Cited by 65Circadian rhythm and melatoninBlood Pressure and Hypertension StudiesHeart Rate Variability and Autonomic Control

Repeated assessment of the endogenous 24-hour profile of blood pressure under constant routine

Van Dongen, Hans P.A., Maislin, Greg, Kerkhof, Gerard A.·2001·Chronobiology International

Abstract

The impact of environmental and behavioral factors on the 24-h profile of blood pressure (BP) has been well established. Various attempts have been made to control these exogenous factors, in order to investigate a possible endogenous circadian variation of BP. Recently, we reported the results of the first environmentally and behaviorally controlled laboratory study with 24-h recordings of BP and heart rate (HR) during maintained wakefulness. In this constant-routine study, a pronounced endogenous circadian rhythm of HR was found, but circadian variation of BP was absent. This result suggested that the circadian rhythm of BP observed in earlier controlled studies, with sleep allowed, was evoked by the sleep-wake cycle as opposed to the endogenous circadian pacemaker. In order to verify our previous finding during maintained wakefulness, we repeated the experiment five times with six normotensive, healthy young subjects. Statistical analyses of the hourly measurements of BP and HR confirmed the replicable presence of an endogenous circadian rhythm of HR, as well as the consistent absence of an endogenous circadian variation of BP. Thus, this study provided additional evidence that the 24-h profile of BP--as observed under normal circumstances--is the sole result of environmental and behavioral factors such as the occurrence of sleep, and has no endogenous circadian component.

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Crossref · 10.1081/cbi-100001178

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Authors
Van Dongen, H. P. A., Maislin, G., & Kerkhof, G. A.
Affiliations
Leiden University (NL)
Venue
Chronobiology International
Published
2001-01
Volume
18
Issue
1
Pages
85-98
ISSN
  • 0742-0528 (ISSN-L)
  • 1525-6073
OpenAlex
W2134427402
Cited by
65
References
33
Citations by year
2025: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 3 · 2014: 1 · 2013: 4 · 2012: 7
FWCI
1.88
Type
journal article
Language
en
Open access
closed
Locations
  • Chronobiology International (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek
  • National Institute of Nursing Research (NR04281-05, R01NR004281)
  • Army Research Office
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
circadian blood pressure rhythm, 24-hour blood pressure profile, constant routine, sleep-wake cycle, normotensive young adults
MeSH terms
Adolescent, Adult, Biometry, Blood Pressure, Circadian Rhythm, Heart Rate, Humans, Male, Sleep

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