Cited by 422Chemokine receptors and signalingImmune cells in cancerImmune Response and Inflammation

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

Open access

Auffray, Cedric, Fogg, Darin K., Narni-Mancinelli, Emilie, Senechal, Brigitte, Trouillet, Celine, Saederup, Noah, Leemput, Julia, Bigot, Karine, Campisi, Laura, Abitbol, Marc, Molina, Thierry, Charo, Israel, Hume, David A., Cumano, Ana, Lauvau, Gregoire, Geissmann, Frederic·2009·Journal of Experimental Medicine

DOI 10.1084/jem.20081385PMC PMC2699130

Open this paper in CoChat — free account Open PDF

Abstract

CX3CR1 expression is associated with the commitment of CSF-1R+ myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R+ CX3CR1+ macrophage/DC precursor (MDP) with other DC precursors and the role of CX3CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1+ inflammatory monocytes that differentiate into TipDCs during infection. CX3CR1 deficiency selectively impairs the recruitment of blood Gr1+ monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1084/jem.20081385

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,486
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
Self-citation
Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature · doi:10.1038/35004599 · Cited by 2,617
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
Mouse and human dendritic cell subtypes
Shortman, K., & Liu, Y.-J. (2002) · Nature reviews. Immunology · doi:10.1038/nri746 · Cited by 2,289
Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior
Auffray, C., Fogg, D., Garfa, M., Elain, G., Join-Lambert, O., Kayal, S., Sarnacki, S., Cumano, A., Lauvau, G., & Geissmann, F. (2007) · Science · doi:10.1126/science.1142883 · Cited by 1,973
Self-citation
Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
Serbina, N. V., & Pamer, E. G. (2006) · Nature Immunology · doi:10.1038/ni1309 · Cited by 1,658
Control of microglial neurotoxicity by the fractalkine receptor
Cardona, A. E., Pioro, E. P., Sasse, M. E., Kostenko, V., Cardona, S. M., Dijkstra, I. M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1715 · Cited by 1,531
Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion
Imai, T., Hieshima, K., Haskell, C. A., Baba, M., Nagira, M., Nishimura, M., Kakizaki, M., Takagi, S., Nomiyama, H., Schall, T. J., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80438-9 · Cited by 1,472

