Cited by 26Genetic and phenotypic traits in livestockEffects of Environmental Stressors on LivestockLivestock Farming and Management

Exploring the Genomes of East African Indicine Cattle Breeds Reveals Signature of Selection for Tropical Environmental Adaptation Traits

Open access
Taye, Mengistie, Lee, Wonseok, Caetano-Anolles, Kelsey, Dessie, Tadelle, Cho, Seoae, Jong Oh, Sung, Lee, Hak-Kyo, Kim, Heebal·2018·Cogent Food & Agriculture

Abstract

African indigenous cattle breeds have been reared within the continent for millennia. Due to the harsh tropical environmental conditions (e.g. sever disease and parasite prevalence, high temperature, feed and water scarcity) where they evolved, they have developed various levels of tropical environment adaptation attributes. In order to explore the genomic signatures of tropical environment adaptation in African cattle, we compared the whole genomes of East African Indicus cattle breeds with European and Asian Taurine cattle breeds using XP-EHH and XP-CLR population statistical methods. Several genes involved in various biological processes and pathways related to domestication and behavior (dopaminergic and glutamatergic synapse), feeding and metabolism (gastric acid secretion, metabolic pathways), thermotolerance (sphingolipid and Wnt signaling), immune system response (T cell receptor signaling), and growth and reproduction (osteoblast differentiation, fibroblast migration) were identified from our genome analysis. Genes associated with tick and parasite resistance traits such as keratin genes, collagen genes, calcium signaling, and tumor necrosis factor proteins were also identified. The genes and pathways identified in this study improve our understanding of the biological mechanisms of tropical environment adaptation of African Indicus cattle breeds, which may allow us to use them for genomic selection programs. This result presents a basis for further study and may help to develop vaccines for tick and gastrointestinal parasite challenge.

Integrity signals

Registry

Crossref · 10.1080/23311932.2018.1552552

Cites

85 of 85 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Genes involved in heat tolerance have been identified in Indian and African indicine cattle populations, such as heat shock protein genes (HSPA1B, HSPA12A, DNAJC18 and DNAJC8), GRXCR1, FKBP4, HSPA1L, IL6, and HELB.

    “Genes involved in heat tolerance have been identified in Indian and African indicine cattle populations, such as heat shock protein genes (HSPA1B, HSPA12A, DNAJC18 and DNAJC8), GRXCR1, FKBP4, HSPA1L, IL6, and HELB [81,100,112,113].”
  • In African cattle, genomic selection signatures have been identified in genes involved in antigen response, keratin formation, light coat color, and sebum secretion.

    “In African cattle, genomic selection signatures have been identified in genes involved in antigen response (BoLA, SLC25A48), keratin formation (KRT33A, KRT222, KRT24, KRT25, KRT26, KRT27, TGM1, TGM3), light coat color (MLPH), and sebum secretion (MC5R) [81,82,99,103].”
  • The DMBT1 gene, associated with resistance to intestinal parasites, has undergone selection.

    “Regarding intestinal mucosal defense, the DMBT1 gene, associated with resistance to intestinal parasites, has also undergone selection [81].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Taye, M., Lee, W., Caetano-Anolles, K., Dessie, T., Cho, S., Jong Oh, S., Lee, H.-K., & Kim, H.
Affiliations
  • Seoul National University (KR)
  • Bahir Dar University (ET)
  • College of Agriculture and Environmental Sciences, Bahir Dar University
  • International Livestock Research Institute (KE)
  • C&K genomics
  • National Institute of Animal Science, RDA
  • Jeonbuk National University (KR)
Venue
Cogent Food & Agriculture
Published
2018-01
Volume
4
Issue
1
ISSN
2331-1932 (ISSN-L)
OpenAlex
W2903433977
Cited by
26
References
85
Citations by year
2026: 7 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 1
FWCI
1.07
Type
journal article
Language
en
Open access
Locations
  • Cogent Food & Agriculture (publishedVersion, cc-by)
  • CGSPace A Repository of Agricultural Research Outputs (Consultative Group for International Agricultural Research) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Institute of Animal Science
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Effects of Environmental Stressors on Livestock
  • Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Livestock Farming and Management
Keywords
Bos indicus, indigenous cattle breeds, genomic signatures of selection, disease resistance, parasite resistance, heat tolerance, cattle genomics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review