Targeting nonalcoholic fatty liver disease via gut microbiome-centered therapies
Open accessAbstract
Humans possess abundant amounts of microorganisms, including bacteria, fungi, viruses, and archaea, in their gut. Patients with nonalcoholic fatty liver disease (NAFLD) exhibit alterations in their gut microbiome and an impaired gut barrier function. Preclinical studies emphasize the significance of the gut microbiome in the pathogenesis of NAFLD. In this overview, we explore how adjusting the gut microbiome could serve as an innovative therapeutic strategy for NAFLD. We provide a summary of current information on untargeted techniques such as probiotics and fecal microbiota transplantation, as well as targeted microbiome-focused therapies including engineered bacteria, prebiotics, postbiotics, and phages for the treatment of NAFLD.
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Microbiome-centred therapies such as engineered bacteria, postbiotics, and phages have mainly been tested in preclinical models.
“Microbiome-centred therapies such as engineered bacteria, postbiotics, and phages have mainly been tested in preclinical models.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [336]
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- Authors
- Koning, M., Herrema, H., Nieuwdorp, M., & Meijnikman, A. S.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Meijnikman, Abraham S.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2023-06-26
- Volume
- 15
- Issue
- 1
- Pages
- 2226922-2226922
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC10305510
- OpenAlex
- W4382283296
- Cited by
- 56
- References
- 142
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 23 · 2023: 2
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Gut Microbes (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- ZonMw ([09150182010020], 10140262110036)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (015.017.050)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- non-alcoholic fatty liver disease, gut microbiota, microbiome-targeted therapy, probiotics, fecal microbiota transplantation, engineered bacteria, prebiotics, postbiotics, bacteriophages, intestinal barrier, NAFLD pathogenesis
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Humans, Liver, Probiotics, Prebiotics, Microbiota, Non-alcoholic Fatty Liver Disease
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