238-6.00028-5 · Cited by 1 · see citing works
Vazifedoust, S., Ghaleh, H. E. G., Khafaei, M., Azemati, F., & Kondori, B. J. (2022) · PubMed Central · doi:10.30699/ijp.2022.541483.2755 · Cited by 1 · see citing works
Jafari-Nakhjavanlou, A., Irajian, P., & Bialvaei, A. Z. (2025) · Infectious Medicine · doi:10.1016/j.imj.2025.100219 · Cited by 1 · see citing works
Qin, R., Lai, X., Qin, Q., Xu, W., & Chen, L. (2026) · Immunologic Research · doi:10.1007/s12026-025-09742-2 · Cited by 1 · see citing works
Immunotherapies in progressive multiple sclerosis
Neziraj, T., Kappos, L., & Pröbstel, A. (2026) · Handbook of clinical neurology · doi:10.1016/b978-0-323-90887-0.00021-3 · Cited by 1 · see citing works
Self-citationLi, L., Liu, H., Ye, Z., & Xu, W. (2026) · Mediators of Inflammation · doi:10.1155/mi/3572399 · Cited by 1 · see citing works
The Role of Human Microbiota in Autoimmune Diseases: Exploring Dysbiosis and Mechanisms
Liu, S., Sanaie, S., Abdollahi, H., Yazdanfar, F., Khaki, S. N., kheiri, S. V., & Mobed, A. (2026) · Apmis · doi:10.1111/apm.70159 · Cited by 1 · see citing works
Zhang, S.-M., Tang, W.-C., Liu, F.-F., Bai, Q.-Q., Guo, Y., Bai, X.-Z., Wang, Y. J., Xw, M., Pan, S.-J., Yang, Y.-H., et al. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1803309 · Cited by 1 · see citing works
The gut microbiota plays a modifiable role in MS progression—YES
Passali, M., Krishnamoorthy, G., & Pröbstel, A. (2026) · Multiple Sclerosis Journal · doi:10.1177/13524585261471341 · Cited by 1 · see citing works
Self-citationHohlfeld, R. (2021) · Multiple Sclerosis Journal · doi:10.1177/13524585211018990 · Cited by 1 · see citing works
The gut microbiome in neurodegenerative disorders
Abughazaleh, S. J., Euers, L. A., & Quigley, E. M. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821039-0.00006-x · Cited by 1 · see citing works
The next frontier in multiple sclerosis therapies: Current advances and evolving targets
Koduru, T. S., Gupta, N., Kannan, A., Dutta, S., Osmani, R. A. M., Balamuralidhara, V., Ramkishan, A., & Shanmuganathan, S. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177080 · Cited by 1 · see citing works
Sviridova, A. A., Кабаева, А. Р., Rogovskii, V., Kozhieva, M. K., Melnikov, M., & Boyko, A. N. (2019) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20191191028 · Cited by 1 · see citing works
Role of antibodies in autoimmunity of the central nervous system
Gómez, C. C. (2020) · doi:10.53846/goediss-8074 · Cited by 1 · see citing works
Insights into microbiome research 5: Mapping is first but function must come next
Baranzini, S. E. (2019) · Multiple Sclerosis Journal · doi:10.1177/1352458518811203
Self-citationThe future of microbiome research in neuroinflammatory disorders
Waubant, E. L., Pröbstel, A., Levy, M., Hawkes, C. H., Giovannoni, G., Lechner‐Scott, J., & Tremlett, H. L. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102098
Self-citationThe Gut Microbiome in Neurodegenerative Disorders
Euers, L. A., & Quigley, E. M. M. (2020) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190931544.013.11
Human Gut Microbiota: Friend or Foe?
Pliszka, M., & Szablewski, L. (2020) · OBM Hepatology and Gastroenterology · doi:10.21926/obm.hg.2003050
The gut microbiome as a therapeutic target in systemic disease
Morrissette, M. (2021) · doi:10.17760/d20423512
Prognostic Markers in Multiple Sclerosis
Alifirova, V. M., Kamenskikh, E. M., Koroleva, E. S., Kolokolova, E. V., & Petrakovich, A. M. (2022) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-022-01310-7
- Authors
- Pröbstel, A.-K., & Baranzini, S. E.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Baranzini, Sergio E.
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 15
- Issue
- 1
- Pages
- 126-134
- ISSN
- 1878-7479 (ISSN-L)
- PMC
- PMC5794700
- OpenAlex
- W2769299506
- Cited by
- 110
- References
- 76
- Citations by year
- 2026: 11 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 22 · 2021: 13 · 2020: 18 · 2019: 8 · 2018: 9 · 2017: 1
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurotherapeutics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Multiple Sclerosis Society (US) (CA_1072-A)
- U.S. Department of Defense (US) (W81XWH-15-1-0652)
- Valhalla Charitable Foundation (N/A)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CH) (P2SKP3_164938)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- multiple sclerosis, gut microbiota, B cells, autoimmune disease, disease-modifying therapy, anti-B-cell therapy, disease progression, risk factors, core microbiome, therapeutic interventions
- MeSH terms
- Gastrointestinal Microbiome, Animals, B-Lymphocytes, Humans, Multiple Sclerosis, Risk Factors, Disease Progression, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