Flagged first, then by citations

Show all 50 references

Sorted by citations

Items 201–300 of 419

Origin and development of classical dendritic cells
Guermonprez, P., Gerber-Ferder, Y., Vaivode, K., Bourdely, P., & Helft, J. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.08.002 · Cited by 39
Inflammatory mechanisms in atherosclerosis
Wolf, D., Stachon, P., Bode, C., & Zirlik, A. (2013) · Hämostaseologie · doi:10.5482/hamo-13-09-0050 · Cited by 38
The chemokine receptor CX3CR1 coordinates monocyte recruitment and endothelial regeneration after arterial injury
Getzin, T., Krishnasamy, K., Gamrekelashvili, J., Kapanadze, T. G., Limbourg, A., Häger, C., Napp, L. C., Bauersachs, J. K., Haller, H. G., & Limbourg, F. P. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201707502 · Cited by 41
Microparticles derived from obese adipose tissue elicit a pro-inflammatory phenotype of CD16 + , CCR5 + and TLR8 + monocytes
Renovato‐Martins, M., Matheus, M. E., Ramos-Andrade, I., Moraes, J. A., da Silva, S. V., dos Reis, M. C., de Souza, A. A. P., da Silva, C. C., Bouskela, E., & Barja‐Fidalgo, C. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.09.016 · Cited by 38
Isolation and Analysis of Mouse Microglial Cells
Garcia, J. A., Cardona, S. M., & Cardona, A. E. (2014) · Current Protocols in Immunology · doi:10.1002/0471142735.im1435s104 · Cited by 37
Sex differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE)
Jiang, W., & Gilkeson, G. S. (2014) · Journal of Immunotherapy Applications · doi:10.7243/2055-2394-1-1 · Cited by 37
Macrophages in Skeletal Muscle Dystrophies, An Entangled Partner
Théret, M., Saclier, M., Messina, G., & Rossi, F. M. V. (2021) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-210737 · Cited by 41
Clec9a-Mediated Ablation of Conventional Dendritic Cells Suggests a Lymphoid Path to Generating Dendritic Cells In Vivo
Salvermoser, J., van Blijswijk, J., Papaioannou, N. E., Rambichler, S., Pásztói, M., Pakalniškytė, D., Rogers, N. C., Keppler, S. J., Straub, T., Sousa, C. R. E., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00699 · Cited by 39
T Cell CX3CR1 Mediates Excess Atherosclerotic Inflammation in Renal Impairment
Dong, L., Nordlohne, J., Ge, S., Hertel, B., Melk, A., Rong, S., Haller, H. G., & von Vietinghoff, S. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015050540 · Cited by 36
G Protein Signaling Modulator-3 Inhibits the Inflammasome Activity of NLRP3
Giguère, P. M., Gall, B., Ezekwe, E., Laroche, G., Buckley, B. K., Kébaïer, C., Wilson, J. E., Ting, J. P. ‐., Siderovski, D. P., & Duncan, J. A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.578393 · Cited by 35
Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity
Boroumand, P., Prescott, D., Mukherjee, T., Bilan, P. J., Wong, M. D., Shen, J., Tattoli, I., Zhou, Y., Li, A., Sivasubramaniyam, T., et al. (2022) · eLife · doi:10.7554/elife.65553 · Cited by 35
The crosstalk between macrophages and bone marrow mesenchymal stem cells in bone healing
Wang, Y., Zhao, C., Wang, R.-Y., Du, Q.-X., Liu, J., & Pan, J. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03199-y · Cited by 35
Memory CD8(+) T Cells: Innate-Like Sensors and Orchestrators of Protection
Lauvau, G., Boutet, M., Williams, T. M., Chin, S. S., & Chorro, L. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.04.001 · Cited by 35
Self-citation
Recent advances in understanding dendritic cell development, classification, and phenotype
Schlitzer, A., Zhang, W., Song, M. L., & Ma, X. (2018) · F1000Research · doi:10.12688/f1000research.14793.1 · Cited by 36
Isolation and Intravenous Injection of Murine Bone Marrow Derived Monocytes
Wagner, M., Koester, H., Deffge, C., Weinert, S., Lauf, J., Francke, A., Lee, J. C., Dullaeus, R. C. B., & Herold, J. (2014) · Journal of Visualized Experiments · doi:10.3791/52347 · Cited by 34
Chemokine receptor CX3CR1 promotes dendritic cell development under steady‐state conditions
Łyszkiewicz, M., Witzlau, K., Pommerencke, J., & Krueger, A. (2011) · European Journal of Immunology · doi:10.1002/eji.201040977 · Cited by 34
