Tumor-Produced Interleukin-8 Attracts Human Myeloid-Derived Suppressor Cells and Elicits Extrusion of Neutrophil Extracellular Traps (NETs)
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Abstract
Purpose: Myeloid-derived suppressor cells (MDSC) are considered an important T-cell immunosuppressive component in cancer-bearing hosts. The factors that attract these cells to the tumor microenvironment are poorly understood. IL8 (CXCL8) is a potent chemotactic factor for neutrophils and monocytes. Experimental Design: MDSC were characterized and sorted by multicolor flow cytometry on ficoll-gradient isolated blood leucokytes from healthy volunteers (n = 10) and advanced cancer patients (n = 28). In chemotaxis assays, sorted granulocytic and monocytic MDSC were tested in response to recombinant IL8, IL8 derived from cancer cell lines, and patient sera. Neutrophil extracellular traps (NETs) formation was assessed by confocal microscopy, fluorimetry, and time-lapse fluorescence confocal microscopy on short-term MDSC cultures. Results: IL8 chemoattracts both granulocytic (GrMDSC) and monocytic (MoMDSC) human MDSC. Monocytic but not granulocytic MDSC exerted a suppressor activity on the proliferation of autologous T cells isolated from the circulation of cancer patients. IL8 did not modify the T-cell suppressor activity of human MDSC. However, IL8 induced the formation of NETs in the GrMDSC subset. Conclusions: IL8 derived from tumors contributes to the chemotactic recruitment of MDSC and to their functional control. Clin Cancer Res; 22(15); 3924–36. ©2016 AACR.
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These cytokines could enhance migration of macrophages and MDSCs to the liver.
“These cytokines could enhance migration of macrophages and MDSCs to the liver [64, 65] (Fig. 2).”
From Gut microbiota-mediated immunomodulation in tumor (2021) · cites this paper as [65]
Cites
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268 · see citing works
Alternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197 · see citing works
Tumor-Associated Macrophages: From Mechanisms to Therapy
Noy, R., & Pollard, J. W. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.010 · Cited by 4,089 · see citing works
Coordinated regulation of myeloid cells by tumours
Gabrilovich, D. I., Ostrand-Rosenberg, S., & Bronte, V. (2012) · Nature Reviews Immunology · doi:10.1038/nri3175 · Cited by 3,544 · see citing works
The prognostic landscape of genes and infiltrating immune cells across human cancers
Gentles, A. J., Newman, A. M., Liu, C. L., Bratman, S. V., Feng, W., Kim, D., Nair, V. S., Xu, Y., Khuong, A., Hoang, C. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3909 · Cited by 3,097 · see citing works
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Clark, S. R., Ma, A. C., Tavener, S. A., McDonald, B., Goodarzi, Z., Kelly, M. M., Patel, K. D., Chakrabarti, S., McAvoy, E., Sinclair, G. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1565 · Cited by 2,309 · see citing works
The Interleukin-8 Pathway in Cancer
Waugh, D. J. J., & Wilson, C. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4843 · Cited by 2,103 · see citing works
Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.
Baggiolini, M., Walz, A., & Kunkel, S. L. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114265 · Cited by 1,994 · see citing works
Urban, C. F., Ermert, D., Schmid, M., Abed, U. A., Goosmann, C., Nacken, W. K. F., Brinkmann, V., Jungblut, P. R., & Zychlinsky, A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000639 · Cited by 1,677 · see citing works
Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis
Cools-Lartigue, J., Spicer, J., McDonald, B., Gowing, S., Chow, S., Giannias, B., Bourdeau, F., Kubes, P., & Ferri, L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67484 · Cited by 1,395 · see citing works
Pilsczek, F. H., Salina, D., Poon, K. K. H., Fahey, C., Yipp, B. G., Sibley, C. D., Robbins, S. M., Green, F. H. Y., Surette, M. G., Sugai, M., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000675 · Cited by 1,114 · see citing works
Neutrophil extracellular traps: Is immunity the second function of chromatin?
Brinkmann, V., & Zychlinsky, A. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201203170 · Cited by 1,021 · see citing works
Nauseef, W. M., & Borregaard, N. (2014) · Nature Immunology · doi:10.1038/ni.2921 · Cited by 893 · see citing works
Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
Gallina, G., Dolcetti, L., Serafini, P., Santo, C. D., Marigo, I., Colombo, M. P., Basso, G., Brombacher, F., Borrello, I., Zanovello, P., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28828 · Cited by 792 · see citing works
Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy
Highfill, S. L., Cui, Y., Giles, A. J., Smith, J. P., Zhang, H., Morse, E., Kaplan, R. N., & Mackall, C. L. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007974 · Cited by 767 · cited 1× · see citing works
“However, our results further argue in favor of the convenience of pharmacologically inhibiting IL-8 as previously carried out in xenografted mouse models and currently in clinical trials with neutralizing antibodies (51) and small drug inhibitors (52).”
