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RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway

Zhang, Donglei, Isack, Nora R., Glodowski, Doreen R., Liu, Jie, Chen, Carlos Chih-Hsiung, Xu, X.Z. Shawn, Grant, Barth D., Rongo, Christopher·2012·Journal of Cell Biology
DOI 10.1083/jcb.201104141PMC PMC3255976
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Abstract

Regulated membrane trafficking of AMPA-type glutamate receptors (AMPARs) is a key mechanism underlying synaptic plasticity, yet the pathways used by AMPARs are not well understood. In this paper, we show that the AMPAR subunit GLR-1 in Caenorhabditis elegans utilizes the retrograde transport pathway to regulate AMPAR synaptic abundance. Mutants for rab-6.2, the retromer genes vps-35 and snx-1, and rme-8 failed to recycle GLR-1 receptors, resulting in GLR-1 turnover and behavioral defects indicative of diminished GLR-1 function. In contrast, expression of constitutively active RAB-6.2 drove the retrograde transport of GLR-1 from dendrites back to cell body Golgi. We also find that activated RAB-6.2 bound to and colocalized with the PDZ/phosphotyrosine binding domain protein LIN-10. RAB-6.2 recruited LIN-10. Moreover, the regulation of GLR-1 transport by RAB-6.2 required LIN-10 activity. Our results demonstrate a novel role for RAB-6.2, its effector LIN-10, and the retromer complex in maintaining synaptic strength by recycling AMPARs along the retrograde transport pathway.

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  • VPS35 suppression decreased surface levels of GLUT1/SLC2A1, AMPA receptors GRIA2, GRIA3, GRIA4, NMDA receptors GRIN1, GRIN2b, and SLC4A7.

    “Validating our approach, downregulated proteins included the wellestablished Retromer cargo glucose transporter-1 (GLUT1/SLC2A1) [29], the ionotropic glutamate AMPA receptors (GRIA2, GRIA3, GRIA4) and NMDA receptors (GRIN1, GRIN2b) [80][81][82][83][84][85], as well as many other previously identified proteins including the sodium bicarbonate cotransporter-3 (SLC4A7) (Figure 1D, Supplementary Table”

    From Global identification of neuronal and astrocytic integral membrane proteins that require Retromer for their endosomal recycling (2026) · cites this paper as [85]

    The Results section, “The retromer regulates GLR-1 recycling” (page unavailable), reports that vps-35 mutants had fewer and less intense GLR-1 puncta, supporting a retromer-dependent effect on a C. elegans AMPA-type receptor. It does not establish decreased surface levels of the named GRIA or GRIN subunits, GLUT1/SLC2A1, or SLC4A7. In the citing sentence, this source is cited alongside other papers for the glutamate-receptor portion, not specifically for GLUT1. (LLM, conf=0.88)

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Metadata

Authors
Zhang, D., Isack, N. R., Glodowski, D. R., Liu, J., Chen, C. C.-H., Xu, X. Z. S., Grant, B. D., & Rongo, C.
Venue
Journal of Cell Biology
Publisher
Rockefeller University Press
Published
2012-01-02
Volume
196
Issue
1
Pages
85-101
ISSN
  • 1540-8140
  • 0021-9525
DOI
10.1083/jcb.201104141
PMC
PMC3255976
Cited by
66
References
4
Language
en

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