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Cited by 66Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris

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Allert, Stefanie, Schulz, Daniela, Kämmer, Philipp, Großmann, Peter, Wolf, Thomas, Schäuble, Sascha, Panagiotou, Gianni, Brunke, Sascha +1 more·2022·Virulence
DOI 10.1080/21505594.2022.2026037PMC PMC8837256
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Abstract

Candida species are a major cause of invasive fungal infections. While Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis are the most dominant species causing life-threatening candidiasis, C. auris recently emerged as a new species causing invasive infections with high rates of clinical treatment failures. To mimic initial phases of systemic Candida infections with dissemination via the bloodstream and to elucidate the pathogenic potential of C. auris, we used an ex vivo whole blood infection model. Similar to other clinically relevant Candida spp., C. auris is efficiently killed in human blood, but showed characteristic patterns of immune cell association, survival rates, and cytokine induction. Dual-species transcriptional profiling of C. auris-infected blood revealed a unique C. auris gene expression program during infection, while the host response proofed similar and conserved compared to other Candida species. C. auris-specific responses included adaptation and survival strategies, such as counteracting oxidative burst of immune cells, but also expression of potential virulence factors, (drug) transporters, and cell surface-associated genes. Despite comparable pathogenicity to other Candida species in our model, C. auris-specific transcriptional adaptations as well as its increased stress resistance and long-term environmental survival, likely contribute to the high risk of contamination and distribution in a nosocomial setting. Moreover, infections of neutrophils with pre-starved C. auris cells suggest that environmental preconditioning can have modulatory effects on the early host interaction. In summary, we present novel insights into C. auris pathogenicity, revealing adaptations to human blood and environmental niches distinctive from other Candida species.

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  • Conditions favoring the filamentous phase of C. auris, such as blood contact and Hsp90 deprivation, share upregulated genes with UME6HA.

    “Together with other data sets containing genes upregulated in contact with blood cells [node “BLOOD_60 MIN_UP” (36)] and genes upregulated by deprivation of Hsp90 [node “HSP90_TET_UP”, (37)], these conditions have in common that they favor the filamentous phase of C. auris, which is consistent with the morphological effect of UME6HA on C. auris.”

    From Ume6-dependent pathways of morphogenesis and biofilm formation in <i>Candida auris</i> (2024) · cites this paper as [36]

    The Results section on whole-blood infection reports genes upregulated in C. auris at 60 minutes, supporting use of this paper for the blood-response gene set. But the Results section on fungal survival says no switch to hyphal growth was detected in blood, and our copy does not assess overlap with UME6HA-upregulated genes. The separate Hsp90-deprivation data set is cited to another source in the sentence. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Allert, S., Schulz, D., Kämmer, P., Großmann, P., Wolf, T., Schäuble, S., Panagiotou, G., Brunke, S., & Hube, B.
Affiliations
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
Corresponding author
Hube, Bernhard
ORCID
Venue
Virulence
Publisher
Informa UK Limited
Published
2022-02-10
Volume
13
Issue
1
Pages
191-214
ISSN
  • 2150-5594 (ISSN-L)
  • 2150-5608
DOI
10.1080/21505594.2022.2026037
PMC
PMC8837256
OpenAlex
W4211223844
Cited by
66
References
17
Citations by year
2026: 15 · 2025: 12 · 2024: 19 · 2023: 11 · 2022: 9
FWCI
6.23
Type
journal article
Language
en
Open access
Licence
Locations
  • Virulence (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Deutsche Forschungsgemeinschaft (Hu 532/20-1)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
Candida auris, pathogenicity, invasive candidiasis, respiratory burst, stress tolerance, environmental survival, drug transporters, virulence factors, nosocomial transmission, host immune response, cytokine induction
MeSH terms
Candida auris, Antifungal Agents, Candida, Candida albicans, Candidiasis, Humans, Virulence, Candida glabrata

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