ResultInterleukin-8 and human cancer biology
Xie, K. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(01)00016-8 · Cited by 690 · see citing works
Regulation of Tumor Metastasis by Myeloid-Derived Suppressor Cells
Condamine, T., Ramachandran, I., Youn, J., & Gabrilovich, D. I. (2014) · Annual Review of Medicine · doi:10.1146/annurev-med-051013-052304 · Cited by 521 · see citing works
IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice
Bronte, V., Serafini, P., Santo, C. D., Marigo, I., Tosello, V., Mazzoni, A., Segal, D. M., Staib, C., Löwel, M., Sutter, G., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.270 · Cited by 513 · see citing works
Walz, A., Peveri, P., Aschauer, H., & Baggiolini, M. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90432-3 · Cited by 506 · see citing works
Sangaletti, S., Tripodo, C., Chiodoni, C., Guarnotta, C., Cappetti, B., Casalini, P., Piconese, S., Parenza, M., Guiducci, C., Vitali, C., et al. (2012) · Blood · doi:10.1182/blood-2012-03-416156 · Cited by 398 · see citing works
Yalavarthi, S., Gould, T. J., Rao, A. N., Mazza, L. F., Morris, A. E., Núñez‐Álvarez, C. A., Hernández‐Ramírez, D. F., Bockenstedt, P. L., Liaw, P. C., Cabral, A. R., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39247 · Cited by 392 · see citing works
Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer
Di Mitri, D., Toso, A., Chen, J. J., Sarti, M., Pinton, S., Jost, T. R., D’Antuono, R., Montani, E., Garcia-Escudero, R., Guccini, I., et al. (2014) · Nature · doi:10.1038/nature13638 · Cited by 388 · see citing works
Lesokhin, A. M., Hohl, T. M., Kitano, S., Cortez, C. A., Hirschhorn-Cymerman, D., Avogadri, F., Rizzuto, G. A., Lazarus, J. J., Pamer, E. G., Houghton, A. N., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1792 · Cited by 380 · see citing works
Derangement of immune responses by myeloid suppressor cells
Serafini, P., Santo, C. D., Marigo, I., Cingarlini, S., Dolcetti, L., Gallina, G., Zanovello, P., & Bronte, V. (2003) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-003-0443-2 · Cited by 335 · see citing works
Pak, A. S., Wright, M. A., Matthews, J. P., Collins, S. L., Petruzzelli, G. J., & Young, M. R. I. (1995) · PubMed · Cited by 271 · see citing works
Kalathil, S. G., Lugade, A. A., Miller, A., Iyer, R. V., & Thanavala, Y. M. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3381 · Cited by 269 · see citing works
Weide, B., Martens, A., Zelba, H., Stutz, C., Derhovanessian, E., Giacomo, A. M. D., Maio, M., Sucker, A., Schilling, B., Schadendorf, D., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2508 · Cited by 261 · see citing works
Sanmamed, M. F., Carranza-Rua, O., Alfaro, C., Oñate, C., Martín‐Algarra, S., Pérez, G., Landazuri, S. F., González, Á., Groß, S., Rodríguez, I., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3203 · Cited by 256 · see citing works
Self-citationThe role of interleukin-8 in cancer cells and microenvironment interaction
Yuan, A. (2005) · Frontiers in bioscience · doi:10.2741/1579 · Cited by 253 · see citing works
Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells
Singh, J. K., Simões, B. M., Howell, S. J., Farnie, G., & Clarke, R. B. (2013) · Breast Cancer Research · doi:10.1186/bcr3436 · Cited by 250 · see citing works
Myeloid-Derived Suppressor Cells in Human Cancer
Nagaraj, S., & Gabrilovich, D. I. (2010) · The Cancer Journal · doi:10.1097/ppo.0b013e3181eb3358 · Cited by 222 · see citing works
Bizzarri, C., Beccari, A. R., Bertini, R., Cavicchia, M. R., Giorgini, S., & Allegretti, M. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.04.002 · Cited by 206 · see citing works
Self-citationTherapeutic targeting of myeloid-derived suppressor cells
Ugel, S., Delpozzo, F., Desantis, G., Papalini, F., Simonato, F., Sonda, N., Zilio, S., & Bronte, V. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.06.014 · Cited by 206 · see citing works
Cancer‐promoting tumor‐associated macrophages: New vistas and open questions
Mantovani, A., Germano, G., Marchesi, F., Locatelli, M., & Biswas, S. K. (2011) · European Journal of Immunology · doi:10.1002/eji.201141894 · Cited by 205 · see citing works
Murine CXCR1 Is a Functional Receptor for GCP-2/CXCL6 and Interleukin-8/CXCL8
Fan, X., Patera, A. C., Pong-Kennedy, A., Deno, G., Gonsiorek, W., Manfra, D. J., Vassileva, G., Zeng, M., Jackson, C., Sullivan, L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607705200 · Cited by 204 · see citing works
Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samples
Kotsakis, A. P., Harasymczuk, M., Schilling, B., Georgoulias, V., Argiris, A. E., & Whiteside, T. L. (2012) · Journal of Immunological Methods · doi:10.1016/j.jim.2012.04.004 · Cited by 199 · see citing works
Glioblastoma Stem Cells Are Regulated by Interleukin-8 Signaling in a Tumoral Perivascular Niche
Infanger, D. W., Cho, Y., Lopez, B. S., Mohanan, S., Liu, S. C., Gursel, D. B., Boockvar, J. A., & Fischbach, C. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1355 · Cited by 184 · see citing works
On the armament and appearances of human myeloid-derived suppressor cells
Poschke, I. C., & Kiessling, R. W. (2012) · Clinical Immunology · doi:10.1016/j.clim.2012.06.003 · Cited by 176 · see citing works
Tanaka, K., Koike, Y., Shimura, T., Okigami, M., Ide, S., Toiyama, Y., Okugawa, Y., Inoue, Y., Araki, T., Uchida, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111888 · Cited by 156 · see citing works
CXCR1/2 inhibition enhances pancreatic islet survival after transplantation.
