Repeated assessment of the endogenous 24-hour profile of blood pressure under constant routine
Abstract
The impact of environmental and behavioral factors on the 24-h profile of blood pressure (BP) has been well established. Various attempts have been made to control these exogenous factors, in order to investigate a possible endogenous circadian variation of BP. Recently, we reported the results of the first environmentally and behaviorally controlled laboratory study with 24-h recordings of BP and heart rate (HR) during maintained wakefulness. In this constant-routine study, a pronounced endogenous circadian rhythm of HR was found, but circadian variation of BP was absent. This result suggested that the circadian rhythm of BP observed in earlier controlled studies, with sleep allowed, was evoked by the sleep-wake cycle as opposed to the endogenous circadian pacemaker. In order to verify our previous finding during maintained wakefulness, we repeated the experiment five times with six normotensive, healthy young subjects. Statistical analyses of the hourly measurements of BP and HR confirmed the replicable presence of an endogenous circadian rhythm of HR, as well as the consistent absence of an endogenous circadian variation of BP. Thus, this study provided additional evidence that the 24-h profile of BP--as observed under normal circumstances--is the sole result of environmental and behavioral factors such as the occurrence of sleep, and has no endogenous circadian component.
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Two studies using constant routine protocols found no evidence for an endogenous circadian rhythm in blood pressure.
“two studies using constant routine protocols found no evidence for an endogenous circadian rhythm in blood pressure”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Van Dongen et al., 2001
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- Authors
- Van Dongen, H. P. A., Maislin, G., & Kerkhof, G. A.
- Affiliations
- Leiden University (NL)
- ORCID
- Maislin, Greg
- Venue
- Chronobiology International
- Publisher
- Informa UK Limited
- Published
- 2001-01
- Volume
- 18
- Issue
- 1
- Pages
- 85-98
- ISSN
- 0742-0528 (ISSN-L)
- 1525-6073
- OpenAlex
- W2134427402
- Cited by
- 65
- References
- 33
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 3 · 2014: 1 · 2013: 4 · 2012: 7
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chronobiology International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- National Institute of Nursing Research (NR04281-05, R01NR004281)
- Army Research Office
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- circadian blood pressure rhythm, 24-hour blood pressure profile, constant routine, sleep-wake cycle, normotensive young adults
- MeSH terms
- Adolescent, Adult, Biometry, Blood Pressure, Circadian Rhythm, Heart Rate, Humans, Male, Sleep
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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