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Widespread transcription at neuronal activity-regulated enhancers

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Transcription factors: from enhancer binding to developmental control

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Protein Phase Separation: A New Phase in Cell Biology

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Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

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ChIP-seq accurately predicts tissue-specific activity of enhancers

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Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

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Modification of Enhancer Chromatin: What, How, and Why?

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The Bromodomain Protein Brd4 Is a Positive Regulatory Component of P-TEFb and Stimulates RNA Polymerase II-Dependent Transcription

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Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation

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A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers

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Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA

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Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription

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NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis

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Functions of bromodomain-containing proteins and their roles in homeostasis and cancer

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Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA

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Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

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Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

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Mapping Human Epigenomes

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Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

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Genome-wide profiling of PPARγ:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesisPreprint

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eRNAs Promote Transcription by Establishing Chromatin Accessibility at Defined Genomic Loci

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A Rapid, Extensive, and Transient Transcriptional Response to Estrogen Signaling in Breast Cancer Cells

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BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

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Enhancer RNA Facilitates NELF Release from Immediate Early Genes

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Bromodomains as therapeutic targets

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TRIM24 links a non-canonical histone signature to breast cancer

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RNA Binding to CBP Stimulates Histone Acetylation and Transcription

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Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation

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Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly

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Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting

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Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters

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Integrator mediates the biogenesis of enhancer RNAs

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BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones

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Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and Regeneration

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Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes

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The degree of enhancer or promoter activity is reflected by the levels and directionality of eRNA transcription

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High-Resolution Mapping of RNA-Binding Regions in the Nuclear Proteome of Embryonic Stem Cells

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Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA

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Bcl-6 and NF-κB cistromes mediate opposing regulation of the innate immune responsePreprint

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Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization

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Structure and function of SWI/SNF chromatin remodeling complexes and mechanistic implications for transcription

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Cell-Specific Determinants of Peroxisome Proliferator-Activated Receptor γ Function in Adipocytes and Macrophages

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Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors

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Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription

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A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans

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RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation

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Affinity Map of Bromodomain Protein 4 (BRD4) Interactions with the Histone H4 Tail and the Small Molecule Inhibitor JQ1

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Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer

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A bromodomain–DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT

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R-DeeP: Proteome-wide and Quantitative Identification of RNA-Dependent Proteins by Density Gradient Ultracentrifugation

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Enhancer deregulation in cancer and other diseases

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Intragenic Enhancers Attenuate Host Gene Expression

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BRD 4 associates with p53 in DNMT 3A‐mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor JQ 1

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DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes

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Reading More than Histones: The Prevalence of Nucleic Acid Binding among Reader Domains

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Genomics, molecular and evolutionary perspective of NAC transcription factors

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ALKBH1 promotes lung cancer by regulating m6A RNA demethylation

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The pleiotropic roles of SPT5 in transcription

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Non-Coding RNA Editing in Cancer Pathogenesis

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Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis

Soliman, S. H. A., Orlacchio, A., & Verginelli, F. (2021) · Microorganisms · doi:10.3390/microorganisms9061179 · Cited by 24 · see citing works

Revisiting Epigenetics Fundamentals and Its Biomedical Implications

Meza-Menchaca, T., Albores-Medina, A., Heredia-Mendez, A. J., Ruíz-May, E., Ricaño-Rodríguez, J., Gallegos-García, V., Esquivel, A., Vettoretti-Maldonado, G., & Campos-Parra, A. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147927 · Cited by 15 · see citing works

Noncoding RNAs Set the Stage for RNA Polymerase II Transcription.

Studniarek, C., Egloff, S., & Murphy, S. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.09.013 · Cited by 10 · see citing works

TET3-Interacting LncRNA TILR Is Essential for DNA Hydroxymethylation–Mediated Neuroprotection After Ischemic Stroke

Arruri, V. K., Morris-Blanco, K. C., Mehta, S. L., Kaur, M., & Vemuganti, R. (2025) · Stroke · doi:10.1161/strokeaha.125.052347 · Cited by 7 · see citing works

Emerging Roles of SPT5 in Transcription

Pandey, V. P., Punniyamoorthy, S., & Pokharel, Y. R. (2023) · Cellular Physiology and Biochemistry · doi:10.33594/000000665 · Cited by 5 · see citing works

The untold story between enhancers and skeletal muscle development

Zhang, Y., Lü, D., Yu-wen, L. I. U., Yi, G., & Tang, Z. (2020) · Journal of Integrative Agriculture · doi:10.1016/s2095-3119(20)63235-x · Cited by 4 · see citing works

The Promising Epigenetic Regulators for Refractory Epilepsy: An Adventurous Road Ahead

Suvekbala, V., Ramachandran, H., Veluchamy, A., Bruno-Mascarenhas, M., Ramprasath, T., Nair, M. K. C., Garikipati, V. N. S., Gundamaraju, R., & Ramasamy, S. (2022) · NeuroMolecular Medicine · doi:10.1007/s12017-022-08723-0 · Cited by 3 · see citing works

Identification and expression analysis of NAC family genes in Eleutherococcus senticosus under salt stress

He, J., Kong, L., Wang, P., He, L., Cao, H., Chen, Q., Ren, W., Liu, X., & Ma, W. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10830-7 · Cited by 2 · see citing works

Transcriptional control by enhancers: working remotely for improved performance

Espinosa, J. M. (2020) · Transcription · doi:10.1080/21541264.2020.1724673 · Cited by 2 · see citing works

Interaction Between Enhancers and Promoters in Chicken Genome

Grushina, V. A., Filatova, A. P., Gagarina, V. S., Prasolov, D. E., Kolpakov, F., Gusev, O., & Pintus, S. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311407

H3K9me3 as a gatekeeper of lineage-specific enhancers in embryonic progenitor cellsPreprint

Ito, K., Donahue, G., Katsuda, T., Kamimoto, K., & Zaret, K. S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.03.722466

Applications of Epigenetics to Forensic Sciences. Introduction

Zapico, S. C. (2026) · Epigenetics and human health · doi:10.1007/978-3-032-23085-0_1

RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation

Rahnamoun, H., Lee, J. H., Sun, Z., Lu, H., Ramsey, K. M., Komives, E. A., & Lauberth, S. M. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0102-0 · Cited by 176 · see citing works

Enhancer RNAs are an important regulatory layer of the epigenome

Sartorelli, V., & Lauberth, S. M. (2020) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-0446-0 · Cited by 367 · see citing works

Enhancer RNAs: Insights Into Their Biological Role

de Lara, J. C.-F., Arzate‐Mejía, R. G., & Targa, F. R. (2019) · Epigenetics Insights · doi:10.1177/2516865719846093 · Cited by 28 · see citing works

Enhancer RNA: Biogenesis, function, and regulation

Ye, R., Cao, C., & Xue, Y. (2020) · Essays in Biochemistry · doi:10.1042/ebc20200014 · Cited by 71 · see citing works

Enhancer RNAs and regulated transcriptional programs

Lam, M. T. Y., Li, W., Rosenfeld, M. G., & Glass, C. K. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.007 · Cited by 502 · see citing works