Citro, A., Cantarelli, E., Maffi, P., Nano, R., Melzi, R., Mercalli, A., Dugnani, E., Sordi, V., Magistretti, P., Daffonchio, L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63089 · Cited by 151 · see citing works
Self-citationRole of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis
Ferrara, N. (2010) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3283386660 · Cited by 139 · see citing works
Kitano, S., Postow, M. A., Ziegler, C. G. K., Kuk, D., Panageas, K. S., Cortez, C. A., Rasalan, T. S., Adamow, M. J., Yuan, J. D., Wong, P., et al. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0013 · Cited by 130 · see citing works
Dendritic cells delivered inside human carcinomas are sequestered by interleukin‐8
Feijoó, E., Alfaro, C., Mazzolini, G. D., Serra, P., Peñuelas, I., Arina, A., Huarte, E., Tirapu, I., Palencia, B., Murillo, O., et al. (2005) · International Journal of Cancer · doi:10.1002/ijc.21046 · Cited by 119 · see citing works
Self-citationBerraondo, P., Nouzé, C., Préville, X., Ladant, D., & Leclerc, C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0321 · Cited by 108 · see citing works
Self-citationCXCR1/2 Inhibition Blocks and Reverses Type 1 Diabetes in Mice
Citro, A., Valle, A., Cantarelli, E., Mercalli, A., Pellegrini, S., Liberati, D., Daffonchio, L., Kastsiuchenka, O., Ruffini, P. A., Battaglia, M., et al. (2014) · Diabetes · doi:10.2337/db14-0443 · Cited by 90 · see citing works
Self-citationBoppana, N. B., Devarajan, A., Gopal, K., Barathan, M., AbuBakar, S., Shankar, E. M., Ebrahim, A. S., & Farooq, S. M. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370213520110 · Cited by 57 · see citing works
Myeloid-derived suppressor cell impact on endogenous and adoptively transferred T cells
Arina, A., & Bronte, V. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.02.006 · Cited by 53 · see citing works
Antitumor Immunotherapeutic and Toxic Properties of an HDL-Conjugated Chimeric IL-15 Fusion Protein
Ochoa, M. C., Fioravanti, J., Rodríguez, I., Hervás‐Stubbs, S., Azpilikueta, A., Mazzolini, G. D., Gúrpide, A., Prìeto, J., Pardo, J., Berraondo, P., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2660 · Cited by 48 · see citing works
Self-citationAlfaro, C., Suárez, N., Martínez‐Forero, I., Palazón, A., Rouzaut, A., Solano, S., Feijoó, E., Gúrpide, A., Bolaños, E., Erro, L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017922 · Cited by 43 · see citing works
Self-citationMyeloid-derived suppressor cells and their role in CTLA-4 blockade therapy
de Coaña, Y. P., Masucci, G. V., Hansson, J., & Kiessling, R. W. (2014) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-014-1570-7 · Cited by 36 · see citing works
Kotyza, J. (2012) · The International Journal of Biological Markers · doi:10.5301/jbm.2012.9261 · Cited by 27 · see citing works
Ochoa, M. C., Fioravanti, J., Duitman, E. H., Medina‐Echeverz, J., Palazón, A., Arina, A., Dubrot, J., Alfaro, C., Morales‐Kastresana, A., Murillo, O., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052370 · Cited by 18 · see citing works
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1 of the 53 references couldn’t be matched to a known paper.
