The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Where is mTOR and what is it doing there?
Open accessAbstract
Target of rapamycin (TOR) forms two conserved, structurally distinct kinase complexes termed TOR complex 1 (TORC1) and TORC2. Each complex phosphorylates a different set of substrates to regulate cell growth. In mammals, mTOR is stimulated by nutrients and growth factors and inhibited by stress to ensure that cells grow only during favorable conditions. Studies in different organisms have reported localization of TOR to several distinct subcellular compartments. Notably, the finding that mTORC1 is localized to the lysosome has significantly enhanced our understanding of mTORC1 regulation. Subcellular localization may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.
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Citations
Cites
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“Zoncu et al. (2011) have proposed that amino acids are sensed in the lumen of the lysosome via the v-ATPase, which then activates Rag via Ragulator and possibly the recently described Rag GAPs (Bar-Peled et al., 2013; Panchaud et al., 2013; Petit et al., 2013; Tsun et al., 2013).”
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Self-citationAn Ancient, Unified Mechanism for Metformin Growth Inhibition in C. Elegans and Cancer
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Metadata
- Authors
- Betz, C., & Hall, M. N.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2013-11-25
- Volume
- 203
- Issue
- 4
- Pages
- 563-574
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2117002197
- Cited by
- 527
- References
- 25
- FWCI
- 18.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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