The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Postnatal NG2 proteoglycan–expressing progenitor cells are intrinsically multipotent and generate functional neurons
Open accessAbstract
Neurogenesis is known to persist in the adult mammalian central nervous system (CNS). The identity of the cells that generate new neurons in the postnatal CNS has become a crucial but elusive issue. Using a transgenic mouse, we show that NG2 proteoglycan–positive progenitor cells that express the 2′,3′-cyclic nucleotide 3′-phosphodiesterase gene display a multipotent phenotype in vitro and generate electrically excitable neurons, as well as astrocytes and oligodendrocytes. The fast kinetics and the high rate of multipotent fate of these NG2+ progenitors in vitro reflect an intrinsic property, rather than reprogramming. We demonstrate in the hippocampus in vivo that a sizeable fraction of postnatal NG2+ progenitor cells are proliferative precursors whose progeny appears to differentiate into GABAergic neurons capable of propagating action potentials and displaying functional synaptic inputs. These data show that at least a subpopulation of postnatal NG2-expressing cells are CNS multipotent precursors that may underlie adult hippocampal neurogenesis.
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Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
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Functional neurogenesis in the adult hippocampus
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Metadata
- Authors
- Belachew, S., Chittajallu, R., Aguirre, A. A., Yuan, X., Kirby, M., Anderson, S., & Gallo, V.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2003-04-07
- Volume
- 161
- Issue
- 1
- Pages
- 169-186
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1977732674
- Cited by
- 488
- References
- 48
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Belachew, S., Chittajallu, R., Aguirre, A. A., Yuan, X., Kirby, M., Anderson, S., & Gallo, V. (2003). Postnatal NG2 proteoglycan–expressing progenitor cells are intrinsically multipotent and generate functional neurons. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200210110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