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Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression
Groth, C., Hu, X., Weber, R., Fleming, V., Altevogt, P., Utikal, J. S., & Umansky, V. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0333-1 · Cited by 846 · see citing works
Teijeira, Á., Garasa, S., Gato, M., Alfaro, C., Miguéliz, I., Cirella, A., de Andrea, C., Ochoa, M. C., Otano, I., Etxeberría, I., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.03.001 · Cited by 799 · see citing works
Self-citationThe CXCL8-CXCR1/2 pathways in cancer
Liu, Q., Li, A., Tian, Y., Wu, J. D., Liu, Y., Li, T., Chen, Y., Han, X., & Wu, K. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.08.002 · Cited by 666 · see citing works
Ponziani, F. R., Bhoori, S., Castelli, C., Putignani, L., Rivoltini, L., CHIERICO, F. D., Sanguinetti, M., Morelli, D., Sterbini, F. P., Petito, V., et al. (2018) · Hepatology · doi:10.1002/hep.30036 · Cited by 670 · see citing works
Macrophage-Based Approaches for Cancer Immunotherapy
Anderson, N. R., Minutolo, N. G., Gill, S., & Klichinsky, M. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-2990 · Cited by 698 · see citing works
A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics
Mutua, V. N., & Gershwin, L. J. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08804-7 · Cited by 647 · see citing works
Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review
Lee, K. H., Kronbichler, A., Park, D. D.-Y., Park, Y. M., Moon, H., Kim, H., Choi, J. H., Choi, Y., Shim, S., Lyu, I. S., et al. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.09.012 · Cited by 626 · see citing works
Circulating and disseminated tumour cells — mechanisms of immune surveillance and escape
Mohme, M., Riethdorf, S., & Pantel, K. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.144 · Cited by 603 · see citing works
The hallmarks of cancer immune evasion
Galassi, C., Chan, T. A.-T., Vitale, I., & Galluzzi, L. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.09.010 · Cited by 595 · see citing works
Neutrophil extracellular traps in homeostasis and disease
Wang, H., Kim, S. J., Yu, L., Wang, S., Wang, H., Huang, H., Zhang, H., & Tsung, A. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01933-x · Cited by 579 · see citing works
Schalper, K. A., Carleton, M. O., Zhou, M., Chen, T., Feng, Y., Huang, S., Walsh, A. M., Baxi, V. A., Pandya, D., Baradet, T. C., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0856-x · Cited by 550 · see citing works
Self-citationSanmamed, M. F., Perez‐Gracia, J. L., Schalper, K. A., Fusco, J. P., González, Á., Rodriguez-Ruiz, M. E., Oñate, C., Perez, G., Alfaro, C., Martín‐Algarra, S., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx190 · Cited by 458 · see citing works
Self-citationBoeltz, S., Amini, P., Anders, H., Andrade, F., Bilyy, R. O., Chatfield, S. M., Cichoń, I., Clancy, D. M., Desai, J., Dumych, T. I., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-018-0261-x · Cited by 439 · see citing works
High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade
Yuen, K. C. Y., Liu, L.-F., Gupta, V., Madireddi, S., Keerthivasan, S., Li, C., Rishipathak, D., Williams, P. T., Kadel, E. E., Koeppen, H., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0860-1 · Cited by 433 · see citing works
Neutrophil Extracellular Traps
Thålin, C., Hisada, Y., Lundström, S., Mackman, N., & Wallén, H. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312463 · Cited by 408 · see citing works
The IL-8/IL-8R Axis: A Double Agent in Tumor Immune Resistance
David, J. M., Dominguez, C. L., Hamilton, D. H., & Palena, C. (2016) · Vaccines · doi:10.3390/vaccines4030022 · Cited by 397 · see citing works
CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
Jin, L., Tao, H., Karachi, A., Long, Y., Hou, A. Y., Meng, N., Dyson, K. A., Grippin, A., Deleyrolle, L. P., Zhang, W., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11869-4 · Cited by 388 · see citing works
Interleukin-8 in cancer pathogenesis, treatment and follow-up
Alfaro, C., Sanmamed, M. F., Rodriguez-Ruiz, M. E., Teijeira, Á., Oñate, C., González, Á., Ponz‐Sarvisé, M., Schalper, K. A., Perez‐Gracia, J. L., & Melero, I. (2017) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2017.08.004 · Cited by 373 · see citing works
Self-citationFousek, K., Horn, L. A., & Palena, C. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107692 · Cited by 361 · see citing works
Neutrophil phenotypes and functions in cancer: A consensus statement