Plenary Perspective: The complexity of constitutive and inducible gene expression in mononuclear phagocytes
Hume, D. A. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0312166 · Cited by 37
Self-citation
IL-6 contributes to metastatic switch via the differentiation of monocytic-dendritic progenitors into prometastatic immune cells
Magidey, K., Cooper, T. J., Kveler, K., Normand, R., Zhang, T., Timaner, M., Raviv, Z., James, B. P., Gazit, R., Ronai, Z. A., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002856 · Cited by 34
Amelioration of Experimental Autoimmune Encephalomyelitis by the Quinoline-3-Carboxamide Paquinimod
Helmersson, S., Sundstedt, A., Deronic, A., Leanderson, T., & Ivars, F. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.01.032 · Cited by 33
The Spatial and Developmental Relationships in the Macrophage Family
Świrski, F. K. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.221150 · Cited by 33
IL-6 selectively suppresses cDC1 specification via C/EBPβ
Kim, S. K., Chen, J., Jo, S., Ou, F., Ferris, S. T., Liu, T., Ohara, R. A., Anderson, D. A., Wu, R., Chen, M., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221757 · Cited by 32
Transplacental immune modulation with a bacterial-derived agent protects against allergic airway inflammation
Mincham, K. T., Scott, N. M., Lauzon‐Joset, J., Leffler, J., Larcombe, A. N., Stumbles, P. A., Robertson, S. A., Pasquali, C., Holt, P. G., & Strickland, D. H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci122631 · Cited by 32
The Role of Angiogenesis and Arteriogenesis in Myocardial Infarction and Coronary Revascularization
Spadaccio, C., Nenna, A., Rose, D., Piccirillo, F., Nusca, A., Grigioni, F., Chello, M., & Vlahakes, G. J. (2022) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-022-10241-0 · Cited by 32
Dendritic Cells and Their Immunotherapeutic Potential for Treating Type 1 Diabetes
Khan, F. U., Khongorzul, P., Raki, A. A., Rajasekaran, A., Gris, D., & Amrani, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094885 · Cited by 32
A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation
Ralvenius, W. T., Mungenast, A. E., Woolf, H., Huston, M. M., Gillingham, T. Z., Godin, S. K., Penney, J., Cam, H. P., Gao, F., Fernandez, C. G., et al. (2023) · Journal of Experimental Medicine · doi:10.1084/jem.20222105 · Cited by 29
“Thus, we crossed CK-p25 mice with CX 3 CR 1 :CreERT2:PU.1 fl/fl mice to enable conditional ablation of the PU.1 gene in a majority of myeloid cells, including most microglia (Auffray et al., 2009; Wolf et al., 2013), through induction of Cre expression.”
Reparative System Arising from CCR2(+) Monocyte Conversion Attenuates Neuroinflammation Following Ischemic Stroke
Park, J., Kim, J. Y., Kim, Y. R., Huang, M., Chang, J. Y., Sim, A. Y., Jung, H., Lee, W. T., Hyun, Y., & Lee, J. E. (2021) · Translational Stroke Research · doi:10.1007/s12975-020-00878-x · Cited by 32
Unravelling monocyte functions: from the guardians of health to the regulators of disease
Mildner, A., Kim, K.-W., & Yona, S. (2024) · Discovery Immunology · doi:10.1093/discim/kyae014 · Cited by 35
Heterogeneity of Microglia Phenotypes: Developmental, Functional and Some Therapeutic Considerations
Yuan, Y., Wu, C., & Ling, E. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190722114248 · Cited by 31
High MafB expression following burn augments monocyte commitment and inhibits DC differentiation in hemopoietic progenitors
Howell, K., Posluszny, J. A., He, L.-K., Szilágyi, A., Halerz, J., Gamelli, R. L., Shankar, R., & Muthu, K. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0711338 · Cited by 30
Variety matters: Diverse functions of monocyte subtypes in vascular inflammation and atherogenesis
Vlacil, A.-K., Schuett, J., Schieffer, B., & Grote, K. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.12.002 · Cited by 29
Upregulation of type 1 conventional dendritic cells implicates antigen cross-presentation in multisystem inflammatory syndrome
Huang, J. J., Gaines, S. B., Amezcua, M. L., Lubell, T. R., Dayan, P. S., Dale, M., Boneparth, A. D., Hicar, M. D., WINCHESTER, R. J., & Gorelik, M. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.10.015 · Cited by 29
