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Cited by 270

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/β-catenin activity

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Westfall, Trudi A., Brimeyer, Ryan, Twedt, Jen, Gladon, Jean, Olberding, Andrea, Furutani-Seiki, Makoto, Slusarski, Diane C.·2003·The Journal of Cell Biology
DOI 10.1083/jcb.200303107
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Abstract

We provide genetic evidence defining a role for noncanonical Wnt function in vertebrate axis formation. In zebrafish, misexpression of Wnt-4, -5, and -11 stimulates calcium (Ca2+) release, defining the Wnt/Ca2+ class. We describe genetic interaction between two Wnt/Ca2+ members, Wnt-5 (pipetail) and Wnt-11 (silberblick), and a reduction of Ca2+ release in Wnt-5/pipetail. Embryos genetically depleted of both maternal and zygotic Wnt-5 product exhibit cell movement defects as well as hyperdorsalization and axis-duplication phenotypes. The dorsalized phenotypes result from increased β-catenin accumulation and activation of downstream genes. The Wnt-5 loss-of-function defect is consistent with Ca2+ modulation having an antagonistic interaction with Wnt/β-catenin signaling.

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Metadata

Authors
Westfall, T. A., Brimeyer, R., Twedt, J., Gladon, J., Olberding, A., Furutani-Seiki, M., & Slusarski, D. C.
Venue
The Journal of Cell Biology
Publisher
Rockefeller University Press
Published
2003-09-01
Volume
162
Issue
5
Pages
889-898
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.200303107
OpenAlex
W2140328069
Cited by
270
References
8
FWCI
5.47
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/β-catenin activity. https://app.cochat.ai/papers/10.1083/jcb.200303107
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Westfall, T. A., Brimeyer, R., Twedt, J., Gladon, J., Olberding, A., Furutani-Seiki, M., & Slusarski, D. C. (2003). Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/β-catenin activity. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200303107

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