Quail, D. F., Amulic, B., Aziz, M., Barnes, B. J., Eruslanov, E. B., Fridlender, Z. G., Goodridge, H. S., Granot, Z., Hidalgo, A., Huttenlocher, A., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220011 · Cited by 336 · see citing works
Taki, M., Abiko, K., Baba, T., Hamanishi, J., Yamaguchi, K. D., Murakami, R., Yamanoi, K., Horikawa, N., Hosoe, Y., Nakamura, E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03966-7 · Cited by 296 · see citing works
MDSCs: Key Criminals of Tumor Pre-metastatic Niche Formation
Wang, Y., Ding, Y., Guo, N., & Wang, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00172 · Cited by 282 · see citing works
Human neutrophils in the saga of cellular heterogeneity: insights and open questions
Scapini, P., Marini, O., Tecchio, C., & Cassatella, M. A. (2016) · Immunological Reviews · doi:10.1111/imr.12448 · Cited by 275 · see citing works
IL8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy
Teijeira, Á., Garasa, S., Ochoa, M. C., Villalba-Esparza, M., Olivera, I., Cirella, A., Eguren‐Santamaría, I., Berraondo, P., Schalper, K. A., de Andrea, C. E., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1319 · Cited by 270 · see citing works
Self-citationNeutrophil Extracellular Traps (NETs) in Cancer Invasion, Evasion and Metastasis
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The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape
de Jong, M. M. E., Kellermayer, Z., Papazian, N., Tahri, S., Hofste op Bruinink, D., Hoogenboezem, R., Sanders, M. A., van de Woestijne, P. C., Bos, P. K., Khandanpour, C., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00931-3 · Cited by 250 · see citing works
Chao, T., Furth, E. E., & Vonderheide, R. H. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0188 · Cited by 248 · see citing works
Neutrophil extracellular traps in cancer
Cristinziano, L., Modestino, L., Antonelli, A., Marone, G., Simon, H., Varricchi, G., & Galdiero, M. R. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.07.011 · Cited by 247 · see citing works
How to turn up the heat on the cold immune microenvironment of metastatic prostate cancer
Stultz, J., & Fong, L. (2021) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-021-00340-5 · Cited by 242 · see citing works
Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer
Thålin, C., Lundström, S., Seignez, C., Daleskog, M., Lundström, A., Henriksson, P., Helleday, T., Phillipson, M., Wallén, H., & Demers, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191231 · Cited by 228 · see citing works
Neutrophil extracellular traps in the pathology of cancer and other inflammatory diseases
Herre, M., Cedervall, J., Mackman, N., & Olsson, A. (2022) · Physiological Reviews · doi:10.1152/physrev.00062.2021 · Cited by 232 · see citing works
Exploiting innate immunity for cancer immunotherapy
Yi, M., Li, T., Niu, M., Mei, Q., Zhao, B., Chu, Q., Dai, Z., & Wu, K. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01885-w · Cited by 236 · see citing works
Li, B., Garstka, M. A., & Li, Z. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.11.014 · Cited by 220 · see citing works
Bruno, A., Mortara, L., Baci, D., Noonan, D. M., & Albini, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00771 · Cited by 216 · see citing works
In vitro induction of NETosis: Comprehensive live imaging comparison and systematic review
Hoppenbrouwers, T., Autar, A. S. A., Sultan, A. R., Abraham, T. E., van Cappellen, W. A., Houtsmuller, A. B., van Wamel, W. J. B., van Beusekom, H. M. M., van Neck, J. W., & de Maat, M. P. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176472 · Cited by 206 · see citing works
The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment
Susek, K. H., Karvouni, M., Alici, E., & Lundqvist, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02159 · Cited by 212 · see citing works
Human Tumor-Infiltrating Myeloid Cells: Phenotypic and Functional Diversity
Elliott, L., Doherty, G. A., Sheahan, K. D., & Ryan, E. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00086 · Cited by 208 · see citing works
Lin, X., Wang, S., Sun, M., Zhang, C., Chen, W., Yang, C., Dou, R., Liu, Q., & Xiong, B. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0708-7 · Cited by 208 · see citing works
RetractedTreffers, L. W., Hiemstra, I. H., Kuijpers, T. W., van den Berg, T. K., & Matlung, H. L. (2016) · Immunological Reviews · doi:10.1111/imr.12444 · Cited by 204 · see citing works
Neutrophil extracellular traps: protagonists of cancer progression?
