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Plasmodium falciparum Associated with Severe Childhood Malaria Preferentially Expresses PfEMP1 Encoded by Group A var Genes

Open access
Jensen, Anja T.R., Magistrado, Pamela, Sharp, Sarah, Joergensen, Louise, Lavstsen, Thomas, Chiucchiuini, Antonella, Salanti, Ali, Vestergaard, Lasse S., Lusingu, John P., Hermsen, Rob, Sauerwein, Robert, Christensen, Jesper, Nielsen, Morten A., Hviid, Lars, Sutherland, Colin, Staalsoe, Trine, Theander, Thor G.·2004·The Journal of Experimental Medicine
DOI 10.1084/jem.20040274
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Abstract

Parasite-encoded variant surface antigens (VSAs) like the var gene–encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family are responsible for antigenic variation and infected red blood cell (RBC) cytoadhesion in P. falciparum malaria. Parasites causing severe malaria in nonimmune patients tend to express a restricted subset of VSA (VSASM) that differs from VSA associated with uncomplicated malaria and asymptomatic infection (VSAUM). We compared var gene transcription in unselected P. falciparum clone 3D7 expressing VSAUM to in vitro–selected sublines expressing VSASM to identify PfEMP1 responsible for the VSASM phenotype. Expression of VSASM was accompanied by up-regulation of Group A var genes. The most prominently up-regulated Group A gene (PFD1235w/MAL7P1.1) was translated into a protein expressed on the infected RBC surface. The proteins encoded by Group A var genes, such as PFD1235w/MAL7P1.1, appear to be involved in the pathogenesis of severe disease and are thus attractive candidates for a vaccine against life-threatening P. falciparum malaria.

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Metadata

Authors
Jensen, A. T. R., Magistrado, P., Sharp, S., Joergensen, L., Lavstsen, T., Chiucchiuini, A., Salanti, A., Vestergaard, L. S., Lusingu, J. P., Hermsen, R., Sauerwein, R., Christensen, J., Nielsen, M. A., Hviid, L., Sutherland, C., Staalsoe, T., & Theander, T. G.
Venue
The Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
2004-05-03
Volume
199
Issue
9
Pages
1179-1190
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.20040274
OpenAlex
W2103171514
Cited by
322
References
5
FWCI
22.66
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Plasmodium falciparum Associated with Severe Childhood Malaria Preferentially Expresses PfEMP1 Encoded by Group A var Genes. https://app.cochat.ai/papers/10.1084/jem.20040274
The paper
Jensen, A. T. R., Magistrado, P., Sharp, S., Joergensen, L., Lavstsen, T., Chiucchiuini, A., Salanti, A., Vestergaard, L. S., Lusingu, J. P., Hermsen, R., Sauerwein, R., Christensen, J., Nielsen, M. A., Hviid, L., Sutherland, C., Staalsoe, T., & Theander, T. G. (2004). Plasmodium falciparum Associated with Severe Childhood Malaria Preferentially Expresses PfEMP1 Encoded by Group A var Genes. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20040274

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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