The seven faces of SIRT7
Open accessAbstract
-dependent protein deacetylases, is a key mediator of many cellular activities. SIRT7 expression is linked to cell proliferation and oncogenic activity, connecting SIRT7-dependent regulation of ribosome biogenesis with checkpoints controlling cell cycle progression, metabolic homeostasis, stress resistance, aging and tumorigenesis. Despite this important functional link, the enzymatic activity, the molecular targets and physiological functions of SIRT7 are poorly defined. Here, we review recent progress in SIRT7 research and elaborate the main pathways in which SIRT7 participates.
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SIRT7 appears necessary for preserving active rDNA transcription under conditions of cellular growth and stress.
“In contrast to the broadly repressive actions often attributed to other sirtuins, SIRT7 appears necessary for preserving active rDNA transcription under conditions of cellular growth and stress [183,184].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [184]
The section “SIRT7 promotes pre-rRNA transcription and processing” says SIRT7 facilitates rDNA transcription and links its activity to cell proliferation. But “SIRT7 attenuates cellular stress” says osmotic or transcriptional stress releases SIRT7 from nucleoli and downregulates Pol I transcription, rather than preserving active rDNA transcription during stress. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredGiven its dependence on intracellular NAD+ availability, SIRT7 may provide a mechanistic link between cellular energetic status and nucleolar function.
“Given its dependence on intracellular NAD+ availability, SIRT7 may provide a mechanistic link between cellular energetic status and nucleolar function [184].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [184]
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- Authors
- Blank, M. F., & Grummt, I.
- Affiliations
- German Cancer Research Center (DE)
- Corresponding author
- Grummt, Ingrid
- Venue
- Transcription
- Publisher
- Informa UK Limited
- Published
- 2017-01-23
- Volume
- 8
- Issue
- 2
- Pages
- 67-74
- ISSN
- 2154-1264 (ISSN-L)
- 2154-1272
- PMC
- PMC5423475
- OpenAlex
- W2571520146
- Cited by
- 111
- References
- 44
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 9 · 2023: 14 · 2022: 21 · 2021: 12 · 2020: 15 · 2019: 13 · 2018: 9 · 2017: 5
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Transcription (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- SIRT7, ribosome biogenesis, cell cycle checkpoints, metabolic homeostasis, stress tolerance, aging, carcinogenesis, cell proliferation, molecular targets
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Energy Metabolism, Humans, Ribosomes, DNA-Directed RNA Polymerases, Stress, Physiological, Transcription, Genetic, Sirtuins, Genomic Instability, Cell Cycle Checkpoints
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