Erpenbeck, L., & Schön, M. P. (2017) · Oncogene · doi:10.1038/onc.2016.406 · Cited by 199 · see citing works
CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy
Huseni, M. A., Wang, L., Klementowicz, J. E., Yuen, K. C. Y., Bréart, B., Orr, C., Liu, L.-F., Li, Y., Gupta, V., Li, C., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100878 · Cited by 192 · see citing works
Snoderly, H. T., Boone, B. A., & Bennewitz, M. F. (2019) · Breast Cancer Research · doi:10.1186/s13058-019-1237-6 · Cited by 192 · see citing works
Cicco, S., Cicco, G., Racanelli, V., & Vacca, A. (2020) · Mediators of Inflammation · doi:10.1155/2020/7527953 · Cited by 190 · see citing works
Hyperprogressive disease during PD-1 blockade in patients with advanced hepatocellular carcinoma
Kim, C. G., Kim, C., Yoon, S. E., Kim, K. H., Choi, S. J., Kang, B., Kim, H. R., Park, S., Shin, E., Kim, Y., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.08.010 · Cited by 186 · see citing works
Neutrophils in the tumor microenvironment: trying to heal the wound that cannot heal
Singel, K. L., & Segal, B. H. (2016) · Immunological Reviews · doi:10.1111/imr.12459 · Cited by 182 · see citing works
Circulating tumor cell-blood cell crosstalk: Biology and clinical relevance
Pereira‐Veiga, T., Schneegans, S., Pantel, K., & Wikman, H. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111298 · Cited by 179 · see citing works
Hwang, W., Lan, H., Cheng, W., Huang, S., & Yang, M. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0699-4 · Cited by 175 · see citing works
Dominguez, C. L., McCampbell, K. K., David, J. M., & Palena, C. (2017) · JCI Insight · doi:10.1172/jci.insight.94296 · Cited by 167 · see citing works
Epithelial-mesenchymal transition and inflammation at the site of the primary tumor
Dominguez, C. L., David, J. M., & Palena, C. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.08.002 · Cited by 160 · see citing works
Higashino, N., Koma, Y., Hosono, M., Takase, N., Okamoto, M., Kodaira, H., Nishio, M., Shigeoka, M., Kakeji, Y., & Yokozaki, H. (2019) · Laboratory Investigation · doi:10.1038/s41374-018-0185-6 · Cited by 158 · see citing works
Utilizing chemokines in cancer immunotherapy
Märkl, F., Huynh, D., Endres, S., & Kobold, S. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.04.001 · Cited by 157 · see citing works
Veatch, J. R., Lee, S. M., Shasha, C., Singhi, N., Szeto, J. L., Moshiri, A. S., Kim, T. S., Smythe, K. S., Kong, P., Fitzgibbon, M., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.03.006 · Cited by 153 · see citing works
The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases
Bonaventura, A., Liberale, L., Carbone, F., Vecchié, A., Díaz-Cañestro, C., Camici, G. G., Montecucco, F., & Dallegri, F. (2018) · Thrombosis and Haemostasis · doi:10.1160/th17-09-0630 · Cited by 154 · see citing works
Mi, Y., Guo, N., Luan, J., Cheng, J., Hu, Z., Jiang, P., Jin, W., & Gao, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00737 · Cited by 150 · see citing works
Neutrophil elastase in the tumor microenvironment
Lerman, I., & Hammes, S. R. (2017) · Steroids · doi:10.1016/j.steroids.2017.11.006 · Cited by 149 · see citing works
Neutralizing IL-8 potentiates immune checkpoint blockade efficacy for glioma
Liu, H., Zhao, Q., Tan, L., Wu, X., Huang, R., Zuo, Y., Chen, L., Yang, J.-G., Zhang, Z., Ruan, W., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.03.004 · Cited by 148 · see citing works
Cytokine and Chemokine Signals of T‐Cell Exclusion in Tumors
Zhang, Y., Guan, X.-Y., & Jiang, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594609 · Cited by 133 · see citing works
Allogeneic CAR T Cells: An Alternative to Overcome Challenges of CAR T Cell Therapy in Glioblastoma
Bedoya, D. M., Dutoit, V., & Migliorini, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.640082 · Cited by 147 · see citing works
Yang, L., Liu, L., Zhang, R., Hong, J., Wang, Y.-P., Wang, J., Zuo, J., Zhang, J., Chen, J., & Hao, H. (2020) · Journal of Cancer · doi:10.7150/jca.44215 · Cited by 150 · see citing works
Tobin, R. P., Jordan, K. R., Kapoor, P., Spongberg, E., Davis, D. M., Vorwald, V. M., Couts, K. L., Gao, D., Smith, D. E., Borgers, J. S. W., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01223 · Cited by 144 · see citing works
Castration-mediated IL-8 promotes myeloid infiltration and prostate cancer progression
Bujanda, Z. A. L., Haffner, M. C., Chaimowitz, M. G., Chowdhury, N., Venturini, N. J., Patel, R. A., Obradović, A., Hansen, C. S., Jackow, J., Maynard, J. P., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00227-3 · Cited by 141 · see citing works
Hahn, J., Schauer, C., Czegley, C., Kling, L., Hasíková, L., Schmid, B., Weidner, D., Reinwald, C., Biermann, M. H. C., Blunder, S., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800752r · Cited by 137 · see citing works