A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice
Ovchinnikov, D. A., DeBats, C. E. E., Sester, D. P., Sweet, M. J., & Hume, D. A. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809557 · Cited by 29
Self-citation
The diverse roles of monocytes in inflammation caused by protozoan parasitic diseases
Sheel, M., & Engwerda, C. R. (2012) · Trends in Parasitology · doi:10.1016/j.pt.2012.07.008 · Cited by 28
Distinct CCR2+Gr1+Cells Control Growth of theYersinia pestisΔyopMMutant in Liver and Spleen during Systemic Plague
Ye, Z., Uittenbogaard, A., Cohen, D. A., Kaplan, A. M., Ambati, J., & Straley, S. C. (2010) · Infection and Immunity · doi:10.1128/iai.00808-10 · Cited by 27
Analyses of Microglia Effector Function Using CX3CR1-GFP Knock-In Mice
Garcia, J. A., Cardona, S. M., & Cardona, A. E. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-520-0_27 · Cited by 27
Transcription factors TCF4 and KLF4 respectively control the development of the DC2A and DC2B lineages
Zhu, Y., Cai, P., Li, Z., Zhang, S., Kong, W. T., Wang, H., Gao, F., Zeng, Y., Qian, J., Su, B., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02208-5 · Cited by 26
Monocyte function and trafficking in cardiovascular disease
Pardali, E., & Waltenberger, J. L. (2012) · Thrombosis and Haemostasis · doi:10.1160/th12-04-0276 · Cited by 26
Transcription factor C/EBPα is required for the development of Ly6C hi monocytes but not Ly6C lo monocytes
Kim, S. K., Chen, J., Ou, F., Liu, T., Jo, S., Gillanders, W. E., Murphy, T. L., & MURPHY, K. M. M. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315659121 · Cited by 24
Acute resistance training affects cell surface markers for apoptosis and migration in CD4+ and CD8+ lymphocytes
Pereira, G. B., Prestes, J., Tibana, R. A., Shiguemoto, G. E., Navalta, J. W., & Perez, S. (2012) · Cellular Immunology · doi:10.1016/j.cellimm.2012.11.002 · Cited by 24
Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer's disease
Salazar, A., Osse, A. M. L., Ortiz, A. A., Murtishaw, A. S., & Kinney, J. W. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.10.013 · Cited by 26
Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis
Thierry, G. R., Baudon, É. M., Bijnen, M., Bellomo, A., Lagueyrie, M., Mondor, I., Simonnet, L., Carrette, F., Fenouil, R., Keshvari, S., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.07.005 · Cited by 27
Self-citation
Tumor necrosis factor drives increased splenic monopoiesis in old mice
Loukov, D., Naidoo, A., Puchta, A., Marin, J. L. A., & Bowdish, D. M. E. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ma0915-433rr · Cited by 26
Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies
Zhang, G., Yao, Q., Long, C., Yi, P., Song, J., Wu, L., Wan, W., Rao, X., Lin, Y., Wei, G., et al. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01508 · Cited by 25
Classical monocyte ontogeny dictates their functions and fates as tissue macrophages
Trzebanski, S., Kim, J.-S., Larossi, N., Raanan, A., Kancheva, D., Bastos, J., Haddad, M., Solomon, A., Sivan, E., Aizik, D., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.06.011 · Cited by 23
PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia
Wang, T., Zhou, Y., Fan, Y., Duan, H., Guo, X., Chang, J., Jiang, Y., Li, C., Zhang, F., Gao, Y., et al. (2023) · Advanced Science · doi:10.1002/advs.202205949 · Cited by 23
Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling
Frías-Anaya, E., Gallego-Gutiérrez, H., Gongol, B., Weinsheimer, S., Lai, C. C., Orecchioni, M., Sriram, A., Bui, C., Nelsen, B., Hale, P., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.320367 · Cited by 23
Sleep enhances numbers and function of monocytes and improves bacterial infection outcome in mice
Hahn, J. K., Günter, M., Schuhmacher, J., Bieber, K., Pöschel, S., Schütz, M., Engelhardt, B., Oster, H., Sina, C., Lange, T., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.01.001 · Cited by 23
Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta
