The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
Open accessAbstract
Macrophages (Mϕ) are prominent components of solid tumors and exhibit distinct phenotypes in different microenvironments. We have recently found that tumors can alter the normal developmental process of Mϕ to trigger transient activation of monocytes in peritumoral stroma. We showed that a fraction of monocytes/Mϕ in peritumoral stroma, but not in cancer nests, expresses surface PD-L1 (also termed B7-H1) molecules in tumors from patients with hepatocellular carcinoma (HCC). Monocytes activated by tumors strongly express PD-L1 proteins with kinetics similar to their activation status, and significant correlations were found between the levels of PD-L1+ and HLA-DRhigh on tumor-infiltrating monocytes. Autocrine tumor necrosis factor α and interleukin 10 released from activated monocytes stimulated monocyte expression of PD-L1. The PD-L1+ monocytes effectively suppressed tumor-specific T cell immunity and contributed to the growth of human tumors in vivo; the effect could be reversed by blocking PD-L1 on those monocytes. Moreover, we found that PD-L1 expression on tumor-infiltrating monocytes increased with disease progression, and the intensity of the protein was associated with high mortality and reduced survival in the HCC patients. Thus, expression of PD-L1 on activated monocytes/Mϕ may represent a novel mechanism that links the proinflammatory response to immune tolerance in the tumor milieu.
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Cites
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Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
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Ido expression by dendritic cells: tolerance and tryptophan catabolism
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Regulation of lung injury and repair by Toll-like receptors and hyaluronan
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Cited by
The blockade of immune checkpoints in cancer immunotherapy
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Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
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Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
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“Similarly, monocytes from patients with hepatocellular carcinoma express PD-L1 that contributes to human tumor xenograft growth in vivo, while the blocking of PD-L1 reverses this effect (Kuang et al., 2009).”
BackgroundMacrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
Metadata
- Authors
- Kuang, D.-M., Zhao, Q., Peng, C., Xu, J., Zhang, J.-P., Wu, C., & Zheng, L.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2009-05-18
- Volume
- 206
- Issue
- 6
- Pages
- 1327-1337
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2111161262
- Cited by
- 903
- References
- 12
- FWCI
- 9.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kuang, D.-M., Zhao, Q., Peng, C., Xu, J., Zhang, J.-P., Wu, C., & Zheng, L. (2009). Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20082173
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