Cell‐Based Delivery Systems: Emerging Carriers for Immunotherapy
Li, Z., Wang, Y., Ding, Y., Repp, L., Kwon, G. S., & Hu, Q. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202100088 · Cited by 137 · see citing works
Roles of the CXCL8-CXCR1/2 Axis in the Tumor Microenvironment and Immunotherapy
Han, Z., Li, Y.-B., Yang, L., Cheng, H., Liu, X., & Chen, H. (2021) · Molecules · doi:10.3390/molecules27010137 · Cited by 138 · see citing works
Mechanisms and biomarkers of cancer-associated thrombosis
Kim, A. S., Khorana, A. A., & McCrae, K. R. (2020) · Translational research · doi:10.1016/j.trsl.2020.06.012 · Cited by 136 · see citing works
Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target
Qian, W., Zhao, M., Wang, R., & Li, H. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01161-8 · Cited by 136 · see citing works
Innate immune mediators in cancer: between defense and resistance
Berraondo, P., Minute, L., Ajona, D., Corrales, L. P., Melero, I., & Pı́o, R. (2016) · Immunological Reviews · doi:10.1111/imr.12464 · Cited by 132 · see citing works
Self-citationOrtiz‐Espinosa, S., Morales, X., Senent, Y., Alignani, D., Tavira, B., Macaya, I., de Córdoba, B. R., Moreno, H., Remírez, A., Sainz, C., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.12.027 · Cited by 130 · see citing works
Self-citationHarnessing the chemokine system to home CAR-T cells into solid tumors
Foeng, J., Comerford, I., & McColl, S. R. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100543 · Cited by 127 · see citing works
The pro-inflammatory role of platelets in cancer
Olsson, A., & Cedervall, J. (2018) · Platelets · doi:10.1080/09537104.2018.1453059 · Cited by 126 · see citing works
CXCL8 in Tumor Biology and Its Implications for Clinical Translation
Xiong, X., Liao, X., Qiu, S., Xu, H., Zhang, S., Wang, S., Ai, J., & Yang, L. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.723846 · Cited by 124 · see citing works
Increased incidence of venous thromboembolism with cancer immunotherapy
Roopkumar, J., Swaidani, S., Kim, A. S., Thapa, B., Gervaso, L., Hobbs, B. P., Wei, W., Alban, T. J., Funchain, P., Kundu, S., et al. (2021) · Med · doi:10.1016/j.medj.2021.02.002 · Cited by 124 · see citing works
González-Aparicio, M., & Alfaro, C. (2019) · Journal of Immunology Research · doi:10.1155/2019/6252138 · Cited by 122 · see citing works
Self-citationShang, A., Gu, C., Zhou, C., Yang, Y., Chen, C., Zeng, B., Wu, J., Lu, W., Wang, W., Sun, Z., et al. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-0517-1 · Cited by 123 · see citing works
Tuning the Tumor Myeloid Microenvironment to Fight Cancer
Jahchan, N. S., Mujal, A. M., Pollack, J. L., Binnewies, M., Sriram, V., Reyno, L. M., & Krummel, M. F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01611 · Cited by 120 · see citing works
Platelets in the NETworks interweaving inflammation and thrombosis
Wienkamp, A.-K., Erpenbeck, L., & Rossaint, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.953129 · Cited by 118 · see citing works
Gut microbiota-mediated immunomodulation in tumor
Liu, X., Chen, Y., Zhang, S., & Dong, L. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01983-x · Cited by 112 · see citing works
Huang, M., Wu, R., Chen, L., Peng, Q., Li, S., Zhang, Y., Zhou, L., & Duan, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02243 · Cited by 113 · see citing works
Plasticity in Pro- and Anti-tumor Activity of Neutrophils: Shifting the Balance
Furumaya, C., Martínez-Sanz, P., Bouti, P., Kuijpers, T. W., & Matlung, H. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02100 · Cited by 113 · see citing works
Sacchi, A., Grassi, G., Bordoni, V., Lorenzini, P., Cimini, E., Casetti, R., Tartaglia, E., Marchioni, L., Petrosillo, N., Palmieri, F., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03125-1 · Cited by 115 · see citing works
Neutrophil Extracellular Traps, Angiogenesis and Cancer
Poto, R., Cristinziano, L., Modestino, L., de Paulis, A., Marone, G., Loffredo, S., Galdiero, M. R., & Varricchi, G. (2022) · Biomedicines · doi:10.3390/biomedicines10020431 · Cited by 115 · see citing works
In vivo evidence for extracellular DNA trap formation
Yousefi, S., Simon, D., Stojkov, D., Васильевна, К. А., Karaulov, A. V., & Simon, H. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2497-x · Cited by 111 · see citing works
Neutrophil Extracellular Traps in Colorectal Cancer Progression and Metastasis
Khan, U., Chowdhury, S., Billah, M. M., Islam, K. M. D., Thorlacius, H., & Rahman, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147260 · Cited by 108 · see citing works
Palangat, M., Anastasakis, D. G., Fei, D. L., Lindblad, K. E., Bradley, R. K., Hourigan, C. S., Hafner, M., & Larson, D. R. (2019) · Genes & Development · doi:10.1101/gad.319590.118 · Cited by 98 · see citing works
The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.09.001 · Cited by 100 · see citing works