Williamson, A. E., Liyanage, S., Hassanshahi, M., Dona, M. S. I., Toledo‐Flores, D., Tran, D. X. A., Dimasi, C. G., Schwarz, N., Fernando, S., Salagaras, T., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51637-7 · Cited by 22
Regulation of Macrophage and Dendritic Cell Responses by Their Lineage Precursors
Cortez‐Retamozo, V., Etzrodt, M., & Pittet, M. J. (2012) · Journal of Innate Immunity · doi:10.1159/000335733 · Cited by 22
Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion
Li, M. M. H., Bozzacco, L., Hoffmann, H.-H., Breton, G., Loschko, J., Xiao, J., Monette, S., Rice, C. M., & MacDonald, M. R. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160303 · Cited by 22
Models of dendritic cell development correlate ontogeny with function
Anderson, D. A., & MURPHY, K. M. M. (2019) · Advances in immunology · doi:10.1016/bs.ai.2019.09.001 · Cited by 22
Transplacental Innate Immune Training via Maternal Microbial Exposure: Role of XBP1-ERN1 Axis in Dendritic Cell Precursor Programming
Mincham, K. T., Jones, A. C., Bodinier, M., Scott, N. M., Lauzon‐Joset, J., Stumbles, P. A., Bosco, A., Holt, P. G., & Strickland, D. H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.601494 · Cited by 23
Renal Mononuclear Phagocytes in Lupus Nephritis
Davidson, A. (2021) · ACR Open Rheumatology · doi:10.1002/acr2.11269 · Cited by 22
A method for the isolation and purification of mouse peripheral blood monocytes
Houthuys, E., Movahedi, K., BAETSELIER, P. D., Ginderachter, J. A. V., & Brouckaert, P. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2010.04.004 · Cited by 22
Understanding the Cellular Origin of the Mononuclear Phagocyte System Sheds Light on the Myeloid Postulate of Immune Paralysis in Sepsis
Poulin, L. F., Lasseaux, C., & Chamaillard, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00823 · Cited by 23
Intravenous Infusion of Monocytes Isolated from 2-Week-Old Mice Enhances Clearance of Beta-Amyloid Plaques in an Alzheimer Mouse Model
Hohsfield, L. A., & Humpel, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121930 · Cited by 21
Hematopoietic Stem Cell Molecular Targets and Factors Essential for Hematopoiesis
Raghav, P. K., & Gangenahalli, G. U. (2018) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.1000441 · Cited by 22
Cellular biodistribution of polymeric nanoparticles in the immune system
Yang, Y., & Luo, W.-H. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.011 · Cited by 21
The quest for faithful in vitro models of human dendritic cells types
Luo, X., & Dalod, M. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.04.018 · Cited by 21
Numbers and phenotype of non-classical CD14dimCD16+ monocytes are predictors of adverse clinical outcome in patients with coronary artery disease and severe SARS-CoV-2 infection
Mueller, K. A. L., Langnau, C., Günter, M., Pöschel, S., Gekeler, S., Petersen-Uribe, Á., Kreißelmeier, K., Klingel, K., Bösmüller, H. C., Li, B., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa328 · Cited by 20
CX3CR1 is a prerequisite for the development of cardiac hypertrophy and left ventricular dysfunction in mice upon transverse aortic constriction
Weisheit, C. K., Kleiner, J. L., Rodrigo, M. B., Niepmann, S. T., Zimmer, S., Duerr, G. D., Coburn, M., Kurts, C., Frede, S., & Eichhorn, L. (2021) · PLoS ONE · doi:10.1371/journal.pone.0243788 · Cited by 20
Terminal Differentiation of Dendritic Cells
Seillet, C., & Belz, G. T. (2013) · Advances in immunology · doi:10.1016/b978-0-12-417028-5.00007-7 · Cited by 25
Loss of TNF Signaling Facilitates the Development of a Novel Ly-6Clow Macrophage Population Permissive for Leishmania major Infection
Fromm, P. D., Kling, J. C., Mack, M., Sedgwick, J. D., & Körner, H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1100977 · Cited by 20
Role of Inflammatory Monocytes in Vaccine-Induced Reduction of Helicobacter felis Infection
Moyat, M., Mack, M., Bouzourène, H., & Velin, D. (2015) · Infection and Immunity · doi:10.1128/iai.01026-15 · Cited by 19
Shared Transcriptional Control of Innate Lymphoid Cell and Dendritic Cell Development
