Cited by 68Genetic and phenotypic traits in livestockGenetic Mapping and Diversity in Plants and AnimalsLivestock Farming and Management

Signatures of positive selection in African Butana and Kenana dairy zebu cattle

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Bahbahani, Hussain, Salim, Bashir, Almathen, Faisal, Al Enezi, Fahad, Mwacharo, Joram M., Hanotte, Olivier·2018·PLOS ONE

Abstract

Butana and Kenana are two types of zebu cattle found in Sudan. They are unique amongst African indigenous zebu cattle because of their high milk production. Aiming to understand their genome structure, we genotyped 25 individuals from each breed using the Illumina BovineHD Genotyping BeadChip. Genetic structure analysis shows that both breeds have an admixed genome composed of an even proportion of indicine (0.75 ± 0.03 in Butana, 0.76 ± 0.006 in Kenana) and taurine (0.23 ± 0.009 in Butana, 0.24 ± 0.006 in Kenana) ancestries. We also observe a proportion of 0.02 to 0.12 of European taurine ancestry in ten individuals of Butana that were sampled from cattle herds in Tamboul area suggesting local crossbreeding with exotic breeds. Signatures of selection analyses (iHS and Rsb) reveal 87 and 61 candidate positive selection regions in Butana and Kenana, respectively. These regions span genes and quantitative trait loci (QTL) associated with biological pathways that are important for adaptation to marginal environments (e.g., immunity, reproduction and heat tolerance). Trypanotolerance QTL are intersecting candidate regions in Kenana cattle indicating selection pressure acting on them, which might be associated with an unexplored level of trypanotolerance in this cattle breed. Several dairy traits QTL are overlapping the identified candidate regions in these two zebu cattle breeds. Our findings underline the potential to improve dairy production in the semi-arid pastoral areas of Africa through breeding improvement strategy of indigenous local breeds.

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  • Rsb is a powerful method to detect selection signature when the selected allele has reached fixation.

    “in agreement with Rsb being a powerful method to detect selection signature when the selected allele has reached fixation (Tang et al., 2007; Oleksyk et al., 2010; Bahbahani et al., 2018).”

    From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Bahbahani et al., 2018

    The Methods section uses Rsb to detect signatures of positive selection, and the Discussion contrasts it with iHS, which the authors say is weak at detecting haplotypes approaching fixation. The paper does not establish that Rsb is powerful when a selected allele has reached fixation; it also notes that Rsb cannot detect selection when the same region is under selection in both populations compared. Page numbers are unavailable in our copy. (LLM, conf=0.84)

    Experimental — accuracy not yet measured
  • K=2 highlights best the ancient divergence between indicine and taurine cattle.

    “Consistent with the previous findings and the origins of the genetic backgrounds of the cattle breeds worldwide (Mbole-Kariuki et al., 2014; Bahbahani et al., 2018), K = 2 highlights best the ancient divergence between indicine and taurine cattle.”

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Research works printed but not linked: 2

  1. [10]Madani MAA. Animal Resources and Animal Production in Sudan. Sudan: University of Khartoum Press 1996.
  2. [65]Parsell DA, Lindquist S. In The Biology of Heat Schock Proteins and Molecular Chaperones: Cold Spring Harbor Laboratory Press; 1994.

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Authors
Bahbahani, H., Salim, B., Almathen, F., Al Enezi, F., Mwacharo, J. M., & Hanotte, O.
Affiliations
  • Kuwait University (KW)
  • University of Khartoum (SD)
  • King Faisal University (SA)
  • International Center for Agricultural Research in the Dry Areas (LB)
  • University of Nottingham (GB)
Corresponding author
Bahbahani, Hussain
Venue
PLOS ONE
Published
2018-01-04
Volume
13
Issue
1
Pages
e0190446
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2782475854
Cited by
67
References
74
Citations by year
2026: 3 · 2025: 9 · 2024: 6 · 2023: 4 · 2022: 11 · 2021: 10 · 2020: 5 · 2019: 12 · 2018: 7
FWCI
5.20
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • MELSpace (ICARDA (The International Center for Agricultural Research in Dry Areas)) (submittedVersion, cc-by)
  • RePEc: Research Papers in Economics (submittedVersion)
  • CGSPace A Repository of Agricultural Research Outputs (Consultative Group for International Agricultural Research) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Greater South Information System
Funders
  • University of Nottingham
  • Islamic Development Bank
  • Kuwait University (SRUL01/13)
  • Consortium of International Agricultural Research Centers
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
  • Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Livestock Farming and Management
Keywords
Bos indicus, positive selection, selection signatures, admixture, European admixture, trypanotolerance, dairy traits, milk production, heat tolerance, immune-related genes, indigenous cattle breeds
MeSH terms
Animals, Cattle, Dairying, Selection, Genetic, Sudan, Genome, Polymorphism, Single Nucleotide, Quantitative Trait Loci

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