de Andrea, C. E., Ochoa, M. C., Villalba-Esparza, M., Teijeira, Á., Schalper, K. A., Abengozar‐Muela, M., Eguren‐Santamaría, I., Sainz, C., Sánchez‐Gregorio, S., Garasa, S., et al. (2021) · The Journal of Pathology · doi:10.1002/path.5753 · Cited by 101 · see citing works
Self-citationConvergent inducers and effectors of T cell paralysis in the tumour microenvironment
Hanahan, D., Michielin, O. A., & Pittet, M. J. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00761-z · Cited by 106 · see citing works
Targeting myeloid-derived suppressor cells in tumor immunotherapy: Current, future and beyond
Zhao, Y., Du, J., & Shen, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1157537 · Cited by 103 · see citing works
Formation of Neutrophil Extracellular Traps under Low Oxygen Level
Branitzki‐Heinemann, K., Möllerherm, H., Völlger, L., Husein, D. M., de Buhr, N., Blodkamp, S., Reuner, F., Brogden, G., Naim, H. Y., & von Köckritz‐Blickwede, M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00518 · Cited by 99 · see citing works
Guan, X., Lu, Y., Zhu, H., Yu, S., Zhao, W., Chi, X., Xie, C., & Yin, Z. (2021) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s303588 · Cited by 97 · see citing works
Zalfa, C., & Paust, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.633205 · Cited by 95 · see citing works
Landscape of Myeloid-derived Suppressor Cell in Tumor Immunotherapy
Hao, Z., Li, R., Wang, Y., Li, S., Hong, Z., & Han, Z. (2021) · Biomarker Research · doi:10.1186/s40364-021-00333-5 · Cited by 94 · see citing works
Fang, Q., Stehr, A. M., Naschberger, E., Knopf, J., i, M. H., & Stürzl, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1075260 · Cited by 98 · see citing works
Infiltrating Myeloid Cells Exert Protumorigenic Actions via Neutrophil Elastase
Lerman, I., García-Hernández, M. D. L. L., Rangel‐Moreno, J., Chiriboga, L. A., Pan, C., Nastiuk, K. L., Krolewski, J. J., Sen, A., & Hammes, S. R. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0003 · Cited by 89 · see citing works
Bendib, I., de Chaisemartin, L., Granger, V., Schlemmer, F., Maître, B., Hüe, S., Surénaud, M., Beldi‐Ferchiou, A., Carteaux, G., Razazi, K., et al. (2019) · Anesthesiology · doi:10.1097/aln.0000000000002619 · Cited by 89 · see citing works
Cristinziano, L., Modestino, L., Loffredo, S., Varricchi, G., Braile, M., Ferrara, A. L., de Paulis, A., Antonelli, A., Marone, G., & Galdiero, M. R. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900543 · Cited by 88 · see citing works
The Resistance Mechanisms of Lung Cancer Immunotherapy
Wang, F., Wang, S., & Zhou, Q. H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.568059 · Cited by 88 · see citing works
Liu, S., Wu, W., Du, Y., Yin, H., Chen, Q., Yu, W., Wang, W., Yu, J., Liu, L., Lou, W., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01843-6 · Cited by 92 · see citing works
Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence
Salminen, A., Kauppinen, A., & Kaarniranta, K. (2018) · Biogerontology · doi:10.1007/s10522-018-9762-8 · Cited by 84 · see citing works
Cedervall, J., Dragomir, A., Saupe, F., Zhang, Y., Ärnlöv, J., Larsson, E., Dimberg, A., Larsson, A. O., & Olsson, A. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1320009 · Cited by 86 · see citing works
- Authors
- Alfaro, C., Teijeira, A., Oñate, C., Pérez, G., Sanmamed, M. F., Andueza, M. P., Alignani, D., Labiano, S., Azpilikueta, A., Rodriguez-Paulete, A., Garasa, S., Fusco, J. P., Aznar, A., Inogés, S., De Pizzol, M., Allegretti, M., Medina-Echeverz, J., Berraondo, P., Perez-Gracia, J. L., & Melero, I.
- Affiliations
- Clinica Universidad de Navarra (ES)
- 1Division of Gene Therapy and Hepatology, Centre for Applied Medical Research (CIMA), Pamplona, Spain.
- Centro de Investigación Médica Aplicada (ES)
- 5Dompé Farmaceutici SpA, L'Aquila, Italy.
- 2Department of Oncology, University Clinic of Navarra, Pamplona, Spain.
- ORCID
- Venue
- Clinical Cancer Research
- Published
- 2016-07-31
- Volume
- 22
- Issue
- 15
- Pages
- 3924-3936
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- OpenAlex
- W2298626553
- Cited by
- 417
- References
- 53
- Citations by year
- 2026: 35 · 2025: 33 · 2024: 44 · 2023: 54 · 2022: 54 · 2021: 59 · 2020: 46 · 2019: 35 · 2018: 22 · 2017: 21 · 2016: 13
- FWCI
- 18.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- interleukin-8, myeloid-derived suppressor cells, neutrophil extracellular traps, tumor microenvironment, chemotaxis, granulocytic MDSCs, monocytic MDSCs, T cell suppression, tumor immunosuppression, tumor-derived cytokines
- MeSH terms
- Myeloid-Derived Suppressor Cells, Animals, Chemotaxis, Leukocyte, Disease Models, Animal, Humans, Neoplasms, Neutrophils, Sulfonamides, Biomarkers, T-Lymphocyte Subsets, Interleukin-8, Mice, Knockout, Cell Line, Tumor, Mice, Extracellular Traps
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