Bagadia, P., Huang, X., Liu, T., & MURPHY, K. M. M. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125403 · Cited by 19
Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity
Hams, E., Roberts, J., Bermingham, R., Hogan, A. E., O'Shea, D. B., O'Neill, L. A. J., & Fallon, P. G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01966 · Cited by 20
Novel population of human monocyte and osteoclast progenitors from pluripotent stem cells and peripheral blood
Root, S. H., & Aguila, H. L. (2021) · Blood Advances · doi:10.1182/bloodadvances.2021004552 · Cited by 19
Dendritic cell lineage commitment is instructed by distinct cytokine signals
Seré, K. M., Lin, Q., Felker, P., Rehage, N., Klisch, T., Ortseifer, I., Hieronymus, T., Rose‐John, S., & Zenke, M. (2011) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2011.09.007 · Cited by 19
Immunobiology of Dendritic Cells and the Influence of HIV Infection
Cunningham, A. L., Harman, A. N., Kim, M., Nasr, N., & Lai, J. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4433-6_1 · Cited by 20
Hyaluronan Binding Identifies a Functionally Distinct Alveolar Macrophage–like Population in Bone Marrow–Derived Dendritic Cell Cultures
Poon, G. F. T., Dong, Y., Marshall, K. C., Arif, A., Deeg, C., Dosanjh, M., & Johnson, P. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402506 · Cited by 18
Détergents: Triton X-100, Tween-20, et autres
Johnson, M. (2013) · Materials and Methods · doi:10.13070/mm.fr.3.163 · Cited by 18
Cryopreservation of primary human monocytes does not negatively affect their functionality or their ability to be labelled with radionuclides: basis for molecular imaging and cell therapy
Pardali, E., Schmitz, T., Borgscheiper, A., Iking, J., Stegger, L., & Waltenberger, J. L. (2016) · EJNMMI Research · doi:10.1186/s13550-016-0232-5 · Cited by 18
Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy
Sirkis, D. W., Solsberg, C. W., Johnson, T. P., Bonham, L. W., Sturm, V. E., Lee, S. E., Rankin, K. P., Rosen, H. J., Boxer, A. L., Seeley, W. W., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01205-3 · Cited by 19
Expression of C-type lectin, SIGNR3, on subsets of dendritic cells, macrophages, and monocytes
Nagaoka, K., Takahara, K., Minamino, K., Takeda, T., Yoshida, Y., & Inaba, K. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0510251 · Cited by 17
Indispensable Role of CX3CR1+ Dendritic Cells in Regulation of Virus-Induced Neuroinflammation Through Rapid Development of Antiviral Immunity in Peripheral Lymphoid Tissues
Choi, J., Kim, J. H., Hossain, F. M. A., Uyangaa, E., Park, S. O., Kim, B., Kim, K., & Eo, S. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01467 · Cited by 17
Corticosterone-Mediated Body Weight Loss Is an Important Catabolic Process for Poststroke Immunity and Survival
Yang, J., Kim, E., Beltran, C., & Cho, S. (2019) · Stroke · doi:10.1161/strokeaha.119.026053 · Cited by 17
CX3CR1 is critical for Salmonella-induced migration of dendritic cells into the intestinal lumen
Nicoletti, C., Arqués, J. L., & Bertelli, E. (2010) · Gut Microbes · doi:10.4161/gmic.1.3.11711 · Cited by 17
Tight Control of STAT5 Activity Determines Human CD34-Derived Interstitial Dendritic Cell and Langerhans Cell Development
van de Laar, L., van den Bosch, A., Wierenga, A. T. J., Janssen, H. L. A., Coffer, P. J., & Woltman, A. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003977 · Cited by 16
The role of monocytes in models of infection by protozoan parasites
Hu, S., Wei, W., & Körner, H. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.06.020 · Cited by 17
CX3CR1 delineates temporally and functionally distinct subsets of myeloid‐derived suppressor cells in a mouse model of ovarian cancer
Hart, K. M., Usherwood, E. J., & Berwin, B. L. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.13 · Cited by 15
Analysis of the developmental stages, kinetics, and phenotypes exhibited by myeloid cells driven by GM-CSF in vitro
Rogers, P. B., Driessnack, M. G., & Schwartz, E. H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181985 · Cited by 15
Plasmacytoid dendritic cells: Biomarkers or potential therapeutic targets in atherosclerosis?
Grassia, G., MacRitchie, N. A., Platt, A. M., Brewer, J. M., Garside, P., & Maffia, P. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.10.001 · Cited by 16
Inflammatory cells dynamics control neovascularization and tissue healing after localized radiation induced injury in mice
Loinard, C., Benadjaoud, M. A., L’Homme, B., Flamant, S., Baijer, J., & Tamarat, R. (2023) · Communications Biology · doi:10.1038/s42003-023-04939-3 · Cited by 14
Bone marrow chimeric mice reveal a role for CX3CR1 in maintenance of the monocyte-derived cell population in the olfactory neuroepithelium
Vukovic, J., Blomster, L. V., Chinnery, H. R., Weninger, W., Jung, S., McMenamin, P. G., & Ruitenberg, M. J. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0410194 · Cited by 14
Cord-Blood-Stem-Cell-Derived Conventional Dendritic Cells Specifically Originate from CD115-Expressing Precursors
Plantinga, M., de Haar, C. G., Dünnebach, E., van den Beemt, D. A. M. H., Bloemenkamp, K. W. M., Mokrý, M., Boelens, J. J., & Nierkens, S. (2019) · Cancers · doi:10.3390/cancers11020181 · Cited by 14
The need to identify myeloid dendritic cell progenitors in human blood
Mortellaro, A., Wong, S. C., Frič, J., & Ricciardi‐Castagnoli, P. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.09.010 · Cited by 13
Fate‐mapping studies in inbred mice: A model for understanding macrophage development and homeostasis?
Hume, D. A. (2023) · European Journal of Immunology · doi:10.1002/eji.202250242 · Cited by 14
Self-citation
Intestinal Mononuclear Phagocytes in Health and Disease
Sanders, T. J., Yrlid, U., & Maloy, K. J. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0047-2016 · Cited by 13
Monocyte subsets and monocyte-related chemokines in Takayasu arteritis
de Aguiar, M. F., Torquato, H. F. V., Salu, B. R., Oliveira, A. C. D., Oliva, M. L. V., Paredes‐Gamero, E. J., Abdulahad, W. H., Brouwer, E., & de Souza, A. W. S. (2023) · Scientific Reports · doi:10.1038/s41598-023-29369-3 · Cited by 12
Monocytes/Macrophages Mobilization Orchestrate Neovascularization after Localized Colorectal Irradiation
Loinard, C., Vilar, J., Milliat, F., Levy, B. I., & Benderitter, M. (2017) · Radiation Research · doi:10.1667/rr14398.1 · Cited by 12
Endoplasmic Reticulum-Associated Degradation-Dependent Processing in Cross-Presentation and Its Potential for Dendritic Cell Vaccinations: A Review
Imai, J., Ohashi, S., & Sakai, T. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020153 · Cited by 12
Salmonella inhibits monocyte differentiation into CD11chiMHC-IIhi cells in a MyD88-dependent fashion
Rydström, A., & Wick, M. J. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0909615 · Cited by 11
What are CX3CR1+mononuclear cells in the intestinal mucosa?
Niess, J. H. (2010) · Gut Microbes · doi:10.4161/gmic.1.6.13939 · Cited by 11
The dynamics of monocytes in the process of collateralization
Liao, L., & Bai, Y. (2019) · Aging Medicine · doi:10.1002/agm2.12054 · Cited by 10
Reactive Oxygen and Nitrogen Species and Liver Ischemia-Reperfusion Injury: An Overview
Alban, F. T. E., Gyamfi, D., van Golen, R. F., & Heger, M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-803951-9.00008-2 · Cited by 11
Distinct Subcellular Compartments of Dendritic Cells Used for Cross-Presentation
Imai, J., Otani, M., & Sakai, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225606 · Cited by 11
Inflammatory status of transmigrating primary rat monocytes in a novel perfusion model simulating blood flow
Hohsfield, L. A., Ammann, C. G., & Humpel, C. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.02.005 · Cited by 10
Macrophages in Kidney Injury and Repair
Lin, S., & Duffield, J. S. (2012) · Acta Nephrologica · doi:10.6221/an.2012009 · Cited by 9
Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow
Yáñez, A., & Goodridge, H. S. (2018) · Journal of Visualized Experiments · doi:10.3791/58061 · Cited by 9
MCSF drives regulatory DC development in stromal co-cultures supporting hematopoiesis
Petvises, S., Periasamy, P., & O'Neill, H. C. (2018) · BMC Immunology · doi:10.1186/s12865-018-0255-y · Cited by 9

Authors: Auffray, C., Fogg, D. K., Narni-Mancinelli, E., Senechal, B., Trouillet, C., Saederup, N., Leemput, J., Bigot, K., Campisi, L., Abitbol, M., Molina, T., Charo, I., Hume, D. A., Cumano, A., Lauvau, G., & Geissmann, F.
Affiliations: Laboratory of Biology of the Mononuclear Phagocyte System, Institut National de la Santé et de la Recherche Médicale (INSERM) U838, Université Paris-Descartes, 75015 Paris, France 1
Inserm (FR)
INSERM U924, Université de Nice-Sophia Antipolis, 06560 Valbonne, France 2
University of California, San Francisco (US)
Université Paris Descartes (FR)
Roslin Institute (GB)
ORCID: Leemput, Julia
Campisi, Laura
Abitbol, Marc
Molina, Thierry
Hume, David A.
Cumano, Ana
Lauvau, Gregoire
Venue: Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 2009-03-09
Volume: 206
Issue: 3
Pages: 595-606
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.20081385
PMC: PMC2699130
OpenAlex: W2142750845
Cited by: 422
References: 50
Citations by year: 2026: 4 · 2025: 7 · 2024: 14 · 2023: 17 · 2022: 16 · 2021: 21 · 2020: 17 · 2019: 26 · 2018: 21 · 2017: 28 · 2016: 32 · 2015: 24 · 2014: 33 · 2013: 43 · 2012: 36
FWCI: 19.67
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
HAL (submittedVersion, other-oa)
Research Portal (King's College London) (submittedVersion)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: CX3CR1, CSF1R, myeloid dendritic cells, plasmacytoid dendritic cells, monocytes, Listeria monocytogenes infection, monocyte recruitment, spleen, inflammation, myeloid development
MeSH terms: CX3C Chemokine Receptor 1, Animals, Bone Marrow Cells, Cell Differentiation, Cell Movement, Cell Survival, Dendritic Cells, Inflammation, Listeriosis, Listeria monocytogenes, Macrophages, Monocytes, Phenotype, Spleen, Stem Cells, Tumor Necrosis Factor-alpha, Receptor, Macrophage Colony-Stimulating Factor, Reactive Oxygen Species, Receptors, Chemokine, Cell Proliferation, Mice, fms-Like Tyrosine Kinase 3, Nitric Oxide Synthase Type II

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks